scholarly journals Colorectal Cancer in Young Adult Population in Kashmir Valley: Tertiary Care Centre Experience

JMS SKIMS ◽  
2019 ◽  
Vol 22 (2) ◽  
Author(s):  
Peerzada Umar Farooq Baba ◽  
Ajaz Ahmad Malik ◽  
Yaqoob Hassan ◽  
Khurshid Alam Wani ◽  
Abdul Rashid Lone
Keyword(s):  
Colorectal Cancer ◽  
Young Adults ◽  
Adjuvant Therapy ◽  
Colorectal Carcinoma ◽  
Adult Population ◽  
Tertiary Care ◽  
Young Patients ◽  
Kashmir Valley ◽  
Female Ratio

Background: Colorectal cancer has been defined and discussed as a disease of middle or late life. However, no age-group is exempt, and adenocarcinoma of the colon has been reported in young age. Malignant disease is frequently found in young adults in our Kashmir valley. Objective (s): This aim was to study the clinic pathological features, diagnosis, management and outcome of colorectal cancer in young adults under the age of 40. Material and Methods: This combined Retrospective (January 2002 to May, 2004) Prospective (June 2004 to September 2006) Observational Study was conducted in the department of General and Minimal Access Surgery, SKIMS,. Total of 62 young colorectal carcinoma patients were studied. The case records of all the patients of colorectal cancer less than 40years of age admitted in the department of General Surgery were reviewed retrospectively. In the prospective study all the patients less than 40 years of age with colorectal carcinoma admitted in our department were registered. Following the confirmation of diagnosis, the patients were subjected to exploratory laparotomy. The nature of the surgical procedure depended upon the intra-operative findings. All the patients were subjected to postoperative chemotherapy and in selected cases to postoperative chemo-radiation. The patients were followed for a period of five years .The patients were thoroughly examined and investigated on follow up to rule out any recurrence or metastasis. Results: Most of our patients (83.9%) were admitted through outpatient department (OPD) and only 10 patients (16.1%) were admitted through emergency. In our study, the male: female ratio was 1.58: 1.The mean age in our study was 30.2 years. Bleeding per rectum was the most common (74.2%) presenting symptom followed by altered bowel habits (72.6%). Carcinoembryonic antigen (CEA) levels show significant decline after surgery/adjuvant therapy. Colonoscopy detected synchronous growths in 5.3% of patients. Rectum was the most common site of lesion (32.2%) while combined rectum and sigmoid colon (including recto sigmoid) accounted for 62.7% of lesions. Resection with intention of cure was performed in 68.3% of patients, palliative procedure in 26.7% and biopsy in 5% of patients. Postoperative complications were recorded and managed accordingly. Typical adenocarcinoma was seen in 80.6% of patients. None of our patients had Dukes stage A presentation. 13.6% of patients had local recurrence and 25.4% had metastasis on follow up.                                                 Conclusion: Colorectal cancers in young adults are quite common in Kashmir valley. Outcome of CRC in young patients is significantly related to the procedure - whether done with curative intention or for palliation. Henceforth, surgical treatment should be radical and optimized with adjuvant therapy where possible to achieve the best prognosis. The diagnosis of colorectal cancer should be done at the early and curable stage for better outcome.

scholarly journals COLORECTAL CARCINOMA

2011 ◽  
Vol 18 (04) ◽  
pp. 566-570
Author(s):  
AYAZ GUL ◽  
SYED IFTIKHAR ALAM ◽  
RASHID ASLAM ◽  
Waqar Alam
Keyword(s):  
Colorectal Cancer ◽  
Colorectal Carcinoma ◽  
Tertiary Care ◽  
Young Patients ◽  
Age Group ◽  
Surgical Department ◽  
Male Preponderance ◽  
Histologic Types ◽  
Hospital Study

Objective: Colorectal cancer is the second commonest cause of death in the world. Its incidence in young patients is on rise. Objective: To determine the common types of colorectal carcinoma in patients below 40 years of age presenting to tertiary care level hospital. Study Design: Descriptive study Setting: It was carried out at Surgical Department, KTH, Peshawar Period: January 2007 to January 2008. Materials and methods: Total of 50 patients younger than forty years of age with colorectal cancer were included in study for the determination of histologic types. Results: There were 66% males and 34% were females. The commonest affected age group was 31-35 years old having 46% cases. On history 86% patients complained of altered bowel habits and on clinical examination anemia was present in 72% patients. Left and right sided tumors were found in 70% and 30% patients respectively. Adenocarcinoma was the commonest type found in 94% cases followed by lymphoma (4%). Conclusions: The incidence in young age group (≤ 39 years) was highest There was slight male preponderance. Adenocarcinoma was the commonest tumor.

scholarly journals Hypertension among Young Adults with Ischemic Stroke of a Tertiary Care Centre in Nepal: A Descriptive Cross-sectional Study

2021 ◽  
Vol 59 (240) ◽  
Author(s):  
Dilli Ram Kafle ◽  
Sudhakar Jha
Keyword(s):  
Young Adults ◽  
Ischemic Stroke ◽  
Confidence Interval ◽  
Tertiary Care ◽  
Young Patients ◽  
Cross Sectional Study ◽  
Care Hospital ◽  
Sectional Study ◽  
Cross Sectional

Introduction: Ischemic strokes in young patients have been increasing. Younger patients with ischemic stroke tend to have a different long-term prognosis than older patients. Young patients who have residual neurological deficits following ischemic stroke affect their quality of life. This study was carried out to find out the prevalence of hypertension among patients with ischemic stroke in a tertiary care hospital. Methods: This descriptive cross-sectional study was conducted in all the patients who were admitted with young ischemic stroke in the Department of Neurology, Nobel Medical College Biratnagar from December 2019 to December 2020 after taking ethical clearance from the Institutional Review Committee (reference number: 332/2019). Convenience sampling was done and data was collected, entered in Microsoft Excel, and analysis was done using Statistical Package for the Social Science software version 16. Point estimate at 95% Confidence Interval was calculated along with frequency and proportion for binary data. Results: Out of the total patients with ischemic stroke in the young adults 30 (40%) (95% Confidence Interval= 28.91-51.08) had hypertension. During follow-up at 6 months, 20 (66.7%) of the patients with hypertension had favorable outcomes with a Modified Rankin Score of 0 or 1. Death during a hospital stay or during follow-up was observed in 2 (7%) of patients with hypertension. Mean age of the patients was 40±4.87 years. Most patients were in the age range of 36-45, 24 (80%). Conclusions: Prevalence of hypertension among young patients with ischemic stroke was high compared to other studies.

The Ozaki Procedure With CardioCel Patch for Children and Young Adults With Aortic Valve Disease: Preliminary Experience – a Word of Caution

2019 ◽  
Vol 10 (6) ◽  
pp. 724-730 ◽  
Author(s):  
Sian C. Chivers ◽  
Carine Pavy ◽  
Ricky Vaja ◽  
Cesare Quarto ◽  
Olivier Ghez ◽  
...  
Keyword(s):  
Young Adults ◽  
Aortic Valve ◽  
Adult Population ◽  
Published Data ◽  
Bovine Pericardial Patch ◽  
Valve Position ◽  
Children And Young Adults ◽  
Ischemic Attack

Background: The Ozaki procedure is a surgical technique for patients with significant aortic stenosis or regurgitation or both where valve repair cannot be performed. Individual cusps are cut from glutaraldehyde-treated autologous pericardium or bovine pericardium and implanted into the aortic valve position. Encouraging results have been reported within the adult population. There are limited published data on success of this procedure in younger patients. Methods: We present a series of five children and young adults who underwent the Ozaki procedure with neoaortic valve cusps made from CardioCel, a decellularized bovine pericardial patch treated with a monomeric glutaraldehyde. Results: There were no complications in the initial postoperative period and short inpatient stay. At a mean follow-up of 29.6 months (range: 22-36 months), 4 patients had no evidence of stenosis and 3 patients had trivial or no regurgitation from the neoaortic valve. Overall, two patients had complications related to the valve and underwent reintervention during the follow-up period with a Ross procedure. One of these patients who was not taking long-term anticoagulation experienced a transient ischemic attack. Conclusions: Our experience demonstrates that the Ozaki procedure with CardioCel in pediatric and young adult patients should be approached with caution. Further research with larger groups of pediatric patients, comparison of different graft materials, and longer follow-up is required to ascertain long-term success in children.

Identification of 11 Different HPV Subtypes in Adult Patients With Recurrent Respiratory Papillomatosis

2020 ◽  
Vol 163 (4) ◽  
pp. 785-790
Author(s):  
Rebecca C. Hoesli ◽  
Melissa L. Wingo ◽  
Brent E. Richardson ◽  
Robert W. Bastian
Keyword(s):  
Human Papillomavirus ◽  
Patient Outcomes ◽  
Clinical Course ◽  
Adult Population ◽  
Tertiary Care ◽  
Recurrent Respiratory Papillomatosis ◽  
Definition Of ◽  
Large Adult

Objective To define the human papillomavirus (HPV) subtypes seen in a large adult population with traditionally defined recurrent respiratory papillomatosis. Study Design Retrospective review. Setting Tertiary care laryngology practice. Subjects and Methods All patients had a firm diagnosis of recurrent respiratory papillomatosis defined by (1) visually obvious papillomas, (2) recurrence requiring multiple surgeries, and (3) pathology diagnosis of “papilloma.” Each patient had also undergone HPV subtyping. Age, sex, presence of malignancy, and HPV subtypes were tabulated and correlated with long-term patient outcomes. Results A total of 184 patients were identified who fulfilled the above criteria. In total, 87.0% (160) had a low risk subtype; 9.2% had an alternative subtype. These consisted of subtypes 16, 18, 31, 44, 45, 55, and 70. Four patients (2.2%) had combinations of subtypes, with 1 patient with HPV 11 and 16, 1 patient with HPV 11 and 76, 1 patient with 11 and 84, and 1 patient with 18 and 45. Finally, 3.8% of patients were HPV negative, despite fulfilling all 3 criteria listed above. Conclusion In the patient population above, almost 10% of patients had an HPV subtype other than 6 and 11. This suggests that traditionally defined recurrent respiratory papillomatosis (RRP) can be caused by HPV subtypes other than 6 and/or 11. In addition, the clinical course of persons with this definition of RRP appears to vary by subtype, and this information may offer the ability to nuance follow-up instructions, reducing in particular the burden placed upon patients who have RRP caused by subtypes 6 and 11.

Colorectal cancer in young adults in a tertiary care hospital in Chhattisgarh, Raipur

2013 ◽  
Vol 50 (4) ◽  
pp. 337 ◽  
Author(s):  
N Hussain ◽  
R Gahine ◽  
J Mourya ◽  
V Sudarshan
Keyword(s):  
Colorectal Cancer ◽  
Young Adults ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital

scholarly journals A Study on the Clinicopathological Profile of the Cases of Colorectal Carcinoma

2021 ◽  
pp. 493-500
Author(s):  
Dhanya Menon ◽  
Iniya Sudhan ◽  
Ganthimathy Sekhar
Keyword(s):  
Colorectal Cancer ◽  
Colorectal Carcinoma ◽  
Sampling Method ◽  
Tertiary Care ◽  
Tumour Site ◽  
Tertiary Care Centre ◽  
Medical College ◽  
Female Predominance ◽  
Clinicopathological Profile ◽  
The Mean

Aim: To assess the clinicopathological details of patients with colorectal cancer in a tertiary care centre in India and compare it other studies reported in the literature. Study Design: This is a retrospective study conducted on all the patients who were admitted in the period of 2017 to 2020. Place and Duration of Study: Department of Pathology, Saveetha Medical College, Thandalam, Chennai. The data was processed and the manuscript was prepared between June 2020 and January 2021. Methodology: Patient details were collected from the histopathology records and the parameters studied were age, gender, tumour site, histological type, differentiation and tumour stage of the colorectal carcinoma. The sampling was done using the complete enumerate sampling method. The patients diagnosed histopathologically as colorectal carcinoma were included in our study. Results: A total of 51 patients had been admitted in the years 2017, 2018, and 2019 in our institute. There was a female predominance among the patients. The mean age of the patients was lesser than the mean age of colorectal cancer cases in other studies which have been reported in the country. The most common tumour site was rectum in both the sexes and the most common histologic type was adenocarcinoma. The most common histological differentiation was moderate differentiation. Conclusion: The increased incidence in younger patients as compared to previous studies may be attributable to the lifestyle and dietary changes.

scholarly journals Population characteristics of colorectal cancer in the Ulyanovsk region according to the regional cancer register

2021 ◽  
Vol 20 (2) ◽  
pp. 97-104
Author(s):  
I. A. Bogomolova ◽  
I. I. Antoneeva ◽  
T. V. Abakumova ◽  
T. P. Gening
Keyword(s):  
Colorectal Cancer ◽  
Adult Population ◽  
Incidence Rates ◽  
Population Characteristics ◽  
Female Ratio ◽  
Cancer Register ◽  
Male Female Ratio ◽  
Ulyanovsk Region ◽  
Regional Population ◽  
Poorly Differentiated

Aim: to analyze the structure and changes of colorectal cancer (CRC) epidemiology in the Ulyanovsk region in 2005–2019 according to the regional cancer register.Materials and methods: the study is based on statistical data on the primary detection of CRC in the districts of the Ulyanovsk region (form No. 7) in 2005–2019. Standardized rates of morbidity and mortality were evaluated. Data on the number, gender and age of the regional population were obtained in Ulyanovsk State Statistics Service.Results: the incidence of CRC in the region increased by 1.51 times over the analyzed period (from 31.12 to 49.58 per 100 thousand people). From the total number of newly diagnosed CRC in 2019, the urban population was 25%, and the rural population — 75%. The incidence rates in the districts of the region were assessed. The highest morbidity in males was detected at the age of 60–64 years old, and it was 1.58 times higher than in females. In the adult population under 30 years old, only few cases of colorectal cancer were detected. The main histological type of tumors was adenocarcinoma. Poorly differentiated tumors accounted for about 3%. The highest age-standardized rates for rectal tumors were 10.1 and 12.8 per 100 thousand people in 2005 and 2019, respectively; for the recto sigmoid tumors — 0.9 and 2.3 per 100 thousand people; and for the anal cancer — 0.4 cases per 100 thousand people in 2019. The male/female ratio of deaths from CRC in 2019 was 1.005:1.000.Conclusion: there has been a trend to an increase in the incidence of colorectal cancer among the Ulyanovsk region population in the period from 2005 to 2019. We identified some areas of the region that significantly differ in the incidence of colorectal cancer.

scholarly journals Clinicopathological Study of 50 Cases Colorectal Carcinoma At Tertiary Care Hospital

2013 ◽  
Vol 4 (2) ◽  
pp. 53-56
Author(s):  
Md Abdul Quddus ◽  
Md Alimunzzaman ◽  
Md Zilluar Rahman ◽  
Md Kausar Alam
Keyword(s):  
Colorectal Cancer ◽  
Colorectal Carcinoma ◽  
Rectal Carcinoma ◽  
Colonic Cancer ◽  
Tumour Size ◽  
Tertiary Care ◽  
Bowel Habit ◽  
Care Hospital ◽  
College Hospital ◽  
Serum Cea

Background: Colorectal carcinoma is a major causes of mortality and morbidity worldwide. Objective: The purpose of the present study was to consider the socio-demographic status and serum CEA level as diagnostic tool for advanced stages of colorectal cancer. Methodology: This analytical cross-sectional study was conducted in the Department of Surgery at Shaheed Ziaur Rahman Medical College Hospital, Bogra during the period of January 2010 to December 2011. Patients age ranged from 15 years to 75 years and above were included in this study. All efforts and available modern technologies including ultrasonography (USG), CT scan, endo-anal USG, chest X-ray were done to detect the primary site and metastasis of colorectal cancer. Result: The most frequent colorectal cancer was detected in 35-44 years age group with 60.0% male and 40.0% female patients. A total number of 41(82%) cases had been suffering from rectal carcinoma and 9(18%) with colonic cancer. Abdominal pain, anorexia, altered bowel habit, per rectal bleeding and abdominal lump were the cardinal features in clinical presentation. This study showed that serum CEA level was raised in 3(11.11%) cases with tumour size 2-5 cm and 21(91.30%) cases with tumor size >5cm. It was observed that serum CEA level was raised in 100% cases of Dukes stage 'D', 92.31% cases of stage 'C' and 30.56% cases of stage 'B' colorectal cancer. The serum CEA level in relation with tumour size and stage has been proved highly significant (p<0.001). Conclusion: Rectal carcinoma is found common than colonic cancer and level of serum CEA is directly related to the cancer stage. DOI: http://dx.doi.org/10.3329/jssmc.v4i2.14413 J Shaheed Suhrawardy Med Coll, 2012;4(2):53-56

scholarly journals Newer techniques in diagnostic imaging of colorectal carcinoma

2009 ◽  
Vol 56 (4) ◽  
pp. 113-119
Author(s):  
M.A. Lucic ◽  
I.S. Miucin-Vukadinovic ◽  
S.M. Lucic ◽  
K.M. Koprivek ◽  
M. Spirovski ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Colorectal Carcinoma ◽  
Diagnostic Imaging ◽  
Wide Spectrum ◽  
Imaging Techniques ◽  
Diagnostic Evaluation ◽  
Diagnostic Assessment ◽  
Colorectal Malignancy ◽  
Imaging Methods

A wide spectrum of nowadays availible radiological and imaging methods in the diagnostic evaluation of patients with colorectal cancer enabled not only the improvement of primary colorectal malignancy detection, precise staging, regional involvement and metastatic spread assessment, but also the posttherapeutical estimation and follow- up. Having in mind that the exact diagnostic assessment of colorectal carcinoma by use of different imaging modalities still raises a lots of contradictories, in this report we have tried to present the possibilities of newer imaging techniques in the diagnostic evaluation of the patients with colorectal cancer.

scholarly journals Histopathology of Polyps and Cancer of Colorectum: A ten years study from a tertiary care center

2021 ◽  
Vol 14 (2) ◽  
pp. 100-106
Author(s):  
Binita Goyal
Keyword(s):  
Colorectal Cancer ◽  
Care Center ◽  
Correct Diagnosis ◽  
Tertiary Care ◽  
Older Age ◽  
Histologic Grade ◽  
Age Group ◽  
Female Ratio ◽  
Pathologic Stage ◽  
Male Female Ratio

Introduction and objectives: Polyps and colorectal cancer have overlapping clinical presentation and may be difficult to diagnose on clinical grounds alone and close clinicopathological correlation is required for correct diagnosis and management. This study was aimed to see the spectrum of polyps and cancer in colorectum, see the percentage of colorectal cancer in younger individuals, see association between histologic grade and pathologic stage at presentation and compare site of tumor and pathologic stage at presentation in younger and older age group. Methods: This study was carried out on 138 consecutive cases of polyps and malignant lesions of colorectum during a time period of 10 years from January 2011 to December 2020. Results: Age of the patients ranged from 2 – 90 years with mean 45.1 years and a male female ratio 2:1. There were 58 (42.0%) cases of polyps and 80 (58.0%) cases of malignancies. 37 (46.3%) malignancy cases were seen in individuals ≤ 50 years of age. Most common site of involvement was rectum in 80 (58.0%) cases. Most common non-neoplastic polyp was retention polyp comprising 25 (67.6%) and most common neoplastic polyp was adenoma comprising of 18 (85.7%) cases. Most common malignancy was adenocarcinoma comprising 75 (93.8%) cases. Conclusion: Significant number of malignancies is seen in younger individuals stressing the need for suspicion and surveillance in this age group. Histologic grade is an important prognostic parameter and there is no difference in site of tumor and stage at presentation between younger and older age group.

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