scholarly journals The Potential Role of Probiotics (nutraceuticals) in Gut Health of Domestic Animals; an Alternative to Antibiotic Growth Promoters

2019 ◽  
Vol 69 (4) ◽  
pp. 1169 ◽  
Author(s):  
A. NAWAB ◽  
W. LIU ◽  
G. LI ◽  
F. IBTISHAM ◽  
D P. FOX ◽  
...  
Keyword(s):  
Animal Health ◽  
Scientific Information ◽  
Domestic Animals ◽  
Feed Additives ◽  
Production Performance ◽  
Farm Animals ◽  
Gut Health ◽  
Growth Promoters ◽  
Wide Range ◽  
Antibiotic Growth Promoters

The term gut health is currently becoming more important for domestic animals including poultry. Gut health refers to the fundamental organ system which covers multiple positive functions like effective digestion, stabilizing intestinal microbiota, gut pH and modulation of effective immune response. Gut health depends on proper balance of microbial population. A wide range of feed and pathogen associated factors influence this balance, and adversely affect the animal health status and production performance. Antibiotic stimulators have been used in farm animals to achieve maximum production. But drug resistance and residual effects of antibiotics in animal products (milk, meat and egg etc.) have raised serious issues in human life. Therefore, The European Union (EU) has strictly banned the application of antibiotic stimulators in livestock nutrition in several others countries including China. As a result, an alternative to antibiotic growth promoters are required to support the profitable and sustainable animal production system. Probiotics as nutraceuticals has been categorized as an alternative natural feed supplement for commercial utilization. Such products have been recognized as safe feed additives in animal industry. Very few studies have comparatively described the effect of probiotics on gut health of domestic animals. Therefore, the aim of this review is not only to explore the beneficial effects of probiotics in improving gut health of domestic animals as an alternative to antibiotic growth promoters, but also to evaluate the probiotics associated health and risk factors, and to provide comprehensive scientific information for researchers, scientists and commercial producers.

scholarly journals Effects of a blend of chestnut and quebracho tannins on gut health and performance of broiler chickens

2021 ◽  
Author(s):  
Enzo A Redondo ◽  
Leandro M Redondo ◽  
Octavio A Bruzzone ◽  
Juan M Diaz-Carrasco ◽  
Claudio Cabral ◽  
...  
Keyword(s):  
Broiler Chickens ◽  
Health Indicators ◽  
Feed Additives ◽  
Farm Animals ◽  
In Vivo Model ◽  
Necrotic Enteritis ◽  
Gut Health ◽  
Growth Promoters ◽  
Gross Lesions

Consumer demands and increased regulations on the use of antimicrobials in farm animals accentuated the need to develop strategies to replace antimicrobial growth promoters (AGPs) in food-producing animals. The present study evaluates the productive and gut health outcomes during the implementation of AGPs free programs based on the inclusion of a tannin blend compared with AGPs based program under commercial conditions. In the first trial, 6 farms were randomly assigned to AGP or tannin-based programs. In a second trial, both programs were applied simultaneously in one farm and the results were studied over 1 year. Although productive results from both trials were similar among treatments, evaluations of gut health indicators show improvements in the tannins treated flocks. Frequency and severity of intestinal gross lesions were reduced in jejunum (42% vs 23%; p<0.05 – 1.37 vs. 0.73; p<0.01, respectively) and ileum (25% vs. 10%; p<0.0.5 – 1.05 vs. 0.58; p<0.01) in tannins treated birds. Results from 16S studies, show that cecal microbiota diversity was not differentially affected by AGPs or tannins, but changes in the relative abundance of certain taxa were described, including Lactobacillus and Bifidobacterium groups. Additional evaluations using an in vivo model for C. perfringens necrotic enteritis showed that tannins treated birds had reduced incidence of gross lesions in jejunum (43.75 vs. 74.19%; p<0.01) and ileum (18.75% vs. 45.16%; p<0.05) compared with control. These results suggest that AGPs can be replaced by tannins feed additives, and contribute in the implementation of antimicrobial-free programs in broilers without affecting health or performance.

scholarly journals Phytogenic Compounds for Enhancing Intestinal Barrier Function in Poultry–A Review

Planta Medica ◽  
2021 ◽  
Author(s):  
Urszula Latek ◽  
Magdalena Chłopecka ◽  
Wojciech Karlik ◽  
Marta Mendel
Keyword(s):  
Barrier Function ◽  
Current Knowledge ◽  
Intestinal Barrier ◽  
Feed Additives ◽  
Intestinal Barrier Function ◽  
Poultry Production ◽  
Gut Health ◽  
Growth Promoters ◽  
Gut Barrier Function ◽  
Antibiotic Growth Promoters

AbstractAfter the European Union ban of antibiotic growth promoters, works on different methods of improving gut health have intensified. The poultry industry is struggling with problems that were previously controlled by antibiotic growth promoters, therefore the search for optimal solutions continues. Simultaneously, there is also increasing social pressure to minimize the use of antibiotics and replace them with alternative feed additives. A variety of available alternatives is considered safe by consumers, among which phytogenics play a significant role. However, there are still some limitations that need to be considered. The most questionable are the issues related to bioavailability, metabolism of plant derivatives in birds, and the difficulty of standardizing commercial products. There is still a need for more evidence-based recommendations for the use of phytogenics in livestock. On the other hand, a positive influence of phytogenic compounds on the health of poultry has been previously described by many researchers and practical application of these compounds has auspicious perspectives in poultry production. Supplementation with phytogenic feed additives has been shown to protect birds from various environmental threats leading to impaired intestinal barrier function. Phytogenic feed additives have the potential to improve the overall structure of intestinal mucosa as well as gut barrier function on a molecular level. Recognition of the phytogenicsʼ effect on the components of the intestinal barrier may enable the selection of the most suitable ones to alleviate negative effects of different agents. This review aims to summarize current knowledge of the influence of various phytogenic constituents on the intestinal barrier and health of poultry.

scholarly journals Global Restriction of Using Antibiotic Growth Promoters and Alternative Strategies in Poultry Production

2018 ◽  
Vol 101 (1) ◽  
pp. 52-75 ◽  
Author(s):  
Hossan MD. Salim ◽  
Khan Shahidul Huque ◽  
Kazi M. Kamaruddin ◽  
Anwarul Haque Beg
Keyword(s):  
Value Chain ◽  
Value Added ◽  
Cost Effective ◽  
Feed Additives ◽  
Production Performance ◽  
Poultry Production ◽  
Health Food ◽  
Growth Promoters ◽  
Poultry Products ◽  
Antibiotic Growth Promoters

A growing global concern of antibiotic use in poultry diets due to its potential adverse effects on birds and human health, food safety and the environment has led to a complete ban or restricted use in some countries, and, at the same time, expanding options for the use of alternative feed additives. Multiple, rather than a single additive may replace antibiotic growth promoters (AGPs) in poultry. Blending of feeding additives and hygienic farm management, vaccination and biosecurity may help achieve good intestinal health, stabilise enteric ecosystems and result in sustainable and cost effective production performance of birds. Moreover, controlling unsolicited ingredients at the production level must have the support of different markets responsible for the supply of safe and quality poultry products for consumers. This requires the further increase and diversification of value added poultry products and the expansion of their markets through strategic planning and gradual limitation of live bird markets. More research is warranted in order to explore suitable, reliable and cost effective alternatives to AGPs for commercial use, and strategic poultry value chain development.

Novel marine polysaccharides and maternal nutrition to stimulate gut health and performance in post-weaned pigs

2017 ◽  
Vol 57 (12) ◽  
pp. 2376 ◽  
Author(s):  
J. V. O'Doherty ◽  
M. A. Bouwhuis ◽  
T. Sweeney
Keyword(s):  
Gastrointestinal Tract ◽  
Maternal Nutrition ◽  
Maternal Diet ◽  
Feed Additives ◽  
Resistant Bacteria ◽  
Gut Health ◽  
Terrestrial Plants ◽  
Growth Promoters ◽  
Susceptibility To Infection ◽  
Antibiotic Growth Promoters

Post-weaning complications in piglets are characterised by a reduction in feed intake and growth, atrophy of small-intestine architecture, upregulation of intestinal inflammatory cytokines, alterations in gastrointestinal microflora, diarrhoea and heightened susceptibility to infection. Traditional measures to reduce weaning-associated intestinal dysfunction have centred on dietary inclusion of antibiotic growth promoters in weaning pig diets, or high concentrations of dietary minerals in the form of zinc oxide. However, these strategies are under scrutiny because of their role in promoting multi-drug resistant bacteria and the accumulation of minerals in the environment. Up to recently, the main focus on finding alternatives to in-feed antibiotic growth promoters has been on dietary manipulations post-weaning, through the use of feed additives in the post-weaning diet. However, there are also other strategies that could enhance the growth and health of the newly weaned pig. One of these strategies is the use of maternal nutrition to improve growth and health in her offspring. The development of the immune system begins in utero and is further developed after the colonisation of the gastrointestinal tract with microbiota during birth and post-natal life. The early establishment of this relationship is fundamental to the development and long-term maintenance of gut homeostasis. There are significant efforts being made to identify natural alternatives to support the development of the piglet gastrointestinal tract, in particular during the weaning period. Chemodiversity in nature, including microorganisms, terrestrial plants, seaweeds and marine organisms, offers a valuable source of novel bioactives. This review will discuss the development of the intestinal tract in the pig during gestation, lactation and post-weaning periods and the factors that influence intestinal health post-weaning. It will also discuss how feeding marine bioactives in both the maternal diet and the piglet diet can be used to alleviate the negative effects associated with weaning.

scholarly journals Immunomodulation of Domestic Animals Using Conventional Methods and Panchgavya

2021 ◽  
Vol 10 (9) ◽  
pp. 140-145
Author(s):  
Rinkal Sundriyal Aarti Adhikari ◽  
Siddharth Chaudhary
Keyword(s):  
Drug Resistance ◽  
New World ◽  
Animal Health ◽  
Domestic Animals ◽  
Emerging Diseases ◽  
Feed Additives ◽  
The Body ◽  
Production Performance ◽  
Livestock Sector ◽  
Sick Animal

With increase in the prevalence of diseases mainly the new emerging diseases, finding a cure is like dodging a bullet. Not only this, but the new world also has to fight against emerging drug resistance among pathogens. Overall, the possibility of survival not only depends on combating the diseases by using expensive resources but it now relies more on immunity building. This fact is applicable in the livestock sector as well. The farmer's economy mainly depends upon the production performance of his livestocks. Also, maximum part of his earnings spends on the feed, fodder, feed additives and other production enhancing drugs. But a single sick animal can disturb the entire planning of a small farmer. Hence the main objective of this article is to focus on the herbal ways that could help in the immunomodulation of livestock and thus conserving both time and money of the farmers. Many villagers of India use their heritage and knowledge to defeat the diseases and enhance the productivity of their livestock. On other side, Panchgavya came like a missile against the body ailments of humans. Research product of algae and their use as immunomodulators and production enhancers is now available as a boon in the market. But still there is a lot to search. Overall, relying totally on the drugs for relief, creates loss both in terms of animal health, productivity and farmer's economy. So, prevention via immunomodulators is the best weapon to make our animals healthy and to be wealthy.

scholarly journals Organic Acids Mixture as a Dietary Additive for Pigs—A Review

Animals ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. 952
Author(s):  
Dinh Hai Nguyen ◽  
Woo Jeong Seok ◽  
In Ho Kim
Keyword(s):  
Organic Acids ◽  
Synergistic Effects ◽  
Nutrient Digestibility ◽  
Farm Animals ◽  
Gut Health ◽  
Growth Promoters ◽  
Bacterial Populations ◽  
Animal Products ◽  
Spectrum Activity ◽  
Antibiotic Growth Promoters

Due to the increasing safety concerns about the risk of spreading antibiotic resistance in the environment, and the presence of chemical residues in animal products, using organic acids (OAs) to replace antibiotic in the diet of farm animals has increased considerably in recent years. It has been suggested that OAs could attribute to diverse elements such as antimicrobial activity, decreasing the pH of digesta particularly in the gastrointestinal tract (GIT), slowing feed transit in the GIT to maximize feed digestion and nutrient absorption, inducing enzyme secretion and activity in the small intestine, and providing nutrients to intestinal tissue. It has been reported that OAs mixture might be more effective than individual OAs due to the synergistic effects of different pKa values and have a broad-spectrum activity. In conclusion, this review showed that an OA mixture, which can improve nutrient digestibility and growth performance, modulate intestinal bacterial populations and improve gut health, as well as decreasing gas emission, can be used as alternative to antibiotic growth promoters. However, the results of OA mixtures are not always consistent, and the response to dietary OAs could be affected by the type of OAs, dosage, feed formula, and the age of animals. In this review, we will give an overview of the current use of OAs mixture in swine feed.

scholarly journals Pretreatment with probiotics ameliorate gut health and necrotic enteritis in broiler chickens, a substitute to antibiotics

AMB Express ◽  
2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Danish Sharafat Rajput ◽  
Dong Zeng ◽  
Abdul Khalique ◽  
Samia Sharafat Rajput ◽  
Hesong Wang ◽  
...  
Keyword(s):  
Broiler Chickens ◽  
Production Systems ◽  
Economic Losses ◽  
Necrotic Enteritis ◽  
Poultry Production ◽  
Gut Health ◽  
Growth Promoters ◽  
Broiler Performance ◽  
Antibiotic Growth Promoters ◽  
Microbial Strains

AbstractNecrotic enteritis (NE) is being considered as one of the most important intestinal diseases in the recent poultry production systems, which causes huge economic losses globally. NE is caused by Clostridium perfringens, a pathogenic bacterium, and normal resident of the intestinal microflora of healthy broiler chickens. Gastrointestinal tract (GIT) of broiler chicken is considered as the most integral part of pathogen’s entrance, their production and disease prevention. Interaction between C. perfringens and other pathogens such as Escherichia coli and Salmonella present in the small intestine may contribute to the development of NE in broiler chickens. The antibiotic therapy was used to treat the NE; however European Union has imposed a strict ban due to the negative implications of drug resistance. Moreover, antibiotic growth promoters cause adverse effects on human health as results of withdrawal of antibiotic residues in the chicken meat. After restriction on use of antibiotics, numerous studies have been carried out to investigate the alternatives to antibiotics for controlling NE. Thus, possible alternatives to prevent NE are bio-therapeutic agents (Probiotics), prebiotics, organic acids and essential oils which help in nutrients digestion, immunity enhancement and overall broiler performance. Recently, probiotics are extensively used alternatives to antibiotics for improving host health status and making them efficient in production. The aim of review is to describe a replacement to antibiotics by using different microbial strains as probiotics such as bacteria and yeasts etc. having bacteriostatic properties which inhibit growth of pathogens and neutralize the toxins by different modes of action.

scholarly journals A Review of the Effects and Production of Spore-Forming Probiotics for Poultry

Animals ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1941
Author(s):  
Igor V. Popov ◽  
Ammar Algburi ◽  
Evgeniya V. Prazdnova ◽  
Maria S. Mazanko ◽  
Vladimir Elisashvili ◽  
...  
Keyword(s):  
Health Promotion ◽  
One Health ◽  
Mechanisms Of Action ◽  
Human Medicine ◽  
Poultry Industry ◽  
Growth Promoters ◽  
Wide Range ◽  
Antibiotic Growth Promoters ◽  
Spore Forming Bacteria ◽  
Unique Ability

One of the main problems in the poultry industry is the search for a viable replacement for antibiotic growth promoters. This issue requires a “one health” approach because the uncontrolled use of antibiotics in poultry can lead to the development of antimicrobial resistance, which is a concern not only in animals, but for humans as well. One of the promising ways to overcome this challenge is found in probiotics due to their wide range of features and mechanisms of action for health promotion. Moreover, spore-forming probiotics are suitable for use in the poultry industry because of their unique ability, encapsulation, granting them protection from the harshest conditions and resulting in improved availability for hosts’ organisms. This review summarizes the information on gastrointestinal tract microbiota of poultry and their interaction with commensal and probiotic spore-forming bacteria. One of the most important topics of this review is the absence of uniformity in spore-forming probiotic trials in poultry. In our opinion, this problem can be solved by the creation of standards and checklists for these kinds of trials such as those used for pre-clinical and clinical trials in human medicine. Last but not least, this review covers problems and challenges related to spore-forming probiotic manufacturing.

scholarly journals Role of probiotics in nutrition and health of small ruminants

2016 ◽  
Vol 19 (4) ◽  
pp. 893-906 ◽  
Author(s):  
M.M. Abd El-Tawab ◽  
I.M.I. Youssef ◽  
H.A. Bakr ◽  
G.C. Fthenakis ◽  
N.D. Giadinis
Keyword(s):  
Volatile Fatty Acids ◽  
Animal Health ◽  
Small Ruminants ◽  
Nutrient Digestibility ◽  
Feed Additives ◽  
Feed Conversion ◽  
Growth Promoters ◽  
Livestock Farming ◽  
Main Component ◽  
Research On Application

AbstractSmall ruminants represent an important economic source in small farm systems and agriculture. Feed is the main component of livestock farming, which has gained special attention to improve animal performance. Many studies have been done to improve feed utilisation through addition of feed additives. For a long period, antibiotics have been widely used as growth promoters in livestock diets. Due to their ban in many countries, search for alternative feed additives has been intensified. Probiotics are one of these alternatives recognised to be safe to the animals. Use of probiotics in small ruminant nutrition has been confirmed to improve animal health, productivity and immunity. Probiotics improved growth performance through enhancing of rumen microbial ecosystem, nutrient digestibility and feed conversion rate. Moreover, probiotics have been reported to stabilise rumen pH, increase volatile fatty acids production and to stimulate lactic acid utilising protozoa, resulting in a highly efficient rumen function. Furthermore, use of probiotics has been found to increase milk production and can reduce incidence of neonatal diarrhea and mortality. However, actual mechanisms through which probiotics exert these functions are not known. Since research on application of probiotics in small ruminants is scarce, the present review attempts to discuss the potential roles of this class of feed additives on productive performance and health status of these animals.

195 Does Feeding a Protease and Probiotic (Bacillus Subtilis) Combination (Syncra® SWI) Result in Improved Growth Performance and Mortality in a Commercial Wean-to-finish Swine Feeding Program?

2021 ◽  
Vol 99 (Supplement_1) ◽  
pp. 77-78
Author(s):  
Trey A Kellner ◽  
Josh Ellingson ◽  
Ana L P de Souza ◽  
Janet C Remus
Keyword(s):  
Growth Performance ◽  
Experimental Period ◽  
Feed Additives ◽  
Control Treatment ◽  
Experimental Unit ◽  
Gut Health ◽  
Wide Range ◽  
Feeding Program ◽  
Feed Costs ◽  
Combined Feed

Abstract The response to probiotics and enzymes is often documented in research facilities with a high degree of control and via pigs with no insults to health or feed intake. However, in commercial conditions, the response to feed additives promoting advanced gut health and improved digestion must be consistent and defined over a wide range of health statuses, stocking densities, feed intakes, environments, and diet formulations. The objective of this experiment was to determine if a combined feed protease and probiotic system (Syncra® SWI 201, DuPont, Wilmington, DE) would improve growth performance and mortality under commercial conditions. A total of 127,092 pigs (6.0 ± 0.1 kg; PIC 337 sired, Hendersonville, TN) from a sow farm producing porcine reproductive and respiratory virus and rotavirus positive weaned pigs were placed in 53 2,400-head commercial wean-to-finish barns that were alternated to 1 of 2 treatments (a control treatment without Syncra® SWI (SSWI) or with SSWI included at 72.6 g/ton of finished feed from 22.7 kg of BW to harvest) in a rolling allotment over a 12-month period. Pigs were on the experiment for an average of 162 ± 1.0 days (until harvest). Throughout the 12-month experimental period, diets (outside of the SSWI inclusion) could change in order to maximize return over feed costs. Data were analyzed using Proc MIXED (SAS 9.4; Cary, NC) with treatment as the main effect and barn as the experimental unit. Compared to the control, adding SSWI improved mortality by 1.9% and percent grade 1 marketed pigs by 2.2% (P ≤ 0.025). Compared to the control, SSWI did not improve ADG (control = 0.75 vs. SSWI = 0.78 kg) or gain:feed (control = 0.401 vs. SSWI = 0.396). In conclusion, the inclusion of the SSWI combined feed protease and probiotic system can improve mortality and grade 1 marketed pigs, but not growth performance under commercial conditions.

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