scholarly journals Organic Acids Mixture as a Dietary Additive for Pigs—A Review

Animals ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. 952
Author(s):  
Dinh Hai Nguyen ◽  
Woo Jeong Seok ◽  
In Ho Kim
Keyword(s):  
Organic Acids ◽  
Synergistic Effects ◽  
Nutrient Digestibility ◽  
Farm Animals ◽  
Gut Health ◽  
Growth Promoters ◽  
Bacterial Populations ◽  
Animal Products ◽  
Spectrum Activity ◽  
Antibiotic Growth Promoters

Due to the increasing safety concerns about the risk of spreading antibiotic resistance in the environment, and the presence of chemical residues in animal products, using organic acids (OAs) to replace antibiotic in the diet of farm animals has increased considerably in recent years. It has been suggested that OAs could attribute to diverse elements such as antimicrobial activity, decreasing the pH of digesta particularly in the gastrointestinal tract (GIT), slowing feed transit in the GIT to maximize feed digestion and nutrient absorption, inducing enzyme secretion and activity in the small intestine, and providing nutrients to intestinal tissue. It has been reported that OAs mixture might be more effective than individual OAs due to the synergistic effects of different pKa values and have a broad-spectrum activity. In conclusion, this review showed that an OA mixture, which can improve nutrient digestibility and growth performance, modulate intestinal bacterial populations and improve gut health, as well as decreasing gas emission, can be used as alternative to antibiotic growth promoters. However, the results of OA mixtures are not always consistent, and the response to dietary OAs could be affected by the type of OAs, dosage, feed formula, and the age of animals. In this review, we will give an overview of the current use of OAs mixture in swine feed.

scholarly journals The Potential Role of Probiotics (nutraceuticals) in Gut Health of Domestic Animals; an Alternative to Antibiotic Growth Promoters

2019 ◽  
Vol 69 (4) ◽  
pp. 1169 ◽  
Author(s):  
A. NAWAB ◽  
W. LIU ◽  
G. LI ◽  
F. IBTISHAM ◽  
D P. FOX ◽  
...  
Keyword(s):  
Animal Health ◽  
Scientific Information ◽  
Domestic Animals ◽  
Feed Additives ◽  
Production Performance ◽  
Farm Animals ◽  
Gut Health ◽  
Growth Promoters ◽  
Wide Range ◽  
Antibiotic Growth Promoters

The term gut health is currently becoming more important for domestic animals including poultry. Gut health refers to the fundamental organ system which covers multiple positive functions like effective digestion, stabilizing intestinal microbiota, gut pH and modulation of effective immune response. Gut health depends on proper balance of microbial population. A wide range of feed and pathogen associated factors influence this balance, and adversely affect the animal health status and production performance. Antibiotic stimulators have been used in farm animals to achieve maximum production. But drug resistance and residual effects of antibiotics in animal products (milk, meat and egg etc.) have raised serious issues in human life. Therefore, The European Union (EU) has strictly banned the application of antibiotic stimulators in livestock nutrition in several others countries including China. As a result, an alternative to antibiotic growth promoters are required to support the profitable and sustainable animal production system. Probiotics as nutraceuticals has been categorized as an alternative natural feed supplement for commercial utilization. Such products have been recognized as safe feed additives in animal industry. Very few studies have comparatively described the effect of probiotics on gut health of domestic animals. Therefore, the aim of this review is not only to explore the beneficial effects of probiotics in improving gut health of domestic animals as an alternative to antibiotic growth promoters, but also to evaluate the probiotics associated health and risk factors, and to provide comprehensive scientific information for researchers, scientists and commercial producers.

scholarly journals Pretreatment with probiotics ameliorate gut health and necrotic enteritis in broiler chickens, a substitute to antibiotics

AMB Express ◽  
2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Danish Sharafat Rajput ◽  
Dong Zeng ◽  
Abdul Khalique ◽  
Samia Sharafat Rajput ◽  
Hesong Wang ◽  
...  
Keyword(s):  
Broiler Chickens ◽  
Production Systems ◽  
Economic Losses ◽  
Necrotic Enteritis ◽  
Poultry Production ◽  
Gut Health ◽  
Growth Promoters ◽  
Broiler Performance ◽  
Antibiotic Growth Promoters ◽  
Microbial Strains

AbstractNecrotic enteritis (NE) is being considered as one of the most important intestinal diseases in the recent poultry production systems, which causes huge economic losses globally. NE is caused by Clostridium perfringens, a pathogenic bacterium, and normal resident of the intestinal microflora of healthy broiler chickens. Gastrointestinal tract (GIT) of broiler chicken is considered as the most integral part of pathogen’s entrance, their production and disease prevention. Interaction between C. perfringens and other pathogens such as Escherichia coli and Salmonella present in the small intestine may contribute to the development of NE in broiler chickens. The antibiotic therapy was used to treat the NE; however European Union has imposed a strict ban due to the negative implications of drug resistance. Moreover, antibiotic growth promoters cause adverse effects on human health as results of withdrawal of antibiotic residues in the chicken meat. After restriction on use of antibiotics, numerous studies have been carried out to investigate the alternatives to antibiotics for controlling NE. Thus, possible alternatives to prevent NE are bio-therapeutic agents (Probiotics), prebiotics, organic acids and essential oils which help in nutrients digestion, immunity enhancement and overall broiler performance. Recently, probiotics are extensively used alternatives to antibiotics for improving host health status and making them efficient in production. The aim of review is to describe a replacement to antibiotics by using different microbial strains as probiotics such as bacteria and yeasts etc. having bacteriostatic properties which inhibit growth of pathogens and neutralize the toxins by different modes of action.

scholarly journals Butyric and Citric Acids and Their Salts in Poultry Nutrition: Effects on Gut Health and Intestinal Microbiota

2021 ◽  
Vol 22 (19) ◽  
pp. 10392
Author(s):  
Mebratu Melaku ◽  
Ruqing Zhong ◽  
Hui Han ◽  
Fan Wan ◽  
Bao Yi ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Organic Acids ◽  
Growth Performance ◽  
Pathogenic Bacteria ◽  
Intestinal Inflammation ◽  
Farm Animals ◽  
Gut Health ◽  
Intestinal Health ◽  
Poultry Products ◽  
Poultry Nutrition

Intestinal dysfunction of farm animals, such as intestinal inflammation and altered gut microbiota, is the critical problem affecting animal welfare, performance and farm profitability. China has prohibited the use of antibiotics to improve feed efficiency and growth performance for farm animals, including poultry, in 2020. With the advantages of maintaining gut homeostasis, enhancing digestion, and absorption and modulating gut microbiota, organic acids are regarded as promising antibiotic alternatives. Butyric and citric acids as presentative organic acids positively impact growth performance, welfare, and intestinal health of livestock mainly by reducing pathogenic bacteria and maintaining the gastrointestinal tract (GIT) pH. This review summarizes the discovery of butyric acid (BA), citric acid (CA) and their salt forms, molecular structure and properties, metabolism, biological functions and their applications in poultry nutrition. The research findings about BA, CA and their salts on rats, pigs and humans are also briefly reviewed. Therefore, this review will fill the knowledge gaps of the scientific community and may be of great interest for poultry nutritionists, researchers and feed manufacturers about these two weak organic acids and their effects on intestinal health and gut microbiota community, with the hope of providing safe, healthy and nutrient-rich poultry products to consumers.

scholarly journals Modulation of the Immune Response to Improve Health and Reduce Foodborne Pathogens in Poultry

2019 ◽  
Vol 7 (3) ◽  
pp. 65 ◽  
Author(s):  
Christina Swaggerty ◽  
Todd Callaway ◽  
Michael Kogut ◽  
Andrea Piva ◽  
Ester Grilli
Keyword(s):  
Immune Response ◽  
Immune System ◽  
Foodborne Pathogens ◽  
Feed Additive ◽  
Gut Health ◽  
Growth Promoters ◽  
Poultry Products ◽  
Antibiotic Growth Promoters ◽  
Increasing Demand ◽  
Production Animals

Salmonella and Campylobacter are the two leading causes of bacterial-induced foodborne illness in the US. Food production animals including cattle, swine, and chickens are transmission sources for both pathogens. The number of Salmonella outbreaks attributed to poultry has decreased. However, the same cannot be said for Campylobacter where 50–70% of human cases result from poultry products. The poultry industry selects heavily on performance traits which adversely affects immune competence. Despite increasing demand for poultry, regulations and public outcry resulted in the ban of antibiotic growth promoters, pressuring the industry to find alternatives to manage flock health. One approach is to incorporate a program that naturally enhances/modulates the bird’s immune response. Immunomodulation of the immune system can be achieved using a targeted dietary supplementation and/or feed additive to alter immune function. Science-based modulation of the immune system targets ways to reduce inflammation, boost a weakened response, manage gut health, and provide an alternative approach to prevent disease and control foodborne pathogens when conventional methods are not efficacious or not available. The role of immunomodulation is just one aspect of an integrated, coordinated approach to produce healthy birds that are also safe and wholesome products for consumers.

Antimicrobial peptides isolated from the blood of farm animals

2010 ◽  
Vol 50 (7) ◽  
pp. 660 ◽  
Author(s):  
Pak-Lam Yu ◽  
Danitsja S. van der Linden ◽  
Haryadi Sugiarto ◽  
Rachel C. Anderson
Keyword(s):  
Antimicrobial Peptides ◽  
Pathogenic Bacteria ◽  
Synergistic Effects ◽  
Waste Product ◽  
Pharmaceutical Products ◽  
Farm Animals ◽  
Antimicrobial Substances ◽  
Spectrum Activity ◽  
Conventional Antibiotics

The development of antimicrobial resistance by pathogenic bacteria has fuelled the search for alternatives to conventional antibiotics. Endogenous antimicrobial peptides have the potential to be used as new antimicrobial substances because they have low minimum inhibitory concentration in vitro, have broad-spectrum activity, neutralise lipopolysaccharides, promote wound healing and have synergistic effects with conventional antibiotics. Farm animals, in particular the blood that is a by-product of the meat and poultry industries, are an abundant, and currently underutilised, source of such antimicrobial peptides. These antimicrobial peptides could be isolated and developed into high-value products such as biopreservatives, topical neutraceutical products and pharmaceuticals. There have been some clinical trials of antimicrobial peptides as pharmaceutical products, but up to now, the trials have shown disappointing results. Further research and development is still needed before such peptides can be commercialised and full advantage taken of this waste product of the meat and poultry industries.

scholarly journals Effects of a blend of chestnut and quebracho tannins on gut health and performance of broiler chickens

2021 ◽  
Author(s):  
Enzo A Redondo ◽  
Leandro M Redondo ◽  
Octavio A Bruzzone ◽  
Juan M Diaz-Carrasco ◽  
Claudio Cabral ◽  
...  
Keyword(s):  
Broiler Chickens ◽  
Health Indicators ◽  
Feed Additives ◽  
Farm Animals ◽  
In Vivo Model ◽  
Necrotic Enteritis ◽  
Gut Health ◽  
Growth Promoters ◽  
Gross Lesions

Consumer demands and increased regulations on the use of antimicrobials in farm animals accentuated the need to develop strategies to replace antimicrobial growth promoters (AGPs) in food-producing animals. The present study evaluates the productive and gut health outcomes during the implementation of AGPs free programs based on the inclusion of a tannin blend compared with AGPs based program under commercial conditions. In the first trial, 6 farms were randomly assigned to AGP or tannin-based programs. In a second trial, both programs were applied simultaneously in one farm and the results were studied over 1 year. Although productive results from both trials were similar among treatments, evaluations of gut health indicators show improvements in the tannins treated flocks. Frequency and severity of intestinal gross lesions were reduced in jejunum (42% vs 23%; p<0.05 – 1.37 vs. 0.73; p<0.01, respectively) and ileum (25% vs. 10%; p<0.0.5 – 1.05 vs. 0.58; p<0.01) in tannins treated birds. Results from 16S studies, show that cecal microbiota diversity was not differentially affected by AGPs or tannins, but changes in the relative abundance of certain taxa were described, including Lactobacillus and Bifidobacterium groups. Additional evaluations using an in vivo model for C. perfringens necrotic enteritis showed that tannins treated birds had reduced incidence of gross lesions in jejunum (43.75 vs. 74.19%; p<0.01) and ileum (18.75% vs. 45.16%; p<0.05) compared with control. These results suggest that AGPs can be replaced by tannins feed additives, and contribute in the implementation of antimicrobial-free programs in broilers without affecting health or performance.

scholarly journals Comparative Effect of Potentiated Zinc Oxide and Antibiotic Growth Promoters on Intestinal  Morphometry and Nutrient Digestibility in Broiler Chickens

2021 ◽  
Author(s):  
Babylyn Alday Moog ◽  
Amado Angeles ◽  
Florinia Merca ◽  
Percival Sangel
Keyword(s):  
Zinc Oxide ◽  
Broiler Chickens ◽  
Nutrient Digestibility ◽  
Broiler Chicks ◽  
Growth Promoters ◽  
Crypt Depth ◽  
Study Results ◽  
Antibiotic Growth Promoters ◽  
Intestinal Morphometry ◽  
Dietary Treatments

Abstract This study aims to determine the comparative effects of potentiated zinc oxide (pZnO) and antibiotic growth promoters (AGP) supplementation on intestinal morphometry and nutrient digestibility in broiler chickens. Four hundred straight-run day-old broiler chicks were randomly allotted to one of four dietary treatments replicated 10 times with 10 birds per replicate. Dietary treatments were: T1: Basal diets without AGP (negative control; NC), T2: Basal diets with 500 g/ton Maduramicin 10g and 500 g/ton Zinc bacitracin 150 (positive control; PC), T3: NC added with 150g/ton pZnO, and T4: PC added with 150g/ton pZnO in a 2x2 factorial design in RCBD. At days and 35, 10 birds were randomly selected per treatment 18 for morphometry of the duodenum, jejunum and ileum. At day 38, eight birds per treatment were used for the nutrient digestibility study. Results showed significant interaction effects (P<0.05) of AGP and pZnO supplementation on day 35 intestinal morphometry of duodenum’s villi height and villi height: crypt depth, and ileum’s crypt depth; apparent CODGE, AME, CP, DM and EE. Significant differences (P<0.05) with pZnO supplementation were only observed on feed intake and FCR of birds fed with pZnO at days 8-14 and fecal quality at days 0-7. Results of the study suggest that pZnO has the potential to replace AGPs without negatively affecting the intestinal morphometry, digestibility and growth performance of broiler chickens.

Effects of phytogenics and organic acids alone and in combination on growth performance of weaned piglets

2007 ◽  
Vol 2007 ◽  
pp. 200-200
Author(s):  
T. Steiner ◽  
C. Lückstädt
Keyword(s):  
Organic Acids ◽  
Essential Oils ◽  
Growth Performance ◽  
Antimicrobial Properties ◽  
Nutrient Digestibility ◽  
Growth Promoters ◽  
Commercial Diet ◽  
Beneficial Effects

Intensive research has been directed to the potential of Natural Growth Promoters (NGPs) to replace antibiotics. Phytogenics and organic acids (OA) have been shown to be effective in reducing the incidence of gastrointestinal disorders, thereby improving growth performance in pigs (Steiner, 2006). The addition of OA to nonruminant diets is supposed to have beneficial effects on feed safety since OA have a detrimental impact on moulds and other feed contaminants. Moreover, due to a decrease in gastric pH, acidification of the diets creates favourable conditions for nutrient digestibility, especially in young piglets (Radcliffe et al., 1998). Dietary supplementation with essential oils originating from aromatic plants may directly affect the intestinal microflora, both in quantitative and qualitative terms. As shown under in vitro (Helander et al., 1998) and in vivo conditions (Kroismayr et al., 2005), oregano essential oils have strong antimicrobial properties. Finally, it has been confirmed that addition of fructooligosaccharides (FOS) to diets for nonruminants may stabilize the gut microflora by selectively supporting the growth of beneficial bacteria (Macfarlane et al., 2006). Depending on individual farm conditions, a well-adjusted combination of different strategies is supposed to maximize the efficacy of NGPs in antibiotic-free feeding systems. The aim of the trial was to investigate the effects of phytogenics and OA alone and in combination in comparison with a commercial diet containing no additives.

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