scholarly journals The Role of Feed Restriction on DNA Methylation, Feed Efficiency, Metabolome, Biochemical Profile, and Progesterone Patterns in the Female Filial Generation (F1) Obtained From Early Feed Restricted Ewes (F0)

2021 ◽  
Vol 12 ◽  
Author(s):  
Sonia Andrés ◽  
Ole Madsen ◽  
Olimpio Montero ◽  
Alba Martín ◽  
F. Javier Giráldez
Keyword(s):  
Dna Methylation ◽  
Feed Efficiency ◽  
Reproductive Function ◽  
Reproductive Traits ◽  
Feed Restriction ◽  
Biochemical Profile ◽  
Negative Consequences ◽  
Intergenerational Effects ◽  
Cellular Processes ◽  
Filial Generation

Deficient management of replacement animals in the farm during early developmental windows may promote adverse programming effects on reproductive traits and subsequent transmission to the next generation. In this sense, DNA methylation profiles allow researchers to decode epigenetic regulation mechanisms in mammals and identify novel candidate genes correlated with phenotype differences in both dams and offspring. Therefore, improving knowledge in the field of epigenetics and intergenerational effects caused by prenatal and postnatal early nutritional events (e.g., feed restriction) is crucial for refining strategies dedicated to animal breeding. In this study, we determined differences in the global blood methylation patterns, biochemical profile, and metabolome of ewe lambs (F1) born from either early feed restricted dams (F0-RES) or fed ad libitum (F0-ADL). Our data show that functional categories such as those related to cellular processes, phosphorylation, nervous system, immunity response, or reproductive function were enriched significantly in the F1-RES lambs due to differences in the methylation of genes in these categories. These F1-RES lambs did not show differences in feed efficiency during the replacement period but presented higher levels of insulin and triglycerides and reduced concentration of progesterone, whereas the metabolome profile demonstrated variations in the bile acid composition when compared with the F1-ADL lambs. Taken together, all these results suggest that intergenerational effects caused by early feed restriction of dams (F0) may persist in the F1 female lambs with negative consequences on genes involved in cellular processes and reproductive traits.

scholarly journals Productive performance, body chemical composition, and deposition of 42-day-old quail for meat subjected to quantitative dietary restriction

2017 ◽  
Vol 38 (2) ◽  
pp. 855 ◽  
Author(s):  
Daiane De Oliveira Grieser ◽  
Simara Márcia Marcato ◽  
Mariana Fátima Zanon Ferreira ◽  
Taciana Maria de Oliveira-Bruxel ◽  
Vittor Zancanela ◽  
...  
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Chemical Composition ◽  
Dietary Restriction ◽  
Feed Efficiency ◽  
Daily Intake ◽  
Feed Restriction ◽  
Coturnix Coturnix ◽  
Protein Deposition ◽  
Ad Libitum

This study aimed to assess the effect of quantitative dietary restriction during refeeding on the performance, body chemical composition, and deposition, weight gain of organs and carcass parts of quails reared for meat (Coturnix coturnix coturnix). A total of 144 quails, between 11 to 42 days old, were distributed in a completely randomized design, 4x2 factorial scheme, at four levels of feed restriction (ad libitum, 30%, 50% and 70% restrictions on the daily intake ad libitum) for both genders. Therefore, there was eight treatments with three replicates and six birds each. At the tenth day of age, the animals were housed in cages, where remained for four days under adaptation. Dietary restriction was applied between the days 15 and 35 while refeeding was carried out from day 36 to 42. Compensatory weight gain (CWG), i.e. weight gain of organs and carcass parts, and feed efficiency (FE) were improved for quails under feed restriction. Fat (F), crude protein (CP), protein deposition rate (PDR) and fat in females (FDf) and carcass retained energy in females (CREf) increased linearly as restriction levels decreased. Maximum estimates of feed intake for males (MFIm), compensatory weight gain for males (CWGm) and females (CWGf), feed efficiency for males (FEm), protein deposition for males (PDm) and carcass retained energy in males (CREm) were obtained with restriction levels of 43.56%, 30.56%, 63.93%, 62.63%, 80.25%, 1.94% and 09.34% if compared to ad libitum, respectively. As a result, we concluded that according to quantitative feed restriction level, significant increases in feed efficiency and body weight gain, as well as decreases in carcass fat throughout quail refeeding period. As for gender, given the existing sexual dimorphism, females lost greater body weight than males under dietary restriction, besides showing higher protein and fat gains in the carcass and an enhanced feed efficiency during refeeding.

scholarly journals Feed Restriction Reveals Distinct Serum Metabolome Profiles in Chickens Divergent in Feed Efficiency Traits

Metabolites ◽  
2019 ◽  
Vol 9 (2) ◽  
pp. 38 ◽  
Author(s):  
Barbara Metzler-Zebeli ◽  
Sina-Catherine Siegerstetter ◽  
Elizabeth Magowan ◽  
Peadar Lawlor ◽  
Niamh O’Connell ◽  
...  
Keyword(s):  
Feed Intake ◽  
Feed Efficiency ◽  
Energy Demand ◽  
Body Weight Gain ◽  
Serum Glucose ◽  
Arachidonic Acid Metabolism ◽  
Feed Restriction ◽  
Physiological Factors ◽  
Ad Libitum ◽  
Almost All

Restrictive feeding influences systemic metabolism of nutrients; however, this impact has not been evaluated in chickens of diverging feed efficiency. This study investigated the effect of ad libitum versus restrictive feeding (85% of ad libitum) on the serum metabolome and white blood cell composition in chickens of diverging residual feed intake (RFI; metric for feed efficiency). Blood samples were collected between days 33 and 37 post-hatch. While serum glucose was similar, serum uric acid and cholesterol were indicative of the nutritional status and chicken’s RFI, respectively. Feed restriction and RFI rank caused distinct serum metabolome profiles, whereby restrictive feeding also increased the blood lymphocyte proportion. Most importantly, 10 amino acids were associated with RFI rank in birds, whereas restrictive feeding affected almost all detected lysophosphatidylcholines, with 3 being higher and 6 being lower in restrictively compared to ad libitum fed chickens. As indicated by relevance networking, isoleucine, lysine, valine, histidine, and ornithine were the most discriminant for high RFI, whereas 3 biogenic amines (carnosine, putrescine, and spermidine) and 3 diacyl-glycerophospholipids (38:4, 38:5, and 40:5) positively correlated with feed intake and body weight gain, respectively. Only for taurine, feed intake mostly explained the RFI-associated variation, whereas for most metabolites, other host physiological factors played a greater role for the RFI-associated differences, and was potentially related to insulin-signaling, phospholipase A2, and arachidonic acid metabolism. Alterations in the hepatic synthesis of long-chain fatty acids and the need for precursors for gluconeogenesis due to varying energy demand may explain the marked differences in serum metabolite profiles in ad libitum and restrictively fed birds.

Effect Of L-Thyroxin Hormone (T4) On Compensatory Growth In Broiler Chicks

2002 ◽  
Vol 2002 ◽  
pp. 84-84
Author(s):  
A. Hassanabadi ◽  
A. golian
Keyword(s):  
Feed Efficiency ◽  
Broiler Chickens ◽  
Compensatory Growth ◽  
Specific Dynamic Action ◽  
Abdominal Fat ◽  
Feed Restriction ◽  
Broiler Chicks ◽  
Fat Pad ◽  
Heat Increment ◽  
Maintenance Requirements

Purpose of researches in feed restriction area is improvement of feed efficiency, decrease of carcass fat content and abdominal fat pad size (Plavnik and Hurvitz,1991).Birds after early life feed restriction have less maintenance requirements due to decrease of heat increment and decrease of basal metabolic rate and specific dynamic action of food (Forsum et al.,1981).In many investigations, compensatory growth have not observed (Summers et al.,1990).It seems administration of Thyroid hormone after feed restriction can induce compensatory growth. The objective of the present study was to investigate the effect of early feed restriction and L-Thyroxin administration after early feed restriction on compensatory growth in broiler chickens.

scholarly journals A paternal methyl donor depleted diet leads to increased anxiety- and depression-like behavior in adult rat offspring

2018 ◽  
Vol 38 (4) ◽  
Author(s):  
Chelsea R. McCoy ◽  
Nateka L. Jackson ◽  
Rachel L. Brewer ◽  
Mohamad M. Moughnyeh ◽  
Daniel L. Smith ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Germ Line ◽  
Emotional Health ◽  
Forced Swim Test ◽  
Emotional Behavior ◽  
Male Rats ◽  
Anxiety And Depression ◽  
Intergenerational Effects ◽  
Methyl Donor ◽  
Adult Rat

Epigenetic mechanisms such as DNA methylation elicit lasting changes in gene expression and likely mediate gene–environment interactions that shape brain development, behavior, and emotional health. Myriad environmental factors influence DNA methylation, including methyl donor content in the paternal diet, could influence methylation in offspring via changes in the paternal germ line. The present study examines the effects of paternal methyl donor dietary deficiency on offspring’s emotional behaviors, including anxiety, social interaction, and depression-like behavior. We previously found that rats bred to display high levels of anxiety- and depression-like behavior exhibit diminished DNA methylation in the amygdala. We also observed that depleting dietary methyl donor content exacerbated the rats’ already high levels of anxiety- and depression-like behavior. Here we sought to determine whether paternal dietary methyl donor depletion elicits intergenerational effects on first generation (F1) offspring’s behavior (potentially triggering a similar increase in anxiety- and/or depression-like behavior). Thus, adult male rats prone to high anxiety/depression-like behavior, were fed either a methyl donor depleted (DEP) or control (CON) diet for 5 weeks prior to mating. They were paired with females and resultant F1 male offspring were subjected to a behavioral test battery in adulthood. F1-DEP offspring showed a similar behavioral profile to the F0 males, including greater depression-like behavior in the forced swim test (FST) and increased anxiety-like behavior in the open field test (OFT). Future work will interrogate molecular changes in the brains of F1 offspring that mediate these intergenerational effects of paternal methyl donor dietary content on offspring emotional behavior.

Growth and feed conversion of Jersey and Friesian bulls in relation to plane of nutrition

1971 ◽  
Vol 22 (5) ◽  
pp. 829 ◽  
Author(s):  
TF Leche
Keyword(s):  
Body Composition ◽  
Treatment Group ◽  
Feed Efficiency ◽  
Milk Replacer ◽  
Feed Restriction ◽  
Feed Conversion ◽  
Bull Calves ◽  
Before And After ◽  
The Difference ◽  
Mature Size

Sixty Jersey and 48 Friesian bull calves were reared from birth on either of two planes of nutrition. A milk replacer and a concentrate diet were given before and after weaning respectively. The Jerseys were weaned at 45 kg and the Friesians at 77 kg. At liveweights arranged in logarithmic progression between birth and 249 kg, three calves of each treatment group were killed for analysis of body composition. Before and after weaning, the Friesians grew more rapidly than the Jerseys on the same treatment. They were also more efficient in terms of feed intake per liveweight gain. Similarly, calves of both breeds on the high plane of nutrition grew faster and more efficiently than the corresponding calves on the low plane. The growth of the Friesians was affected less by the feed restriction than was that of the Jerseys. After weaning, the feed conversion efficiency of the Friesians did not change significantly with increasing liveweight. Feed efficiency was reduced in the Jerseys as they grew larger. These results are compared with others from the literature and are discussed in relation to the difference in mature size between these breeds.

scholarly journals Research Note: Effect of Feed Restriction on Feed Efficiency and Incidence of Sudden Death Syndrome in Broiler Chickens

1988 ◽  
Vol 67 (7) ◽  
pp. 1102-1104 ◽  
Author(s):  
VICTORIA A. BOWES ◽  
R.J. JULIAN ◽  
STEVEN LEESON ◽  
TANYA STIRTZINGER
Keyword(s):  
Sudden Death ◽  
Feed Efficiency ◽  
Broiler Chickens ◽  
Sudden Death Syndrome ◽  
Research Note ◽  
Feed Restriction

scholarly journals Community-wide epigenetics provides novel perspectives on the ecology and evolution of marine microbiome

2021 ◽  
Author(s):  
Hoon Je Seong ◽  
Simon Roux ◽  
Chung Yeon Hwang ◽  
Woo Jun Sul
Keyword(s):  
Cell Cycle ◽  
Dna Methylation ◽  
Dna Methyltransferase ◽  
Distribution Patterns ◽  
Cellular Processes ◽  
Genome Wide ◽  
Methylation Mark ◽  
Domains Of Life ◽  
Epigenetic Analysis ◽  
Cycle Regulation

DNA methylation in prokaryotes is involved in many different cellular processes including cell cycle regulation and defense against viruses. To date, most prokaryotic methylation systems have been studied in culturable microorganisms, resulting in a limited understanding of DNA methylation from a microbial ecology perspective. Here, we analyze the distribution patterns of several microbial epigenetics marks in the ocean microbiome through genome-centric metagenomics across all domains of life. We show that overall, DNA methylation can readily be detected across dominant oceanic bacterial, archaeal, and viral populations, and microbial epigenetic changes correlate with population differentiation. Furthermore, our genome-wide epigenetic analysis of Pelagibacter suggests that GANTC, a DNA methyltransferase target motif, is related to the cell cycle and is affected by environmental conditions. Yet, the presence of this motif also partitions the phylogeny of the Pelagibacter phages, possibly hinting at a competitive co-evolutionary history and multiple effects of a single methylation mark.

Sign in / Sign up

Export Citation Format

Share Document