Biologics for Psoriasis During the COVID-19 Pandemic

Coronavirus disease 2019 (COVID-19), a new form of acute infectious respiratory syndrome first reported in 2019, has rapidly spread worldwide and has been recognized as a pandemic by the WHO. It raised widespread concern about the treatment of psoriasis in this COVID-19 pandemic era, especially on the biologics use for patients with psoriasis. This review will summarize key information that is currently known about the relationship between psoriasis, biological treatments, and COVID-19, and vaccination-related issues. We also provide references for dermatologists and patients when they need to make clinical decisions. Currently, there is no consensus on whether biological agents increase the risk of coronavirus infection; however, current research shows that biological agents have no adverse effects on the prognosis of patients with COVID-19 with psoriasis. In short, it is not recommended to stop biological treatment in patients with psoriasis to prevent the infection risk, and for those patients who tested positive for SARS-CoV-2, the decision to pause biologic therapy should be considered on a case-by-case basis, and individual risk and benefit should be taken into account. Vaccine immunization against SARS-CoV-2 is strictly recommendable in patients with psoriasis without discontinuation of their biologics but evaluating the risk-benefit ratio of maintaining biologics before vaccination is mandatory at the moment.

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The importance and significance of gene polymorphisms in preeclampsia

HEALTH OF WOMAN ◽

10.15574/hw.2016.114.45 ◽

2016 ◽

pp. 45-49

Author(s):

P.N. Veropotvelyan ◽

◽

I.S. Tsehmistrenko ◽

N.P. Veropotvelyan ◽

N.S. Rusak ◽

...

Keyword(s):

Oxidative Stress ◽

Systematic Review ◽

Early Diagnosis ◽

Gene Polymorphisms ◽

Individual Risk ◽

Extended Study ◽

Stress Genes ◽

Detoxification System ◽

The Individual ◽

The Relationship

Was to conduct a systematic review of data on the relationship between polymorphisms genes of detoxification system and development of preeclampsia (РЕ). Рresents the main genes of detoxification system (GSTPI, GSTМI, GSTТI, GРХI, ЕРНХI, SOD-2, SOD-3, CYPIAL, MTHЕR, MTR) and their functions. Of interest is the possibility of calculating the individual risk of PE based on the results about the presence of a combination of different polymorphisms in the genotype of the female. Question about early diagnosis of РЕ remains controversial and not fully understood. It is necessary to conduct further in-depth, extended study of this problem. Key words: preeclampsia, oxidative stress, genes of the detoxification system.

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Gossip about Coronavirus: Infection status and norm adherence shape social responses

Group Processes & Intergroup Relations ◽

10.1177/1368430221991232 ◽

2021 ◽

Vol 24 (4) ◽

pp. 658-679

Author(s):

Terence D. Dores Cruz ◽

Romy van der Lee ◽

Bianca Beersma

Keyword(s):

Social Exclusion ◽

Behavioral Intentions ◽

Infection Risk ◽

Infection Status ◽

Social Responses ◽

Social Distancing ◽

Important Pathway ◽

Group Members ◽

Coronavirus Infection

To stop the spread of the Coronavirus, people must avoid infection risk. Given widespread skepticism regarding information concerning the Coronavirus received from authorities, one potentially important pathway to estimate the infectiousness of one’s group members could be through gossip (i.e., information about an absent target). Infection risk is reflected by both infection status and adherence to social distancing norms. In hypothetical scenarios ( N = 837), participants received gossip that we manipulated to describe a group member’s infection status and/or norm adherence. Results showed people tended to believe gossip and that gossip influenced behavioral intentions to avoid and punish targets of gossip as well as the perception of targets. We conclude that gossip, while potentially unreliable, could affect how people treat group members. We discuss how gossip could alleviate the Coronavirus crisis by contributing to slowing the Coronavirus’s spread, as well as exacerbate it through increased social exclusion based on unverified information.

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ACE2 Is an Adjacent Element of Atherosclerosis and COVID-19 Pathogenesis

International Journal of Molecular Sciences ◽

10.3390/ijms22094691 ◽

2021 ◽

Vol 22 (9) ◽

pp. 4691

Author(s):

Anastasia V. Poznyak ◽

Evgeny E. Bezsonov ◽

Ali H. Eid ◽

Tatyana V. Popkova ◽

Ludmila V. Nedosugova ◽

...

Keyword(s):

Cardiovascular System ◽

Renin Angiotensin System ◽

Myocardial Damage ◽

Angiotensin Converting Enzyme 2 ◽

Adjacent Element ◽

Chinese Province ◽

Coronavirus Infection ◽

First Time ◽

The Relationship ◽

Interspecies Barrier

COVID-19 is a highly contagious new infection caused by the single-stranded RNA Sars-CoV-2 virus. For the first time, this infection was recorded in December 2019 in the Chinese province of Wuhan. The virus presumably crossed the interspecies barrier and passed to humans from a bat. Initially, the disease was considered exclusively in the context of damage to the respiratory system, but it quickly became clear that the disease also entails serious consequences from various systems, including the cardiovascular system. Among these consequences are myocarditis, myocardial damage, subsequent heart failure, myocardial infarction, and Takotsubo syndrome. On the other hand, clinical data indicate that the presence of chronic diseases in a patient aggravates the course and outcome of coronavirus infection. In this context, the relationship between COVID-19 and atherosclerosis, a condition preceding cardiovascular disease and other disorders of the heart and blood vessels, is particularly interesting. The renin-angiotensin system is essential for the pathogenesis of both coronavirus disease and atherosclerosis. In particular, it has been shown that ACE2, an angiotensin-converting enzyme 2, plays a key role in Sars-CoV-2 infection due to its receptor activity. It is noteworthy that this enzyme is important for the normal functioning of the cardiovascular system. Disruptions in its production and functioning can lead to various disorders, including atherosclerosis.

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Feelings of Guilt and Fantasies in Life Experiences of Brazilian Parents Due to Death of their Newborn: A Clinical-qualitative Study Conducted at a University Hospital

European Psychiatry ◽

10.1016/j.eurpsy.2017.01.986 ◽

2017 ◽

Vol 41 (S1) ◽

pp. S616-S616

Author(s):

L. Rodrigues ◽

J.V. Freitas-de-Jesus ◽

G. Lavorato-Neto ◽

D.D. Lima ◽

E.R. Turato ◽

...

Keyword(s):

Neonatal Intensive Care ◽

Life Experiences ◽

Technological Development ◽

Emotional Experience ◽

University Hospital ◽

Parents And Children ◽

Cultural Pattern ◽

Competing Interest ◽

The Moment ◽

The Relationship

IntroductionThe relationship between parents and children is a complex link. In the process of pregnancy-birth-puerperium, frequent feelings such as responsibility, love, fear, uncertainty, generate strong expectations at birth. The death of a newborn may not be perceived as natural by the parents, considering the local culture and the context of great technological development of neonatology.ObjectiveTo explore possible guilt and fantasies in life experiences of parents during mourning process due to death of their newborn.MethodClinical-qualitative design, a particularization of qualitative methods here applied in clinical assistance settings with highlight to psychological aspects. Data collection with the technique of semi-directed interview with open-ended questions, in-depth. Sample intentionally constructed, with closure by theoretical saturation of information. The participants were 7 parents, mourning by the death of their child at the neonatal intensive care unit, in a university hospital of Campinas, São Paulo State.ResultsFeelings of guilt - conscious or not - lead to an internal and particular movement so that mourning can be lived. The participants showed certain embarrassment, accompanied by natural suffering facing to the cultural pattern that permeates the emotional experience. It predicts types of psychological meanings that the experience will give to the person.ConclusionHealth professionals working with bereaved parents should consider more deeply the moment these one experienced, with emphasis on the details of the death scenery, beside the problems of illness and death properly so called.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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Embodying the Site: the Here and Now in Site-Specific Dance Performance

New Theatre Quarterly ◽

10.1017/s0266464x05000230 ◽

2005 ◽

Vol 21 (4) ◽

pp. 367-381 ◽

Cited By ~ 7

Author(s):

Victoria Hunter

Keyword(s):

Creative Process ◽

Dance Performance ◽

Site Specific ◽

The Creation ◽

Spirit Of Place ◽

The Moment ◽

The University ◽

The Relationship

In this article, Victoria Hunter explores the concept of the ‘here and now’ in the creation of site-specific dance performance, in response to Doreen Massey's questioning of the fixity of the concept of the ‘here and now’ during the recent RESCEN seminar on ‘Making Space’, in which she challenged the concept of a singular fixed ‘present’, suggesting instead that we exist in a constant production of ‘here and nows’ akin to ‘being in the moment’. Here the concept is applied to an analysis of the author's recent performance work created as part of a PhD investigation into the relationship between the site and the creative process in site-specific dance performance. In this context the notion of the ‘here and now’ is discussed in relation to the concept of dance embodiment informed by the site and the genius loci, or ‘spirit of place’. Victoria Hunter is a Lecturer in Dance at the University of Leeds, who is currently researching a PhD in site-specific dance performance.

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Predicting emotions in music using the onset curve

Psychology of Music ◽

10.1177/03057356211031658 ◽

2021 ◽

pp. 030573562110316

Author(s):

Elena Saiz-Clar ◽

Miguel Ángel Serrano ◽

José Manuel Reales

Keyword(s):

Emotional Response ◽

Principal Component ◽

Musical Instrument ◽

Musical Score ◽

Musical Note ◽

Human Voice ◽

Frequency Domains ◽

Complete Set ◽

The Moment ◽

The Relationship

The relationship between parameters extracted from the musical stimuli and emotional response has been traditionally approached using several physical measures extracted from time or frequency domains. From time-domain measures, the musical onset is defined as the moment in that any musical instrument or human voice issues a musical note. The onsets’ sequence in the performance of a specific musical score creates what is known as the onset curve (OC). The influence of the structure of OC on the emotional judgment of people is not known. To this end, we have applied principal component analysis on a complete set of variables extracted from the OC to capture their statistical structure. We have found a trifactorial structure related to activation and valence dimensions of emotional judgment. The structure has been cross-validated using different participants and stimuli. In this way, we propose the factorial scores of the OC as a reliable and relevant piece of information to predict the emotional judgment of music.

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ON THE EXTREMAL DEPENDENCE COEFFICIENTS OF GAUSSIAN DISTRIBUTIONS

Vestnik NSUEM ◽

10.34020/2073-6495-2021-1-161-167 ◽

2021 ◽

pp. 161-167

Author(s):

S. E. Khrushchev

Keyword(s):

Close Correlation ◽

Gaussian Copula ◽

Marginal Distributions ◽

Gaussian Distributions ◽

Extremal Dependence ◽

Zero Values ◽

Coronavirus Infection ◽

The Russian Federation ◽

The One ◽

The Relationship

The paper considers a way to represent the relationship between indicators in the form of copulas. Copulas are popular mathematical tools. This is due to the fact that, on the one hand, the marginal distributions of indicators are divided in the copulas, and on the other hand, the structure of the relationship between these marginal distributions is divided, which makes it possible to very effectively study the connections that arise in real populations. Special attention in the work is paid to extremal dependence coefficients - important numerical characteristics of the connection in conditions of extreme small or extremely large values of indicators. It is shown that even under conditions of close correlation between the indices for a two-dimensional Gaussian distribution, the lower and upper coefficients of the extreme dependence take zero values. This indicates the impossibility of predicting the values of one indicator when fixing too small or too large values of another indicator. This work shows that the relationship between the number of COVID-19 coronavirus infections per 100,000 people and the number of deaths from COVID-19 coronavirus infection per 100,000 people in the regions of the Russian Federation can be represented in the form of a Gaussian copula.

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Nitrogen management in wheat based on the normalized difference vegetation index (NDVI)

Ciência Rural ◽

10.1590/0103-8478cr20170743 ◽

2018 ◽

Vol 48 (9) ◽

Cited By ~ 2

Author(s):

André Luis Vian ◽

Christian Bredemeier ◽

Marcos Alexandre Turra ◽

Cecília Paz da Silva Giordano ◽

Elizandro Fochesatto ◽

...

Keyword(s):

Technical Efficiency ◽

Vegetation Index ◽

Normalized Difference Vegetation Index ◽

Field Experiments ◽

Shoot Biomass ◽

Sensor Field ◽

N Dose ◽

Plant Emergence ◽

The Moment ◽

The Relationship

ABSTRACT: Biomass production and nitrogen (N) accumulated in wheat shoots may be used for quantifying optimal topdressing nitrogen doses. The objective of this study was to develop and validate models for estimating the amount of biomass and nitrogen accumulated in shoots and the N topdressing dose of maximum technical efficiency in wheat using the normalized difference vegetation index (NDVI) measured by an active optical canopy sensor. Field experiments were carried out in two years and treatments consisted of N doses applied at plant emergence and as topdressing. NDVI, shoot biomass and N accumulated in shoots at the growth stage of six fully expanded leaves and grain yield were evaluated, being determined the topdressing N dose of maximum technical efficiency (DMTE). The NDVI was positively correlated to shoot biomass and N content in shoots and models for the relationship between these variables were developed and validated. The DMTE was negatively correlated with the NDVI value evaluated at the moment of N topdressing application. Thus, NDVI evaluation by an active optical canopy sensor can be used for nitrogen fertilization in variable rate, allowing the adjustment of applied N doses in different areas within a field.

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Interpersonal Conflicts in the Relationship of Twins

Acta geneticae medicae et gemellologiae twin research ◽

10.1017/s0001566000000040 ◽

1998 ◽

Vol 47 (3-4) ◽

pp. 153-160

Author(s):

S. A. Gruszewska

Keyword(s):

Social Life ◽

Interpersonal Conflict ◽

The Other ◽

Psychological Space ◽

Interpersonal Conflicts ◽

Educational Methods ◽

The Moment ◽

Relationship Of ◽

The Relationship

AbstractTaking into consideration two facts: that the structure of social life forces twins to part and that the presented roles in a pair are not equal, (one of the twins plays the role of a leader (L) and the other, the subordinate (P.)), one can ask the question — what meaning does the moment of parting have and what are its consequences?In order to do that, a survey was conducted, (a sample of 31 pairs of twins above the age of 30), in which every pair was asked the question: “Which one of you made the decision about parting?” The answer had two options: A – I, B – brother/sister. Out of 31 pairs of twins, 16 pairs chose the variant different from his brother or sister – that is A, B, admitting that the interpersonal conflict was the result of the parting. In 7 pairs, both twins chose the B variant – they withdrew from the conflict; and in 8 pairs they chose the A variant – looking for a compromise as the means of agreement.When analyzing the results of the survey, we can state the following:– in the relationship of twins, there is an interpersonal conflict;– the decision about parting is difficult with prevalent feelings of sadness and sorrow;– after parting, at least one of the twins has problems with preserving his identity and integrity of psychological space.Since the moment of parting is necessary and difficult, specialists and mainly parents are required to consciously change their position towards the relationship of twins. It has to be the result of applied educational methods which aim at creating subjectivity and equality of each of the twins before the moment of parting.

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Hues of Color Afterimages

i-Perception ◽

10.1177/2041669520903553 ◽

2020 ◽

Vol 11 (1) ◽

pp. 204166952090355 ◽

Cited By ~ 1

Author(s):

Jan Koenderink ◽

Andrea van Doorn ◽

Christoph Witzel ◽

Karl Gegenfurtner

Keyword(s):

Iterative Method ◽

Fixation Mark ◽

Narrow Region ◽

Left And Right ◽

The Moment ◽

Color Circle ◽

The Relationship ◽

Method Of Adjustment

We studied the relationship between color afterimages and complementary colors. The hues of afterimages of 24 inducer hues, uniformly distributed over the rgb color circle, were measured by an iterative method of adjustment. The judgment of equality of hue of the afterimage and a synthesized patch was effectively judged at the moment immediately after the switch-off of the inducer, when the synthesized patch went through any number of iterative adjustments. The two patches—both phenomenally present, but only one optically presented—appeared to the left and right of a fixation mark that was fixated throughout the whole procedure. Thus, both patches were present in eccentric vision. The hues of afterimages were found to be quite different from the hue of the complementary of the inducer. Almost one half of the color circle (orange to chartreuse) leads to afterimage hues in a narrow region of purples. This implies that color circles based on diametrically opposed inducer–afterimage hues are necessarily inconsistent. Yet, perhaps surprisingly, the relation between primary and afterimage hues is still approximately an involution (they are reciprocally related).

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