scholarly journals Effect of Feeding a High Calcium: Phosphorus Ratio, Phosphorous Deficient Diet on Hypophosphatemic Rickets Onset in Broilers

Agriculture ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 955
Author(s):  
Lei Xu ◽  
Lin Li ◽  
Yuhua Z. Farnell ◽  
Xiaoli Wan ◽  
Haiming Yang ◽  
...  

Recently, a P-deficient diet caused rickets in commercial chicks within three days. This study aimed to investigate the duration of onset of rickets in chicks. Data were collected from 3–11 day old chicks raised on 88 commercial farms. Male day-old Arbor Acres Plus broilers (n = 450) were studied in three trials, with three to four treatments each. Each treatment used one of the following crumbled feeds: control feed (calcium (Ca): phosphorus (P)-1.41), slightly high Ca:P feed (SHCa:P, Ca:P-2.69), high Ca:P ratio, P deficient feed (HCa:P, Ca:P-3.08), and HCa:P feed plus 1.5% dicalcium phosphate (HCa:P + DP). Each treatment had three replicates with 15 birds each. Rickets was induced by HCa:P, and cured by HCa:P + DP, confirmed by gross anatomy, gait score, serum P concentration and growth performance. Lameness was not found in control groups, whereas, observed in the HCa:P groups as early as day 2.7 on commercial farms and day 3 in experimental farm. Serum P was reduced in HCa:P (p < 0.01). Bodyweight and feed intake started decreasing at day 3 on commercial farms and in all trials (p < 0.01). The duration of onset of hypophosphatemic rickets in broiler chicks fed HCa:P crumbled feed is approximately three days.

1971 ◽  
Vol 49 (12) ◽  
pp. 1059-1062 ◽  
Author(s):  
S. T. Chou

Day-old broiler chicks of both sexes were used in three experiments to determine the effect of riboflavin deficiency on oxypurine metabolism catalyzed by xanthine dehydrogenase, a riboflavin-containing enzyme. Chicks fed a riboflavin-deficient diet (1.38 mg/kg) for 3 weeks exhibited depressed growth and a high incidence of curled-toe paralysis (higher than 80%) as compared to control chicks (15.1 mg riboflavin per kilogram diet; no incidence of curled-toe paralysis). In addition, the precursors of uric acid, hypoxanthine and/or xanthine, accumulated in the liver and kidney of deficient chicks showing curled-toe paralysis. These observations show that dietary riboflavin being incorporated into xanthine dehydrogenase is essential for oxypurine metabolism. Moreover in the chick, the liver and the kidney may be important sites of uric acid synthesis. The low uric acid concentration in the plasma of the deficient chicks appeared to be indicative of a disturbance in uric acid synthesis in the liver and kidney.


1972 ◽  
Vol 27 (2) ◽  
pp. 305-312 ◽  
Author(s):  
Sharad V. Apte ◽  
Leela Iyengar

1. The body composition was determined of forty-one fetuses of different gestational ages born to mothers belonging to a low socio-economic group of the population.2. With increasing gestational age the water content fell from 88% at 28 weeks to 76% at term; the fat content increased from 2.1% to 11.2% and the protein content increased from 6.9 to 9.3%.3. The changes in body composition were more closely related to body-weight than to gestational age.4. The calcium, Phosphorus and magnesium contents of the body per unit fat-free weight progressively increased with gestational age, and at term the values appeared to be considerably lower than those reported in the literature. The Ca:P ratio was constant at different body-weights.5. The body iron content per unit of fat-free weight increased marginally with increasing gestational age. The value was almost 30% lower than the values reported from elsewhere.6. It is suggested that chemical composition and nutrient stores of the developing foetus can be considerably influenced by the state of maternal nutrition.


1990 ◽  
Vol 69 (8) ◽  
pp. 1271-1280 ◽  
Author(s):  
C.L. WYATT ◽  
L.S. JENSEN ◽  
G.N. ROWLAND

2020 ◽  
Vol 10 (4) ◽  
pp. 168
Author(s):  
Ainia Herminiati

Background: Dried yogurt enriched by Difructose Anhydride III when used as a functional food has been observed to increase calcium absorption, making it useful in osteoporosis prevention. The objective of this study was to analyze the effectiveness of Difructose Anhydride III in increasing the absorption of calcium in female rat models, strain Sprague Dawley, in the pre-menopausal age during which they’re calcium deficient.Methods: The effectiveness test of Difructose Anhydride III to increase absorption of calcium in pre-menopausal Sprague Dawley rats was performed in calcium-deficient conditions. A completely randomized experimental design was used with 4 treatments for 6 weeks and 4 replications: normal rats fed with purified diet (C), calcium-deficient rats fed with calcium-deficient diet (CD), calcium-deficient rats fed with calcium-deficient diet and DFA III (dahlia tubers) fortified in dry yogurt (CD+DFA III dahlia), and calcium-deficient rats fed with a calcium-deficient diet and DFA III (chicory roots) fortified in dry yogurt (CD+DFA III chicory). The parameters measured were serum calcium concentration, femur bone calcium concentration, femur bone matrix condition, and femur bone strength.Results: DFA III (dahlia tubers and chicory roots) fortified in dry yogurt contained 0.334% and 0.322% of calcium concentration. The provision of a calcium-deficient diet for 12 weeks was shown to reduce the serum calcium concentration of the deficient calcium rat to 7.72±1.08 mg dL-1 and the control rat to 11.60±0.85 mg dL-1. CD+DFA III chicory treatments also showed a high calcium concentration in the femur bone (34.94±3.21%), a relatively higher bone strength (9.34±3.61 kg cm-2), and a denser femur bone matrix condition than the control. The femur bone calcium level of rats treated with CD+DFA III dahlia and chicory tubers was 28.95±1.95% and 34.94±3.21%, respectively. These results were significantly different than the CD treatment (17.49±4.38%).Conclusion: The evidence from this study suggests that sufficient calcium intake could provide high calcium deposits in the bones. Diets containing 3.60% w/w DFA III fortified in dry yogurt have been shown to enhance calcium absorption in calcium-deficient rats. Additionally, the effectiveness of dried yogurt enriched by DFA III from chicory tubers was higher than that of the dried yogurt enriched by DFA III from dahlia tubers.Preclinical Trial Registration: Animal Ethics Committee at IPB University No. 12-2013Keywords: Bone femur; calcium deficiency; effectivity of Difructose Anhydride III


1946 ◽  
Vol 36 (4) ◽  
pp. 283-288 ◽  
Author(s):  
Cyril Tyler

1. The daily retention of calcium, carbonate, phosphorus and chloride was studied using four birds and changing the calcium carbonate content of the ration every 5 days for 15 days.2. It was shown that high calcium diets result in a much lower retention of calcium and thin-shelled eggs are produced.3. Retention of calcium was higher in the laying than in the non-laying bird when calcium carbonate was fed.4. High calcium diets depressed the retention of phosphorus, and in one case the retention was negative, even when no eggs were laid. Laying birds gave negative values for retention because of the heavy phosphorus excretion associated with egg laying.5. High calcium diets also depressed the retention of chloride, and on occasion led to negative retention values.


1992 ◽  
Vol 262 (3) ◽  
pp. R370-R381 ◽  
Author(s):  
M. G. Tordoff

Spontaneously hypertensive rats (SHRs) fed nutritionally complete diets voluntarily ingest more calcium and more NaCl solution than do their normotensive Wistar-Kyoto (WKY) controls. SHRs also have several anomalies in calcium metabolism. Given that calcium availability modulates NaCl intake of other rat strains, we examined whether sodium and calcium intake of the SHR was unusually responsive to manipulations of dietary calcium. In three experiments, groups of SHRs and WKYs ate diets differing in calcium content (0-1,000 mmol/kg) and drank solutions of sodium (50 and 300 mM NaCl or 50 mM sodium lactate) and/or calcium (50 and 110 mM calcium lactate or 50 mM CaCl2). Relative to WKYs, SHRs fed calcium-deficient diet (0 mmol Ca2+/kg) drank the same amount or less calcium solution, drank more NaCl, and increased NaCl intake more rapidly when the diet was first introduced. SHRs fed diets sufficient for normal growth (50-1,000 mmol Ca2+/kg) drank consistently more calcium and sodium solution than did WKYs. However, NaCl intake of SHRs was decreased by high-calcium diets, whereas NaCl intake of WKYs was not. Taken together, these results suggest that a mechanism dependent on the availability of calcium is at least partially responsible for the high salt intake of the SHR.


1986 ◽  
Vol 23 (4) ◽  
pp. 485-498 ◽  
Author(s):  
O. R. Hedstrom ◽  
N. F. Cheville ◽  
R. L. Horst

Turkey poults were fed a vitamin D-deficient diet and examined for clinical signs and structural changes of bone and parathyroid glands. Vitamin D-deficient poults developed ricketic changes during days 10 to 14. Control poults (deficient diet plus vitamin D) did not develop rickets. In deficient poults, lengths of proliferating-prehypertrophied zones of growth plates increased significantly in the proximal tibiotarsus but were only slightly elongated in the distal tibiotarsus. Unmineralized hypertrophic chondrocyte zones increased in length rapidly in conjunction with a decrease in the length of mineralized hypertrophic degenerative zones; this occurred more rapidly in proximal than in distal tibiotarsus. Other ricketic changes included decreases in bone ash, total femoral bone ash (calcium, phosphorus, magnesium), bone length, and body weight. Plasma alkaline phosphatase was increased, calcium was normal, and phosphorus was normal or elevated. Parathyroids were hyperplastic and had foci of degeneration. Vitamin D3 metabolites 25OHD3, 1,25(OH)2D3, and 24,25(OH)2D3 were rapidly depleted. Increase in bone ash Ca/P ratios in deficient poults suggests that phosphorus may be selectively released from ricketic bone. Low 25OHD3 and 1,25(OH)2D3 of control poults early in the experiment suggests that 1,400 IU of vitamin D3/kg of feed may not be an adequate level of vitamin D3 for growing turkey poults.


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