scholarly journals A comparative study on the effects of various factors to the revalence of pelvic inflammatory disease in North central Nigeria

2021 ◽  
Vol 2 (2) ◽  
pp. 108-117
Author(s):  
U M Oyedum ◽  
F A Kuta ◽  
A A Saidu ◽  
H Babayi
Keyword(s):  
Pelvic Inflammatory Disease ◽  
Inflammatory Disease ◽  
Reproductive Age ◽  
High Rate ◽  
North Central ◽  
High Prevalence ◽  
Tubal Blockage ◽  
Rural Dwellers ◽  
And Control ◽  
Gynaecological Disease

Pelvic inflammatory disease is a gynaecological disease that affects the upper genital organs of reproductive age females. It is a disease associated with clinical sequalae such as tubal blockage, oophoritis and cervicitis which are said to result to high rate of disease (such as female infertility) and deaths among the females. This study therefore attempts to evaluate the association of various factors to high prevalence of pelvic inflammatory disease among women residing in developing countries such as Nigeria. Questionnaires were administered to all women enrolled for this study too obtain their data. Seven hundred and twenty (720) patients out of 1170 patients enrolled for this study were recorded to be pelvic inflammatory disease patients, of which 380(85%) were rural dwellers; 452(87.6%) were ignorant of pelvic inflammatory disease and were thus easily prone to the disease; 285(86.4%) were within the reproductive ages of 25-29 years; 350(85.2%) previously had urinary tract infection a year ago; 496(85.8%) and 343(83.5%) were both married and uneducated females. The high prevalence of pelvic inflammatory disease recorded in this study is due to certain predisposing factors practiced among females in their reproductive ages, hence it is necessary for government to enforce certain measures such as establishment of free education, continuous awareness of pelvic inflammatory disease and establishment of free medical check up to help prevent and control the spread of pelvic inflammatory disease.

Peritoneal Fluid and Plasma Fibrinolytic Activity in Women with Pelvic Inflammatory Disease

1992 ◽  
Vol 68 (02) ◽  
pp. 102-105 ◽  
Author(s):  
P J Dörr ◽  
E J P Brommer ◽  
G Dooijewaard ◽  
H M Vemer
Keyword(s):  
Pelvic Inflammatory Disease ◽  
Inflammatory Disease ◽  
Peritoneal Fluid ◽  
Fibrinolytic Activity ◽  
Degradation Products ◽  
Adhesion Formation ◽  
High Rate ◽  
Control Group ◽  
The Difference ◽  
Fibrinolytic Parameters

SummaryPrevious studies have shown that the fibrinolytic activity of peritoneum is depressed in local inflammation. We measured fibrinolytic parameters in peritoneal fluid and in plasma of 10 women with pelvic inflammatory disease (PID). Nine women, in whom laparoscopy for sterilisation was performed, served as a control group.In the peritoneal fluid of women with PID, PAI-Ag, t-PA-Ag and u-PA-Ag were many times higher than in the control group. In contrast to the antigens which may be present in inert complexes, the potentially active compounds, measured as t-PA activity and plasmin-activable scu-PA, were not significantly different in the two groups, and in none of the samples was the active enzyme tcu-PA detectable. Nevertheless, the mean peritoneal fluid TDP and FbDP concentrations were about twenty times higher in the PID group than in the control group. In plasma of PID patients, none of the parameters except u-PA-Ag differed from those in the control group. The difference between control and patient plasma u-PA-Ag was statistically significant, but too small to attach any relevance to the observation.Our data suggest that, in contrast to the classical concept of decreased fibrinolytic activity as a cause of adhesion formation, intraperitoneal fibrinolysis is enhanced in peritoneal inflammation through stimulation of the local production of t-PA and u-PA. Despite concomitant production of PAI, fibrinolysis occurs at a high rate, resulting in high levels of fibrin degradation products. Since this activated fibrinolysis does not meet the demand, therapeutic enhancement should be considered to prevent adhesions.

scholarly journals 183. chlamydia Trachomatis Seroprevalence with a pgp3 Serologic Assay and Association with Pelvic Inflammatory Disease Among Women, United States, 2013–2016

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S220-S220
Author(s):  
Gloria E Anyalechi ◽  
Damien Danavall ◽  
Brian H Raphael ◽  
Katherine E Bowden ◽  
Jaeyoung Hong ◽  
...  
Keyword(s):  
Black Women ◽  
Chlamydia Trachomatis ◽  
Pelvic Inflammatory Disease ◽  
Inflammatory Disease ◽  
White Women ◽  
Transmitted Disease ◽  
Population Level ◽  
Reproductive Age ◽  
Nucleic Acid Amplification ◽  
Sexually Transmitted

Abstract Background Chlamydia trachomatis (CT) causes pelvic inflammatory disease (PID) and other sequelae; however, these associations are not fully characterized. CT serologic assays including Pgp3 ELISA may detect prior CT infection and may better elucidate these associations. We used a serologic Pgp3 multiplex bead array assay (Pgp3MBA) to measure CT seroprevalence in reproductive-age US women and assess the association with PID. Methods We performed CT Pgp3MBA on sera collected from women 18–39 years old during the 2013–2016 cycles of the National Health and Nutrition Examination Survey (NHANES) who had available urine CT nucleic acid amplification test results. Weighted Pgp3MBA CT seroprevalence and 95% confidence intervals (95% CI) were calculated. We also determined weighted prevalence ratios (PRs) and 95% CIs of self-reported lifetime PID among women with and without detectable Pgp3MBA and other characteristics to estimate these US national statistics. Results Among 2,339 women, 1,725 (73.7%) had available sera. Of these women, 1,425 (or 93.4% of those with data) were sexually experienced and had a CT seroprevalence of 35.9% (95% CI 33.4–38.4). When weighted for US women, CT seroprevalence was 30.5% (95% CI 26.6–34.4%), ranging from 16.9% (95% CI 11.0–22.8%) among non-Hispanic Asian women to 70.2% (95% CI 62.4–78.0%) among non-Hispanic black women. PID was reported by 4.2% (95% CI 3.1–5.2) of 1,413 sexually-experienced women with PID data or an estimated 3.8% (95% CI 2.6–5.0) of US women. Among US women, estimated PID varied by Pgp3MBA status; 7.3% (95% CI 4.3–10.2) of Pgp3MBA-positive women were estimated to report PID versus 2.3% (95% CI 1.3–3.4) of Pgp3MBA-negative women (PR 3.1; 95% CI 1.7–5.9). PID prevalence did not vary by age, nor self-reported recent sexually transmitted disease among US women, but was higher among non-Hispanic black women compared to non-Hispanic white women (PR 2.2; 95% CI 1.4–3.5). Conclusion Nearly one-third of US women have had CT by Pgp3MBA, with differences by race/ethnicity. Women with prior CT had three times the reported PID prevalence of women without CT. Further serologic research may refine the population-level impact of CT prevention activities, such as recommended annual CT screening, on PID incidence, particularly among non-Hispanic black women. Disclosures All Authors: No reported disclosures

scholarly journals Clinico-Ultrasonographic Profile of Ectopic Pregnancy in Western Nepal

2018 ◽  
Vol 8 (1) ◽  
pp. 2-6
Author(s):  
Sangeeta Devi Gurung ◽  
Prakash Sharma
Keyword(s):  
Ectopic Pregnancy ◽  
Pelvic Inflammatory Disease ◽  
Inflammatory Disease ◽  
Radiological Finding ◽  
Previous History ◽  
First Trimester ◽  
Reproductive Age ◽  
Age Group ◽  
Type Iii ◽  
Reproductive Age Group

Introduction: Ectopic pregnancy (EP) is one of the major complications in first trimester pregnancy, resulting in increased maternal morbidity and mortality. It accounts for 1.3-2.4% of all pregnancies. Previously, though laparoscopy was considered as the gold standard for diagnosis of ectopic pregnancy, due to availability of high resolution ultrasound, it has become the first line investigation for the diagnosis of ectopic pregnancy.Methods: It is a prospective study conducted in Manipal Teaching Hospital, Pokhara, from January 2015 till December 2017. All the cases diagnosed with ectopic pregnancy were included in the study.  Ultrasonological and intraoperative findings were recorded. Data was analyzed using SPSS (VERSION 16).Results: Twenty six patients were diagnosed with ectopic pregnancies. The incidence was 0.35%. It was most common among the reproductive age group between 20-40 years with mean age of 30.50 years. Pelvic inflammatory disease (n=10, 38.5%) was considered as risk factor. Radiological finding of Type III ectopic pregnancy (n=21, 80.8%) was the most common type.Conclusion: Ectopic pregnancy is common among reproductive age group with previous history of pelvic inflammatory disease. Type III is the most common type.

Treatment of mild-to-moderate pelvic inflammatory disease with a short-course azithromycin-based regimen versus ofloxacin plus metronidazole: results of a multicentre, randomised controlled trial

2020 ◽  
pp. sextrans-2020-054468
Author(s):  
Gillian Dean ◽  
Suneeta Soni ◽  
Rachel Pitt ◽  
Jonathan Ross ◽  
Caroline Sabin ◽  
...  
Keyword(s):  
Antimicrobial Resistance ◽  
Pelvic Inflammatory Disease ◽  
Inflammatory Disease ◽  
Clinical Cure ◽  
Primary Outcome ◽  
Controlled Trial ◽  
High Rate ◽  
Resistance Testing ◽  
Short Course

ObjectiveA multicentre, randomised non-inferiority trial compared the efficacy and safety of 14 days of ofloxacin and metronidazole (standard-of-care (SoC)) versus a single dose of intramuscular ceftriaxone followed by 5 days of azithromycin and metronidazole (intervention arm (IA)) in women with mild-to-moderate pelvic inflammatory disease (PID).MethodsWomen with a clinical diagnosis of PID presenting at sexual health services were randomised to the SoC or IA arms. Treating clinicians and participants were not blinded to treatment allocation but the clinician performing the assessment of primary outcome was blinded. The primary outcome was clinical cure defined as ≥70% reduction in the modified McCormack pain score at day 14–21 after starting treatment. Secondary outcomes included adherence, tolerability and microbiological cure.ResultsOf the randomised population 72/153 (47.1%) reached the primary end point in the SoC arm, compared with 68/160 (42.5%) in the IA (difference in cure 4.6% (95% CI −15.6% to 6.5%). Following exclusion of 86 women who were lost to follow-up, attended outside the day 14–21 follow-up period, or withdrew consent, 72/107 (67.3%) had clinical cure in the SoC arm compared with 68/120 (56.7%) in the IA, giving a difference in cure rate of 10.6% (95% CI −23.2% to 1.9%). We were unable to demonstrate non-inferiority of the IA compared with SoC arm. Women in the IA took more treatment doses compared with the SoC group (113/124 (91%) vs 75/117 (64%), p=0.0001), but were more likely to experience diarrhoea (61% vs 24%, p<0.0001). Of 288 samples available for analysis, Mycoplasma genitalium was identified in 10% (28/288), 58% (11/19) of which had baseline antimicrobial resistance-associated mutations.ConclusionA short-course azithromycin-based regimen is likely to be less effective than the standard treatment with ofloxacin plus metronidazole. The high rate of baseline antimicrobial resistance supports resistance testing in those with M. genitalium infection to guide appropriate therapy.Trial registration number2010-023254-36.

Toxoplasmosis in humans and animals in Brazil: high prevalence, high burden of disease, and epidemiology

Parasitology ◽  
2012 ◽  
Vol 139 (11) ◽  
pp. 1375-1424 ◽  
Author(s):  
J. P. DUBEY ◽  
E. G. LAGO ◽  
S. M. GENNARI ◽  
C. SU ◽  
J. L. JONES
Keyword(s):  
Health Workers ◽  
Congenital Toxoplasmosis ◽  
Protozoan Parasite ◽  
High Rate ◽  
Genetic Characteristics ◽  
Brazilian Government ◽  
Child Bearing ◽  
High Prevalence ◽  
And Control ◽  
Very High

SUMMARYInfections by the protozoan parasiteToxoplasma gondiiare widely prevalent in humans and animals in Brazil. The burden of clinical toxoplasmosis in humans is considered to be very high. The high prevalence and encouragement of the Brazilian Government provides a unique opportunity for international groups to study the epidemiology and control of toxoplasmosis in Brazil. Many early papers on toxoplasmosis in Brazil were published in Portuguese and often not available to scientists in English-speaking countries. In the present paper we review prevalence, clinical spectrum, molecular epidemiology, and control ofT. gondiiin humans and animals in Brazil. This knowledge should be useful to biologists, public health workers, veterinarians, and physicians. Brazil has a very high rate ofT. gondiiinfection in humans. Up to 50% of elementary school children and 50–80% of women of child-bearing age have antibodies toT. gondii. The risks for uninfected women to acquire toxoplasmosis during pregnancy and fetal transmission are high because the environment is highly contaminated with oocysts. The burden of toxoplasmosis in congenitally infected children is also very high. From limited data on screening of infants forT. gondiiIgM at birth, 5–23 children are born infected per 10 000 live births in Brazil. Based on an estimate of 1 infected child per 1000 births, 2649 children with congenital toxoplasmosis are likely to be born annually in Brazil. Most of these infected children are likely to develop symptoms or signs of clinical toxoplasmosis. Among the congenitally infected children whose clinical data are described in this review, several died soon after birth, 35% had neurological disease including hydrocephalus, microcephaly and mental retardation, 80% had ocular lesions, and in one report 40% of children had hearing loss. The severity of clinical toxoplasmosis in Brazilian children may be associated with the genetic characteristics ofT. gondiiisolates prevailing in animals and humans in Brazil.

scholarly journals Effect of Sharbat-e-Deenarin uncomplicated Pelvic Inflammatory Disease- A Clinical study

2020 ◽  
Vol 11 (4) ◽  
pp. 7634-7643
Author(s):  
Ghazala Ahmad ◽  
Ismath Shameem
Keyword(s):  
Clinical Study ◽  
Pelvic Inflammatory Disease ◽  
Inflammatory Disease ◽  
White Blood Cells ◽  
Female Genital Tract ◽  
Lower Abdominal Pain ◽  
Reproductive Age ◽  
Gynecologic Surgery ◽  
Discharge Data ◽  
Vas Score

Pelvic inflammatory disease (Waram al-Rahim)is one of the most serious gynaecological infections of the upper female genital tract with the worldwide annual rate of 10-20/1000 women of reproductive age.  The objective planned for the study was to evaluate the effect of Sharbat-e-Deenar in uncomplicated Pelvic Inflammatory Disease (uPID).  A pre and post observational single group clinical study was carried out in the Department of IlmulQabalatwaAmrazeNiswan, National Institute of Unani Medicine, Hospital, Bengaluru. Diagnosed cases (n=30) of uPID were included in the study. Patients with complicated PID, history of antibiotic therapy within seven days of recruitment; delivery, abortion or gynecologic surgery within the last 30 days,  systemic diseases, malignancies, pregnancy & lactation were excluded. Sharbat-e-Deenarconsists of Poste baikhekasniandTukhmekasni(Cichorium intybus  Linn.), Gulesurkh (Rosa damascene mill.), Tukhmekasoos(CuscutareflexaRoxb.)  and Rewandchini (Rheum emodiWall. ex Meissn) were administered orally in a dose of 20 ml twice daily for 14 days. Outcome measures were 30-70% clinical improvement in Visual Analogue Scale (VAS) score for lower abdominal pain and McCormack Pain Scale (McPS) score for abdominopelvic tenderness and White Blood Cells (WBCs) count <10 on saline microscopy of discharge. Data were analyzed using paired Student ‘t’ test, Wilcoxon Signed rank test and Paired Proportion test.Clinical improvement of 30-70% in McPS and VAS score was achieved in 96.7% (p<0.001**) and 93.3% (p<0.001**) patients respectively. WBCs count <10 on saline microscopy of discharge was achieved in 70% patients (p<0.001**).Sharbat-e-Deenarwas effective in improving the sign & symptoms of PID due to its anti-microbial, anti-inflammatory, anti-spasmodic and anti-oxidant properties. No adverse effect of the research drug was encountered during the study. Hence, Sharbat-e-Deenar serves as an effective alternative in patients with PID, proving the research hypothesis.

scholarly journals Epidemiology and Risk Factors of Pelvic Inflammatory Disease.

2015 ◽  
Vol 13 (1) ◽  
pp. 4-8
Author(s):  
Bandana Pandey
Keyword(s):  
Abdominal Pain ◽  
Pelvic Inflammatory Disease ◽  
Inflammatory Disease ◽  
Rural Areas ◽  
Lower Abdominal Pain ◽  
Reproductive Age ◽  
Modern Contraceptive ◽  
Age Group ◽  
Increased Risk ◽  
Reproductive Age Group

Introduction: Knowledge of pelvic inflammatory disease and its epidemiology is essential to understand reproductive morbidity in women. This paper estimates the level of association between demographic factors and pelvic inflammatory disease in women in their reproductive age. Methods: A descriptive study done in Humla, Kritipur and Baudha by organizing a health camp. Women of reproductive age group and who have lower abdominal pain, pervaginal discharge, fever, and dysparunia were included in the study after taking informed verbal consent from the patient. Patients who have lower abdominal pain and pervaginal discharge were diagnosed as pelvic inflammatory disease. Results: Diagnoses of pelvic inflammatory disease were made in 30% of attendances amongst women aged between 16 to 48. Increased risk of pelvic inflammatory disease was associated with smoking (P<0.0001), age groups 31 – 40 yrs (44.6%),in rural areas(45%) and people who are illiterate (P<0.0001). Among 400, 383(95%) were reported ever using a modern contraceptive. Conclusion: The prevalence of pelvic inflammatory disease was 30% in reproductive age group and was significantly associated with smoking.doi: http://dx.doi.org/10.3126/mjsbh.v13i1.12992 

scholarly journals Laparoscopic evaluation of female infertility in low socioeconomic status

2018 ◽  
Vol 7 (8) ◽  
pp. 3232
Author(s):  
Chesta Saini ◽  
Ashoo Gupta ◽  
Kishore Rajurkar ◽  
Kartik Saxena ◽  
Kanchan Saini ◽  
...  
Keyword(s):  
Pelvic Inflammatory Disease ◽  
Low Socioeconomic Status ◽  
Inflammatory Disease ◽  
Reproductive Age ◽  
Age Group ◽  
Women Of Reproductive Age ◽  
Low Socioeconomic ◽  
Infertile Women ◽  
Major Factors ◽  
Reproductive Age Group

Background: Infertility is a multidimensional health issue which is rising dramatically. The common causes include ovarian, uterine, tubal disorders, hormonal imbalance, age-related factors and lifestyle factors. The low economic strata poses a subset of problems like difficulty in seeking healthcare, treatment costs and poor compliance. Authors sought to evaluate the factors for primary and secondary infertility in women of reproductive age group who belong to low socio-economic strata using laparoscopy.Methods: A prospective observational study was conducted in the obstetrics and gynaecology department at Sanjay Gandhi memorial hospital, Delhi comprising 50 infertile women of reproductive age group belonging to low socioeconomic class for a period of 2 years from June 2015 onwards.Results: Among primary infertility, tuberculosis (27.02%), ovarian cyst (16.22%), adhesions (10.81%), polycystic ovaries (10.81%) and Pelvic inflammatory disease (10.81%) were the major findings whereas in secondary infertility Pelvic inflammatory disease (23.07%), tuberculosis (15.38%), adhesions (15.38%) and endometriosis (7.69%) were the major factors seen in the study.Conclusions: Tuberculosis and pelvic inflammatory disease were the major factors seen in infertile women of low socioeconomic status thus, they should be kept high on the list of differential diagnosis even if the investigative work up is negative.

scholarly journals Cross-sectional imaging of acute gynaecologic disorders: CT and MRI findings with differential diagnosis—part II: uterine emergencies and pelvic inflammatory disease

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Pietro Valerio Foti ◽  
Massimo Tonolini ◽  
Valeria Costanzo ◽  
Luca Mammino ◽  
Stefano Palmucci ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Pelvic Inflammatory Disease ◽  
Inflammatory Disease ◽  
Reproductive Age ◽  
Mri Findings ◽  
Cross Sectional ◽  
Pictorial Review ◽  
Cross Sectional Imaging ◽  
Sectional Imaging ◽  
Ct And Mri

AbstractDue to the growing use of cross-sectional imaging in emergency departments, acute gynaecologic disorders are increasingly diagnosed on urgent multidetector computed tomography (CT) studies, often requested under alternative presumptive diagnoses in reproductive-age women. If clinical conditions and state-of-the-art scanner availability permit, magnetic resonance imaging (MRI) is superior to CT due to its more in-depth characterisationof abnormal or inconclusive gynaecological findings, owing to excellent soft-tissue contrast, intrinsic multiplanar capabilities and lack of ionising radiation.This pictorial review aims to provide radiologists with a thorough familiarity with gynaecologic emergencies by illustrating their CT and MRI appearances, in order to provide a timely and correct imaging diagnosis. Specifically, this second instalment reviews with examples and emphasis on differential diagnosis the main non-pregnancy-related uterine emergencies (including endometrial polyps, degenerated leiomyomas and uterine inversion) and the spectrum of pelvic inflammatory disease.

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