scholarly journals Comparing the Self- and External Assessment Versions of the HCL-33 as Screening Instruments for Bipolar Disorder in Older Depressed Patients

2021 ◽  
Vol 12 ◽  
Author(s):  
Xinqiao Zhang ◽  
Wen Li ◽  
Na Zhao ◽  
Yu Jin ◽  
Teris Cheung ◽  
...  
Keyword(s):  
Older Adults ◽  
Bipolar Disorder ◽  
Correlation Coefficient ◽  
Intraclass Correlation Coefficient ◽  
Roc Curve ◽  
Positive Response ◽  
Intraclass Correlation ◽  
The Self ◽  
Optimal Cutoff ◽  
External Assessment

Objectives: The misdiagnosis of bipolar disorder (BD) as major depressive disorder (MDD) is common in depressed older adults. The self-rated HCL-33 and its external assessment version (HCL-33-EA) have been developed to screen for hypomanic symptoms. This study compared the screening ability of these two instruments to discriminate BD from MDD.Methods: A total of 215 patients (107 with BD and 108 with MDD) and their carers were recruited. Patients and their carers completed the HCL-33 and HCL-33-EA, respectively. The consistency of the total score and the positive response to each item between the two scales was calculated with the intraclass correlation coefficient (ICC) and Cohen's kappa coefficient separately. Receiver operating characteristics (ROC) curves were drawn for both instruments. The optimal cut-off points were determined according to the maximum Youden's Index. The areas under the ROC curve (AUC) of the HCL-33 and HCL-33-EA were calculated separately and compared. The sensitivity and specificity at the optimal cut-off values were also calculated separately for the HCL-33 and HCL-33-EA.Results: The intraclass correlation coefficient (ICC) between the total scores of the HCL-33 and HCL-33-EA was 0.823 (95% CI = 0.774–0.862). The positive response rate on all items showed high agreement between the two instruments. ROC curve analysis demonstrated that the total scores of both HCL-33 and HCL-33-EA differentiated well between MDD and BD, while there was no significant difference in the AUCs between the two scales (Z = 0.422, P = 0.673). The optimal cutoff values for the HCL-33 and HCL-33-EA were 14 and 12, respectively. With the optimal cutoff value, the sensitivities of the HCL-33 and HCL-33-EA were 88.8% and 93.5%, and their specificities were 82.4% and 79.6%.Conclusion: Both the HCL-33 and HCL-33-EA had good screening ability for discriminating BD from MDD in depressed older adults.

scholarly journals Reliability of Measures of N1 Peak Amplitude of the Compound Action Potential in Younger and Older Adults

2018 ◽  
Vol 61 (9) ◽  
pp. 2422-2430 ◽  
Author(s):  
Carolyn M. McClaskey ◽  
James W. Dias ◽  
Judy R. Dubno ◽  
Kelly C. Harris
Keyword(s):  
Older Adults ◽  
Action Potential ◽  
Correlation Coefficient ◽  
Intraclass Correlation Coefficient ◽  
Measurement Techniques ◽  
Intraclass Correlation ◽  
Compound Action Potential ◽  
Retest Reliability ◽  
Test Retest Reliability ◽  
Compound Action

Purpose Human auditory nerve (AN) activity estimated from the amplitude of the first prominent negative peak (N1) of the compound action potential (CAP) is typically quantified using either a peak-to-peak measurement or a baseline-corrected measurement. However, the reliability of these 2 common measurement techniques has not been evaluated but is often assumed to be relatively poor, especially for older adults. To address this question, the current study (a) compared test–retest reliability of these 2 methods and (b) tested the extent to which measurement type affected the relationship between N1 amplitude and experimental factors related to the stimulus (higher and lower intensity levels) and participants (younger and older adults). Method Click-evoked CAPs were recorded in 24 younger (aged 18–30 years) and 20 older (aged 55–85 years) adults with clinically normal audiograms up to 3000 Hz. N1 peak amplitudes were estimated from peak-to-peak measurements (from N1 to P1) and baseline-corrected measurements for 2 stimulus levels (80 and 110 dB pSPL). Baseline-corrected measurements were made with 4 baseline windows. Each stimulus level was presented twice, and test–retest reliability of these 2 measures was assessed using the intraclass correlation coefficient. Linear mixed models were used to evaluate the extent to which age group and click level uniquely predicted N1 amplitude and whether the predictive relationships differed between N1 measurement techniques. Results Both peak-to-peak and baseline-corrected measurements of N1 amplitude were found to have good-to-excellent reliability, with intraclass correlation coefficient values > 0.60. As expected, N1 amplitudes were significantly larger for younger participants compared with older participants for both measurement types and were significantly larger in response to clicks presented at 110 dB pSPL than at 80 dB pSPL for both measurement types. Furthermore, the choice of baseline window had no significant effect on N1 amplitudes using the baseline-corrected method. Conclusions Our results suggest that measurements of AN activity can be robustly and reliably recorded in both younger and older adults using either peak-to-peak or baseline-corrected measurements of the N1 of the CAP. Peak-to-peak measurements yield larger N1 response amplitudes and are the default measurement type for many clinical systems, whereas baseline-corrected measurements are computationally simpler. Furthermore, the relationships between AN activity and stimulus- and participant-related variables were not affected by measurement technique, which suggests that these relationships can be compared across studies using different techniques for measuring the CAP N1.

Reliability and Fall-Risk Predictability of the Short Form of the Fullerton Advanced Balance Scale in Iranian Older Adults

2021 ◽  
pp. 1-8
Author(s):  
Ehsan Sinaei ◽  
Debra J. Rose ◽  
Samira Javadpour ◽  
Amin Kordi Yoosefinejad
Keyword(s):  
Older Adults ◽  
Correlation Coefficient ◽  
Intraclass Correlation Coefficient ◽  
Short Form ◽  
Intraclass Correlation ◽  
Community Dwelling ◽  
Intrarater Reliability ◽  
Falls In Older Adults ◽  
Community Dwelling Older Adults ◽  
Acceptable Internal Consistency

Recently, a short form of the Fullerton Advanced Balance (SF-FAB) scale was reported as a good predictor of falls in older adults. However, we found no evidence regarding its reliability in non-American older adults. Therefore, we aimed to analyze the reliability and homogeneity of the SF-FAB scale to measure postural balance in Iranian older adults. Eighty-five community-dwelling older adults (70.75 ± 4.97 years) performed the SF-FAB test on two occasions 1 week apart. In both instances, four raters assessed the performance on the test. The SF-FAB scale (mean total score: 12.46 ± 3.53) revealed acceptable internal consistency (Cronbach’s α = .77), excellent intrarater reliability (intraclass correlation coefficient = .94–.99), and excellent interrater reliability (intraclass correlation coefficient = .92–.99). The overall prediction success rate was 83.5% with correctly classifying 95.6% of nonfallers and 35.3% of fallers. The SF-FAB scale can provide a quick screen of balance status in older adults to trigger referral to clinicians for a more comprehensive assessment.

Reliability and Validity of the Sit-to-Stand as a Muscular Power Measure in Older Adults

2020 ◽  
Vol 28 (3) ◽  
pp. 455-466 ◽  
Author(s):  
Jennifer J. Sherwood ◽  
Cathy Inouye ◽  
Shannon L. Webb ◽  
Jenny O
Keyword(s):  
Older Adults ◽  
Correlation Coefficient ◽  
Intraclass Correlation Coefficient ◽  
Handgrip Strength ◽  
Intraclass Correlation ◽  
Negative Relationship ◽  
Reliability And Validity ◽  
Sit To Stand ◽  
Relationship Of ◽  
The Relationship

The study aims were to analyze the reliability and validity of the GymAware™ linear position transducer’s velocity and power measures during the sit-to-stand, compared with the Dartfish 2D videography analysis, and to assess the relationship of age and handgrip strength with velocity and power in 48 older men and women (77.6 ± 11.1 years). The results showed excellent agreement between GymAware- and Dartfish-derived sit-to-stand velocity (intraclass correlation coefficient2-1 = .94 and power intraclass correlation coefficient2-1 = .98) measures. A moderate and negative relationship was found between age and velocity (r = −.62; p < .001) and age and power (r = −.63; p < .001). A moderate and positive relationship was found between handgrip strength and velocity (r = .43; p = .002) and handgrip strength and power (r = .54; p < .001). The results show the GymAware velocity and power measures during the sit-to-stand in older adults to be reliable and valid.

Comparability of the 6-min Walk Test Using Different Test Configurations

2008 ◽  
Vol 16 (3) ◽  
pp. 355-361 ◽  
Author(s):  
Del N. Konopka ◽  
Robin P. Shook ◽  
Marian L. Kohut ◽  
Rosalie Vos Tulp ◽  
Warren D. Franke
Keyword(s):  
Older Adults ◽  
Correlation Coefficient ◽  
Intraclass Correlation Coefficient ◽  
Intraclass Correlation ◽  
Walking Distance ◽  
Walk Test ◽  
Common Component ◽  
Rectangular Configuration

The 6-min walk test (6MWT) is a common component of fitness assessments of older adults; however, differing course configurations might affect 6MWT performance. It is unclear how comparable 2 different configurations are. To determine the comparability of 2 courses, 35 adults ≥65 years of age completed two 6MWT, once walking around a 20- by 5-yd outdoor rectangle and once on an indoor oval track (circumference 144.3 yd). Scores for the 2 tests were internally consistent (intraclass correlation coefficient = .95). The participants walked farther on the oval track than around the rectangle (639 ± 19 vs. 582 ± 16 yd; p < .0001), but responses to the rectangular configuration could be readily estimated using the equation 66.7 yd + 0.807 × (oval walking distance), R2 = .85. Thus, within-participant responses are similar across both 6MWT, but the course configuration affects the distance walked.

Validity and Interinstrument Reliability of a Medical Grade Physical Activity Monitor in Older Adults

2021 ◽  
Vol 4 (1) ◽  
pp. 31-38
Author(s):  
Myles W. O’Brien ◽  
William R. Wojcik ◽  
Jonathon R. Fowles
Keyword(s):  
Physical Activity ◽  
Older Adults ◽  
Correlation Coefficient ◽  
Intraclass Correlation Coefficient ◽  
Vigorous Physical Activity ◽  
Intraclass Correlation ◽  
Activity Monitor ◽  
Moderate Physical Activity ◽  
Step Rate ◽  
Medical Grade

Wearable physical activity monitors are associated with an increase in user’s habitual physical activity levels. Most of the older adult population do not meet the national moderate- to vigorous-intensity physical activity (MVPA) recommendations and may benefit from being prescribed a physical activity monitor. The PiezoRx is a class one medical grade device that uses step rate thresholds to measure MVPA. The validity and reliability of the PiezoRx in measuring MVPA has yet to be determined in older persons. We assessed the validity and interinstrument reliability of the PiezoRx to measure steps and MVPA in older adults. Participants (n = 19; 68.8 ± 2.3 years) wore an Omron HJ-320 pedometer, ActiGraph GT3X accelerometer, and four PiezoRx monitors during a five-stage treadmill walking protocol. The PiezoRx devices were set at moderate physical activity and vigorous physical activity step rate thresholds (steps per minute) of 100/120, 110/130, adjusted for height and adjusted for height + fitness. The PiezoRx exhibited a stronger correlation (intraclass correlation coefficient = .82) with manually counted steps than the ActiGraph (intraclass correlation coefficient = .53) and Omron (intraclass correlation coefficient = .54) and had a low absolute percentage error (3 ± 6%). The PiezoRx with moderate physical activity/vigorous physical activity step thresholds adjusted to 110/130 was strongly correlated to indirect calorimetry (0.84, p < .001) and best distinguished each walking stage as MVPA or not (sensitivity: 88%; specificity: 95%). The PiezoRx monitor is a valid and reliable measure of step count and MVPA among older adults. The device’s ability to measure MVPA in absolute terms was improved when step rate thresholds for moderate physical activity/vigorous physical activity were increased to 110/130 steps per minute in this population.

Agreement of body weight of older adults measured on digital chair scale and mechanical platform scale

2021 ◽  
Vol 34 ◽  
Author(s):  
Maria Luiza Freitas ANNES ◽  
Fernanda Beck TABAJARA ◽  
Rosane Dias da ROSA ◽  
Rita MATTIELLO ◽  
Ana Luisa Sant’Anna ALVES ◽  
...  
Keyword(s):  
Older Adults ◽  
Correlation Coefficient ◽  
Intraclass Correlation Coefficient ◽  
Intraclass Correlation ◽  
University Hospital ◽  
Scale Model ◽  
Average Weight ◽  
Altman Plot ◽  
Cross Sectional ◽  
Bland Altman Plot

ABSTRACT Objective The aim of the study was to evaluate the agreement between the weight of older adults measured on a chair scale and a platform scale. Methods This is a cross-sectional study. We evaluated 131 older adults (?60 years old), walk-in patients, admitted to a university hospital. Weight was measured on a digital chair scale model MS5811 (Charder® brand) and after on a mechanical platform scale (Filizola® brand). For the agreement analysis, the intraclass correlation coefficient and the Bland-Altman plot were used. Results Most of the sample consisted of males individuals (57.3%; n= 75). The average age was 70.47±7.59 years (60-96 years old). Measured by both methods, weight showed normal distribution. The average weight measured was 67.99±14.03 kg on the chair scale and 68.04±14.02 kg on the platform scale. The intraclass correlation coefficient of weight measured by the two methods was 1.00 (IC95%=1.00-1.00; p<0.001). In the Bland-Altman plot, the mean bias for the weight measured on the chair scale and the platform scale was 0.049 (IC95%=-0.011 to 0.110; p=0.1084). Conclusions The agreement between the weight measured on a chair scale and on a platform scale was almost excellent. Thus, the chair scale can be used as an alternative method of measuring weight, especially in the older adults with postural instability, mobility restrictions or immobility syndrome.

scholarly journals Biomechanical Measurement of Rabbit Cornea by a Modified Scheimpflug Device

2016 ◽  
Vol 2016 ◽  
pp. 1-6
Author(s):  
Bo Zhang ◽  
Jianjun Gu ◽  
Xiaoxiao Zhang ◽  
Bin Yang ◽  
Zheng Wang ◽  
...  
Keyword(s):  
Bulk Modulus ◽  
Correlation Coefficient ◽  
Intraclass Correlation Coefficient ◽  
Intraclass Correlation ◽  
Anterior Segment ◽  
Intraobserver Reliability ◽  
Rabbit Cornea ◽  
Deformation Response ◽  
Biomechanical Measurements ◽  
Biomechanical Measurement

Purpose. To explore the probability and variation in biomechanical measurements of rabbit cornea by a modified Scheimpflug device.Methods. A modified Scheimpflug device was developed by imaging anterior segment of the model imitating the intact eye at various posterior pressures. The eight isolated rabbit corneas were mounted on the Barron artificial chamber and images of the anterior segment were taken at posterior pressures of 15, 30, 45, 60, and 75 mmHg by the device. The repeatability and reliability of the parameters including CCT, ACD, ACV, and CV were evaluated at each posterior pressure. All the variations of the parameters at the different posterior pressures were calculated.Results. All parameters showed good intraobserver reliability (Cronbach’s alpha; intraclass correlation coefficient,α, ICC > 0.96) and repeatability in the modified Scheimpflug device. With the increase of posterior pressures, the ratio of CCT decreased linearly and the bulk modulus gradually reduced to a platform. The increase of ACD was almost linear with the posterior pressures elevated.Conclusions. The modified Scheimpflug device was a valuable tool to investigate the biomechanics of the cornea. The posterior pressure 15–75 mmHg range produced small viscoelastic deformations and nearly linear pressure-deformation response in the rabbit cornea.

scholarly journals A preliminary study of intensivist-performed DVT ultrasound screening in trauma ICU patients (APSIT Study)

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Lloyd Roberts ◽  
Tom Rozen ◽  
Deirdre Murphy ◽  
Adam Lawler ◽  
Mark Fitzgerald ◽  
...  
Keyword(s):  
Intensive Care ◽  
Deep Vein Thrombosis ◽  
High Risk ◽  
Correlation Coefficient ◽  
Intraclass Correlation Coefficient ◽  
Major Trauma ◽  
Intraclass Correlation ◽  
Trauma Patients ◽  
Vein Thrombosis ◽  
Deep Vein

Abstract Background Multiple screening Duplex ultrasound scans (DUS) are performed in trauma patients at high risk of deep vein thrombosis (DVT) in the intensive care unit (ICU). Intensive care physician performed compression ultrasound (IP-CUS) has shown promise as a diagnostic test for DVT in a non-trauma setting. Whether IP-CUS can be used as a screening test in trauma patients is unknown. Our study aimed to assess the agreement between IP-CUS and vascular sonographer performed DUS for proximal lower extremity deep vein thrombosis (PLEDVT) screening in high-risk trauma patients in ICU. Methods A prospective observational study was conducted at the ICU of Alfred Hospital, a major trauma center in Melbourne, Australia, between Feb and Nov 2015. All adult major trauma patients admitted with high risk for DVT were eligible for inclusion. IP-CUS was performed immediately before or after DUS for PLEDVT screening. The paired studies were repeated twice weekly until the DVT diagnosis, death or ICU discharge. Written informed consent from the patient, or person responsible, or procedural authorisation, was obtained. The individuals performing the scans were blinded to the others’ results. The agreement analysis was performed using Cohen’s Kappa statistics and intraclass correlation coefficient for repeated binary measurements. Results During the study period, 117 patients had 193 pairs of scans, and 45 (39%) patients had more than one pair of scans. The median age (IQR) was 47 (28–68) years with 77% males, mean (SD) injury severity score 27.5 (9.53), and a median (IQR) ICU length of stay 7 (3.2–11.6) days. There were 16 cases (13.6%) of PLEDVT with an incidence rate of 2.6 (1.6–4.2) cases per 100 patient-days in ICU. The overall agreement was 96.7% (95% CI 94.15–99.33). The Cohen’s Kappa between the IP-CUS and DUS was 0.77 (95% CI 0.59–0.95), and the intraclass correlation coefficient for repeated binary measures was 0.75 (95% CI 0.67–0.81). Conclusions There is a substantial agreement between IP-CUS and DUS for PLEDVT screening in trauma patients in ICU with high risk for DVT. Large multicentre studies are needed to confirm this finding.

Test-Retest-Reliability of Computer-Based Metamorphopsia Measurement in Macular Diseases

2020 ◽  
Author(s):  
Daniela Claessens ◽  
Alexander K. Schuster ◽  
Ronald V. Krüger ◽  
Marian Liegl ◽  
Laila Singh ◽  
...  
Keyword(s):  
Macular Edema ◽  
Correlation Coefficient ◽  
Intraclass Correlation Coefficient ◽  
Intraclass Correlation ◽  
Measuring Method ◽  
Repeated Measurements ◽  
Retest Reliability ◽  
Macular Diseases ◽  
Computer Based ◽  
Test Retest Reliability

AbstractIn this study, the test-retest-reliability as one aspect of reliability of metamorphopsia measurements using a computer-based measuring method was determined in patients with macular diseases. Metamorphopsia amplitude, position, and area were quantified using AMD – A Metamorphopsia Detector software (app4eyes GmbH & Co. KG, Germany) in patients with diabetic, myopic, or uveitic macular edema, intermediate or neovascular age-associated macular degeneration, epiretinal membrane, vitelliform maculopathy, Irvine-Gass syndrome, or macular edema due to venous retinal occlusion. The intraclass correlation coefficient (ICC) was calculated in order to determine the repeatability of two repeated measurements and was used as an indicator of the reliability of the measurements. In this study, metamorphopsia measurements were conducted on 36 eyes with macular diseases. Metamorphopsia measurements made using AMD – A Metamorphopsia Detector software were highly reliable and repeatable in patients with maculopathies. The intraclass correlation coefficient of all indices was excellent (0.95 – 0.97). For diseases of the vitreoretinal interface or macular diseases with intra- or subretinal edema, this metamorphopsia measurement represents a supplement for visual function testing in the clinic, as well as in clinical studies.

Sign in / Sign up

Export Citation Format

Share Document