scholarly journals Population characteristics of colorectal cancer in the Ulyanovsk region according to the regional cancer register

2021 ◽  
Vol 20 (2) ◽  
pp. 97-104
Author(s):  
I. A. Bogomolova ◽  
I. I. Antoneeva ◽  
T. V. Abakumova ◽  
T. P. Gening
Keyword(s):  
Colorectal Cancer ◽  
Adult Population ◽  
Incidence Rates ◽  
Population Characteristics ◽  
Female Ratio ◽  
Cancer Register ◽  
Male Female Ratio ◽  
Ulyanovsk Region ◽  
Regional Population ◽  
Poorly Differentiated

Aim: to analyze the structure and changes of colorectal cancer (CRC) epidemiology in the Ulyanovsk region in 2005–2019 according to the regional cancer register.Materials and methods: the study is based on statistical data on the primary detection of CRC in the districts of the Ulyanovsk region (form No. 7) in 2005–2019. Standardized rates of morbidity and mortality were evaluated. Data on the number, gender and age of the regional population were obtained in Ulyanovsk State Statistics Service.Results: the incidence of CRC in the region increased by 1.51 times over the analyzed period (from 31.12 to 49.58 per 100 thousand people). From the total number of newly diagnosed CRC in 2019, the urban population was 25%, and the rural population — 75%. The incidence rates in the districts of the region were assessed. The highest morbidity in males was detected at the age of 60–64 years old, and it was 1.58 times higher than in females. In the adult population under 30 years old, only few cases of colorectal cancer were detected. The main histological type of tumors was adenocarcinoma. Poorly differentiated tumors accounted for about 3%. The highest age-standardized rates for rectal tumors were 10.1 and 12.8 per 100 thousand people in 2005 and 2019, respectively; for the recto sigmoid tumors — 0.9 and 2.3 per 100 thousand people; and for the anal cancer — 0.4 cases per 100 thousand people in 2019. The male/female ratio of deaths from CRC in 2019 was 1.005:1.000.Conclusion: there has been a trend to an increase in the incidence of colorectal cancer among the Ulyanovsk region population in the period from 2005 to 2019. We identified some areas of the region that significantly differ in the incidence of colorectal cancer.

CLINICAL, ENDOSCOPIC AND PATHOGICAL CHARACTERISTICS OF COLORECTAL CANCER AT DA NANG HOSPITAL FROM 2016 TO 2017

2018 ◽  
pp. 9-14
Author(s):  
Thanh Trung Nguyen ◽  
Duc Nhan Le ◽  
Van Xung Nguyen ◽  
Hieu Trung Doan
Keyword(s):  
Colorectal Cancer ◽  
Descriptive Study ◽  
Bloody Stool ◽  
Key Words Colorectal Cancer ◽  
Right Colon ◽  
Female Ratio ◽  
Histopathological Classification ◽  
Male Female Ratio ◽  
Female Male Female ◽  
Colorectal Cancer Patients

Objective: To study the clinical, endoscopy and pathogical characteristics of colorectal cancer at Da Nang Hospital. Methods: A retrospectively descriptive study, performed from 01/01/2016 to 31/12/2017 at Da Nang Hospital. Results: During two years, there were 205 cases of colorectal cancer patients hospitalized to Da Nang Hospital. Male: 59.51%, female: 40.49%, mean age: 65.8 ± 16.07. Male is higher than female, male/ female ratio is 1.4/1. The period from the first symptoms to admission < 3months predominated (83.8%). The predominant symptoms: Abdominal pain (85.85%), bloody stool (63.41%), defecation (62.44%), anemia (34.63%), weight loss (25.85%), fatigue (17.56%), abdominal distention (12.19%), nausea and vomiting (5.36%). Location of Lesions: Rectum (43.42%), sigmoid colon (20%), right colon (10.73%),cecum (10.73%), transverse colon (7.80%), left-colon (7.32%). Type of lesion on endoscopy: Exophytic (63.41%), ulceration-Exophytic (21.95%), ulceration (7.32%), polyp chemotherapy (7.32). Tumor size: ≥ 3/4 perimeter (39%), occupying the whole circumference (37.0%), occupying ≥ 1/2 perimeter (15.6%), accounting for 1/4 Perimeter (8.4%). The colon completely narrowed rate: 70.73%., incompletely was 29.27%. Histopathological classification: adenocarcinoma (85.85%), Mucinous adenocarcinoma: (9.27%) and non-differentiated epithelial carcinoma was 4.88%. Conclusion: Colorectal cancer was quite popular and was usually detected at advanced stages.Therefore, screening for subjects with risk factors for early detection and treatment is recommended. Key words: Colorectal cancer, endoscopy, pathogical characteristics...

scholarly journals Histopathology of Polyps and Cancer of Colorectum: A ten years study from a tertiary care center

2021 ◽  
Vol 14 (2) ◽  
pp. 100-106
Author(s):  
Binita Goyal
Keyword(s):  
Colorectal Cancer ◽  
Care Center ◽  
Correct Diagnosis ◽  
Tertiary Care ◽  
Older Age ◽  
Histologic Grade ◽  
Age Group ◽  
Female Ratio ◽  
Pathologic Stage ◽  
Male Female Ratio

Introduction and objectives: Polyps and colorectal cancer have overlapping clinical presentation and may be difficult to diagnose on clinical grounds alone and close clinicopathological correlation is required for correct diagnosis and management. This study was aimed to see the spectrum of polyps and cancer in colorectum, see the percentage of colorectal cancer in younger individuals, see association between histologic grade and pathologic stage at presentation and compare site of tumor and pathologic stage at presentation in younger and older age group. Methods: This study was carried out on 138 consecutive cases of polyps and malignant lesions of colorectum during a time period of 10 years from January 2011 to December 2020. Results: Age of the patients ranged from 2 – 90 years with mean 45.1 years and a male female ratio 2:1. There were 58 (42.0%) cases of polyps and 80 (58.0%) cases of malignancies. 37 (46.3%) malignancy cases were seen in individuals ≤ 50 years of age. Most common site of involvement was rectum in 80 (58.0%) cases. Most common non-neoplastic polyp was retention polyp comprising 25 (67.6%) and most common neoplastic polyp was adenoma comprising of 18 (85.7%) cases. Most common malignancy was adenocarcinoma comprising 75 (93.8%) cases. Conclusion: Significant number of malignancies is seen in younger individuals stressing the need for suspicion and surveillance in this age group. Histologic grade is an important prognostic parameter and there is no difference in site of tumor and stage at presentation between younger and older age group.

Age disparities in the trend of colorectal cancer incidence in California.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. e12528-e12528
Author(s):  
Jason A. Zell ◽  
Kathryn E. Singh ◽  
Thomas H. Taylor ◽  
Chuan-Ju G. Pan ◽  
Michael J. Stamos
Keyword(s):  
Colorectal Cancer ◽  
Ethnic Groups ◽  
Metastatic Disease ◽  
Adult Population ◽  
Tumor Location ◽  
Incidence Rates ◽  
Average Risk ◽  
Annual Percent Change ◽  
Hispanic Males ◽  
Incidence Trends

e12528 Background: Colorectal cancer (CRC) incidence has decreased over the past three decades, due in part to screening for pre-malignant polyps. Relatively little is known about CRC incidence among adults under age 50 (when screening recommendations commence for average-risk individuals). We examined CRC incidence trends with a focus on adults under age 50, in order to identify high-risk subgroups. Methods: 231,544 incident CRC cases (including 21,220 adults <50) from the California Cancer Registry from 1988-2009 were analyzed. We assessed age-specific incidence rates by race/ethnic group, gender, and tumor location within the colorectum, and calculated annual percent change (APC) to monitor change in incidence over the 21-year study period. Results: We observed increased CRC incidence rates in the adult population under age 50 in all examined race/ethnic groups, especially in Hispanic males (APC=+7.5%/p=0.0001) and Caucasian females (APC=+6.5%/p<0.0001). Young individuals were also more likely to present with metastatic disease at diagnosis. Overall, African Americans had the highest overall incidence rates and were most likely to present with metastatic disease compared to other groups. Conclusions: Incidence of CRC in adults under 50 is increasing across all race/ethnic groups. The high frequency of metastatic disease at initial presentation in this age group is particularly concerning. However, a considerable limitation of this analysis is the lack of data on family history of CRC. Our observations highlight the importance of identifying at-risk adults under age 50, especially those in higher-risk race/ethnic groups, with the overarching goal of decreasing the burden of CRC through screening and early detection.

scholarly journals Incidence of rectosigmoid adenomatous polyps in subjects without prior colorectal adenoma or cancer: a prospective cohort study

Gut ◽  
1999 ◽  
Vol 44 (3) ◽  
pp. 372-376 ◽  
Author(s):  
B Paillot ◽  
P Czernichow ◽  
P Michel ◽  
V Merle ◽  
A-M Queuniet ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cohort Study ◽  
Incidence Rate ◽  
Selection Criteria ◽  
Incidence Rates ◽  
Colorectal Adenomas ◽  
Population Characteristics ◽  
The Third ◽  
Mean Delay ◽  
Screening Strategies

BACKGROUNDSubjects without known colorectal adenomas or cancer constitute a large majority of the population where 85% of all cases of colorectal cancer are thought to occur. Consequently these people should be considered for screening to decrease mortality from colorectal cancer in the general population.AIMSTo estimate the incidence rate of rectosigmoid adenomas in these subjects.METHODSSubjects without adenomas or cancer at a previous examination which had visualised the rectosigmoid underwent a fibre endoscopy every three years. Endoscopic data and population characteristics were collected prospectively.RESULTSA total of 450 subjects fulfilled the selection criteria; 287 (64%) underwent at least two examinations, and 163 had three or more. At the second examination, with a mean delay of 39 months, the incidence rate of rectosigmoïd adenomas was 1.50% per patient year. The rate was 1.75% per patient year (95% CI 0.80–3.33) at the third endoscopy with an additional mean delay of 38 months. The cumulative incidence rate at six years was 7.3% (95% CI 4.3–10.3), representing a mean of 1.2% per patient year. This rate increased with age and was higher for men than for women after age adjustment (p< 0.03).CONCLUSIONSThe incidence rates are very low compared with those of patients with prior adenomas. These results should be considered in establishing rectosigmoid adenoma screening strategies.

Epidemiologic Pictures of Kawasaki Disease in Japan: From the Nationwide Incidence Survey in 1991 and 1992

PEDIATRICS ◽  
1995 ◽  
Vol 95 (4) ◽  
pp. 475-479 ◽  
Author(s):  
Hiroshi Yanagawa ◽  
Mayumi Yashiro ◽  
Yosikazu Nakamura ◽  
Tomisaku Kawasaki ◽  
Hirohisa Kato
Keyword(s):  
Kawasaki Disease ◽  
Disease Onset ◽  
Incidence Rates ◽  
Descriptive Epidemiology ◽  
Female Ratio ◽  
Number Of Patients ◽  
Yearly Incidence ◽  
Male Female Ratio ◽  
History Of ◽  
Questionnaire Form

Objective. Since 1970, twelve nationwide epidemiologic surveys of Kawasaki disease (KD) have been conducted throughout Japan every two years to describe KD in Japan. By the end of 1992, a total of 116 848 cases were reported. This paper summarizes the statistical analysis of the latest survey for the 2-year period from January 1991 through December 1992. Method. A questionnaire form and diagnostic guidelines for KD were sent to all pediatric departments of hospitals with 100 or more beds throughout Japan and information was obtained on patients with KD diagnosed during the 2-year period from January 1991 through December 1992. Results. The summary of the results is: 1) the number of patients reported was 11 221 (6604 males and 4617 females; male/female ratio = 1.43) with a yearly incidence rate of 90 per 100 000 children &lt;5 years old; 2) the monthly number of patients was higher in winter and summer, although the monthly difference was not marked; 3) age-specific incidence rates showed a unimodal peak at 1 year of age; 4) the proportion of patients with a family history of KD in a sibling was 1%; 5) the proportion of recurrent patients was 3%; 6) the proportion of patients with cardiac sequelae 1 month after disease onset was 13%; and 7) the number of patients who died was 9, which conforms to 0.08% of total patients. Conclusion. The incidence rates of KD in Japan are ten times higher than those reported in western countries and almost constant over 6 years. The descriptive epidemiology of the disease, which supports the infection theory, does not change for years.

scholarly journals Etiology and Outcome of Burns in Tabriz, Iran an Analysis of 2963 Cases

2005 ◽  
Vol 94 (1) ◽  
pp. 77-81 ◽  
Author(s):  
H. Maghsoudi ◽  
A. Pourzand ◽  
G. Azarmir
Keyword(s):  
Incidence Rates ◽  
Inhalation Injury ◽  
Burn Injuries ◽  
High Rate ◽  
Female Ratio ◽  
Burn Victims ◽  
Burn Center ◽  
Major Burn ◽  
Male Female Ratio ◽  
The Mean

Background and aims: Burn injuries still produce a significant morbidity and mortality in Iran. A 3-year retrospective review of burn victims hospitalized at a major burn center was conducted to determine the etiology and outcome of patients in Tabriz. Material and Methods: Two thousand nine hundred sixty + three patients were iden tified and stratified by age, sex, burn size, presence or absence of inhalation injury, cause of burn. There is one burn center in the East Azarbygan province serving 3.3 million people over an area of 47,830 sq.km. Results: The overall incidence rates of hospitalization and death were 30.5 % and 5.6 % per 100000 person years. The mean patient age was 22 years, and the male: female ratio was 1.275. There were 555 deaths altogether (18.7 %). The highest incidence of burns was in the 1–9 age group (29.2 %). Patients with less than 40 percent of burned surface constituted 79.8 % of injuries. The most common cause of burns was kerosene accident in adults and scald injuries in children. The mean length of hospitalization was 13 days. The mean body surface area burned was larger with higher mortality in females than in males (p < 0.001). Inhalation injuries were strongly associated with large burns and were present in all flame-burn fatalities. Conclusion: In our opinion, social factors are the main drive leading to an unacceptably high rate of burn injuries in our societies. Most of the burn injuries were caused by domestic accidents and were, therefore, preventable; educational programs might reduce the incidence of burn injuries.

scholarly journals Substantial underreporting of tuberculosis in West Greece - implications for local and national surveillance

2009 ◽  
Vol 14 (11) ◽  
Author(s):  
E Jelastopulu ◽  
E C Alexopoulos ◽  
D Venieri ◽  
G Tsiros ◽  
G Komninou ◽  
...  
Keyword(s):  
Public Health ◽  
Incidence Rates ◽  
Female Ratio ◽  
Case Detection Rate ◽  
Male Predominance ◽  
Public Health Departments ◽  
Male Female Ratio ◽  
National Tuberculosis ◽  
National Public Health ◽  
The Face

In order to estimate the reliability of the officially reported national tuberculosis (TB) incidence rates we performed a retrospective review of data collected in regional and national public health framework. TB notifications for the period 2000-2003 were obtained from two major hospitals and three relevant Public Health Departments (PHDs) in the region of West Greece, and subsequently compared with the data reported to the Hellenic Centre for Diseases Control (KEELPNO). During the four-year study period a total of 161 cases of TB were reported to the PHDs in West Greece; 70% of these cases were reported to the KEELPNO. Furthermore only 72 (38.7%) out of the 186 cases of TB identified in the two hospitals were notified to the PHDs. Assuming that the degree of undernotification observed for the two hospitals is the same throughout the region, we estimated that the case detection rate was 14 cases per 100,000 persons per year, i.e. 3.7 times higher than the rate officially reported for the period 2000-2003. Male predominance (2.1, male/female ratio) and an increased incidence in the elders (older than 60 years) and adolescents (10-14 years old) were also evident. The study demonstrated a substantial underestimation of TB burden in West Greece. In the face of the massive influx of immigrants and refugees coming from regions with high TB incidence and the increase of the number of drug-resistant cases a reliable and complete notification of TB is crucial in the planning of programs and development of appropriate control policies.

Mitomycin-C and capecitabine as salvage chemotherapy in pre-treated patients with advanced colorectal cancer

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 14595-14595 ◽  
Author(s):  
C. G. Gennatas ◽  
V. Michalaki ◽  
S. Gennatas ◽  
J. Kouvaris ◽  
V. Smyrniotis ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Mitomycin C ◽  
Median Overall Survival ◽  
Advanced Colorectal Cancer ◽  
Patient Characteristics ◽  
Median Number ◽  
Salvage Chemotherapy ◽  
Female Ratio ◽  
Significant Toxicity ◽  
Male Female Ratio

14595 Background: To assess the activity and tolerability of the combination of Mitomycin C and Capecitabine in patients with metastatic colorectal cancer after failure of irinotecan, 5-fluorouracil (5-FU), folinic acid and oxaliplatin-containing regimens. Methods: We retrospectively reviewed 31 patients with pre-treated advanced colorectal cancer. At the time of their relapse or progression, cytotoxic chemotherapy, consisting of intravenous mitomycin C, 6 mg/m2 on day 1, and capecitabine, 1000 mg/m2 twice daily on days 1–14, was initiated. Cycles were repeated every 3 weeks. Tumor assessment was performed every 3 cycles, toxicity assessed at each cycle. Results: Main patient characteristics were median age 63 years (range, 45–73); male/female ratio, 19/12. One hundred forty- six courses of therapy were given (median number, 3; range, 2–9). All patients were assessable for response, and all were assessable for toxicity. Fourteen patients had stable disease (45%). Median time to progression was 3 months (range, 1–10) and median overall survival was 8 months (range, 3–28). The regimen was very well tolerated without significant toxicity. Grade 2 toxicities were palmar-plantar erythema 6%, hematological 35%. Conclusions: Our findings suggest that the combination of Mitomycin C and Capecitabine in pre-treated patients with advanced colorectal cancer is safe and effective with an acceptable toxicity profile and a convenient administration schedule. However, further evaluation of other salvage regimens seems to be warranted. No significant financial relationships to disclose.

scholarly journals Colorectal Cancer in Young Adult Population in Kashmir Valley: Tertiary Care Centre Experience

JMS SKIMS ◽  
2019 ◽  
Vol 22 (2) ◽  
Author(s):  
Peerzada Umar Farooq Baba ◽  
Ajaz Ahmad Malik ◽  
Yaqoob Hassan ◽  
Khurshid Alam Wani ◽  
Abdul Rashid Lone
Keyword(s):  
Colorectal Cancer ◽  
Young Adults ◽  
Adjuvant Therapy ◽  
Colorectal Carcinoma ◽  
Adult Population ◽  
Tertiary Care ◽  
Young Patients ◽  
Kashmir Valley ◽  
Female Ratio

Background: Colorectal cancer has been defined and discussed as a disease of middle or late life. However, no age-group is exempt, and adenocarcinoma of the colon has been reported in young age. Malignant disease is frequently found in young adults in our Kashmir valley. Objective (s): This aim was to study the clinic pathological features, diagnosis, management and outcome of colorectal cancer in young adults under the age of 40. Material and Methods: This combined Retrospective (January 2002 to May, 2004) Prospective (June 2004 to September 2006) Observational Study was conducted in the department of General and Minimal Access Surgery, SKIMS,. Total of 62 young colorectal carcinoma patients were studied. The case records of all the patients of colorectal cancer less than 40years of age admitted in the department of General Surgery were reviewed retrospectively. In the prospective study all the patients less than 40 years of age with colorectal carcinoma admitted in our department were registered. Following the confirmation of diagnosis, the patients were subjected to exploratory laparotomy. The nature of the surgical procedure depended upon the intra-operative findings. All the patients were subjected to postoperative chemotherapy and in selected cases to postoperative chemo-radiation. The patients were followed for a period of five years .The patients were thoroughly examined and investigated on follow up to rule out any recurrence or metastasis. Results: Most of our patients (83.9%) were admitted through outpatient department (OPD) and only 10 patients (16.1%) were admitted through emergency. In our study, the male: female ratio was 1.58: 1.The mean age in our study was 30.2 years. Bleeding per rectum was the most common (74.2%) presenting symptom followed by altered bowel habits (72.6%). Carcinoembryonic antigen (CEA) levels show significant decline after surgery/adjuvant therapy. Colonoscopy detected synchronous growths in 5.3% of patients. Rectum was the most common site of lesion (32.2%) while combined rectum and sigmoid colon (including recto sigmoid) accounted for 62.7% of lesions. Resection with intention of cure was performed in 68.3% of patients, palliative procedure in 26.7% and biopsy in 5% of patients. Postoperative complications were recorded and managed accordingly. Typical adenocarcinoma was seen in 80.6% of patients. None of our patients had Dukes stage A presentation. 13.6% of patients had local recurrence and 25.4% had metastasis on follow up.                                                 Conclusion: Colorectal cancers in young adults are quite common in Kashmir valley. Outcome of CRC in young patients is significantly related to the procedure - whether done with curative intention or for palliation. Henceforth, surgical treatment should be radical and optimized with adjuvant therapy where possible to achieve the best prognosis. The diagnosis of colorectal cancer should be done at the early and curable stage for better outcome.

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