scholarly journals Simulating the Intraoral Aging of Dental Bonding Agents: A Narrative Review

2022 ◽  
Vol 10 (1) ◽  
pp. 13
Author(s):  
Tomas Vilde ◽  
Cameron A. Stewart ◽  
Yoav Finer
Keyword(s):  
Resin Composite ◽  
Dental Materials ◽  
Thermal Fluctuations ◽  
Narrative Review ◽  
Mechanical Degradation ◽  
Hybrid Layer ◽  
Bonding Agents ◽  
Dental Bonding

Despite their popularity, resin composite restorations fail earlier and at higher rates than comparable amalgam restorations. One of the reasons for these rates of failure are the properties of current dental bonding agents. Modern bonding agents are vulnerable to gradual chemical and mechanical degradation from a number of avenues such as daily use in chewing, catalytic hydrolysis facilitated by salivary or bacterial enzymes, and thermal fluctuations. These stressors have been found to work synergistically, all contributing to the deterioration and eventual failure of the hybrid layer. Due to the expense and difficulty in conducting in vivo experiments, in vitro protocols meant to accurately simulate the oral environment’s stressors are important in the development of bonding agents and materials that are more resistant to these processes of degradation. This narrative review serves to summarize the currently employed methods of aging dental materials and critically appraise them in the context of our knowledge of the oral environment’s parameters.

The Toxic Effects of Two Dental Materials on Human Buccal Epithelium In Vitro and Monkey Buccal Epithelium In Vivo

1987 ◽  
Vol 14 (3) ◽  
pp. 166-167
Author(s):  
D. Arenholt-Bindslev ◽  
P. Hørsted-Bindslev ◽  
H.P. Philipsen
Keyword(s):  
Dental Materials ◽  
Microscopical Examination ◽  
Buccal Epithelium ◽  
Cytotoxic Effects ◽  
Buccal Epithelial Cells ◽  
Toxicity In Vitro ◽  
Toxic Reactions ◽  
Light Microscopical Examination

The aim of the present study was to compare the toxicity in vitro with the toxicity in vivo of two commercial chemicals marketed for use in the oral cavity (GLUMA BondR and 3M Etching LiquidR). Confluent cultures of human buccal epithelial cells were exposed to graded concentrations of GLUMA Bond or 3M Etching Liquid for 5 minutes. The cytotoxic effects induced by this treatment were observed (cytomorphology, proliferation rate). In vivo, monkey buccal epithelium was exposed to GLUMA Bond or 3M Etching Liquid for 5 minutes. Biopsies were taken after 24 hours, and the buccal epithelium processed for light microscopical examination. In both models, the toxic reactions to GLUMA Bond were far more extensive than those caused by 3M Etching Liquid.

scholarly journals COMPARATIVE EVALUATION OF THE SHEAR BOND STRENGTH OF THREE SELF-ETCH DENTIN BONDING AGENTS TO DENTIN: AN IN-VITRO STUDY

2020 ◽  
Vol 8 (10) ◽  
pp. 454-459
Author(s):  
Bhalla V. ◽  
◽  
K. Goud M. ◽  
Chockattu S. ◽  
Khera A ◽  
...  
Keyword(s):  
Bond Strength ◽  
Shear Bond Strength ◽  
Resin Composite ◽  
Testing Machine ◽  
Group Analysis ◽  
In Vitro Study ◽  
Bonding Agents ◽  
Mandibular Molar ◽  
Self Etch

Background:Dentin bonding is an ever-evolving field in adhesive dentistry. With the introduction of newer systems into the market, there is a crucial need to test their efficiency in terms of bond strength. Dual-cured adhesives in theory may provide for a better degree of conversion as compared to conventional light-cured adhesives .Thus, the aim of this study was to compare the shear bond strength of three different self-etch adhesives namely ClearfilSE bond (Kuraray), Tetric N Bond Universal (IvoclarVivadent) and Futura Bond DC (Voco) to dentin. Materials & Methods: Ninety extracted non-carious, intact human mandibular molar teeth were selected for this study. Each tooth was decoronated using a double-sided diamond disc with water coolant to a depth of 2mm from the cusp tip .The cut dentin surface was then abraded against 600-grit wet silicon carbide papers for 60 seconds to produce a uniform smear layer. The root portion of each tooth was mounted on a plastic ring using cold cure acrylic resin. Specimens were then divided into three adhesive groups of 30 teeth each, Group A: ClearfilSE Bond (Kuraray), Group B: Tetric N Bond Universal (IvoclarVivadent), Group C :Futura Bond DC (Voco). All bonding agents were used according to the manufacturers’ instructions, in combination with the resin composite Tetric N Ceram (IvoclarVivadent). The samples were thermocycled, followed by shear bond strength testing using a Universal testing machine (Hounsfield). Data were subjected to statistical analysis using one-way analysis of variance (ANOVA) (P<0.05) and Post hoc Tukey’s test for inter- and intra- group analysis respectively. Results: Clearfil SE Bond yielded the highest shear bond strength values (30.9 ±4.66 MPa) which were statistically significant, followed byTetric N Bond Universal group (29.8 ±4.34) and the lowest shear bond strength values were recorded for Futura Bond DC (18.2 ±3.13). Conclusion: Clearfil SE bond and Tetric N bond Universal can be considered as better options than Futura Bond DC.

scholarly journals Avaliação in vitro da resistência de duas resinas compostas submetidas a teste de compressão

2020 ◽  
Vol 8 (9) ◽  
Author(s):  
Mirla Lays Dantas de Almeida ◽  
Gymenna Maria Tenório Guênes ◽  
Luanna Abílio Diniz Melquiades de Medeiros ◽  
Mylena de Araújo Régis ◽  
Marcus Vinícius Lia Fook ◽  
...  
Keyword(s):  
Filler Content ◽  
State Of The Art ◽  
Resin Composite ◽  
Dental Materials ◽  
Santa Cruz ◽  
Porto Alegre ◽  
Composite State ◽  
Fernando Pessoa ◽  
Dent Assoc

Introdução: O aumento da demanda pela odontologia estética guiou o desenvolvimento de resinas compostas com melhores propriedades físicas e mecânicas. Por isso, percebe-se que há atualmente disponibilidade de uma grande variedade desse material. Dessa forma faz-se necessário a realização de estudos científicos acerca das resinas composta. Objetivo: Avaliar comparativamente, in vitro, à resistência de duas resinas compostas fotopolimerizáveis encontrados no mercado: a Filtek Z350 XT da 3M e a Zirconfill da Technw, após teste mecânico de compressão e análise estatística dos resultados. Material e método: Quatro amostras de cada resina composta foram submetidas ao teste de resistência à compressão numa máquina de ensaio universal. Os resultados foram analisados estatisticamente através do teste de Mann-Whitney com margem de erro 5.0%. Para digitar os dados e obter os cálculos estatísticos foi utilizado o programa IBM SPSS na versão 23. Resultados: A média da força foi mais elevada na resina Zirconfill do que na resina Z350; entretanto, a mediana foi mais elevada na resina Z350. Para a margem de erro fixada (5,0%) não há comprovação de diferença significativa (p > 0,05) entre as duas resinas em relação à força de resistência analisada. Conclusão: As resinas compostas testadas mostram valores de resistência a compressão semelhantes e não apresentam diferenças relevantes.Descritores: Resinas Compostas; Nanotecnologia; Odontologia.ReferênciasBowen RL. Use of epoxy resins in restorative materials. J Dent Res. 1956;35(3):360-69.Chagas LS. Avaliação da resistência flexural e módulo de elasticidade de uma resina do tipo Bulk Fill em comparação com uma resina convencional [monografia de conclusão de curso]. Santa Cruz do Sul: Universidade de Santa Cruz do Sul - UNISC; 2016.Behr M, Proff P, Kollbeck C, Langriegr S, Kunze J, Handel G et al. The bond strength of the resin-to-zirconia interface using diferente bonding concepts. J Mech Behav Biomed Mater. 2011;4(1):2-8.Rodrigues DS. Análise da porosidade, resistência mecânica e desgaste de cimentos de ionômero de vidro e resina composta [dissertação]. Porto: Faculdade de Ciências da Saúde, Universidade Fernando Pessoa; 2014.Pereira AFV, Miranda Junior WG. Avaliação in vitro da microinfiltração e adaptação marginal em restaurações classe v simulando lesões de abfração: estudo piloto. Arq Cent Estud Curso Odontol Univ Fed Minas Gerais. 2008;44(2):18-25.Ferracane JL. Resin composite – state of the art. Dent Mater. 2011; 27(1):29-38.Han JM, Lin H, Zheng G, Shinya A, Gomi H, Shinya A et al. Effect of nanofiller on wear resistance and surface roughness of resin composites. Chin J Dent Res. 2012;15(1):41-7.Mitra SB, Wu D, Holmes B. An application of nanotechnology in advanced dental materials. J Am Dent Assoc. 2003;134(10):1382-90.Mota EG, Weiss A, Spohr AM, Oshima HMS, Carvalho LMN. Relationship between filler content and selected mechanical properties of six microhybrid composites. Rev odonto cienc. 2011;26(2):151-55.Rosa RS. Propriedades mecânicas de resinas compostas com nanopartículas [tese]. Porto Alegre: Pontifícia Universidade Católica do Rio Grande do Sul, Faculdade de Odontologia; 2010.Souza ALT, Oliveira FMMPC, Moysés MR, Assis CPD, Ribeiro JCR, Dias SC. Avaliação da resistência à compressão de resinas compostas fotopolimerizáveis. Arq Odontol. 2007;43(1):30-5.

scholarly journals Cardiovascular, carcinogenic and reproductive effects of nicotine exposure: A narrative review of the scientific literature

F1000Research ◽  
2020 ◽  
Vol 8 ◽  
pp. 1586
Author(s):  
Leonie R. Price ◽  
Javier Martinez
Keyword(s):  
Cardiovascular Risk ◽  
Cancer Progression ◽  
Animal Studies ◽  
Scientific Literature ◽  
Human Cancer ◽  
Narrative Review ◽  
Nicotine Exposure ◽  
Health Related

The emergence of new tobacco heating products and electronic nicotine delivery systems (ENDS) is changing the way humans are exposed to nicotine. The purpose of this narrative review is to provide a broad overview of published scientific literature with respect to the effects of nicotine on three key health-related areas: 1) cardiovascular risk, 2) carcinogenesis and 3) reproductive outcomes. These areas are known to be particularly vulnerable to the effects of cigarette smoke, and in addition, nicotine has been hypothesized to play a role in disease pathogenesis. Acute toxicity will also be discussed. The literature to February 2019 suggests that there is no increased cardiovascular risk of nicotine exposure in consumers who have no underlying cardiovascular pathology. There is scientific consensus that nicotine is not a direct or complete carcinogen, however, it remains to be established whether it plays some role in human cancer propagation and metastasis. These cancer progression pathways have been proposed in models in vitro and in transgenic rodent lines in vivo but have not been demonstrated in cases of human cancer. Further studies are needed to determine whether nicotine is linked to decreased fertility in humans. The results from animal studies indicate that nicotine has the potential to act across many mechanisms during fetal development. More studies are needed to address questions regarding nicotine exposure in humans, and this may lead to additional guidance concerning new ENDS entering the market.

scholarly journals Antiparasitary Activity Of The Juglone Compound: A Narrative Review

2021 ◽  
pp. 13
Author(s):  
◽  
Keyword(s):  
Mortality Rate ◽  
Leishmania Donovani ◽  
Inhibitory Concentration ◽  
Narrative Review ◽  
Hymenolepis Nana ◽  
Compound A ◽  
Living Organisms ◽  
Nanomolar Range

Objective: To report, based on the literature, the action of the compound 5-hydroxy-1,4-naphthoquinone against parasites (protozoa and helminths) that affect humans. Methods: This is a narrative review that used Pubmed and Google Scholar as a data tool. This work included articles published until September 2020 that were directly related to the use of the compound juglone in antiparasitic trials. Results: The compound juglone demonstrated promising effects as a human and animal antiparasitic substance. In protozoa, the Apicomplexo Toxoplasma gondii parasite showed a high mortality rate in concentrations of juglone in the nanomolar range. The juglone showed an average inhibitory concentration (IC50) of 1.62 µM, >100 µM, and 2.02 µM µM for Trypanosoma cruzi, T. brucei rhodesiense, and Leishmania donovani, respectively. Also, the juglone showed antihelmintic activity on Hymenolepis nana in mice, and on adult worms of Schistosoma mansoni (LE strain) with IC50 34.16 µM, 32.14 µM, and 25 µM in the 24h, 48h, and 72 h, respectively. Conclusion: The results published so far show the in vitro antiparasitic potential of juglone, and the need for further studies on the specific mode of action that interacts with parasites. Besides, the literature is still limited to studies that evaluate in vivo the compound juglone, requiring better information on its interaction with living organisms.

scholarly journals Tissue-engineered Oral Mucosa

2012 ◽  
Vol 91 (7) ◽  
pp. 642-650 ◽  
Author(s):  
K. Moharamzadeh ◽  
H. Colley ◽  
C. Murdoch ◽  
V. Hearnden ◽  
W.L. Chai ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Soft Tissue ◽  
Oral Mucosa ◽  
Dental Materials ◽  
Three Dimensional ◽  
Bacterial Invasion ◽  
Graft Material ◽  
Oral Diseases

Advances in tissue engineering have permitted the three-dimensional (3D) reconstruction of human oral mucosa for various in vivo and in vitro applications. Tissue-engineered oral mucosa have been further optimized in recent years for clinical applications as a suitable graft material for intra-oral and extra-oral repair and treatment of soft-tissue defects. Novel 3D in vitro models of oral diseases such as cancer, Candida, and bacterial invasion have been developed as alternatives to animal models for investigation of disease phenomena, their progression, and treatment, including evaluation of drug delivery systems. The introduction of 3D oral mucosal reconstructs has had a significant impact on the approaches to biocompatibility evaluation of dental materials and oral healthcare products as well as the study of implant-soft tissue interfaces. This review article discusses the recent advances in tissue engineering and applications of tissue-engineered human oral mucosa.

Comparison of in vivo vs. in vitro Bonding of Composite Resin to the Dentin of Canine Teeth

1988 ◽  
Vol 67 (2) ◽  
pp. 467-470 ◽  
Author(s):  
E.L. Pashley ◽  
L. Tao ◽  
J.R. Mackert ◽  
D.H. Pashlety
Keyword(s):  
Composite Resin ◽  
Bonding Agents ◽  
Dentin Bonding ◽  
Dentin Bonding Agents ◽  
Time Period ◽  
Bond Strengths ◽  
Made In

Dogs were utilized in a study to compare the bond strengths of dentin bonding agents made to dentin in vivo and then again in vitro in the same teeth 30 min, one day, one week, and one month post-extraction. No statistically significant differences were observed between bonds made in vivo and those made in vitro at any time period. Contamination of the dentin surfaces with blood or saliva lowered the bond strengths, but these could be restored to control values by re-surfacing of the dentin with a bur.

Comparison of Enamel and Dentin Shear Bond Strengths of Current Dental Bonding Adhesives From Three Bond Generations

2013 ◽  
Vol 38 (6) ◽  
pp. E237-E245 ◽  
Author(s):  
MR Meharry ◽  
SM Moazzami ◽  
Y Li
Keyword(s):  
Resin Composite ◽  
Acrylic Resin ◽  
Fourth Generation ◽  
Test Surface ◽  
Bonding Agents ◽  
Dental Bonding ◽  
Adhesive Dentistry ◽  
Sixth Generation ◽  
Post Hoc ◽  
Main Effects

SUMMARY Objective: Durability is still a major challenge in adhesive dentistry. One of the biggest areas of development has been to simplify the bonding process by using all-in-one adhesives. The aim of this study was to compare the shear bond strength (SBS) to dentin and enamel of nine dental bonding agents (DBAs) from three generations after simulated aging. Methods and Materials: For this study, 108 sound extracted human molars were randomly assigned to nine groups (n=12). The sample teeth were mounted in self-cure acrylic resin sectioned to provide paired enamel and dentin samples. All samples were polished with 240 and 600-grit silicon carbide sandpaper and randomly grouped according to the product and substrates (enamel or dentin). Herculite Ultra resin composite cylinders were bonded on each test surface, stored in 100% humidity at 37°C for 24 hours, and then thermocyled for 1,000 cycles at 5°C and 55°C. SBS testing was performed using an Ultratester at a crosshead speed of 0.5 mm/min. Statistical analysis included two-factor analysis of variance, one-sample Wilcoxon and Kruskal-Wallis tests, and the Scheffe post hoc test at an alpha level of 0.05 using SAS version 9.2. Results: Significant differences in SBS were observed between the sixth- and seventh-generation DBAs (p=0.002) but not between the sixth- and fourth-generation DBAs. Scheffe post hoc tests for the sixth-generation DBAs showed that some DBAs yielded significantly higher enamel SBS than others, but not as much as dentin SBS. As for the seventh-generation DBAs, similar post hoc tests showed significant variations in SBS between substrates (enamel and dentin) and DBAs tested. Significant main effects were also found for the different substrates for the fourth-generation (F[1,96]=10.532; p=0.003) and seventh-generation (F[1,96]=22.254; p&lt;0.001) DBAs, but not for the sixth-generation DBAs (F[1,96]=1.895, p=0.172). The SBS was higher on dentin than enamel for the fourth- and seventh-generation DBAs. Conclusion: As expected, fourth- and sixth-generation DBAs generally showed stronger SBS values than the seventh-generation all-in-one DBAs. The new sixth-generation DBA OptiBond XTR (Kerr) showed strong SBS values to both substrates and performed well in comparison to the other DBAs tested.

scholarly journals Application of Silver-Inorganic Anti-Microbial Reagent for Dental Materials. Part 1 In vivo and in vitro Toxicity Testings for IonpureTM.

1996 ◽  
Vol 40 (5) ◽  
pp. 927-932 ◽  
Author(s):  
Kazuhiro Mizukawa ◽  
Takaaki Tanaka ◽  
Jun-ichi Mega ◽  
Taira Kobayashi ◽  
Tsukasa Watanabe
Keyword(s):  
Dental Materials ◽  
In Vitro Toxicity
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