scholarly journals Comparison of Muscle Density in Middle-Aged and Older Chinese Adults Between a High-Altitude Area (Kunming) and a Low-Altitude Area (Beijing)

2021 ◽  
Vol 12 ◽  
Author(s):  
Xingli Liu ◽  
Ling Wang ◽  
Meng Gao ◽  
Gang Wang ◽  
Kai Tang ◽  
...  
Keyword(s):  
High Altitude ◽  
Gluteus Maximus ◽  
Community Dwelling ◽  
Trunk Muscles ◽  
Muscle Quality ◽  
Thigh Muscle ◽  
Quantitative Ct ◽  
Cross Sectional ◽  
Muscle Density ◽  
Low Altitude

Background and PurposeA high-altitude environment was known to have a negative effect on bone and lead to a higher incidence of hip fracture. However, the dependence of muscle composition on altitude is unclear. Thus, we aimed to compare muscle density and area in plateau and low altitude area and to determine the effect of the altitude on these outcomes.MethodsCommunity dwelling adults over 60 years old living in Beijing (elevation 50 m; 300 subjects,107 men and 193 women) or Kunming (elevation 2000 m; 218 subjects,83 men and 135 women) for more than 10 years were enrolled. Quantitative CT was performed in all subjects and cross-sectional area and attenuation measured in Hounsfield units (HU) were determined for the trunk, gluteus, and mid-thigh muscles.ResultsCompared to Beijing, Kunming adults were slimmer (Beijing men vs Kunming men: 25.08 ± 2.62 vs 23.94 ± 3.10kg/m2, P=0.013; Beijing women vs Kunming women: 25.31 ± 3.1 vs 23.98 ± 3.54 kg/m2, P= 0.001) and had higher muscle density in the L2-trunk and gluteus maximus muscles after adjustment for age and BMI (L2-trunk muscles: Beijing men 29.99 ± 4.17 HU vs Kunming men 37.35 ± 4.25 HU, P< 0.0001; Beijing women 27.37 ± 3.76 HU vs Kunming women 31.51 ± 5.12 HU, P< 0.0001; Gluteus maximus muscle: Beijing men 35.11 ± 6.54 HU vs Kunming men 39.36 ± 4.39 HU, P= 0.0009; Beijing women 31.47 ± 6.26 HU vs Kunming women 34.20 ± 5.87 HU P=0.0375). Age was similar in both cohorts and no differences were observed in the gluteus medius and minimus muscle or the mid-thigh muscle, either in the area or density.ConclusionsCompared with Beijing, the adults in Kunming had higher muscle density of the gluteus maximus and L2 trunk muscles, showing that living at a higher altitude might be beneficial to muscle quality.

Androgen therapy improves muscle mass and strength but not muscle quality: results from two studies

2003 ◽  
Vol 285 (1) ◽  
pp. E16-E24 ◽  
Author(s):  
E. Todd Schroeder ◽  
Michael Terk ◽  
Fred R. Sattler
Keyword(s):  
Muscle Quality ◽  
Thigh Muscle ◽  
Muscle Area ◽  
Cross Sectional ◽  
Androgen Therapy ◽  
Leg Muscles ◽  
Immunodeficiency Virus ◽  
Relationship Of ◽  
The Relationship ◽  
Flexion And Extension

The relationship of strength to muscle area was used to assess change in muscle quality after anabolic interventions. Study 1: asymptomatic human immunodeficiency virus-positive men (39 ± 9 yr) were randomized to nandrolone (600 mg/wk) ± resistance training (RT). Study 2: older healthy men (72 ± 5 yr) were randomized to oxandrolone (20 mg/day) or placebo. Maximum voluntary strength was determined by the 1-repetition maximum (1-RM) method for leg press, flexion and extension, and cross-sectional area of leg muscles by MRI. From study week 0 to study week 12, muscle quality was unchanged with nandrolone, oxandrolone, or oxandrolone placebo, respectively, for total thigh muscles (1.23 ± 0.012 vs. 1.27 ± 0.29 kg/cm2; 9.0 ± 1.1 vs. 8.9 ± 1.2 N/cm2; 8.9 ± 1.2 vs. 8.9 ± 1.9 N/cm2) and hamstrings (0.41 ± 0.08 vs. 0.43 ± 0.07 kg/cm2; 0.90 ± 0.14 vs. 0.95 ± 0.016 N/cm2; 0.94 ± 0.23 vs. 0.93 ± 0.21 N/cm2). Lower-extremity 1-RM strength increased several times greater with RT+nandrolone (51–63% increases) than with nandrolone alone (4.7–16%), despite similar increases in muscle area; therefore, muscle quality increased from 1.13 ± 0.17 to 1.51 ± 0.18 kg/cm2 (+36 ± 19%; P < 0.001) for total thigh muscle, 0.37 ± 0.10 to 0.53 ± 0.08 kg/cm2 (+49 ± 39%; P < 0.001) for hamstrings, and 0.73 ± 0.19 to 1.07 ± 0.16 kg/cm2 (+55 ± 36%; P < 0.001) for quadriceps. Thus androgen therapy alone did not improve muscle quality, but the addition of RT to nandrolone produced substantive improvements.

Serum levels of adrenal androgens up to adrenarche in Peruvian children living at sea level and at high altitude

1993 ◽  
Vol 136 (3) ◽  
pp. 517-523 ◽  
Author(s):  
C. Goñez ◽  
A. Villena ◽  
G. F. Gonzales
Keyword(s):  
Public Schools ◽  
High Altitude ◽  
Sea Level ◽  
Serum Levels ◽  
Dehydroepiandrosterone Sulphate ◽  
Adrenal Androgen ◽  
Adrenal Androgens ◽  
Cross Sectional ◽  
Low Altitude ◽  
Cross Sectional Design

ABSTRACT Serum levels of adrenal androgens were measured in children of both sexes living at sea level and at high altitude using a cross-sectional design. The levels were compared in relation to age at each altitude (150 m and 3400 m above sea level), and the first significant increase in mean levels compared with values at preceding ages was assessed and defined as adrenarche. A total of 118 boys and 95 girls aged 6–12 years living at low altitude and 95 boys and 104 girls aged 7–15 years living at high altitude, all of them attending public schools, were studied. Serum dehydroepiandrosterone, dehydroepiandrosterone sulphate and androstenedione were measured by radioimmunoassay and height and weight by standard anthropometric techniques. There were two significant increases in serum levels of adrenal androgens, the first observed in children between 6 and 8 years at sea level, and between 7 and 9 years at high altitude, and the second in children between 10 and 12 years at sea level and between 12 and 15 years at high altitude. Serum adrenal androgen levels increased earlier in children at sea level than at high altitude. It is concluded that adrenarche occurs later at high altitude than at sea level. Journal of Endocrinology (1993) 136, 517–523

scholarly journals Perbandingan prevalensi pterygium pada nelayan di Tuminting dengan petani di Rurukan

e-CliniC ◽  
2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Yusuf S. Tangdilintin ◽  
Laya M. Rares ◽  
Yamin Tongku
Keyword(s):  
High Altitude ◽  
Sea Level ◽  
Sun Exposure ◽  
Cross Sectional ◽  
North Sulawesi ◽  
High Prevalence ◽  
High Altitude Area ◽  
Eye Examination ◽  
Low Altitude ◽  
The Difference

Abstract: Based on Riset Kesehatan Dasar 2013, North Sulawesi is one of 10 provinces in Indonesia that have the highest pterygium prevalence. Previous findings at different areas showed that pterygium is more common at areas with high altitude than at areas with low altitude. Topography of North Sulawesi with mountains and hills might be related to the high prevalence of pterygium at this province. This study was aimed to obtain the difference in pterygium prevalence at area with high altitude compared to area with low altitude at North Sulawesi. This study used a cross sectional quantitative design and was conducted at Tuminting (mean altitude about 0 km above sea level) and at Rurukan (mean altitude about 1km above sea level). There were 51 respondents at each location. Eye examination was performed and data about sun exposure were collected among fishermen at Tuminting and farmers at Rurukan. The results showed that the pterygium prevalence at Rurukan was 56.9% and at Tuminting was 41.2%. Conclusion: There was a difference in pterygium prevalence between people at high altitude area from people at low altitude area at North Sulawesi.Keywords: pterygium, altitude Abstrak: Berdasarkan hasil Riset Kesehatan Dasar 2013 Provinsi Sulawesi Utara termasuk dalam 10 provinsi dengan prevalensi pterygium tertinggi di Indonesia. Temuan sebelumnya di daerah yang lain menemukan prevalensi pterygium lebih tinggi di daerah dengan ketinggian dari permukaan laut yang tinggi dibandingkan daerah dengan ketinggian dari permukaan laut yang rendah. Topografi provinsi Sulawesi Utara yang sebagian besar terdiri dari pegunungan dan bukit-bukit mungkin berhubungan dengan tingginya prevalensi pterygium di Sulawesi Utara. Penelitian ini bertujuan untuk mendapatkan perbedaan prevalensi pterygium pada daerah dengan ketinggian yang tinggi dengan daerah dengan ketinggian yang rendah di Sulawesi Utara. Desain penelitian ialah potong lintang kuantitatif yang dilakukan di Tuminting (ketinggian rata-rata sekitar 0 km di atas permukaan laut) dan di Rurukan (ketinggian rata-rata sekitar 1 km di atas permukaan laut). Terdapat 51 responden pada tiap-tiap lokasi penelitian dan dilakukan pemeriksaan mata serta pengumpulan data mengenai paparan terhadap matahari dari responden nelayan di Tuminting dan responden petani di Rurukan. Hasil penelitian mendapatkan prevalensi pterygium di Rurukan 56,9% dan di Tuminting 41,2%. Simpulan: Terdapat perbedaan prevalensi pterygium di daerah dengan ketinggian dari permukaan laut yang tinggi (Rurukan) dibandingkan daerah dengan ketinggian dari permukaan laut yang rendah (Tuminting) di Sulawesi Utara. Kata kunci: pterygium, ketinggian daerah

scholarly journals Prevalence and risk factors of underweight, overweight and obesity among a geriatric population living in a high-altitude region of rural Uttarakhand, India

2018 ◽  
Vol 21 (10) ◽  
pp. 1904-1911 ◽  
Author(s):  
Aakriti Gupta ◽  
Umesh Kapil ◽  
Ritika Khandelwal ◽  
Preetika Khenduja ◽  
Neha Sareen ◽  
...  
Keyword(s):  
Risk Factors ◽  
High Altitude ◽  
The Elderly ◽  
Overweight And Obesity ◽  
Community Dwelling ◽  
North India ◽  
Elderly Subjects ◽  
Anthropometric Parameters ◽  
Geriatric Population ◽  
Cross Sectional

AbstractObjectiveTo assess the prevalence and risk factors of underweight, overweight and obesity among a geriatric population living in a high-altitude region of India.DesignCommunity-based cross-sectional study. Data were collected on sociodemographic profile and anthropometric parameters. Weight and height measurements were utilized for calculation of BMI. Nutrient intake data were collected using 24 h dietary recall.SettingHigh-altitude region of Nainital District, Uttarakhand State, North India.SubjectsCommunity-dwelling geriatric subjects (n981) aged 60 years or above.ResultsWe found that 26·6 % of the elderly subjects were underweight (BMI<18·5 kg/m2). Overweight (BMI 25·0–29·9 kg/m2) and obesity (BMI≥30·0 kg/m2) was seen among 18·0 % and 4·6 %, respectively. After controlling for potential cofounders, risk factors such as low level of education and income, chewing problems and lower number of daily meals were found to be associated with underweight. On the other hand, risk factors for overweight/obesity were lower age, high income and unskilled work.ConclusionsThere is a need to develop and implement intervention strategies to prevent underweight, overweight and obesity among the geriatric population of India.

scholarly journals The Role of Imaging Biomarkers in the Assessment of Sarcopenia

Diagnostics ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. 534 ◽  
Author(s):  
Roberto Sanz-Requena ◽  
Francisco Miguel Martínez-Arnau ◽  
Ana Pablos-Monzó ◽  
Cristina Flor-Rufino ◽  
Joaquín Barrachina-Igual ◽  
...  
Keyword(s):  
Diagnostic Criteria ◽  
Clinical Assessment ◽  
Early Stage ◽  
Fatty Infiltration ◽  
Community Dwelling ◽  
Muscle Quality ◽  
Imaging Biomarkers ◽  
Proton Density ◽  
Cross Sectional ◽  
Preventive Actions

Background: The diagnosis of sarcopenia through clinical assessment has some limitations. The literature advises studies that include objective markers along with clinical assessment in order to improve the sensitivity and specificity of current diagnostic criteria. The decrease of muscle quality precedes the loss of quantity, so we studied the role magnetic resonance imaging biomarkers as indicators of the quantity and quality of muscle in sarcopenia patients. Methods: a cross-sectional analysis was performed to analyze what MR-derived imaging parameters correlate better with sarcopenia diagnostic criteria in women of 70 years of age and over (independent walking and community-dwelling women who were sarcopenic in accordance with EWGSOP criteria with muscle mass adjusted to Spanish population were chosen). Results: The study included 26 women; 81 ± 8 years old. A strong correlation was obtained between cineanthropometric variables (BMI; thigh perimeter and fat mass) and imaging biomarkers (muscle/fat ratio, fatty infiltration, muscle T2*, water diffusion coefficient, and proton density fat fraction) with coefficients around 0.7 (absolute value). Conclusions: Knowing the correlation of clinical parameters and imaging-derived muscle quality indicators can help to identify older women at risk of developing sarcopenia at an early stage. This may allow taking preventive actions to decrease disability, morbidity, and mortality in sarcopenia patients.

scholarly journals Detraining Effects on Muscle Quality in Older Men with Osteosarcopenia. Follow-Up of the Randomized Controlled Franconian Osteopenia and Sarcopenia Trial (FrOST)

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1528
Author(s):  
Mansour Ghasemikaram ◽  
Klaus Engelke ◽  
Matthias Kohl ◽  
Simon von Stengel ◽  
Wolfgang Kemmler
Keyword(s):  
Older Men ◽  
Community Dwelling ◽  
Muscle Quality ◽  
Thigh Muscle ◽  
Control Group ◽  
Multiple Imputations ◽  
Intention To Treat ◽  
Set Protocol ◽  
Magnetic Resonance Imaging Mri

The present study aimed to determine the effect of detraining on muscle quality (MQ) in older men with osteosarcopenia. Forty-three community-dwelling older men (78 ± 4 years) were randomly allocated to a consistently supervised high-intensity resistance exercise training (HIRT) group (n = 21) or a control group (CG, n = 22). The HIRT scheduled a periodized single set protocol twice weekly. After the intervention, the men were subjected to six months of detraining. Muscle quality (MQ), defined as maximum isokinetic hip/leg extensor strength per unit of mid-thigh intra-fascia volume, was determined by magnetic resonance imaging (MRI) or per unit of thigh muscle mass assessed by dual-energy X-ray absorptiometry (DXA). Intention-to-treat analysis with multiple imputations was applied. We observed significant exercise effects for MQ (p = 0.001). During detraining, the HIRT group lost about one-third of the intervention-induced gain and displayed significantly (p = 0.001) higher MQ reductions compared to the CG. Nevertheless, after training and detraining, the overall intervention effect on MQ remained significant (p ≤ 0.004). In summary, six months of absence from HIRT induce a significant deleterious effect on MQ in older osteosarcopenic men. We conclude that intermitted training programs with training breaks of six months and longer should be replaced by largely continuous exercise programs, at least when addressing MQ parameters.

scholarly journals Blood Pressure in Inhabitants of High Altitude of Western Nepal

2012 ◽  
Vol 52 (188) ◽  
Author(s):  
S Shrestha ◽  
A Shrestha ◽  
S Shrestha ◽  
D Bhattarai
Keyword(s):  
Blood Pressure ◽  
High Altitude ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Blood Pressures ◽  
Study Population ◽  
Low Altitude ◽  
The Difference ◽  
The Given ◽  
Permanent Residents

Introduction: Studies conducted amongst the inhabitants of high altitude suggested that systolic and diastolic blood pressures are lower in the high than in low altitude population. So a study was designed to look at the blood pressure values among permanent residents of high altitudes of rural Western Nepal. Methods: This is a descriptive cross sectional study conducted at two different altitudes (2670 and 2950 meters) of Humla District, Nepal, looking at the blood pressure values among the permanent inhabitants at these altitudes.  Results: Total number of 137 subjects with 73 (53.3%) from 2950 meters and 64 (46.7%) from 2670 meters altitude were enrolled. Mean age of the study population was 35.29 years. Male were 57 (41.6%) and female 80 (58.4%). The difference in systolic blood pressures (118.59 and 114.66 mmHg, P=0.01) and mean arterial pressures (92.0 and 89.5 mmHg, P=0.02) at the altitudes of 2670 and 2950 meters were statistically significant whereas the difference in diastolic BP at these altitudes were not statistically significant. There was no significant correlation of BMI with blood pressure values and no difference was noted in the blood pressure values among the two different ethnic groups at the given altitudes.  Conclusions: Lower rate of hypertension was observed among the inhabitants of high altitude of rural western Nepal. Blood pressure was found to decreases with increase in altitude among permanent inhabitants of high altitude.  Keywords: altitude; blood pressure; high altitude inhabitants; hypertension; physiological change.  

Perceived Voice Disorders in Older Adults and Impact on Social Interactions

2021 ◽  
pp. 1-8
Author(s):  
Connie K. Porcaro ◽  
Clare Singer ◽  
Boris Djokic ◽  
Ali A. Danesh ◽  
Ruth Tappen ◽  
...  
Keyword(s):  
Older Adults ◽  
Social Interactions ◽  
Social Engagement ◽  
Leisure Activities ◽  
Treatment Strategies ◽  
Voice Disorders ◽  
Community Dwelling ◽  
Vocal Performance ◽  
Older Individuals ◽  
Cross Sectional

Purpose Many aging individuals, even those who are healthy, report voice changes that can impact their ability to communicate as they once did. While this is commonly reported, most do not seek evaluation or management for this issue. The purpose of this study was to investigate the prevalence and differences in voice disorders in older adults, along with the effect of fatigue on their social interactions. Method This is a cross-sectional investigation of a community-dwelling sample of individuals aged 60 years or older. Participants completed the Questionnaire on Vocal Performance, the Social Engagement Index subset “Engagement in Social or Leisure Activities,” and the Fatigue Severity Scale. Results Results indicated 32.5% of the 332 participants reported symptoms of voice problems with no difference found between male and female respondents. A slight increase in report of voice problems was noted with each year of age. Participants who self-reported voice problems indicated less interaction in social activities involving communication than those who did not. Finally, as severity of self-reported voice problems increased, an increase was reported by the same individuals for signs of fatigue. Conclusions Voice problems and resulting decreased social interaction are commonly experienced by older individuals. Voice symptoms in older adults have been found to benefit from evidence-based treatment strategies. It is critical to provide education to encourage older individuals to seek appropriate evaluation and management for voice issues through a speech-language pathologist or medical professional.

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