scholarly journals No Worm Is an Island; The Influence of Commensal Gut Microbiota on Cyathostomin Infections

Animals ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 2309
Author(s):  
Nicola Walshe ◽  
Grace Mulcahy ◽  
Jane Hodgkinson ◽  
Laura Peachey
Keyword(s):  
Gut Microbiota ◽  
Parasitic Helminths ◽  
Overwhelming Evidence ◽  
Host Health ◽  
Life Threatening ◽  
Complex Ecosystem ◽  
The Subject ◽  
And Control ◽  
The Relationship

The importance of the gut microbiome for host health has been the subject of intense research over the last decade. In particular, there is overwhelming evidence for the influence of resident microbiota on gut mucosal and systemic immunity; with significant implications for the outcome of gastrointestinal (GI) infections, such as parasitic helminths. The horse is a species that relies heavily on its gut microbiota for GI and overall health, and disturbances in this complex ecosystem are often associated with life-threatening disease. In turn, nearly all horses harbour parasitic helminths from a young age, the most prevalent of which are the small strongyles, or cyathostomins. Research describing the relationship between gut microbiota and cyathostomin infection is in its infancy, however, to date there is evidence of meaningful interactions between these two groups of organisms which not only influence the outcome of cyathostomin infection but have long term consequences for equine host health. Here, we describe these interactions alongside supportive evidence from other species and suggest novel theories and avenues for research which have the potential to revolutionize our approach to cyathostomin prevention and control in the future.

Cognitive Treatment for OCD

2012 ◽  
Author(s):  
Maureen L. Whittal ◽  
Melisa Robichaud
Keyword(s):  
Term Treatment ◽  
Future Directions ◽  
Cognitive Treatment ◽  
Long Term Treatment ◽  
Inflated Responsibility ◽  
And Control ◽  
The Relationship ◽  
Control Of Thoughts

The cornerstone of cognitive treatment (CT) for OCD is based upon the knowledge that unwanted intrusions are essentially a universal experience. As such, it is not the presence of the intrusion that is problematic but rather the associated meaning or interpretation. Treatment is flexible, depending upon the nature of the appraisals and beliefs, but can include strategies focused on inflated responsibility and overestimation of threat, importance and control of thoughts, and the need for perfectionism and certainty. The role of concealment and the relationship to personal values are important maintaining and etiological factors. The short-term and long-term treatment outcome is reviewed, along with predictors of treatment response and mechanisms of action, and the chapter concludes with future directions regarding CT for OCD.

scholarly journals Association of Urinary and Plasma Levels of Trimethylamine N-Oxide (TMAO) with Foods

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1426
Author(s):  
Mauro Lombardo ◽  
Giovanni Aulisa ◽  
Daniele Marcon ◽  
Gianluca Rizzo ◽  
Maria Grazia Tarsisano ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Fish Consumption ◽  
Plasma Levels ◽  
Cooking Methods ◽  
Saltwater Fish ◽  
Increased Risk ◽  
Mediator Role ◽  
Fish And Shellfish ◽  
The Relationship

Introduction: Trimethylamine N-oxide (TMAO) may play a key mediator role in the relationship between the diet, gut microbiota and cardiovascular diseases, particularly in people with kidney failure. The aim of this review is to evaluate which foods have a greater influence on blood or urinary trimethylamine N-oxide (TMAO) levels. Methods: 391 language articles were screened, and 27 were analysed and summarized for this review, using the keywords “TMAO” AND “egg” OR “meat” OR “fish” OR “dairy” OR “vegetables” OR “fruit” OR “food” in December 2020. Results: A strong correlation between TMAO and fish consumption, mainly saltwater fish and shellfish, but not freshwater fish, has been demonstrated. Associations of the consumption of eggs, dairy and meat with TMAO are less clear and may depend on other factors such as microbiota or cooking methods. Plant-based foods do not seem to influence TMAO but have been less investigated. Discussion: Consumption of saltwater fish, dark meat fish and shellfish seems to be associated with an increase in urine or plasma TMAO values. Further studies are needed to understand the relationship between increased risk of cardiovascular disease and plasma levels of TMAO due to fish consumption. Interventions coupled with long-term dietary patterns targeting the gut microbiota seem promising.

scholarly journals Objective psychology. Academician V. Bekhterev. Issue I. St. Petersburg. 1907 year

1907 ◽  
Vol XIV (3-4) ◽  
pp. 194-196
Author(s):  
V. Osipova
Keyword(s):  
Mental Life ◽  
Subjective Experiences ◽  
The Subject ◽  
And Control ◽  
Relationship Of ◽  
The Relationship ◽  
Living Creature

The author begins his work with the words that the psychology that he will expound bears little resemblance to the psychology that has been the subject of study until now. In objective psychology, there should be no place for questions about subjective processes or processes of consciousness, therefore there should be no place for introspection. Self-observation is not enough even to study one's own mental life. Objective psychology has in mind to study and explain only the relationship of a living creature to the surrounding conditions that affect it in one way or another, without aiming to find out those internal or subjective experiences, which are known as conscious phenomena and which are accessible only to self-observation. All mental items should only be subject to objective registration and control.

scholarly journals The effect of electroacupuncture on hemodialysis patients with restless legs syndrome (RLS): study protocol for a randomized crossover trial

2020 ◽  
Author(s):  
Jia-Ming Chen ◽  
Ping-Fang Chiu ◽  
Yu-Jun Chang ◽  
Po-Chi Hsu ◽  
Chia-Chu Chang ◽  
...  
Keyword(s):  
Restless Legs Syndrome ◽  
Rating Scale ◽  
Severity Index ◽  
Hemodialysis Patients ◽  
Restless Legs ◽  
The Subject ◽  
Group 2 ◽  
And Control ◽  
The Relationship ◽  
Registration Date

Abstract Background The aim of the present study was to evaluate the effects of electroacupuncture (EA) in hemodialysis patients with restless leg syndrome (RLS) by heart rate variability (HRV) monitor. Methods112 subjects who were hemodialysis patients with RLS will be divided into 2 groups: experimental and control. Each subject will receive the treatment relevant to their group 2 times a week for 4 weeks. After 4 weeks of treatment the subject will enter a 2-week washout period, after which the subjects will switch groups. Measurements will include HRV recordings, International Restless Legs Syndrome Rating Scale (IRLSRS) and Insomnia Severity Index (ISI). DiscussionThis study is the first investigation to analyze the relationship between EA and the change of HRV by an objective monitor. If the findings of the current trial are positive, this study will also help support an effective, safe and cheap approach to clinical treatment of this challenging disorder, help foster improved understanding the relationship between RLS and HRV, and ultimately contribute to elucidate the mechanisms of EA. Trial registrationClinicalTrials.gov Identifier: NCT04356794; registration date: April 22, 2020.

Haemofiltration in the Management of Severe Paediatric Burns – Experience in a UK Burns Centre and Systematic Review

2021 ◽  
Author(s):  
Michael Rice ◽  
Ibrahim Ibrahim ◽  
Mohamed Ismail Aly
Keyword(s):  
Systematic Review ◽  
Metabolic Acidosis ◽  
Acute Injury ◽  
Secondary Complications ◽  
Paediatric Burns ◽  
Life Threatening ◽  
Age Range ◽  
And Control ◽  
Renal Support

Abstract Paediatric burns are life-threatening injuries due to the acute injury and secondary complications. In acute phase burns, hypovolaemia and vasoconstriction cause renal impairment. Sepsis and multi-organ failure compound the problem resulting in morbidity and mortality. This paper outlines 5 years’ experience using haemofiltration in major paediatric burns, and a review of the current literature.Retrospective patient data collection was undertaken identifying relevant paediatric burns undergoing Continuous Veno-Venous Haemofiltration. Data were analysed to identify demographics, indication, duration of therapy, and outcomes. A systematic review was also performed using PRISMA principles. PubMed, Science Direct and OVID databases were explored and relevant papers were included.From January 2015-December 2019, haemofiltration was utilised in 5 cases. Age range 3-15 years (mean: 12), 4 males / 1 female, mean weight 56kg (12-125kg). TBSA 21-61% (mean: 37.6%), mechanism of injury was scald-60%, flame-40%. Overall survival was 100%. 3 patients were filtered for a brief period during the first 24 hours to correct metabolic acidosis and control temperature. 2 patients required prolonged therapy. All patients recovered without further long term renal support. A total of 3814 papers were identified for systematic review. 3 were considered relevant for inclusion.This paper reflects the benefits of haemofiltration in the management of severe paediatric burns. Renal replacement therapy is useful in managing metabolic acidosis, temperature control and renal failure. The current literature supports judicious use on a patient-by-patient basis. Given the lack of evidence in the literature, further studies are required to establish guidelines for the use of haemofiltration in paediatric burns.

scholarly journals The Digital Heritage of Covid-19 's Governance: How to Upgrade and Use the "Health Code" in the Post-Epidemic Era

2021 ◽  
Vol 2 (2) ◽  
pp. 235-241
Author(s):  
Wu Siqi ◽  
Wu Yi
Keyword(s):  
Digital Media ◽  
The Body ◽  
Ethical Problems ◽  
Digital Heritage ◽  
Full State ◽  
The Media ◽  
Digital Projection ◽  
And Control ◽  
The Relationship

The outbreak of Covid-19 accelerated the practice of digital survival, and the "health code" launched based on the needs of epidemic prevention and control has become the representative of digital survival media, which is jointly built by science and technology enterprises and government departments. it has realized the full-state use in China, and accumulated long-term digital survival experience for the country, enterprises and individuals. At the same time, there are some media ethical problems in the use of Health Code, such as distinguishing users, leaking information, imprisoning the body and leading to the lack of subjects. In order to resolve the risk, we should re-examine the relationship between people and the media from the perspective of the subject, treat "health code" as a digital projection of personal health, and regain the service principle of digital technology. Humanize the "health code" and other digital media.

scholarly journals The Role of Microbiota in Infant Health: From Early Life to Adulthood

2021 ◽  
Vol 12 ◽  
Author(s):  
Yao Yao ◽  
Xiaoyu Cai ◽  
Yiqing Ye ◽  
Fengmei Wang ◽  
Fengying Chen ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Pregnancy Outcomes ◽  
Early Life ◽  
Genetic Factors ◽  
Infant Health ◽  
Perinatal Period ◽  
Adverse Pregnancy ◽  
The Relationship

From early life to adulthood, the microbiota play a crucial role in the health of the infant. The microbiota in early life are not only a key regulator of infant health but also associated with long-term health. Pregnancy to early life is the golden time for the establishment of the infant microbiota, which is affected by both environmental and genetic factors. Recently, there is an explosion of the studies on the role of microbiota in human diseases, but the application to disease or health is relatively limited because many aspects of human microbiota remain controversial, especially about the infant microbiota. Therefore, a critical and conclusive review is necessary to understand fully the relationship between the microbiota and the health of infant. In this article, we introduce in detail the role of microbiota in the infant from pregnancy to early life to long-term health. The main contents of this article include the relationship between the maternal microbiota and adverse pregnancy outcomes, the establishment of the neonatal microbiota during perinatal period and early life, the composition of the infant gut microbiota, the prediction of the microbiota for long-term health, and the future study directions of microbiota.

scholarly journals Involvement of Gut Microbiota in the Development of Psoriasis Vulgaris

2021 ◽  
Vol 8 ◽  
Author(s):  
Chaonan Sun ◽  
Ling Chen ◽  
Huan Yang ◽  
Hongjiang Sun ◽  
Zhen Xie ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Abdominal Distension ◽  
Fecal Microbiota ◽  
Ultraviolet B ◽  
Healthy Controls ◽  
Gastrointestinal Discomfort ◽  
Delayed Recovery ◽  
The Relationship ◽  
Gut Microbiota Dysbiosis

Objectives: Psoriasis is a common chronic recurrent dermatitis. Accumulating observations show gut microbiota dysbiosis in psoriasis. We intend to further investigate the relationship between intestinal microbiota and psoriasis development.Design: We first performed an epidemiological investigation on differences of gastrointestinal discomfort symptoms between patients with psoriasis and general population. Then variation of gut microbiota in patients with psoriasis (un)treated with acitretin plus narrow-band ultraviolet B (NB-UVB) was analyzed by 16S rRNA sequencing. We last compared recovery status and vital cytokines (lesion and intestine) of mouse psoriasiform models, which were transplanted with fecal microbiota from patients with psoriasis or healthy controls.Results: (1) About 85.5% of patients with psoriasis vs. 58.1% of healthy controls presented with at least one gastrointestinal symptom. The prevalence of investigated symptoms (e.g., abdominal distension and constipation) were significantly higher in patients, compared with controls (p < 0.05). Passing flatus and constipation were significantly correlated with psoriasis (p < 0.05 in both cases). (2) The abundance of Ruminococcaceae family, Coprococcus_1 genus, and Blautia genus were decreased with psoriasis improvement (p < 0.05, respectively), which had been demonstrated significantly increased in psoriasis. (3) Mice receiving psoriatic microbes transplantation showed delayed recovery of psoriasiform dermatitis and less reduction of interleukin (IL)-17A than those receiving healthy microbiota or blank control (p < 0.05 and p < 0.01, respectively).Conclusion: Multiple evidence we provided here preliminarily demonstrates the involvement of gut microbiota in the different degree of psoriasis activity. The strategy based on overall microbial communities is expected to be a promising supplementary for long-term management of psoriasis.

scholarly journals Angiotensin Converting Enzyme 2 in COVID-19 infections and the implications of COVID-19 on major body systems

2020 ◽  
Vol 9 (2) ◽  
pp. 78-85
Author(s):  
Malyn M.L.K. Antoine ◽  
Yancheng Xu ◽  
Rimanatou Seyni-Boureima ◽  
Chrystal Deniza Antoine-Frank ◽  
Coumba Aicha Thiam ◽  
...  
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Uncertain Information ◽  
Converting Enzyme ◽  
Angiotensin Converting Enzyme 2 ◽  
Modes Of Transmission ◽  
Novel Virus ◽  
And Control ◽  
The Relationship

COVID-19, caused by the severe acute respiratory syndrome coronavirus (SARS-CoV-2), was first identified in China in late 2019 and since then, this disease has become a pandemic affecting many countries across the globe. Due to this outbreak, many researchers have been diligently investigating this disease for the establishment of better methods of its treatment and control. Evidence from research has led to a plethora of valuable but uncertain information on the modes of transmission of COVID-19 and the mechanisms by which SARS-CoV-2 establishes infections in targeted tissues. It is now better understood that in this disease, SARS-CoV-2 gains entrance into cells by specifically binding ACE-2 (angiotensin-converting enzyme 2); ACE-2 serves as a potential receptor for the virus. The lungs, in addition to many other organs and tissues, express ACE-2 in varying degrees. Therefore, this review will examine the role of ACE-2 in COVID-19 and the secondary effects that COVID-19 has on organs that express ACE-2. To this end, it will assist in establishing the relationship between the ACE-2 receptor and SARS-CoV-2, bringing to the forefront the correlation between the symptomatology presentation, as well as the severity of infections experienced with COVID-19. Given this, it may even provide an avenue for the generation of treatment, or create a platform for the enhanced knowledge of this novel virus, and therefore, control, and maybe unravel the mystery for long term complications.  

scholarly journals Le funzioni metacognitive nei pazienti con disturbi del comportamento alimentare. Uno studio sul trattamento di gruppo psicodinamico

2010 ◽  
Vol 12 (1-2) ◽  
Author(s):  
Claudia Prestano ◽  
Viviana Cicero ◽  
Salvatore Gullo ◽  
Grazia Alcuri ◽  
Gianluca Lo Coco ◽  
...  
Keyword(s):  
Group Treatment ◽  
Single Case ◽  
Mental States ◽  
First Year ◽  
Control Data ◽  
Group Sessions ◽  
And Control ◽  
The Relationship

There is an emerging empirical evidence that patients with eating disorders have severe metacognitive concerns, i.e. ability to reflect on mental states. This single-case study aims to explore the relationship between limited metacognition and eating symptoms in six patients who attended a long-term group treatment. This study also aims at analysing the change of patients metacognition over the course of treatment. All the patients were female, with a mean age of 17 years. Three patients have a diagnosis of anorexia nervosa, and three have a diagnosis of bulimia nervosa. The group treatment was delivered in a outpatient clinic of the hospital of Acireale (CT). The SVaM (Carcione et al., 1997) was used to measure metacognition of patients, by analysing the transcripts of group sessions. The preliminary findings, which included the first year of the group treatment (N=27 group sessions) showed that metacognitive dysfunctions more evident concern Understanding One's Own Mind and Mastery. The first concerns abilities to reflect on the own mental states; the second concerns ability of regulation and control. Data show that patients don't present failures in the Understanding Other's Minds. The study has not identified meaningful differences between anorexic patients and bulimic patients.

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