scholarly journals Integrative Lipidomics and Metabolomics for System-Level Understanding of the Metabolic Syndrome in Long-Term Treated HIV-Infected Individuals

2022 ◽  
Vol 12 ◽  
Author(s):  
Sofie Olund Villumsen ◽  
Rui Benfeitas ◽  
Andreas Dehlbæk Knudsen ◽  
Marco Gelpi ◽  
Julie Høgh ◽  
...  
Keyword(s):  
Machine Learning ◽  
Metabolic Syndrome ◽  
Accelerated Aging ◽  
System Level ◽  
People Living With Hiv ◽  
Metabolomics Data ◽  
The Metabolic Syndrome ◽  
Lipid Species ◽  
Living With Hiv ◽  
Visceral Adipose

People living with HIV (PLWH) require life-long anti-retroviral treatment and often present with comorbidities such as metabolic syndrome (MetS). Systematic lipidomic characterization and its association with the metabolism are currently missing. We included 100 PLWH with MetS and 100 without MetS from the Copenhagen Comorbidity in HIV Infection (COCOMO) cohort to examine whether and how lipidome profiles are associated with MetS in PLWH. We combined several standard biostatistical, machine learning, and network analysis techniques to investigate the lipidome systematically and comprehensively and its association with clinical parameters. Additionally, we generated weighted lipid-metabolite networks to understand the relationship between lipidomic profiles with those metabolites associated with MetS in PLWH. The lipidomic dataset consisted of 917 lipid species including 602 glycerolipids, 228 glycerophospholipids, 61 sphingolipids, and 26 steroids. With a consensus approach using four different statistical and machine learning methods, we observed 13 differentially abundant lipids between PLWH without MetS and PLWH with MetS, which mainly belongs to diacylglyceride (DAG, n = 2) and triacylglyceride (TAG, n = 11). The comprehensive network integration of the lipidomics and metabolomics data suggested interactions between specific glycerolipids’ structural composition patterns and key metabolites involved in glutamate metabolism. Further integration of the clinical data with metabolomics and lipidomics resulted in the association of visceral adipose tissue (VAT) and exposure to earlier generations of antiretroviral therapy (ART). Our integrative omics data indicated disruption of glutamate and fatty acid metabolism, suggesting their involvement in the pathogenesis of PLWH with MetS. Alterations in the lipid homeostasis and glutaminolysis need clinical interventions to prevent accelerated aging in PLWH with MetS.

scholarly journals Integrative lipidomics and metabolomics for system-level understanding of the metabolic syndrome in long-term treated HIV-infected individuals

2021 ◽  
Author(s):  
Sofie Olund Villumsen ◽  
Rui Benfeitas ◽  
Andreas D Knudsen ◽  
Marco Gelpi ◽  
Julie Hogh ◽  
...  
Keyword(s):  
Machine Learning ◽  
Metabolic Syndrome ◽  
Fatty Acid ◽  
Acid Metabolism ◽  
System Level ◽  
People Living With Hiv ◽  
Analysis Techniques ◽  
The Metabolic Syndrome ◽  
Living With Hiv

People living with HIV (PLWH) require life-long anti-retroviral treatment and often present with comorbidities such as metabolic syndrome (MetS). A systematic lipidomic characterization and its association with metabolism is currently missing. In this study, we included 100 PLWH with MetS and 100 without MetS from the Copenhagen comorbidity in HIV infection (COCOMO) cohort to examine whether and how lipidome profiles associated with MetS in PLWH. We combined several standard biostatistical, machine learning, and network analysis techniques to investigate the lipidome systematically and comprehensively. Our observations indicate an increased abundance of the glycerolipids and an association between structural composition patterns of glycerolipids in PLWH with MetS. Further integration of the key metabolites identified earlier in the same population and clinical data with lipidomics suggest disruption of the glutamate and fatty acid metabolism. suggest their involvement in pathogenesis of PLWH with MetS.

scholarly journals Impact of Combined Antiretroviral Therapy on Metabolic Syndrome Components in Adult People Living with HIV: A Literature Review

Viruses ◽  
2022 ◽  
Vol 14 (1) ◽  
pp. 122
Author(s):  
Mariusz Sapuła ◽  
Magdalena Suchacz ◽  
Andrzej Załęski ◽  
Alicja Wiercińska-Drapało
Keyword(s):  
Metabolic Syndrome ◽  
Antiretroviral Therapy ◽  
Plasma Lipid ◽  
Hiv Treatment ◽  
New Drugs ◽  
People Living With Hiv ◽  
The Metabolic Syndrome ◽  
Major Interest ◽  
Living With Hiv ◽  
The Impact

The development of metabolic derangements as a result of HIV treatment has been an important area of research since the introduction of zidovudine in the 1980’s. Antiretroviral therapy has intensely evolved in the last three decades, with new drugs gradually incorporated into everyday clinical practice. With the life expectancy of people living with HIV rapidly approaching that of their HIV-negative counterparts, the influence of these antiretrovirals on the development of the components of the metabolic syndrome remains of major interest to clinicians and their patients. In this review, we aimed to discuss the impact of cART on components of the metabolic syndrome, i.e., weight, plasma lipid levels, plasma glucose levels, and blood pressure, describing the influence of cART classes and of individual antiretrovirals. We also aimed to outline the limitations of the research conducted to date and the remaining knowledge gaps in this area.

Metabolic Syndrome in HIV-patients in Antiretroviral Therapy

2020 ◽  
Vol 18 (6) ◽  
pp. 388-395
Author(s):  
Daniel Vargas-Pacherrez ◽  
Helma P. Cotrim ◽  
Leonardo Pires ◽  
Vitor Cunha ◽  
Vitor Coelho ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Antiretroviral Therapy ◽  
International Diabetes Federation ◽  
Cross Sectional Study ◽  
People Living With Hiv ◽  
Anthropometric Data ◽  
Cross Sectional ◽  
History Of ◽  
Family History Of Hypertension ◽  
Living With Hiv

Introduction: The global prevalence of metabolic syndrome (MS) among people living with HIV/AIDS varies from 20% to 33%. Objective: to estimate the prevalence of metabolic syndrome and associated factors in a group of HIV-infected patients on antiretroviral therapy. Methods: This is a cross-sectional study with HIV-infected patients from a reference center in Bahia, Brazil. We evaluated clinical, socio-demographic and anthropometric data. MS was defined according to the guidelines of International Diabetes Federation. Results: We evaluated 152 patients with mean age of 47.3±11.6 years, 59.2% male. The main comorbidities detected were diabetes (3.3%) hypertriglyceridemia (9.3%) and metabolic syndrome (MS,38.2%). Patients with MS were predominantly women (55.2% vs 31.9%; p=0.005), older [52.1 (10.4) vs 44.3 (11.3); p<0.001], and had overweight (74.1% vs 23.4%; p<0.001). After multivariate analysis MS remained associated with age (OR = 1.076; 95% CI: 1.030 – 1.125), female sex (OR = 2.452; 95% CI: 1.114 – 5.374) and family history of hypertension (OR = 3.678; 95% CI: 1.431 – 9.395). Conclusion: Almost half of the HIV-infected patients in Bahia presents with MS which seems to be driven by classical risk factors.

Sarcopenic obesity is associated with lower frequency of CD4+ T cells and high prevalence of metabolic syndrome in people living with HIV

2018 ◽  
Vol 37 ◽  
pp. S21
Author(s):  
I.A. Osuna Padilla ◽  
A. Aguilar Vargas ◽  
A. Villazon de la Rosa ◽  
N.C. Rodriguez Moguel ◽  
Y. Vargas Infante ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
T Cells ◽  
Cd4 T Cells ◽  
Sarcopenic Obesity ◽  
People Living With Hiv ◽  
High Prevalence ◽  
Living With Hiv

scholarly journals Trans cohort metabolic reprogramming towards glutaminolysis in long-term successfully treated HIV-infection

2022 ◽  
Vol 5 (1) ◽  
Author(s):  
Flora Mikaeloff ◽  
Sara Svensson Akusjärvi ◽  
George Mondinde Ikomey ◽  
Shuba Krishnan ◽  
Maike Sperk ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Cell Model ◽  
Antiretroviral Drugs ◽  
Metabolic Reprogramming ◽  
System Level ◽  
People Living With Hiv ◽  
Low Grade ◽  
Middle Income ◽  
Living With Hiv

AbstractDespite successful combination antiretroviral therapy (cART), persistent low-grade immune activation together with inflammation and toxic antiretroviral drugs can lead to long-lasting metabolic flexibility and adaptation in people living with HIV (PLWH). Our study investigated alterations in the plasma metabolic profiles by comparing PLWH on long-term cART(>5 years) and matched HIV-negative controls (HC) in two cohorts from low- and middle-income countries (LMIC), Cameroon, and India, respectively, to understand the system-level dysregulation in HIV-infection. Using untargeted and targeted LC-MS/MS-based metabolic profiling and applying advanced system biology methods, an altered amino acid metabolism, more specifically to glutaminolysis in PLWH than HC were reported. A significantly lower level of neurosteroids was observed in both cohorts and could potentiate neurological impairments in PLWH. Further, modulation of cellular glutaminolysis promoted increased cell death and latency reversal in pre-monocytic HIV-1 latent cell model U1, which may be essential for the clearance of the inducible reservoir in HIV-integrated cells.

Metabolic Syndrome Among People Living with HIV Receiving Medical Care in Southern United States: Prevalence and Risk Factors

2019 ◽  
Vol 23 (11) ◽  
pp. 2916-2925 ◽  
Author(s):  
Sabeena Sears ◽  
Justin R. Buendia ◽  
Sylvia Odem ◽  
Mina Qobadi ◽  
Pascale Wortley ◽  
...  
Keyword(s):  
United States ◽  
Risk Factors ◽  
Metabolic Syndrome ◽  
Medical Care ◽  
Southern United States ◽  
People Living With Hiv ◽  
Living With Hiv

scholarly journals Hyperadiponectinemia protects against premature death in metabolic syndrome model mice by inhibiting AKT signaling and chronic inflammation

2012 ◽  
Vol 213 (1) ◽  
pp. 67-76 ◽  
Author(s):  
S Otabe ◽  
N Wada ◽  
T Hashinaga ◽  
X Yuan ◽  
I Shimokawa ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Accelerated Aging ◽  
Premature Death ◽  
Akt Signaling ◽  
Gene Expressions ◽  
Glucose Levels ◽  
Reactive Protein ◽  
The Metabolic Syndrome ◽  
Daily Food ◽  
Phosphorylated Akt

We previously reported that transgenic (Tg) expression of adiponectin significantly prolonged the lifespan of normal mice. The aim of this study was to elucidate the mechanism involved in the longevity effects of adiponectin using KK/Ta mice, a murine model of metabolic syndrome. We established a Tg line of KK/Ta (Tg-KK/Ta) mice expressing human adiponectin in the liver, and assessed their lifespan. The cause of death was determined by macroscopic and microscopic examinations immediately after death. The expressions of SIRT1, C-reactive protein (CRP), inflammatory cytokines, AMPK, and AKT were measured by quantitative real-time PCR, ELISAs, and/or western blotting. KK/Ta mice had lower serum adiponectin levels and shorter lifespan (57.6±13.9 vs 106.5±18.3 weeks, P<0.0001) than C57BL/6N mice. Tg adiponectin expression significantly extended the lifespan of KK/Ta mice (73.6±16.6 weeks, P<0.001) without affecting body weight, daily food consumption, or plasma glucose levels. Neoplasms were observed in only three of 22 KK/Ta mice that died spontaneously because of tumors. Atherosclerotic lesions were not detected in any mice. SIRT1 levels were not significantly different between KK/Ta and Tg-KK/Ta mice. Gene expressions of Crp, Tnfα, Il6, and Nfκb were increased in KK/Ta mice, but they were significantly attenuated in Tg-KK/Ta mice. Phosphorylated AMPK levels were increased and phosphorylated AKT levels were decreased in Tg-KK/Ta mice. The anti-inflammatory effects of adiponectin, achieved by inhibiting the AKT signaling pathway, may explain how adiponectin slows the accelerated aging process associated with the metabolic syndrome.

Diabetes, Prediabetes, and Metabolic Syndrome Among People Living with HIV

2019 ◽  
pp. 55-75
Author(s):  
Sowmya Chandra Reddy ◽  
William Bealle Moore ◽  
Papita Martina Rozario ◽  
Amy H. Warriner
Keyword(s):  
Metabolic Syndrome ◽  
People Living With Hiv ◽  
Living With Hiv
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