scholarly journals Liriopogons (Genera Ophiopogon and Liriope, Asparagaceae): A Critical Review of the Phytochemical and Pharmacological Research

2021 ◽  
Vol 12 ◽  
Author(s):  
Feiyi Lei ◽  
Caroline S. Weckerle ◽  
Michael Heinrich
Keyword(s):  
Myeloid Leukemia ◽  
Scientific Evidence ◽  
Bioactive Metabolites ◽  
Therapeutic Uses ◽  
Anti Cancer ◽  
Ophiopogon Japonicus ◽  
Anti Oxidant ◽  
Methodological Problems ◽  
Available Information

The closely related genera Liriope and Ophiopogon (Asparagaceae), collectively known in English as liriopogons, have similar therapeutic uses in treating cough, rheumatoid arthritis, and cleaning heat. The main aim of this review is to understand the current phytochemical and pharmacological knowledge including an assessment of the quality of the scientific evidence. A literature search was conducted in line with PRISMA guidelines, by retrieving available information up to 2020 from five online resources. The bioactive metabolites of liriopogons include steroidal saponins, flavonoids, polysaccharides, organic acids, phenols. Cardiovascular protective, anti-inflammatory, anti-diabetic, anti-oxidant, anti-cancer, neuroprotective, anti-viral, anti-acute myeloid leukemia and hepatoprotective effects have been at the center of attention. From a toxicological perspective Ophiopogon japonicus seems to be safe. Some problems with the quality of the pharmacological evidence stand out including the application of excessive dose level and methodological problems in the design. Additionally, a reasonable link between local/traditional uses and pharmacological assessment is often vague or not reflected in the text. Future researches on liriopogons are required to use rigorous scientific approaches in research on evidence-based natural products for the future benefits of patients.

scholarly journals TERMINALIA CHEBULA: SUCCESS FROM BOTANY TO ALLOPATHIC AND AYURVEDIC PHARMACY

2016 ◽  
Vol 9 (5) ◽  
pp. 21
Author(s):  
Varun Garg ◽  
Barinder Kaur ◽  
Sachin Kumar Singh ◽  
Bimlesh Kumar
Keyword(s):  
Chemical Constituents ◽  
Present Review ◽  
Terminalia Chebula ◽  
Pharmacological Activities ◽  
Therapeutic Uses ◽  
Anti Cancer ◽  
Anti Oxidant ◽  
Anti Inflammatory

ABSTRACTTerminalia chebula (TC) is a unique herb having various therapeutic potentials as anti-inflammatory, antioxidant, anticancer, and digestant. It belongsto family Combretaceae. In the present review, an attempt has been made to decipher classification, chemical constituents, therapeutic uses, andpatents that have been reported for TC. Various pharmacological activities of TC that make it as potential medicine and its Ayurvedic formulationsare highlighted.Keywords: Terminalia chebula, Anti-oxidant, Anti-cancer, Ayurvedic formulations, Anti-oxidant.

scholarly journals Pharmacognostical and Phytochemical Evaluation of Haridra (Curcuma Longa Linn.)

AYUSHDHARA ◽  
2021 ◽  
pp. 3309-3315
Author(s):  
Prachisha.P.C ◽  
Sumit Nathani
Keyword(s):  
Tamil Nadu ◽  
Andhra Pradesh ◽  
Curcuma Longa ◽  
Phytochemical Analysis ◽  
Present Sample ◽  
Anti Cancer ◽  
North Eastern ◽  
Anti Oxidant ◽  
Increasing Demand

Curcuma longa Linn. is a very commonly used herb in the day-to-day life for therapeutic and culinary purposes. Haridra commonly known as ‘Golden spice’ belongs to Zingiberaceae  family and is very well known for its pharmacological actions like hepatoprotective, anti-allergic, immune-stimulant, anti-cancer, anti-tumor, anti-hyperlipidemic, anti-oxidant, anti-microbial, anti-diabetic etc. According to the growing regions there are so many varieties of Haridra like Kerala, Tamil Nadu, Maharashtra, Andhra Pradesh, Orissa and North Eastern varieties. All medicinal plants contain phytochemicals or bioactive compounds which plays the key role in its therapeutic action. Most of the drugs show variations in these phytochemicals due to its growing regions which results in severe variations of its quality and efficacy. Also the globalisation and increasing demand for Ayurveda drugs resulted in unavailability of authentic and quality drugs in market which meets the quality standards. Objective: Kerala variety of Turmeric is very well known for its high Curcumin, which is up to 6.5%. Present study is to evaluate the quality of Kerala variety of Haridra sample. Material and methods: This study involves pharmacognostical and phytochemical analysis of Kerala variety of Haridra samples to ensure its purity, safety and quality. Observations and Results: All the findings of the phytochemical and pharmacognostical study were within the standards of quality as per API. Conclusion: The present sample of Haridra, the Kerala variety was found to be rich in Quality and was safe, pure and authentic.

scholarly journals Myristica fragrans (Jaiphal): A Significant Medicinal Herbal Plant

2021 ◽  
Vol 8 (2) ◽  
pp. 213-224
Author(s):  
Isha Kumari ◽  
Hemlata Kaurav ◽  
Gitika Chaudhary
Keyword(s):  
Herbal Remedies ◽  
Herbal Drugs ◽  
Myristica Fragrans ◽  
Therapeutic Uses ◽  
Wide Range ◽  
Anti Cancer ◽  
The World ◽  
Anti Oxidant ◽  
Myristica Fragrans Houtt ◽  
Herbal Plant

The tradition of using herbal drugs and herbal remedies for treating human ailments is very old. From last few years, the demand of herbal remedies has been increased. Myristica fragrans Houtt, commonly known as nutmeg, is a very common spice, which is used around the world. It is described in almost each medicine system such as Ayurveda, Siddha, Unani and folk system. It has wide range of fixed oils and essential oils in it for example myristicin, safrole, myristic acid, trimyristicin, eugenol, elimicin and meso-dihydroguaiaretic acid. Myristica fragrans Houttis well considered medicinal plant for its extraordinary properties like aphrodisiac, hepatoprotective, antimicrobial, anti-diabetic, anti-oxidant, anti-cancer etc. The review aim is to provide data/information related to medicinal herbal plant called Myristica fragrans such as its phytomedicinal value in traditional medicine systems like Ayurveda and folk system, its therapeutic uses and associated toxicity.

scholarly journals POTENTIAL AND THERAPEUTIC BENEFITS OF TINOSPORA CORDIFOLIA

2021 ◽  
Vol 10 (3) ◽  
pp. 2965-2970
Author(s):  
Prashant L Pingale ◽  
Keyword(s):  
Tinospora Cordifolia ◽  
Immunomodulatory Activity ◽  
Antipyretic Activity ◽  
Therapeutic Benefits ◽  
Anti Cancer ◽  
Potential Benefits ◽  
Anti Oxidant ◽  
Large Application ◽  
Ayurvedic Treatment

Essential crude products with potential benefits are steadily achieving significance in clinical studies and research because of their quality of minimal adverse effects as associated with allopathic medications. Tinospora cordifolia usually recognized as Guduchi is known for its large application in the therapy and cure of various diseases in conventional ayurvedic treatment. Recently the classification of active constituents of Guduchi and their inherent function in disease limitation has led us to an active activity in the plant around the globe. This review comprises the genetic variety of the parts of Tinospora cordifolia and active ingredients isolated from Tinospora cordifolia and helps in treating diseases due to their potential benefits such as Anti-oxidant activity, Anti-diabetic activity, Immunomodulatory activity, Anti-cancer activity, Anti-toxic effect, Anti-hyperlipidemic Property, Analgesic, anti-inflammatory, antipyretic activity, and many others. This review aims to utilize the biochemical and significant routes induced by the aggregates separated from Tinospora cordifolia to allow different and efficient therapeutic formulations in disease elimination.

scholarly journals Uncovering expression signatures of synergistic drug response using an ensemble of explainable AI models

2021 ◽  
Author(s):  
Joseph D Janizek ◽  
Ayse Berceste Dincer ◽  
Safiye Celik ◽  
Hugh Chen ◽  
William Chen ◽  
...  
Keyword(s):  
Myeloid Leukemia ◽  
Cancer Drug ◽  
Drug Synergy ◽  
Molecular Features ◽  
Cancer Pharmacology ◽  
Novel Approach ◽  
Anti Cancer ◽  
Explainable Ai ◽  
Highly Correlated

Complex machine learning models are poised to revolutionize the treatment of diseases like acute myeloid leukemia (AML) by helping physicians choose optimal combinations of anti-cancer drugs based on molecular features. While accurate predictions are important, it is equally important to be able to learn about the underlying molecular basis of anti-cancer drug synergy. Explainable AI (XAI) offers a promising new route for data-driven cancer pharmacology, combining highly accurate models with interpretable insights into model decisions. Due to the highly correlated, high-dimensional nature of cancer transcriptomic data, however, we find that existing XAI approaches are suboptimal when applied naively to large transcriptomic datasets. We show how a novel approach based on model ensembling helps to increase the quality of explanations. We then use our method to demonstrate that a hematopoietic differentiation signature underlies synergy for a variety of anti-AML drug combinations.

scholarly journals Acalypha indica L. - an Important Medicinal Plant: A Brief Review of Its Pharmacological Properties and Restorative Potential

2020 ◽  
pp. 1-10
Author(s):  
Sudhakar Chekuri ◽  
Lali Lingfa ◽  
Shivaprasad Panjala ◽  
K. C. Sai Bindu ◽  
Roja Rani Anupalli
Keyword(s):  
Medicinal Plant ◽  
Review Article ◽  
Synthetic Chemicals ◽  
Medicinal Value ◽  
Therapeutic Uses ◽  
Anti Cancer ◽  
Anti Oxidant ◽  
Medicinal Properties ◽  
Important Medicinal Plant ◽  
Acalypha Indica

Medicinal plants are moving from border to mainstream use with a more number of people seeking treatment and health approaches free from side effects caused by synthetic chemicals. India officially recognizes over 3500 plants for their medicinal value. It is generally estimated that over 6000 plants in India are in use in folk, traditional and herbal medicine. This review article aims to provide a comprehensive review on the phytochemical and various pharmacological aspects of Acalypha indica. This plant widely used in traditional medicinal system of India and many other countries has been reported to possess anti-cancer, anti-diabetic, anti-oxidant, anti-bacterial, antifungal hepatoprotective, anti-inflammatory, and also used to check anti-ulcers and wounds healing. It is known as a rich source of glycosides, flavanoids and tannins. The medicinal properties and therapeutic uses of Acalypha indica and its secondary metabolites investigations prove its importance as a valuable medicinal plant.

scholarly journals The Effects of Capsaicin on Gastrointestinal Cancers

Molecules ◽  
2020 ◽  
Vol 26 (1) ◽  
pp. 94
Author(s):  
George Denis Alexandru Popescu ◽  
Cristian Scheau ◽  
Ioana Anca Badarau ◽  
Mihai-Daniel Dumitrache ◽  
Ana Caruntu ◽  
...  
Keyword(s):  
Molecular Mechanisms ◽  
Scientific Evidence ◽  
Inflammatory Cells ◽  
Incidence And Mortality ◽  
Organ Specific ◽  
Anti Oxidant ◽  
The Subject ◽  
Gi Cancers ◽  
High Doses

Gastrointestinal (GI) cancers are a group of diseases with very high positions in the ranking of cancer incidence and mortality. While they show common features regarding the molecular mechanisms involved in cancer development, organ-specific pathophysiological processes may trigger distinct signaling pathways and intricate interactions with inflammatory cells from the tumoral milieu and mediators involved in tumorigenesis. The treatment of GI cancers is a topic of increasing interest due to the severity of these diseases, their impact on the patients’ survivability and quality of life, and the burden they set on the healthcare system. As the efficiency of existing drugs is hindered by chemoresistance and adverse reactions when administered in high doses, new therapies are sought, and emerging drugs, formulations, and substance synergies are the focus of a growing number of studies. A class of chemicals with great potential through anti-inflammatory, anti-oxidant, and anti-tumoral effects is phytochemicals, and capsaicin in particular is the subject of intensive research looking to validate its position in complementing cancer treatment. Our paper thoroughly reviews the available scientific evidence concerning the effects of capsaicin on major GI cancers and its interactions with the molecular pathways involved in the course of these diseases.

scholarly journals Tulsi - A Review Based Upon Its Ayurvedic and Modern Therapeutic Uses

2021 ◽  
Vol 8 (5) ◽  
pp. 263-272
Author(s):  
Shifali Thakur ◽  
Shailja Choudhary ◽  
Bhawna Walia
Keyword(s):  
Neuroprotective Activity ◽  
Ocimum Sanctum ◽  
Indian Culture ◽  
Therapeutic Uses ◽  
Anti Cancer ◽  
Sanskrit Word ◽  
Herbal Plants ◽  
Anti Oxidant ◽  
Ancient Times ◽  
Phytochemical Constituents

Herbal plants are considered as the most significant source of medicines. These herbal plants are in practice from ancient times. Traditionally, all the parts of the plant are used for curing various diseases. One of the most important herbal plants is the Ocimum sanctum also called tulsi. This plant is considered a sacred plant in Indian culture and used for holy purposes as well. The name Tulsi comes from Sanskrit word which means "the incomparable one". Tulsi plant is not only used in ayurvedic medicines but also used in other medicinal systems in Greek, Roman and Unani. Apart from this, the Tulsi plant possesses different therapeutical properties due to the presence of several phytochemical constituents in its roots, stem, fruit, and leaves due to the presence of eugenol, vallinin, gallic acid, palmitic acid, oleic acid, linoleic acid, and many more. These phytochemicals are extracted from the plant and used to cure various types of diseases. Tulsi is reported to have properties like anti-ulcer, anti-oxidant, anti-inflammatory, anti-cancer, antidiabetic, anti-arthritic, analgesic, antistress, anti-asthmatic, antifertility, immunomodulatory, and neuroprotective activity. Keywords: Ocimum sanctum, phytochemicals, Eugenol, Tulsi, Ayurveda.

Role of Rasayan Churna in outbreak of Covid -19 as preventive and curative aspect

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 1208-1212
Author(s):  
Amol Madhav Deshpande ◽  
Mayuri Amol Deshpande
Keyword(s):  
Recurrent Infection ◽  
Symptomatic Patient ◽  
H1n1 Influenza ◽  
Drug Of Choice ◽  
Asymptomatic Patients ◽  
Diseased Person ◽  
Anti Cancer ◽  
Anti Oxidant ◽  
Immune Booster ◽  
Respiratory Droplets

In last two decade world suffer with three epidemic diseases like SARS-CoV, H1N1 influenza, MERS –CoV and presently the world under a pandemic of Covid-19, out of these SARS-CoV, MERS –CoV and Covid-19 are form the same virus call as corona, which primary present on bats and transferred from animal to human, and then it transfer from human to human mostly by respiratory droplets or in the direct contact with the diseased person, these recurrent infection of corona virus is the burning issue in the word, so to avoid these recurrent infections good habitual behaviour with regular immune booster medicine should be taken which can be used in both normal and symptomatic patient for this Rasayan churna  is the best drug of choice as it is used for  rejuvenation therapy. From literally study from various recourses it is found that Rasayan churna have property anti-depressant, anti-xylotic, Immunomodulatory, Anti-diabetes, anti hypertensive, anti-inflammatory, Anti-toxic effects, Anti-arthritic, Anti-cancer effects, Anti-microbial effect, and Anti-oxidant which can be useful in preventive aspect of Covid -19 in all phase like normal individual, also can be used in asymptomatic patients and symptomatic patients, clinical study can be performed for the same to evaluate the result.

Resveratrol: A new potential therapeutic agent for melanoma?

2019 ◽  
Vol 26 ◽  
Author(s):  
Mohamad Hossein Pourhanifeh ◽  
Kazem Abbaszadeh-Goudarzi ◽  
Mohammad Goodarzi ◽  
Sara G.M. Piccirillo ◽  
Alimohammad Shafiee ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Therapeutic Agent ◽  
Current Knowledge ◽  
Treatment Resistance ◽  
Anti Cancer ◽  
Apoptosis Inducer ◽  
Life Threatening ◽  
First Time

: Melanoma is the most life-threatening and aggressive class of skin malignancies. The incidence of melanoma has steadily increased. Metastatic melanoma is greatly resistant to standard anti-melanomatreatments such as chemotherapy, and 5-year survival rate of cases with melanoma who have metastatic form of disease is less than 10%. The contributing role of apoptosis, angiogenesis and autophagy in the pathophysiology of melanoma has been previously demonstrated. Thus, it is extremely urgent to search for complementary therapeutic approachesthat couldenhance the quality of life of subjects and reduce treatment resistance and adverse effects. Resveratrol, known as a polyphenol component present in grapes and some plants, has anti-cancer properties due to its function as an apoptosis inducer in tumor cells, and anti-angiogenic agent to prevent metastasis. However, more clinical trials should be conducted to prove resveratrol efficacy. : Herein, for first time, we summarize current knowledge of anti-cancerous activities of resveratrol in melanoma.

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