scholarly journals Effect of Sea Buckthorn on Plasma Glucose in Individuals with Impaired Glucose Regulation: A Two-Stage Randomized Crossover Intervention Study

Foods ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 804
Author(s):  
Zhongxia Ren ◽  
Huiting Gong ◽  
Ai Zhao ◽  
Jian Zhang ◽  
Chenlu Yang ◽  
...  
Keyword(s):  
Plasma Glucose ◽  
Mixed Model ◽  
Sea Buckthorn ◽  
Wilcoxon Test ◽  
Glucose Regulation ◽  
Impaired Glucose Regulation ◽  
Dietary Intakes ◽  
Blood Samples ◽  
Postprandial Plasma Glucose ◽  
Significant Difference

Sea buckthorn (SB) has been indicated to have hypoglycemic potential, but its effects on glucose in people with impaired glucose regulation (IGR) are still unclear. This work presents a randomized, double-blinded, two-way crossover study. A total of 38 subjects with IGR completed the intervention of consuming sea buckthorn fruit puree (SBFP, 90 mL/day, five weeks), washing out (four weeks), and then consuming placebo (90 mL/day, five weeks) or in reverse order. In our methodology, a unified questionnaire was used to gather information on physical activity and dietary intakes, and physical examinations were performed to measure blood pressure, height, and weight. Fasting blood samples were collected to detect the fasting plasma glucose (FPG) and glycated serum protein (GSP). To calculate the area under the curve of 2 h postprandial plasma glucose (2 h PG-AUC), blood samples at t = 30, 60, and 120 min were also collected and analyzed. Effects of the intervention were evaluated by paired-sample Wilcoxon test and mixed model analyses. Our results show that the FPG in subjects with IGR decreased by a median reduction of 0.14 mmol/L after five weeks’ consumption of SBFP, but increased by a median of 0.07 mmol/L after placebo intervention, and the comparison of these two interventions was statistically significant (p = 0.045). During the wash-out period, a similar difference was observed as the FPG decreased in the group that received SBFP intervention first, but increased in another group (p = 0.043). Both SBFP and placebo significantly raised GSP during the intervention period, but lowered it in the wash-out period (p < 0.05), while no significant difference was found between the two interventions. The 2 h PG-AUC remained relatively stable throughout the study. Our results indicated that consumption of SBFP for five weeks showed a slight downward trend on FPG in subjects with IGR.

scholarly journals Effects of Sea Buckthorn Whole Fruit Puree on Plasma Glucose in People with Impaired Glucose Regulation: A Randomized Crossover Intervention Study

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1479-1479
Author(s):  
Zhongxia Ren ◽  
Huiting Gong ◽  
Ai Zhao ◽  
Peiyu Wang ◽  
Yumei Zhang
Keyword(s):  
Plasma Glucose ◽  
Intervention Study ◽  
Sea Buckthorn ◽  
Glucose Regulation ◽  
Impaired Glucose Regulation ◽  
Daily Consumption ◽  
Double Blind ◽  
Postprandial Plasma Glucose ◽  
Significant Difference ◽  
Fruit Purée

Abstract Objectives To explore the effect of sea buckthorn whole fruit puree (SBFP) on fasting plasma glucose (FPG) and postprandial plasma glucose response in people with impaired glucose regulation (IGR). Methods A two-stage randomized crossover-control and double-blind intervention study was conducted. The SBFP was produced by the Hippophae rhamnoides L. subsp. Sinensis. Forty-five subjects aged 50–70 years old with IGR (6.1 mmol/L ≤ FPG &lt;7.0 mmol/L and/or 5.6% ≤Hemoglobin A1c ≤ 6.5%) were included and randomly divided into two groups (22 subjects in group AB and 23 in BA, respectively). Subject in group AB consumed SBFP (90 mL/d), washed out and then consumed placebo (90 mL/d) for 35, 28, 35 days, respectively, while the sequence of group BA was reversed. Fasting and postprandial (30, 60 and 120 min after a standard meal) blood samples were collected at the start and the end of every intervention period, and the concentration of plasma glucose was detected by the glucose oxidase method. Using a trapezoidal area formula, the area under the curve of 2 hours postprandial plasma glucose (PG-AUC) was calculated. The effect of the intervention was evaluated by general linear model. Results Six subjects in group AB and One in BA voluntarily withdrew before the first period of intervention and other 38 subjects completed the whole intervention. Consumption of 90 mL SBFP for 35 days (n = 38) resulted in a reduction of 0.13 ± 0.56 mmol/L (P = 0.173) on FPG in subjects with IGR, but the placebo intervention (n = 38) resulted in an increase of 0.12 ± 0.47 mmol/L (P = 0.122), and the difference in intervention was statistically significant (P = 0.045). The PG-AUC increased by 0.22 ± 1.02 h mmol/L (P = 0.184) and 0.07 ± 1.38 h mmol/L (P = 0.755), respectively, while no significant difference was observed (P = 0.871). During the wash-out period, the FPG changed with a decrease of 0.28 ± 0.61 mmol/L in the SBFP group (group AB, P = 0.080) but an increase of 0.16 ± 0.82 mmol/L in the placebo group (group BA, P = 0.373), and the effect was significantly different (P = 0.043). No significant difference was found for PG-AUC. Conclusions Daily consumption of 90 mL SBFP for 35 days played a positive role in reducing the FPG in people with IGR, and it might still be effective within 28 days after discontinued use. Funding Sources The National Natural Science Foundation of China (No. 81773420).

scholarly journals Randomized, Double-Blinded, Double-Dummy, Active-Controlled, and Multiple-Dose Clinical Study Comparing the Efficacy and Safety of Mulberry Twig (Ramulus Mori, Sangzhi) Alkaloid Tablet and Acarbose in Individuals with Type 2 Diabetes Mellitus

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Mengyi Li ◽  
Xuemin Huang ◽  
Hui Ye ◽  
Yao Chen ◽  
Jing Yu ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Clinical Trial ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Efficacy And Safety ◽  
Postprandial Plasma Glucose ◽  
Glucose Levels ◽  
Fasting Plasma ◽  
Significant Difference

Aims. To evaluate the efficacy and safety of mulberry twig alkaloid (SZ-A) tablet compared with acarbose in patients with type 2 diabetes.Methods. This clinical trial enrolled 38 patients who were randomized into two groups (SZ-A: 23; acarbose: 15) and were treated for 24 weeks. Patients and clinical trial staffs were masked to treatment assignment throughout the study. The primary outcome measures were glycated hemoglobin (HbA1c) and 1-hour and 2-hour postprandial and fasting plasma glucose levels from baseline to the end of treatment. Analysis included all patients who completed this study.Results. By the end of this study, HbA1c level in SZ-A group was decreased from baseline significantly (P<0.001). No significant difference was found when compared with acarbose group (P=0.652). Similarly, 1-hour and 2-hour postprandial plasma glucose levels in SZ-A group were decreased from baseline statistically (P<0.05), without any significant differences compared with acarbose group (P=0.748and 0.558, resp.). The fasting plasma glucose levels were not significantly changed in both groups. One of 23 patients in SZ-A group (4.76%) and 5 of 15 patients in acarbose group (33.33%) suffered from gastrointestinal adverse events.Conclusions. Compared with acarbose, SZ-A tablet was effective and safe in glycemic control in patients with type 2 diabetes.

scholarly journals Effect of changes in laboratory light intensity on biochemistry and haemogram analysis

2020 ◽  
Vol 45 (3) ◽  
pp. 249-253
Author(s):  
Sedat Yilmaz
Keyword(s):  
Alkaline Phosphatase ◽  
Platelet Count ◽  
Light Intensity ◽  
Whole Blood ◽  
Blood Analysis ◽  
Wilcoxon Test ◽  
Blood Samples ◽  
Significant Difference ◽  
Whole Blood Analysis ◽  
Iron Chemistry

AbstractBackgroundTo investigate the effect of changes in laboratory light intensity on chemistry and whole blood analysis.Materials and MethodsThe light intensity of the laboratory environment was measured and chemical and whole blood analysis was performed on 20 patient blood samples. The light intensity was then increased using projectors and re-measured, and the chemical and whole blood analyses were repeated. The values of the tests pre- and post-light increase were compared by statistical analysis using the Wilcoxon test.ResultsIncreasing light from 195 to 1,168 lux significantly altered the results of the lipase, alkaline phosphatase, creatinine, and iron chemistry tests, (p<0.001 [11.3%], p=0.003 [2.2%], p=0.001 [2%] and p=<0.001 [1.2%], respectively). There was also a significant difference in platelet count (p=<0.001 [188%]).ConclusionsWe show that the platelet count is sensitive to changes in laboratory light intensity at clinically unacceptable levels. The lipase, alkaline phosphatase, creatinine and iron tests are also sensitive to changes in laboratory light intensity, but at clinically acceptable levels.

scholarly journals Effects of lifestyle intervention and meal replacement on glycaemic and body-weight control in Chinese subjects with impaired glucose regulation: a 1-year randomised controlled trial

2012 ◽  
Vol 109 (3) ◽  
pp. 487-492 ◽  
Author(s):  
Dan-Feng Xu ◽  
Jian-Qin Sun ◽  
Min Chen ◽  
Yan-Qiu Chen ◽  
Hua Xie ◽  
...  
Keyword(s):  
Weight Loss ◽  
Body Weight ◽  
Lifestyle Intervention ◽  
Plasma Glucose ◽  
Intervention Group ◽  
Body Weight Loss ◽  
Glucose Regulation ◽  
Control Group ◽  
Impaired Glucose Regulation ◽  
Meal Replacement

The purpose of the present study was to evaluate the impact of a lifestyle intervention programme, combined with a daily low-glycaemic index meal replacement, on body-weight and glycaemic control in subjects with impaired glucose regulation (IGR). Subjects with IGR were randomly assigned to an intervention group (n 46) and a control group (n 42). Both groups received health counselling at baseline. The intervention group also received a daily meal replacement and intensive lifestyle intervention to promote healthy eating habits during the first 3 months of the study, and follow-up visits performed monthly until the end of the 1-year study. Outcome measurements included changes in plasma glucose, glycated Hb (HbA1c), plasma lipids, body weight, blood pressure and body composition (such as body fat mass and visceral fat area). The results showed that body-weight loss after 1 year was significant in the intervention group compared with the control group ( − 1·8 (sem 0·35) v.− 0·6 (sem 0·40) 2·5 kg, P< 0·05). The 2 h plasma glucose concentration decreased 1·24 mmol/l in the intervention group and increased 0·85 mmol/l in the control group (P< 0·05) compared with their baseline, respectively. A 5 kg body-weight loss at 1 year was associated with a decrease of 1·49 mmol/l in 2 h plasma glucose (P< 0·01). The incidence of normal glucose regulation (NGR) in the two groups was significantly different (P= 0·001). In conclusion, the combination of regular contact, lifestyle advice and meal replacement is beneficial in promoting IGR to NGR.

Berries modify the postprandial plasma glucose response to sucrose in healthy subjects

2009 ◽  
Vol 103 (8) ◽  
pp. 1094-1097 ◽  
Author(s):  
Riitta Törrönen ◽  
Essi Sarkkinen ◽  
Niina Tapola ◽  
Elina Hautaniemi ◽  
Kyllikki Kilpi ◽  
...  
Keyword(s):  
Plasma Glucose ◽  
Healthy Subjects ◽  
Postprandial Glucose ◽  
Postprandial Blood Glucose ◽  
Glycaemic Response ◽  
Glucose Response ◽  
Postprandial Plasma Glucose ◽  
Increased Risk ◽  
Significant Difference ◽  
Randomised Controlled

Sucrose increases postprandial blood glucose concentrations, and diets with a high glycaemic response may be associated with increased risk of obesity, type 2 diabetes and CVD. Previous studies have suggested that polyphenols may influence carbohydrate digestion and absorption and thereby postprandial glycaemia. Berries are rich sources of various polyphenols and berry products are typically consumed with sucrose. We investigated the glycaemic effect of a berry purée made of bilberries, blackcurrants, cranberries and strawberries, and sweetened with sucrose, in comparison to sucrose with adjustment of available carbohydrates. A total of twelve healthy subjects (eleven women and one man, aged 25–69 years) with normal fasting plasma glucose ingested 150 g of the berry purée with 35 g sucrose or a control sucrose load in a randomised, controlled cross-over design. After consumption of the berry meal, the plasma glucose concentrations were significantly lower at 15 and 30 min (P < 0·05, P < 0·01, respectively) and significantly higher at 150 min (P < 0·05) compared with the control meal. The peak glucose concentration was reached at 45 min after the berry meal and at 30 min after the control meal. The peak increase from the baseline was 1·0 mmol/l smaller (P = 0·002) after ingestion of the berry meal. There was no statistically significant difference in the 3 h area under the glucose response curve. These results show that berries rich in polyphenols decrease the postprandial glucose response of sucrose in healthy subjects. The delayed and attenuated glycaemic response indicates reduced digestion and/or absorption of sucrose from the berry meal.

Postprandial hormone and metabolic responses in simulated shift work

1996 ◽  
Vol 151 (2) ◽  
pp. 259-267 ◽  
Author(s):  
S M Hampton ◽  
L M Morgan ◽  
N Lawrence ◽  
T Anastasiadou ◽  
F Norris ◽  
...  
Keyword(s):  
Phase Shift ◽  
Shift Work ◽  
Plasma Glucose ◽  
Peak Plasma ◽  
Work Conditions ◽  
Postprandial Glucose ◽  
Clock Time ◽  
Postprandial Plasma Glucose ◽  
Significant Difference ◽  
Before And After

Abstract This study was designed to investigate postprandial responses to a mixed meal in simulated shift work conditions. Nine normal healthy subjects (six males and three females) were studied on two occasions at the same clock time (1330 h) after consuming test meals, first in their normal environment and secondly after a 9 h phase advance (body clock time 2230 h). Plasma glucose, insulin, glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), triacylglycerol (TAG) and non-esterified fatty acids (NEFAs) were determined at intervals for 6 h after each test meal. Postprandial plasma glucose, insulin, GIP and GLP-1 profiles were evaluated by calculating areas under the curve (AUC) for the first 2 h and the last 4 h of the sampling together with total AUC. Significantly higher postprandial glucose responses (total AUC) were observed after the phase shift than before (AUC 0–360 min, 2·01 (1·51–2·19) vs 1·79 (1·56–2·04) mmol/l.min; P<0·02; mean (range)). No significant difference was observed when the first 2 h of each response was compared, but significantly higher glucose levels were observed in the last 4 h of the study after the phase shift than before (AUC 120–360 min, 1·32 (1·08–1·42) vs 1·16 (1·00–1·28) mmol/l.min; P<0·05). Similar results were obtained for insulin (AUC 0—360 min, 81·72 (30·75– 124·97) vs 58·98 (28·03–92·57) pmol/l.min; P<0·01; AUC 120–360 min, 40·73 (16·20–65·25) vs 25·71 (14·25–37·33) pmol/l.min; P<0·02). No differences were observed in postprandial plasma GIP and GLP-1 responses before and after the phase shift. Postprandial circulating lipid levels were affected by phase shifting. Peak plasma TAG levels occurred 5 h postprandially before the phase shift. Postprandial rises in plasma TAG were significantly delayed after the phase shift and TAG levels continued to rise throughout the study. Plasma postprandial NEFA levels fell during the first 3 h both before and after the phase shift. Their rate of return to basal levels was significantly delayed after the phase shift compared with before. This study demonstrates that a simulated phase shift can significantly alter pancreatic B-cell responses and postprandial glucose and lipid metabolism. Journal of Endocrinology (1996) 151, 259–267

Markers of Hemostatic Activation in Affected Coronary Arteries during Angioplasty

1994 ◽  
Vol 72 (05) ◽  
pp. 672-675 ◽  
Author(s):  
Nicolas W Shammas ◽  
Michael J Cunningham ◽  
Richard M Pomearntz ◽  
Charles W Francis
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Venous Blood ◽  
Balloon Inflation ◽  
Blood Samples ◽  
Hemostatic System ◽  
Significant Difference ◽  
Hemostatic Markers ◽  
Artery Disease ◽  
High Doses

SummaryTo characterize the extent of early activation of the hemostatic system following angioplasty, we obtained blood samples from the involved coronary artery of 11 stable angina patients during the procedure and measured sensitive markers of thrombin formation (fibrino-peptide A, prothrombin fragment 1.2, and soluble fibrin) and of platelet activation ((3-thromboglobulin). Levels of hemostatic markers in venous blood obtained from 14 young individuals with low pretest probability for coronary artery disease were not significantly different from levels in venous blood or intracoronary samples obtained prior to angioplasty. Also, there was no translesional (proximal and distal to the lesion) gradient in any of the hemostatic markers before or after angioplasty in samples obtained between 18 and 21 min from the onset of the first balloon inflation. Furthermore, no significant difference was noted between angioplasty and postangioplasty intracoronary concentrations. We conclude that intracoronary hemostatic activation does not occur in the majority of patients during and immediately following coronary angioplasty when high doses of heparin and aspirin are administered.

Effect of Concentration of Trisodium Citrate Anticoagulant on Calculation of the International Normalised Ratio and the International Sensitivity Index of Thromboplastin

1994 ◽  
Vol 72 (01) ◽  
pp. 084-088 ◽  
Author(s):  
E M Duncan ◽  
C R Casey ◽  
B M Duncan ◽  
J V Lloyd
Keyword(s):  
Reference Material ◽  
Oral Anticoagulants ◽  
Reference Method ◽  
Trisodium Citrate ◽  
Sensitivity Index ◽  
Blood Samples ◽  
Orthogonal Regression ◽  
Significant Difference ◽  
International Normalised Ratio ◽  
International Sensitivity Index

SummaryThe aim of this study was to determine whether the concentration of trisodium citrate used to anticoagulate blood has an effect on the INR of the sample and the ISI of the thromboplastin. Five thromboplastins including and Australian reference material were used to measure the prothrombin time of normal and patient samples collected into two concentrations of trisodium citrate - 109 mM and 129 mM. There was no effect of citrate concentration on the INRs determined with the reference material. However for the other four thromboplastins there was a significant difference between INRs for the two citrate groups. The prothrombin times of the samples collected into 129 mM were longer than those collected into 109 mM. This difference was only slight in normal plasma but more marked in patients receiving oral anticoagulants, causing the INRs for patient plasmas collected into 129 mM citrate to be higher then the corresponding samples collected into 109 mM citrate.From orthogonal regression of log prothrombin times by the reference method against each thromboplastin, we found that the ISI for each thromboplastin was approximately 10% lower when determined with samples collected into 129 mM citrate than with samples collected into 109 mM. These results suggest that the concentration of trisodium citrate used for collection of blood samples can affect the calculation of the INR and the calibration of the ISI of thromboplastin. This was found both for commercial thromboplastins prepared by tissue extraction and for a recombinant tissue factor.

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