scholarly journals The 15-Months Clinical Experience of SARS-CoV-2: A Literature Review of Therapies and Adjuvants

Antioxidants ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 881
Author(s):  
Alessio Danilo Inchingolo ◽  
Gianna Dipalma ◽  
Angelo Michele Inchingolo ◽  
Giuseppina Malcangi ◽  
Luigi Santacroce ◽  
...  
Keyword(s):  
Literature Search ◽  
Web Of Science ◽  
Diagnostic Methods ◽  
World Health ◽  
Evidence Based ◽  
Systematic Literature Search ◽  
The World ◽  
Health Organization ◽  
Near Future ◽  
Early Diagnostic

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus responsible for the coronavirus disease of 2019 (COVID-19) that emerged in December 2019 in Wuhan, China, and rapidly spread worldwide, with a daily increase in confirmed cases and infection-related deaths. The World Health Organization declared a pandemic on the 11th of March 2020. COVID-19 presents flu-like symptoms that become severe in high-risk medically compromised subjects. The aim of this study was to perform an updated overview of the treatments and adjuvant protocols for COVID-19. Methods: A systematic literature search of databases was performed (MEDLINE PubMed, Google Scholar, UpToDate, Embase, and Web of Science) using the keywords: “COVID-19”, “2019-nCoV”, “coronavirus” and “SARS-CoV-2” (date range: 1 January 2019 to 31st October 2020), focused on clinical features and treatments. Results: The main treatments retrieved were antivirals, antimalarials, convalescent plasma, immunomodulators, corticosteroids, anticoagulants, and mesenchymal stem cells. Most of the described treatments may provide benefits to COVID-19 subjects, but no one protocol has definitively proven its efficacy. Conclusions: While many efforts are being spent worldwide in research aimed at identifying early diagnostic methods and evidence-based effective treatments, mass vaccination is thought to be the best option against this disease in the near future.

scholarly journals A recent update of the diagnostic methods for tuberculosis and their applicability in Indonesia: a narrative review

2019 ◽  
Vol 28 (3) ◽  
pp. 284-91
Author(s):  
Tri Nugraha Susilawati ◽  
Riska Larasati
Keyword(s):  
Delayed Diagnosis ◽  
Diagnostic Methods ◽  
World Health ◽  
Current State ◽  
Interferon Gamma Release Assays ◽  
High Prevalence ◽  
The World ◽  
Golden Standard ◽  
Tertiary Hospitals ◽  
Health Organization

Tuberculosis (TB) is a major global problem, especially with the high prevalence of HIV-TB co-infection. Delayed diagnosis and continual transmission contribute to high mortality in Indonesia, which has the third highest incidence of TB in the world, after China and India. Therefore, early diagnosis is needed to reduce the number of cases and to administer therapy to prevent the transmission of bacteria. The diagnosis of TB remains a challenge in clinical practice due to poor sensitivity and the requirement of skilled staff in microscopic tests, the slow growth Mycobacterium in culture, and the low number of bacilli present in extrapulmonary TB. Despite being the golden standard for TB diagnosis, cultures require 2–8 weeks to grow. Other methods for diagnosing TB include interferon-gamma release assays and serologic tests such as the tuberculin skin test. Recently, the World Health Organization recommended the GeneXpert MTB/RIF assay for diagnosing TB. This review presents the current state of TB epidemiology and various methods for TB diagnosis. In particular, the paper provides an in-depth discussion about the GeneXpert MTB/RIF assay that has been made available recently in selected tertiary hospitals in Indonesia.

Have interventions been effective at increasing the rates of breastfeeding in the UK?

2019 ◽  
Vol 27 (5) ◽  
pp. 312-319
Author(s):  
Elizabeth Shortis
Keyword(s):  
World Health Organization ◽  
Exclusive Breastfeeding ◽  
Literature Search ◽  
World Health ◽  
Exclusion Criteria ◽  
The World ◽  
Breastfeeding Rates ◽  
Health Organization ◽  
The Uk ◽  
Combined Interventions

Background The World Health Organization recommends exclusive breastfeeding for the first 6 months of life; however, UK breastfeeding rates are some of the lowest worldwide. As such, various interventions have been trialled, aiming to increase breastfeeding rates. Aims To evaluate the effectiveness of interventions to increase breastfeeding rates in the UK and determine the features of successful interventions. Methods A literature search was performed, using four databases. The results were refined by applying inclusion and exclusion criteria. Two additional articles were recognised by scanning the references sections of identified studies, resulting in 12 articles for review. Findings Support-based interventions had predominantly insignificant effects upon breastfeeding rates. Incentives were associated with increases in rates, while combined interventions had mixed success. The interventions were well received by mothers and clinicians and may help to normalise breastfeeding. Conclusions Future interventions should provide targeted, personalised support to overcome breastfeeding difficulties, and reward mothers for their efforts.

scholarly journals A review of studies on the COVID-19 epidemic crisis disease with a preventive approach

Work ◽  
2020 ◽  
Vol 66 (4) ◽  
pp. 717-729 ◽  
Author(s):  
Maryam Feiz Arefi ◽  
Mohsen Poursadeqiyan
Keyword(s):  
Social Distance ◽  
Preventive Measures ◽  
World Health ◽  
Definitive Treatment ◽  
Evidence Based ◽  
Public Places ◽  
Preventive Vaccine ◽  
The World ◽  
Health Organization ◽  
Presence Of People

BACKGROUND: COVID-19 is a highly contagious acute respiratory syndrome and has been declared a pandemic in more than 209 countries worldwide. At the time of writing, no preventive vaccine has been developed and tested in the community. This study was conducted to review studies aimed at preventing the spread of the coronavirus worldwide. METHODS: This study was a review of the evidence-based literature and was conducted by searching databases, including Google Scholar, PubMed, and ScienceDirect, until April 2020. The search was performed based on keywords including “coronavirus”, “COVID-19”, and “prevention”. The list of references in the final studies has also been re-reviewed to find articles that might not have been obtained through the search. The guidelines published by trustworthy organizations such as the World Health Organization and Center for Disease Control have been used in this study. CONCLUSION: So far, no vaccine or definitive treatment for COVID-19 has been invented, and the disease has become a pandemic. Therefore, observation of hand hygiene, disinfection of high-touch surfaces, observation of social distance, and lack of presence in public places are recommended as preventive measures. Moreover, to control the situation and to reduce the incidence of the virus, some of the measures taken by the decision-making bodies and the guidelines of the deterrent institutions to strengthen telecommuting of employees and reduce the presence of people in the community and prevent unnecessary activities, are very important.

scholarly journals Protecting healthcare workers from SARS-CoV-2 infection: practical indications

2020 ◽  
Vol 29 (155) ◽  
pp. 200068 ◽  
Author(s):  
Martina Ferioli ◽  
Cecilia Cisternino ◽  
Valentina Leo ◽  
Lara Pisani ◽  
Paolo Palange ◽  
...  
Keyword(s):  
High Risk ◽  
Severe Acute Respiratory Syndrome ◽  
World Health Organization ◽  
Noninvasive Ventilation ◽  
Healthcare Workers ◽  
World Health ◽  
Evidence Based ◽  
The World ◽  
Health Organization ◽  
Respiratory Devices

The World Health Organization has recently defined the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection a pandemic. The infection, that may cause a potentially very severe respiratory disease, now called coronavirus disease 2019 (COVID-19), has airborne transmission via droplets. The rate of transmission is quite high, higher than common influenza. Healthcare workers are at high risk of contracting the infection particularly when applying respiratory devices such as oxygen cannulas or noninvasive ventilation. The aim of this article is to provide evidence-based recommendations for the correct use of “respiratory devices” in the COVID-19 emergency and protect healthcare workers from contracting the SARS-CoV-2 infection.

Press Report: Who Criticized for Neglecting Evidence

2007 ◽  
Vol 37 (4) ◽  
pp. 783-785
Author(s):  
Maria Cheng ◽  
Jean McMahon
Keyword(s):  
World Health Organization ◽  
World Health ◽  
Evidence Based ◽  
The World ◽  
Press Report ◽  
Health Organization ◽  
Evidence Based Guidelines

A study published in The Lancet reveals that when developing “evidence-based” guidelines, the World Health Organization routinely forgets one key ingredient: evidence. The study is based on interviews with senior WHO officials and analyses of various guidelines to determine how they were produced. The authors found a distinctly non-transparent process.

scholarly journals Protecting Rights and Building Capacities: Challenges to Global Mental Health Policy in Light of the Convention on the Rights of Persons with Disabilities

2013 ◽  
Vol 41 (1) ◽  
pp. 48-73 ◽  
Author(s):  
Sheila Wildeman
Keyword(s):  
Mental Health ◽  
International Development ◽  
Global Mental Health ◽  
Mental Health Policy ◽  
Disabled Persons ◽  
World Health ◽  
Evidence Based ◽  
Persons With Disabilities ◽  
The World ◽  
Health Organization

The World Health Organization (WHO) has in the last decade identified mental health as a priority for global health promotion and international development, to be targeted through promulgation of evidence-based medical practices, health systems reform, and respect for human rights. Yet these overlapping strategies are marked by tensions as the historical primacy of expert-led initiatives is increasingly subject to challenge by new social movements — in particular, disabled persons’ organizations (DPOs). These tensions come into focus upon situating the WHO’s contributions to the analysis of global mental health in light of the negotiation and early stages of implementation of the Convention on the Rights of Persons with Disabilities (CRPD), particularly as it applies to persons with mental disabilities.

scholarly journals Differences and Similarities between Coronaviruses: A Comparative Review

2021 ◽  
Vol 9 (4) ◽  
Author(s):  
Maad M. Mijwil ◽  
Ayser Shamil Alsaadi ◽  
Karan Aggarwal
Keyword(s):  
World Health ◽  
Infected People ◽  
The Past ◽  
Preventive Vaccine ◽  
Comparative Review ◽  
The World ◽  
Structural Differences ◽  
Health Organization ◽  
Near Future ◽  
Future Reference

Today, humans fight powerful and active viruses that never take hold and do not know defeat, named coronaviruses. These viruses have start in 2002 and continued to grow and have changed their chains dramatically until now. They are known for having many similar features in common, and there are also structural differences between them. The most important reason that has turned coronaviruses into a pandemic is that this disease is easily transmitted by droplets near infected people, which leads to the spread of this virus faster worldwide. The more details known about coronaviruses that have profoundly affected humanity in the past and present and the diseases they cause, the more benefit in help designing an immune response or preventive vaccine to these viruses in the near future. In this article, coronaviruses, how they have been started and spread, and what differences and similarities are between them will be briefly covered here. The information of this investigation is taken from articles and the world health organization and are reviewed here. The goal is to document this information for future reference.

scholarly journals A Systematic Review of the Potential Implication of Salivary Secretions in Covid-19 Patients

2021 ◽  
pp. 29-38
Author(s):  
Salem Mohammed Hassan Alharthi ◽  
Laila Mohammed Alanazi ◽  
Dalal Jumah Alturaif ◽  
Wesam Yousef Othman Alibrahim ◽  
Waleed Yahya Binammar ◽  
...  
Keyword(s):  
Infectious Disease ◽  
Systematic Review ◽  
Saudi Arabia ◽  
Salivary Gland ◽  
Oral Cavity ◽  
Web Of Science ◽  
World Health ◽  
Potential Implication ◽  
The World ◽  
Health Organization

As reported on 23rd May 2021, there are a total of 167,313,629 confirmed cases of Covid-19 all across the world with a mortality of about 3,473,851 whereas in Saudi Arabia 439,847 were registered cases of covid-19 and 7,237 deaths. According to the World Health Organization (WHO) a total of 12,244,264 people were vaccinated with Covid-19 vaccination. Covid-19 is a respiratory infectious disease. More recent researches on SARS-COV-2 suggests the entry of the virus into the host cell using the host entry factors like TMPRSS-2, TMPRSS-4 and ACE-2 in the oral tissues. The spike proteins of the SARS COV-2 attaches to the ACE-2 and TMPRSS2 of the salivary gland. Saliva provides the lubrication of the oral cavity, initiation of digestion and provides immunity in host. A complete research of all the articles was done using databases like: SCOPUS, PUBMED, EMBASE and WEB OF SCIENCE. In case of SARS CoV-2, the salivary glands act as reservoir for the virus. Intake of these viruses present in infectious saliva droplets found in the air would lead to the transmission of infection to an individual. Saliva is more efficient when compared to the blood as it doesn't clot. A reduced secretion of saliva is observed in patients post the covid 19 disease.

scholarly journals A database of geopositioned Middle East Respiratory Syndrome Coronavirus occurrences

2019 ◽  
Vol 6 (1) ◽  
Author(s):  
Rebecca E. Ramshaw ◽  
Ian D. Letourneau ◽  
Amy Y. Hong ◽  
Julia Hon ◽  
Julia D. Morgan ◽  
...  
Keyword(s):  
Middle East ◽  
Literature Search ◽  
Web Of Science ◽  
Contextual Information ◽  
Middle East Respiratory Syndrome ◽  
World Health ◽  
Exclusion Criteria ◽  
Information Index ◽  
Health Organization ◽  
Organization Research

AbstractAs a World Health Organization Research and Development Blueprint priority pathogen, there is a need to better understand the geographic distribution of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) and its potential to infect mammals and humans. This database documents cases of MERS-CoV globally, with specific attention paid to zoonotic transmission. An initial literature search was conducted in PubMed, Web of Science, and Scopus; after screening articles according to the inclusion/exclusion criteria, a total of 208 sources were selected for extraction and geo-positioning. Each MERS-CoV occurrence was assigned one of the following classifications based upon published contextual information: index, unspecified, secondary, mammal, environmental, or imported. In total, this database is comprised of 861 unique geo-positioned MERS-CoV occurrences. The purpose of this article is to share a collated MERS-CoV database and extraction protocol that can be utilized in future mapping efforts for both MERS-CoV and other infectious diseases. More broadly, it may also provide useful data for the development of targeted MERS-CoV surveillance, which would prove invaluable in preventing future zoonotic spillover.

Sign in / Sign up

Export Citation Format

Share Document