scholarly journals Agricultural Use of Copper and Its Link to Alzheimer’s Disease

Biomolecules ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. 897 ◽  
Author(s):  
Fábio C. Coelho ◽  
Rosanna Squitti ◽  
Mariacarla Ventriglia ◽  
Giselle Cerchiaro ◽  
João P. Daher ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Plant Protection ◽  
Crop Protection ◽  
Organic Production ◽  
Copper Accumulation ◽  
Human Food Chain ◽  
Protection Strategies ◽  
Essential Nutrient ◽  
Review Reports

Copper is an essential nutrient for plants, animals, and humans because it is an indispensable component of several essential proteins and either lack or excess are harmful to human health. Recent studies revealed that the breakdown of the regulation of copper homeostasis could be associated with Alzheimer’s disease (AD), the most common form of dementia. Copper accumulation occurs in human aging and is thought to increase the risk of AD for individuals with a susceptibility to copper exposure. This review reports that one of the leading causes of copper accumulation in the environment and the human food chain is its use in agriculture as a plant protection product against numerous diseases, especially in organic production. In the past two decades, some countries and the EU have invested in research to reduce the reliance on copper. However, no single alternative able to replace copper has been identified. We suggest that agroecological approaches are urgently needed to design crop protection strategies based on the complementary actions of the wide variety of crop protection tools for disease control.

CERTIFICATION SUBSIDIZING AND ORGANIC PRODUCTION DEVELOPMENT

2020 ◽  
Vol 10 (4) ◽  
pp. 580-593
Author(s):  
M A. Bryzgalina ◽  
Keyword(s):  
Organic Agriculture ◽  
Crop Production ◽  
Plant Protection ◽  
Crop Protection ◽  
Organic Production ◽  
Mineral Fertilizers ◽  
Selling Price ◽  
Saratov Region ◽  
Annual Volume ◽  
The Government

The demand for organic food is a prerequisite for the formation and development of organic agriculture, and the task of promoting it on domestic and foreign markets is among the priority ones. A serious problem in the sale of this category of goods to the domestic food markets of the country is the distrust of potential consumers. It is possible to solve this problem through certification and the use of a well-known brand. Certification of manufacturers of environmentally friendly products is a rather complicated and expensive procedure, therefore it is not available for most agricultural producers in the Saratov region. However, basing on the fact that today the task of developing the organic agriculture industry is set at the level of the government of the country, it is possible to solve this problem with the support of the state. The article examines the enterprises of the Saratov region of various legal forms, which do not use fertilizers and chemical means of crop protection in the production of crop production. Using the example of agricultural organizations and farms in the region, a mechanism for subsidizing certification of the most promising producers of organic wheat (winter and spring) is proposed, which includes the allocation of targeted subsidies for its implementation. As a criterion for the selection of applicants for this type of state support, as well as the distribution of budgetary resources between them, it is proposed to use the average indicator (potential) of the annual volume of organic production in the work. As a result, direct participants in certification subsidies were selected from the compiled sample of the studied enterprises that do not use chemical plant protection products and mineral fertilizers and the total annual volume of their marketable wheat was determined. The author determined the maximum cost of quality confirmation procedures for one enterprise, taking into account the increasing coefficients per one day of inspection, and also established the largest amount of budgetary resources that may be spent on the implementation of the proposed measure. In order to evaluate the effectiveness of the proposed certification subsidy mechanism, the author developed formulas for determining the selling price of products in the promising organic segment, taking into account its increase by the level of premium premiums.

scholarly journals Organic Foods in Diets of Patients with Alzheimer’s Disease

2020 ◽  
Vol 12 (4) ◽  
pp. 1388
Author(s):  
Szymon Dziuba ◽  
Anna Cierniak-Emerych ◽  
Blanka Klímová ◽  
Petra Poulová ◽  
Piotr Napora ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Natural Resources ◽  
Sustainable Consumption ◽  
Crop Protection ◽  
Health Benefits ◽  
Organic Food ◽  
Test Analysis ◽  
Organic Foods ◽  
The Face

Sustainable consumption is increasingly being promoted in the face of the decreasing amount of natural resources in the world. In general, sustainable consumption means using products and services that meet human basic needs while minimizing the consumption of natural resources and reducing waste. At this point, it is worth noting that the production of organic foods is conducive to the development of sustainable consumption through, e.g., natural methods of production, without the use of artificial fertilizers and crop protection chemicals. Nowadays, more and more emphasis is put on the correlations between health and diets. Consumers who care for their health often choose organic food. Therefore, the focus of this study was on the identification and presentation of the interest in organic foods among people who provide care to patients with Alzheimer’s disease. In order to achieve this aim, the theoretical part of the study attempted to demonstrate, on the one hand, the benefits of organic food and, on the other hand, the specific nutrition of patients with Alzheimer’s disease. The achievement of the study aim was supported by the analysis of the related literature, including the results obtained by other authors. The results of the authors’ own survey conducted in 2017–2018 were also used, with the respondents being the carers and potential carers of patients with Alzheimer’s disease and medical specialists. A statistical analysis was also carried out, including Pearson’s test analysis and a correspondence analysis. The literature survey and empirical examinations led to the conclusion that organic food is characterized by health benefits which should be taken into consideration during planning of diets for patients with Alzheimer’s disease. Carers indicated the deficiency of knowledge concerning demanded diet components. They intuitively perceive the need for using organic food due to its health benefits and for the implementation of the principles of sustainable consumption. Carers are unable to identify the values which would help improve the health of patients with Alzheimer’s disease.

Intracellular copper deficiency increases amyloid-β secretion by diverse mechanisms

2008 ◽  
Vol 412 (1) ◽  
pp. 141-152 ◽  
Author(s):  
Michael A. Cater ◽  
Kelly T. McInnes ◽  
Qiao-Xin Li ◽  
Irene Volitakis ◽  
Sharon La Fontaine ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Copper Deficiency ◽  
Human Fibroblasts ◽  
Amyloid Β ◽  
Copper Accumulation ◽  
Amyloid Β Peptide ◽  
Human Neuroblastoma ◽  
Aβ Amyloid ◽  
Intracellular Copper

In Alzheimer's disease there is abnormal brain copper distribution, with accumulation of copper in amyloid plaques and a deficiency of copper in neighbouring cells. Excess copper inhibits Aβ (amyloid β-peptide) production, but the effects of deficiency have not yet been determined. We therefore studied the effects of modulating intracellular copper levels on the processing of APP (amyloid precursor protein) and the production of Aβ. Human fibroblasts genetically disposed to copper accumulation secreted higher levels of sAPP (soluble APP ectodomain)α into their medium, whereas fibroblasts genetically manipulated to be profoundly copper deficient secreted predominantly sAPPβ and produced more amyloidogenic β-cleaved APP C-termini (C99). The level of Aβ secreted from copper-deficient fibroblasts was however regulated and limited by α-secretase cleavage. APP can be processed by both α- and β-secretase, as copper-deficient fibroblasts secreted sAPPβ exclusively, but produced primarily α-cleaved APP C-terminal fragments (C83). Copper deficiency also markedly reduced the steady-state level of APP mRNA whereas the APP protein level remained constant, indicating that copper deficiency may accelerate APP translation. Copper deficiency in human neuroblastoma cells significantly increased the level of Aβ secretion, but did not affect the cleavage of APP. Therefore copper deficiency markedly alters APP metabolism and can elevate Aβ secretion by either influencing APP cleavage or by inhibiting its degradation, with the mechanism dependent on cell type. Overall our results suggest that correcting brain copper imbalance represents a relevant therapeutic target for Alzheimer's disease.

scholarly journals Intact double stranded RNA is mobile and triggers RNAi against viral and fungal plant pathogens

2021 ◽  
Author(s):  
Christopher A Brosnan ◽  
Anne Sawyer ◽  
Filipe Fenselau Felippes ◽  
Bernard J Carroll ◽  
Peter M Waterhouse ◽  
...  
Keyword(s):  
Topical Application ◽  
Plant Pathogens ◽  
Plant Protection ◽  
Critical Role ◽  
Crop Protection ◽  
Double Stranded Rna ◽  
Ability To Act ◽  
Fungal Plant Pathogens ◽  
Transgenic Breeding ◽  
Protection Strategies

Topical application of double-stranded RNA (dsRNA) as RNA interference(RNAi) based biopesticides represents a sustainable alternative to traditional transgenic, breeding-based or chemical crop protection strategies. A key feature of RNAi is its ability to act non-cell autonomously, a process that plays a critical role in plant protection. However, the uptake of dsRNA upon topical application, and its ability to move and act non-cell autonomously remains debated and largely unexplored. Here we show that when applied to a leaf, unprocessed full-length dsRNA enters the vasculature and rapidly moves to multiple distal below ground, vegetative and reproductive tissue types in several model plant and crop hosts. Intact unprocessed dsRNA was detected in the apoplast of leaves, roots and flowers after leaf application and maintained in subsequent new growth. Furthermore, we show mobile dsRNA is functional against root infecting fungal and foliar viral pathogens. Our demonstration of the uptake and maintained movement of intact and functional dsRNA stands to add significant benefit to the emerging field of RNAi-based plant protection.

scholarly journals Designing Hybrids Targeting the Cholinergic System by Modulating the Muscarinic and Nicotinic Receptors: A Concept to Treat Alzheimer’s Disease

Molecules ◽  
2018 ◽  
Vol 23 (12) ◽  
pp. 3230 ◽  
Author(s):  
Daniela Volpato ◽  
Ulrike Holzgrabe
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cholinergic System ◽  
Nicotinic Receptors ◽  
Behavioral Issues ◽  
Bifunctional Compounds ◽  
Molecule Design ◽  
Review Reports ◽  
Muscarinic And Nicotinic Receptors

The cholinergic hypothesis has been reported first being the cause of memory dysfunction in the Alzheimer’s disease. Researchers around the globe have focused their attention on understanding the mechanisms of how this complicated system contributes to processes such as learning, memory, disorientation, linguistic problems, and behavioral issues in the indicated chronic neurodegenerative disease. The present review reports recent updates in hybrid molecule design as a strategy for selectively addressing multiple target proteins involved in Alzheimer’s disease (AD) and the study of their therapeutic relevance. The rationale and the design of the bifunctional compounds will be discussed in order to understand their potential as tools to investigate the role of the cholinergic system in AD.

scholarly journals Intracellular Calcium Dysregulation: Implications for Alzheimer’s Disease

2016 ◽  
Vol 2016 ◽  
pp. 1-14 ◽  
Author(s):  
Simona Magi ◽  
Pasqualina Castaldo ◽  
Maria Loredana Macrì ◽  
Marta Maiolino ◽  
Alessandra Matteucci ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Intracellular Calcium ◽  
Calcium Homeostasis ◽  
Neurodegenerative Disorder ◽  
Neuronal Loss ◽  
Calcium Stores ◽  
Cellular Mechanisms ◽  
Calcium Dysregulation ◽  
Review Reports

Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by progressive neuronal loss. AD is associated with aberrant processing of the amyloid precursor protein, which leads to the deposition of amyloid-βplaques within the brain. Together with plaques deposition, the hyperphosphorylation of the microtubules associated protein tau and the formation of intraneuronal neurofibrillary tangles are a typical neuropathological feature in AD brains. Cellular dysfunctions involving specific subcellular compartments, such as mitochondria and endoplasmic reticulum (ER), are emerging as crucial players in the pathogenesis of AD, as well as increased oxidative stress and dysregulation of calcium homeostasis. Specifically, dysregulation of intracellular calcium homeostasis has been suggested as a common proximal cause of neural dysfunction in AD. Aberrant calcium signaling has been considered a phenomenon mainly related to the dysfunction of intracellular calcium stores, which can occur in both neuronal and nonneuronal cells. This review reports the most recent findings on cellular mechanisms involved in the pathogenesis of AD, with main focus on the control of calcium homeostasis at both cytosolic and mitochondrial level.

scholarly journals Effects of Supplementation with Folic Acid and Its Combinations with Other Nutrients on Cognitive Impairment and Alzheimer’s Disease: A Narrative Review

Nutrients ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 2966
Author(s):  
Ana M. Puga ◽  
Mar Ruperto ◽  
Mª de Lourdes Samaniego-Vaesken ◽  
Ana Montero-Bravo ◽  
Teresa Partearroyo ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Folic Acid ◽  
Dietary Intervention ◽  
Public Health Problem ◽  
Cerebrovascular Diseases ◽  
Vitamin Supplementation ◽  
Major Public Health Problem ◽  
Essential Nutrient

Cognitive impairment and Alzheimer’s Disease, among other cognitive dysfunctions, has been recognized as a major public health problem. Folic acid is a well-known essential nutrient whose deficiency has been linked to neurocognitive dysfunctions, owing to hyperhomocysteinemia, an independent risk factor for cardio- and cerebrovascular diseases, including cognitive impairment, Alzheimer’s Disease, and vascular dementia. However, to date, there is certain controversy about the efficacy of vitamin supplementation in patients with these pathologies. Therefore, we have reviewed the available dietary intervention studies based on folic acid, either alone or in combination with different vitamins or nutrients into the progression of Alzheimer’s Disease and Cognitive impairment, highlighting the cognition and biochemical markers employed for the evaluation of the disease progression. Undeniably, the compiled information supports the potential benefits of vitamin supplementation in these pathologies, especially relevant to the aging process and quality of life, although more research is urgently needed to confirm these positive findings.

Cognitive control constrains memory attributions

2019 ◽  
Vol 42 ◽  
Author(s):  
Colleen M. Kelley ◽  
Larry L. Jacoby
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Cognitive Control

Abstract Cognitive control constrains retrieval processing and so restricts what comes to mind as input to the attribution system. We review evidence that older adults, patients with Alzheimer's disease, and people with traumatic brain injury exert less cognitive control during retrieval, and so are susceptible to memory misattributions in the form of dramatic levels of false remembering.

Formation of paired helical filaments in Alzheimer's disease

1984 ◽  
Vol 42 ◽  
pp. 302-303
Author(s):  
J. Metuzals ◽  
D. F. Clapin ◽  
V. Montpetit
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Frontal Lobe ◽  
Giant Axon ◽  
Paired Helical Filaments ◽  
Normal Brain ◽  
Protein Assemblies ◽  
Electron Microscopic ◽  
Helical Symmetry ◽  
Structural Levels

Information on the conformation of paired helical filaments (PHF) and the neurofilamentous (NF) network is essential for an understanding of the mechanisms involved in the formation of the primary lesions of Alzheimer's disease (AD): tangles and plaques. The structural and chemical relationships between the NF and the PHF have to be clarified in order to discover the etiological factors of this disease. We are investigating by stereo electron microscopic and biochemical techniques frontal lobe biopsies from patients with AD and squid giant axon preparations. The helical nature of the lesion in AD is related to pathological alterations of basic properties of the nervous system due to the helical symmetry that exists at all hierarchic structural levels in the normal brain. Because of this helical symmetry of NF protein assemblies and PHF, the employment of structure reconstruction techniques to determine the conformation, particularly the handedness of these structures, is most promising. Figs. 1-3 are frontal lobe biopsies.

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