scholarly journals Infants of Mothers with Cocaine Use: Review of Clinical and Medico-Legal Aspects

Children ◽  
2022 ◽  
Vol 9 (1) ◽  
pp. 67
Author(s):  
Clara Cestonaro ◽  
Lorenzo Menozzi ◽  
Claudio Terranova
Keyword(s):  
Legal Aspects ◽  
Cocaine Exposure ◽  
Long Term Effects ◽  
Opioid Use ◽  
Negative Effects ◽  
Cocaine Use ◽  
Current State ◽  
Abuse During Pregnancy ◽  
Specific Amount

Illicit drug use is a global problem that also affects pregnant women. Substance use and alcohol abuse during pregnancy may have various harmful consequences for both mothers and foetuses. Intrauterine exposure to illicit substances can be investigated through maternal reports and toxicological tests on mothers’ and/or newborns’ samples. While the negative effects of alcohol and opioid use on pregnancy, the foetus, and/or newborn are well established, the effects of cocaine use remain controversial. We performed a review of the literature to evaluate the current state of knowledge of the effects of intrauterine cocaine exposure on newborns’ and children’s long-term development and to highlight possible implications for health professionals dealing with women who use cocaine during pregnancy. Although intrauterine cocaine exposure has been associated with reduced infant measurements, no specific amount of cocaine use exerting such effects has been determined, and no long-term effects have been confirmed. The evidence of cocaine use during pregnancy justifies a clinical and social takeover of the mother and newborn without assuming that there will certainly be long-term damage related to intrauterine cocaine exposure, but also considering other possible associated factors.

Do researchers impact their study populations? Assessing the effect of field procedures in a long term population monitoring of sea kraits

2012 ◽  
Vol 33 (3-4) ◽  
pp. 365-372 ◽  
Author(s):  
Thomas Fauvel ◽  
François Brischoux ◽  
Marine Jeanne Briand ◽  
Xavier Bonnet
Keyword(s):  
Body Condition ◽  
New Caledonia ◽  
Stress Hormones ◽  
Population Level ◽  
Population Monitoring ◽  
Long Term Effects ◽  
Negative Effects ◽  
Short Term ◽  
Head Morphology

Long term population monitoring is essential to ecological studies; however, field procedures may disturb individuals. Assessing this topic is important in worldwide declining taxa such as reptiles. Previous studies focussed on animal welfare issues and examined short-term effects (e.g. increase of stress hormones due to handling). Long-term effects with possible consequences at the population level remain poorly investigated. In the present study, we evaluated the effects of widely used field procedures (e.g. handling, marking, forced regurgitation) both on short-term (hormonal stress response) and on long-term (changes in body condition, survival) scales in two intensively monitored populations of sea kraits (Laticauda spp.) in New Caledonia. Focusing on the most intensively monitored sites, from 2002 to 2012, we gathered approximately 11 200 captures/recaptures on 4500 individuals. Each snake was individually marked (scale clipping + branding) and subjected to various measurements (e.g. body size, head morphology, palpation). In addition, a subsample of more than 500 snakes was forced to regurgitate their prey for dietary analyses. Handling caused a significant stress hormonal response, however we found no detrimental long-term effect on body condition. Forced regurgitation did not cause any significant effect on both body condition one year later and survival. These results suggest that the strong short-term stress provoked by field procedures did not translate into negative effects on the population. Although similar analyses are required to test the validity of our conclusions in other species, our results suggest distinguishing welfare and population issues to evaluate the potential impact of population surveys.

The long-term effects of cocaine use on cognitive functioning: A systematic critical review

2018 ◽  
Vol 348 ◽  
pp. 241-262 ◽  
Author(s):  
Kirsten M. Frazer ◽  
Qwynten Richards ◽  
Diana R. Keith
Keyword(s):  
Cognitive Functioning ◽  
Critical Review ◽  
Long Term Effects ◽  
Cocaine Use

Long-Term Effects of Pain and Opioid Use in the ICU

2021 ◽  
pp. 213-221
Author(s):  
Mary Ann Hernando ◽  
Mark E. Mikkelsen
Keyword(s):  
Long Term Effects ◽  
Opioid Use

Low Mortality of Larval Lampreys from Electrofishing, Suction-pumping, Anesthesia, and Handling

2017 ◽  
Vol 8 (2) ◽  
pp. 640-647 ◽  
Author(s):  
Jeffrey C. Jolley ◽  
Christina T. Uh ◽  
Gregory S. Silver ◽  
Timothy A. Whitesel
Keyword(s):  
Pacific Northwest ◽  
Control Group ◽  
Long Term Effects ◽  
Negative Effects ◽  
Short Term ◽  
Important Species ◽  
Pacific Lamprey ◽  
The Pacific ◽  
Delayed Mortality

Abstract Native lamprey populations are declining worldwide. In the Pacific Northwest focus on conservation and management of these ecologically and culturally important species has increased. Concern has emerged regarding the effects of sampling and handling of lamprey, with little to no attention given to the larval lifestage. We monitored the survival of larval Pacific Lamprey Entosphenus tridentatus and Lampetra spp. after backpack electrofishing, deepwater electrofishing and suction-pumping, anesthesia, and handling. We performed survival trials on wild-caught lamprey (n = 15 larvae in each trial) collected from the Clackamas River drainage in Oregon, USA, coupled with control group trials from lamprey sourced from a hatchery (n = 10 larvae). Short-term (96 h) survival was >98% with only one observed mortality. Delayed mortality (1 wk) was observed for four individuals that had fungus; two of those were positive for the bacteria Aeromonas hyrdrophila. We recorded blood hematocrit as a secondary measure of stress. The baseline, nonstressed larvae hematocrit levels did not differ from those of fish that had undergone stress through electrofishing, suction-pumping, and handling without anesthesia. Electrofishing, suction-pumping, and anesthesia showed no short-term negative effects on larval lamprey although potential long-term effects remain unstudied. These techniques appear to provide efficient and relatively safe methods for collecting and surveying larval lamprey.

scholarly journals Long Term Risks to Neonatal Health from Exposure to War—9 Years Long Survey of Reproductive Health and Contamination by Weapon-Delivered Heavy Metals in Gaza, Palestine

2020 ◽  
Vol 17 (7) ◽  
pp. 2538 ◽  
Author(s):  
Paola Manduca ◽  
Nabil Al Baraquni ◽  
Stefano Parodi
Keyword(s):  
Heavy Metals ◽  
Reproductive Health ◽  
Birth Defects ◽  
Progressive Increase ◽  
Communicable Diseases ◽  
Data Sets ◽  
Long Term Effects ◽  
Negative Effects ◽  
Non Communicable Diseases

Introduction: High levels of environmental contaminants with long term effects and teratogenic and carcinogenic potential, such as heavy metals, were introduced by weaponry in war areas in the last decades. Poorer reproductive health and increases in non-communicable diseases were reported after wars and are the suspected long term effects of contamination by stable war remnants. Although potentially affecting millions of people, this is still an understudied issue of public health. Background: Gaza, Palestine since 2006 has been an object of repeated severe military attacks that left heavy metals remnants in the environment, in wound tissues and that were assumed by the population. Retrospective studies showed a progressive increase in birth defects since the 2006 attacks. In 2011 we started surveillance at birth alongside analysis of the heavy metals load carried by pregnant women and their babies. Methods: We used protocols for birth registration which also document the extent of exposures to attacks, war remnants and to other environmental risks that allow comparison of 3 data sets—2011, 2016 and 2018–2019 (4000–6000 women in each set). By ICP/MS analysis we determined the content of 23 metals in mothers’ hair. Appropriate statistical analysis was performed. Results: Comparison of data in birth registers showed a major increase in the prevalence in birth defects and preterm babies between 2011 and 2016, respectively from 1.1 to 1.8% and from 1.1 to 7.9%, values remaining stable in 2019. Negative outcomes at birth in 2016 up to 2019 were associated with exposure of the mothers to the attacks in 2014 and/or to hot spots of heavy metals contamination. Metal loads since the attacks in 2014 were consistently high until 2018–2019 for barium, arsenic, cobalt, cadmium, chrome, vanadium and uranium, pointing to these metals as potential inducers for the increased prevalence of negative health outcomes at birth since 2016. Conclusions: Bodily accumulation of metals following exposure whilst residing in attacked buildings predispose women to negative birth outcomes. We do not know if the metals act in synergy. Trial for mitigation of the documented negative effects of high metal load on reproductive health, and ensuing perinatal deaths, could now be done in Gaza, based on this documentary record. High load of heavy metals may explain recent increases in non-communicable diseases and cancers at all ages in Gaza. Modern war’s legacy of diseases and deaths extends in time to populations and demands monitoring.

scholarly journals Mit tudunk az e-cigaretta káros hatásairól?

2019 ◽  
Vol 160 (45) ◽  
pp. 1767-1773
Author(s):  
László Béla Nagy
Keyword(s):  
Public Health ◽  
Animal Studies ◽  
Disease Risk ◽  
Electronic Cigarettes ◽  
Scientific Evidence ◽  
Long Term Effects ◽  
Negative Effects ◽  
New Public Health ◽  
New Public

Abstract: Electronic cigarettes are becoming increasingly popular with smokers worldwide. This has created an entirely new public health dilemma. The central issue in the debate is the disease risk imposed by e-cigarettes. It is generally acknowledged that e-cigarettes are unlikely to be as harmful as conventional cigarettes, but there are little data that quantify their relative harms. Experiments in cell cultures and animal studies show that e-cigarettes can have multiple negative effects. Scientific evidence regarding their human acute health effects is limited. The long term effects in humans are unknown, and there is no evidence that e-cigarettes are safer than tobacco in the long term. This review higlights the recent data regarding e-cigarettes toxicity impact on lung and cardiovascular system. Orv Hetil. 2019; 160(45): 1767–1773.

scholarly journals THE INFLUENCE OF THE COVID 19 ON THE BET AND WIG20 INDICES. COMPARATIVE ASPECTS

2021 ◽  
Vol 6 (1) ◽  
pp. 87-95
Author(s):  
Catalin Florin Barnut
Keyword(s):  
Stock Markets ◽  
Stock Exchange ◽  
Sustainable Growth ◽  
Long Term Effects ◽  
Negative Effects ◽  
State Institutions ◽  
Medical Sector ◽  
Starting Point ◽  
Warsaw Stock Exchange

The aim of the paper is to assess the effects of the coronavirus pandemic (COVID – 19) on two stock market indices: BET index for Bucharest Stock Exchange and WIG20 index for Warsaw Stock Exchange. The negative effects of the pandemic have had an influence on the performance of the stock markets since its debut. Many companies as well as sectors have ceased their activity during the outbreak, causing devastating financial losses worldwide. By comparing indices evolution during 2020 using the data available on the stock markets’ websites, as well as analyzing in part the companies that make up the indices portfolio, we will try to present the sectors most affected by the pandemic as well as their evolution during the analysis period. The results of this research can be a starting point for future empirical analysis on the long-term effects of the pandemic on stock markets’ performance for Romania and Poland. The results could be a source of information for state institutions, companies, investors, analysts but also representatives of the medical sector (responsible for crisis management) - in order to observe the severity and magnitude of the negative effects of the coronavirus pandemic on the financial markets and also help develop and ensue their long-term sustainable growth.

scholarly journals Motor Performance in Children Diagnosed with Cancer: A Longitudinal Observational Study

Children ◽  
2020 ◽  
Vol 7 (8) ◽  
pp. 98
Author(s):  
Lotta Hamari ◽  
Päivi M. Lähteenmäki ◽  
Heidi Pukkila ◽  
Mikko Arola ◽  
Anna Axelin ◽  
...  
Keyword(s):  
Standardized Tests ◽  
Motor Performance ◽  
Longitudinal Design ◽  
Lymphoblastic Leukemia ◽  
Manual Dexterity ◽  
Long Term Effects ◽  
Negative Effects ◽  
Children With Cancer

Children with cancer are dealing with different side and long-term effects caused by cancer and its treatments, like vinca-alkaloids, which may have negative effects on motor performance. However, the affected areas of motor performance (aiming and catching, balance, manual dexterity) and the differences in these areas between boys and girls and diagnoses are not frequently reported in a longitudinal design. Therefore, the aim of this study was to investigate how motor performance changes over the course of cancer treatment. The study was conducted with 3-to 16-year-old children with cancer (N = 36) in 2013–2017. The five assessment points were 0, 2, 6, 12 and 30 months from diagnosis. Movement-ABC2 was used to assess motor performance. We found that aiming and catching skills decreased significantly during the follow-up (p < 0.05). Balance was affected at the 2-month measurement point (p < 0.05) and more in children with acute lymphoblastic leukemia than in children with other cancer diagnoses (p < 0.05). Girls performed better than boys in manual dexterity at 6, 12 and 30 months (p < 0.05, p < 0.05, p < 0.05, respectively). Individual monitoring of motor performance with standardized tests and physical activity/exercise programs during and after treatment are needed.

Long-Term Effects of Total Social Isolation Upon Behavior of Rhesus Monkeys

1966 ◽  
Vol 18 (2) ◽  
pp. 567-580 ◽  
Author(s):  
G. D. Mitchell ◽  
E. J. Raymond ◽  
G. C. Ruppenthal ◽  
H. F. Harlow
Keyword(s):  
Social Behavior ◽  
Social Isolation ◽  
Rhesus Monkeys ◽  
First Year ◽  
Long Term Effects ◽  
Negative Effects ◽  
Cross Sectional ◽  
Follow Up Study

8 isolate monkeys were compared in a follow-up study to 8 sophisticated controls in brief cross-sectional pairings with 12 stimulus strangers: 4 adults, 4 age-mates, and 4 juveniles. The isolates were characterized by infantile disturbance, less environmental orality, more fear, more aggression, less sex, less play, and bizarre ritualistic movements. 12-mo. isolates were fearful and nonaggressive but threatened many attacks. 6-mo. isolates were fearful and physically aggressive. The 12-mo. isolates demonstrated practically no positive social behavior. Conclusions are: (a) 6 mo. of social isolation during the first year has negative effects on social behavior up to puberty, (b) abnormal aggression appears in 3-yr.-old 6-mo. isolates, and (c) 12 mo. of isolation suppress or delay this aggression.

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