scholarly journals Comparison of Procalcitonin Assays on KRYPTOR and LIAISON® XL Analyzers

Diagnostics ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. 94 ◽  
Author(s):  
Mariella Dipalo ◽  
Cecilia Gnocchi ◽  
Paola Avanzini ◽  
Roberta Musa ◽  
Martina Di Pietro ◽  
...  
Keyword(s):  
Sensitivity And Specificity ◽  
Excellent Performance ◽  
Chemiluminescence Immunoassay ◽  
Female Patients ◽  
Minimum Value ◽  
Maximum Value ◽  
Male Patients ◽  
The Mean

Our laboratory performs procalcitonin (PCT) assays on a Brahms KRYPTOR analyzer with the Brahms PCT sensitive Kryptor kit. In this study, we wanted to compare the assays obtained in this way with the ones performed on the LIAISON® XL. From January to May 2017, 171 samples were analyzed, of which 65 from female patients (age: 22–98 years) and 106 from male patients (age: 16–97 years). The PCT determination was performed using the LIAISON® XL and KRYPTOR analyzers, by chemiluminescence (Chemiluminescence immunoassay—CLIA) (LIAISON® BRAHMS PCT® II GEN) and immunofluorescence (Brahms PCT sensitive Kryptor) assay, respectively. For the LIAISON® BRAHMS PCT® II GEN, 52% of the results were placed between 0.0 and 0.5 ng/mL, 18% between 0.5 and 2.0 ng/mL, and 30% between 2.0 and 100 ng/mL; the mean was 4.09 ng/mL, the median 0.456 ng/mL, the maximum value 97.2 ng/mL, and the minimum value 0.02 ng/mL. For the Brahms PCT sensitive Kryptor, 55% of the results were positioned between 0.0 and 0.5 ng/mL, 21% between 0.5 and 2.0 ng/mL, and 24% between 2.0 and 100 ng/mL; the mean was 3.72 ng/mL, the median 0.39 ng/mL, the maximum value 103 ng/mL, and the minimum value 0.01 ng/mL. The mean of the results obtained with the two methods showed no significant differences (3.717 for Kryptor and 4.094 for LIAISON®). PCT assay with Brahms reagents, both on the Kryptor and LIAISON®XL platforms, offers excellent performance in terms of sensitivity and specificity.

scholarly journals Comparison of Clinical Features Between Patients with Positive and Negative Appendectomy

2020 ◽  
Author(s):  
Guner Cakmak ◽  
Baris Mantoglu ◽  
Emre Gonullu ◽  
Kayhan Ozdemir ◽  
Burak Kamburoglu
Keyword(s):  
Acute Appendicitis ◽  
Clinical Features ◽  
Total Bilirubin ◽  
Negative Appendectomy ◽  
C Reactive Protein ◽  
Future Studies ◽  
Female Patients ◽  
Reactive Protein ◽  
Male Patients ◽  
The Mean

Abstract Background: The objective of this study was to retrospectively compare clinical features and prognostic values between the patients who were referred to the general surgery clinic of our hospital with the presumed diagnosis of acute appendicitis and underwent positive or negative appendectomy.Methods: Patients were divided into two groups as positive (PA) (n:362) and negative appendectomy (NA) (n:284) and the data obtained were compared between these two groups.Laboratory investigations were performed in all patients, and white blood cell (WBC), mean platelet volume (MPV), neutrophils count (NEU), neutrophils (%) (NEU%), C-reactive protein (CRP) and total bilirubin (TBIL) values were studied.Results: The mean MPV value was found as 7.88 fl in PA groups and 8.09 fl in NA group, and the mean MPV value was not statistically significantly difference in PA group, compared to NA groups (p=0.012). Laboratory parameters were also compared between genders. Accordingly, the mean MPV value was statistically significantly higher in female patients compared to male patients in PA group (p = 0.04). The mean TBIL value was 0.97 mg/dl in PA group and 0.69 mg/dl in NA group, and the mean TBIL value was statistically significantly higher in PA group (p< 0.001). Finally, TBIL value was statistically significantly lower in female patients compared to male patients in NA and PA group (p < 0.05).Conclusions: According to the results of our study, MPV and T. BIL values differ in PA and NA groups depending on gender. Therefore, these values may not be used as specific biomarkers in predicting positive acute appendicitis. We believe that these results will contribute to the literature and will be guiding for future studies.

scholarly journals Clinical Variables Associated With Statural Growth in Pediatric Crohn’s Disease Differ by Sex (The Growth Study)

2020 ◽  
Author(s):  
Neera Gupta ◽  
Robert H Lustig ◽  
Howard Andrews ◽  
Ranjana Gokhale ◽  
Alka Goyal ◽  
...  
Keyword(s):  
Symptom Onset ◽  
Z Score ◽  
Growth Study ◽  
Growth Impairment ◽  
Clinical Variables ◽  
Female Patients ◽  
Height Gain ◽  
Male Patients ◽  
The Mean ◽  
Initial Classification

Abstract Background Statural growth impairment is more common in male patients with Crohn’s disease (CD). We identified clinical variables associated with height z score differences by sex in children participating in the Growth Study, a prospective multicenter longitudinal study examining sex differences in growth impairment in pediatric CD. Methods Patients with CD (female patients with bone age [BA] ≥4 years 2 months and ≤12 years; male patients with BA ≥5 years and ≤14 years at screening) who had completed study visit 1 qualified. The height z score difference was computed as height z score based on chronological age minus height z score based on BA. Results One hundred thirteen patients with CD (36% female) qualified. The mean chronological age was 12.0 ± 1.8 (SD) years. The magnitude of the mean height z score difference was significantly greater in female patients (–0.9 ± 0.8) than in male patients (–0.5 ± 0.9; P = 0.021). An initial classification of inflammatory bowel disease as CD (P = 0.038) and perianal disease behavior at diagnosis (P = 0.009) were associated with higher standardized height gain with BA progression, and arthralgia at symptom onset (P = 0.016), azathioprine/6-merpcaptopurine (P = 0.041), and probiotics (P ≤ 0.021) were associated with lower standardized height gain with BA progression in female patients. Patient-reported poor growth at symptom onset (P = 0.001), infliximab (P ≤ 0.025), biologics (P ≤ 0.015), methotrexate (P = 0.042), and vitamin D (P ≤ 0.010) were associated with higher standardized height gain with BA progression, and initial classification as CD (P = 0.025) and anorexia (P = 0.005) or mouth sores (P = 0.004) at symptom onset were associated with lower standardized height gain with BA progression in male patients. Conclusions Different clinical variables were associated with statural growth in male patients vs female patients, suggesting that sex-specific molecular pathways lead to statural growth impairment in CD.

scholarly journals Blood Loss of Pedicle Subtraction Osteotomy for Sagittal Imbalance Spinal Deformity

2019 ◽  
Vol 69 (12) ◽  
pp. 3680-3682
Author(s):  
Abu Awwad Ahmed ◽  
Radu Prejbeanu ◽  
Dinu Vermesan ◽  
Ioan Branea ◽  
Bogdan Deleanu ◽  
...  
Keyword(s):  
Blood Loss ◽  
Operating Time ◽  
Pedicle Subtraction Osteotomy ◽  
Neurological Deficits ◽  
Sagittal Imbalance ◽  
Female Patients ◽  
Fixed Sagittal Imbalance ◽  
Male Patients ◽  
The Mean ◽  
Extensive Surgery

Pedicle subtraction osteotomies (PSO) have been used in the treatment of multiple spinal conditions involving a fixed sagittal imbalance. It is a complex, extensive surgery most often performed in the revision settings. The aim of our study is to review the major complications of this surgical technique with a focus on blood loss. Twenty patients were included, treated using PSO for sagittal imbalance, out of 255 corrective surgeries. Of the 12 female patients included in the study, the mean age was 64.33. Of the 8 male patients included in the study, the mean age was 51.85. For female patients, the mean blood loss was 2122.5 mL in comparison with male patients, with mean blood loss 1737.5 mL. The female patients had an operating time of 357.25 minutes in comparasion with male patients with an 328.5 minute operating time. Eight (5 female and 3 male) had postoperative neurological deficits and 6 (5 female and 1 male) had pseudarthrosis of adjacent levels.

scholarly journals Autologous Osteochondral Transplantation for Osteochondral Lesions of the Talus: Does Gender Impact Outcomes?

2020 ◽  
Vol 5 (4) ◽  
pp. 2473011420S0022
Author(s):  
Arianna L. Gianakos ◽  
Olasunmbo Okedele ◽  
Sean Flynn ◽  
John G. Kennedy ◽  
Christopher W. DiGiovanni
Keyword(s):  
Osteochondral Lesions ◽  
Symptom Duration ◽  
Osteochondral Transplantation ◽  
Autologous Osteochondral Transplantation ◽  
Duration Of Symptoms ◽  
Male And Female ◽  
Female Patients ◽  
Male Patients ◽  
The Mean

Category: Ankle; Arthroscopy Introduction/Purpose: Autologous osteochondral transplantation (AOT) is commonly used in the treatment of osteochondral lesions (OCL) of the talus. There is limited data comparing gender differences in the incidence, presentation, and outcomes following AOT. The purpose of this study is to compare these differences between male and female patients. Methods: Eighty-five consecutive patients who underwent AOT were retrospectively reviewed. Patients were divided into two groups based on gender. Demographic data and OCL defect characteristic data were recorded. Functional outcomes were assessed pre- and post-operatively using the Foot and Ankle Outcome Score (FAOS). The Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) score was used to assess cartilage incorporation. The mean clinical follow-up was 47.2 months, with mean MRI follow-up of 24.8 months. Results: Fifty-five (65%) males and 30 (35%) females were included. OCL defect size was significantly larger in men (112.8mm2) when compared with women (88.7mm2) (p<0.0001). Male patients had a significantly longer duration of symptoms (p<0.001) and OCLs were more likely traumatic in nature (p=0.0006) when compared with female patients. Mean FAOS improved pre- to postoperatively from 50 to 81(P < .001) with a statistically significant increase in men (p<0.0001). The mean MOCART score was 82.1 and 86.7 in male and female patients, respectively (p<0.0001). Lesion size was negatively correlated with MOCART score (r = -0.36,P = .004). No differences were found in knee donor site morbidity, complication rate, or revision surgery. Conclusion: Our study demonstrates that male patients typically present with talar OCLs that are larger in size, traumatic in nature, and with longer symptom duration when compared with female patients. In addition, male patients had greater improvement in FAOS scores following AOT. Therefore, understanding these differences may influence the management and treatment of talar OCLs in male and female patients.

Possible circadian periodicity of foetal prolactin secretion late in gestation

1981 ◽  
Vol 98 (1) ◽  
pp. 106-111 ◽  
Author(s):  
Tsutomu Yaginuma
Keyword(s):  
Vaginal Delivery ◽  
Venous Blood ◽  
Prolactin Secretion ◽  
Human Foetus ◽  
Circadian Periodicity ◽  
Minimum Value ◽  
Maximum Value ◽  
The Mean

Abstract. Prolactin levels were determined in samples of umbilical venous blood at vaginal delivery after 38–42 weeks of uncomplicated gestation. The mean level of prolactin for all samples was 328.4 ± 7.4 (se) ng/ml. The levels did not vary significantly during these weeks of gestation, nor correlate with the duration of labour. The means of levels combined every 2 h varied significantly throughout the 24 h period with a maximum value of 460.3 ± 85.1 ng/ml at 2–4 a.m. and a minimum value of 241.4 ± 27.2 ng/ml at 6–8 a.m. and remained relatively constant between 2–4 and 10–12 p.m. These results suggest that a circadian periodicity may exist in the secretion of prolactin by the human foetus, and that this is not affected by labour and delivery.

scholarly journals PENGARUH TERAPI BEKAM BASAH TERHADAP PERUBAHAN SKALA NYERI PADA PASIEN MIGRAIN

2019 ◽  
Vol 1 (2) ◽  
pp. 54-62
Author(s):  
Mulia Mayangsari
Keyword(s):  
Health Workers ◽  
Sampling Technique ◽  
Pain Scale ◽  
Wilcoxon Test ◽  
P Value ◽  
Minimum Value ◽  
Migraine Pain ◽  
Maximum Value ◽  
Before And After ◽  
The Mean

The research design used was Experimental with Kunsekutive Sampling technique. The population in this study were patients who had migraine in Noreh village. The working area of Puskesmas Sreseh was 18 respondents and the result was analyzed using Shapiro Wilk and Wilcoxon test. The results of the study in migraine patients can be seen that the mean pretest scale of migraine pain scale is 4.67 whereas, for the mean posttest of migraine pain scale is 2.22. In the pretest of migraine pain scale the minimum value found is 4 whereas, the maximum value is 6. While in posttest skalanyeri migraine the minimum value found is 1 whereas, the maximum value is 3. In the Shapiro Wilk analysis showed that there were differences in the scale of migraine pain before and after wet bruise therapy. In the Wilcoxon analysis comparing migraine patients, a p-value of 0,000 indicated that there was an effect of wet-brushing therapy on changes in the pain scale. To health workers and educational institutions are expected to use wet brewing therapy as a complementary alternative and as a non-pharmacological treatment that can reduce the scale of pain.

scholarly journals Knowledge, Attitude and Practice of Insulin Use of Diabetic Patients in India

2020 ◽  
Vol 5 (1) ◽  
pp. 23
Author(s):  
Venkataraman A P ◽  
Laxminarayana Kamath ◽  
Samhita Shankar
Keyword(s):  
Statistical Tests ◽  
Good Practice ◽  
Diabetic Patients ◽  
Attitude Score ◽  
Female Patients ◽  
Attitude And Practice ◽  
Male Patients ◽  
The Mean ◽  
Insulin Use ◽  
Knowledge Attitude And Practice

 Diabetes mellitus (DM) is a group of common metabolic disorders that share the phenotype of hyperglycemia. India is emerging as the world diabetic capital. Insulin is a therapeutic option to treat either type 1 and type 2 DM. Inadequate awareness about the use of insulin is likely to influence its acceptance and adherence. The present study was done to assess the knowledge, attitude, and practice regarding insulin use among diabetic patients at Victoria Hospital, Bangalore, India. Knowledge, attitude, and practice of sixty diabetic patients (either inpatients or outpatients) were assessed by using a validated questionnaire consisting of 24 items. Scores were allotted to each question and evaluated after applying appropriate statistical tests. The mean age of the patients was 53.51±6.48 years (58.33% males). The mean knowledge score was 9.06±1.88 out of 22, attitude score was 4.78±1.37 out of 12 and practice score was 7.75±1.24 out of 11. The mean score of attitude was better in females compared to male patients (5.32±1.34 vs. 4.4±1.28). Male patients scored 38.57% compared to female patients (41.33%) for the question regarding symptoms of hypoglycemia. 57.14% of male patients and 72% of female patients carried simple carbohydrates when going out. Despite good practice scores, the knowledge and attitude scores regarding insulin use were inadequate. Potential adverse effects of insulin can be avoided and better knowledge, attitude, and practice can be achieved by providing proper education to patients. Keywords: knowledge, attitude, practice, diabetic, insulin 

scholarly journals CHARACTERISTICS OF PATIENTS WITH ORGANOPHOSPHORUS POISONING AND ITS MANAGEMENT: PHARMACOEPIDEMIOLOGICAL EVALUATION

2019 ◽  
pp. 86-88
Author(s):  
MADHURI KULKARNI ◽  
ANANT PATIL
Keyword(s):  
Total Dose ◽  
Clinical Outcomes ◽  
Female Population ◽  
Male And Female ◽  
Female Patients ◽  
Organophosphorus Poisoning ◽  
Male Patients ◽  
The Mean ◽  
Gastric Irritation ◽  
Acute Organophosphorus Poisoning

Objective: The objective of this study was to analyze demographics, management pattern, and clinical outcomes in patients with organophosphorus poisoning. Methods: In this subgroup analysis of retrospective data of patients admitted in intensive care unit (ICU) with a diagnosis of acute organophosphorus poisoning, demographic details, pattern of use of medicines, dose of atropine and pralidoxime (PRAM), duration of ICU stay, and clinical outcomes were analyzed. Results: A total of 92 patients with organophosphorus poisoning (mean age 34.7 years; male 69 [75%]) were included. The age of male patients was more than female patients (36.2 vs. 30.0 years; p=0.047). Atropine and PRAM were given to all patients. Ondansetron was used in all patients, whereas ranitidine was used in 91 (98.9%) patients. The mean total dose of atropine in male and female population was 99.5 mg and 89.0 mg, respectively (p=0.298). The mean total dose of PRAM in male and female population was 12.2 mg and 12.0 mg, respectively (p=0.772). There was no difference in the mean (standard deviation) duration of stay in ICU between male patients and female patients (7.6 [4.5] vs. 6.4 [3.9] days; p=0.249). A total of 61 (66.3%) patients were transferred to the ward, whereas 30 (32.6%) died. Conclusion: Atropine and PRAM are the primary drugs for the treatment of organophosphorus poisoning. Ondansetron and ranitidine are useful drugs for the treatment of vomiting and gastric irritation, respectively, in these patients.

scholarly journals BIOCHEMICAL COMPOSITIONS OF THE BODY OF TWO-YEAR CARPS OF DIFFERENT MIXED BRED CROSSES

2018 ◽  
Vol 62 (3) ◽  
pp. 374-384
Author(s):  
Ya. I. Sheiko ◽  
D. A. Zhmoidyak
Keyword(s):  
Biochemical Composition ◽  
The Body ◽  
Variation Coefficient ◽  
Slight Variation ◽  
Minimum Value ◽  
Maximum Value ◽  
The Mean ◽  
Biochemical Compositions ◽  
Different Origin

The article presents the results of comparison of the biochemical composition of the muscles of two-year carp of two-way crosses and the breeds and lines of different-origin carp and Amur sazan. The combinations characterized by an increased level of the dry basis content, fat and protein are established in comparison with a mean-population value, a mean level of the Belarusian collection lines, import breeds and Amur sazan bred under the same conditions. The mean mass of two-year carp selected for investigation was 531.3 g within the range from 370.2 to 645.0 g mainly with a low and mean degree ofvariation. The mean level of the dry basis content of all examined crosses was 25.85 %, the maximum value of this parameter of German × three prim was 27.92 %, and the minimum value of Germany ×Lahvin scaleless was 24.08 %. The low values of the variation coefficient (1.0–9.8 %) point to a slight variation of this parameter of different mixed bred crosses.

scholarly journals Occurrence of dolichocolon without megacolon in chronic Chagas disease patients

2012 ◽  
Vol 45 (3) ◽  
pp. 353-356 ◽  
Author(s):  
Cleudson Castro ◽  
Esperanza Bernal Hernandez ◽  
Joffre Rezende ◽  
Aluizio Prata
Keyword(s):  
Chagas Disease ◽  
Iliac Crest ◽  
Distal Colon ◽  
Clinical Findings ◽  
Central Axis ◽  
Female Patients ◽  
Male Patients ◽  
The Mean ◽  
Endemic Areas ◽  
Chronic Chagas Disease

INTRODUCTION: Since 1970, lengthening of the rectosigmoid has been suspected to be a solitary manifestation of Chagas colopathy. METHODS: To test this hypothesis, opaque enema was administered on 210 seropositive and 63 seronegative patients, and radiographs in the anteroposterior and posteroanterior positions were examined blind to the serological and clinical findings. The distal colon was measured using a flexible ruler along the central axis of the image from the anus to the iliac crest. RESULTS: Dolichocolon was diagnosed in 31 (14.8%) seropositive and 3 (4.8%) seronegative patients. The mean length was 57.2 (±12.2)cm in seropositive patients and 52.1 (±8.8)cm in the seronegative patients (p = 0.000), that is, the distal colon in Chagas patients was, on average, 5.1cm longer. Seropositive female patients presented a mean length of 58.8 (±12.3)cm, and seronegative female patients presented 53.2 (±9.1)cm (p = 0.002). Seropositive male patients had a mean length of 55 (±11.6)cm, and seronegative male patients had 49.9 (±7.8)cm (p = 0.02). Among 191 patients without megacolon and suspected megacolon, the mean length was 56.3 (±11.6)cm in seropositive individuals and 52 (±8.8)cm in seronegative patients (p = 0.003). Among individuals with distal colon >70cm, there were 31 Chagas patients with mean length of 77.9 (±7.1)cm and three seronegative with 71.3 (±1.1)cm (p = 0.000). Among 179 with distal colon <70cm, seropositive individuals had a mean length of 53.6 (±8.8)cm, and seronegative patients had 51.2 (±7.8)cm (p = 0.059). Serological positive women had longer distal colon than men (p = 0.02), whereas the mean length were the same among seronegative individuals (p = 0.16). CONCLUSIONS: In endemic areas of Brazil Central, solitary dolichocolon is a radiological Chagas disease signal.

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