scholarly journals Effects of Sea Buckthorn Whole Fruit Puree on Plasma Glucose in People with Impaired Glucose Regulation: A Randomized Crossover Intervention Study

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1479-1479
Author(s):  
Zhongxia Ren ◽  
Huiting Gong ◽  
Ai Zhao ◽  
Peiyu Wang ◽  
Yumei Zhang
Keyword(s):  
Plasma Glucose ◽  
Intervention Study ◽  
Sea Buckthorn ◽  
Glucose Regulation ◽  
Impaired Glucose Regulation ◽  
Daily Consumption ◽  
Double Blind ◽  
Postprandial Plasma Glucose ◽  
Significant Difference ◽  
Fruit Purée

Abstract Objectives To explore the effect of sea buckthorn whole fruit puree (SBFP) on fasting plasma glucose (FPG) and postprandial plasma glucose response in people with impaired glucose regulation (IGR). Methods A two-stage randomized crossover-control and double-blind intervention study was conducted. The SBFP was produced by the Hippophae rhamnoides L. subsp. Sinensis. Forty-five subjects aged 50–70 years old with IGR (6.1 mmol/L ≤ FPG <7.0 mmol/L and/or 5.6% ≤Hemoglobin A1c ≤ 6.5%) were included and randomly divided into two groups (22 subjects in group AB and 23 in BA, respectively). Subject in group AB consumed SBFP (90 mL/d), washed out and then consumed placebo (90 mL/d) for 35, 28, 35 days, respectively, while the sequence of group BA was reversed. Fasting and postprandial (30, 60 and 120 min after a standard meal) blood samples were collected at the start and the end of every intervention period, and the concentration of plasma glucose was detected by the glucose oxidase method. Using a trapezoidal area formula, the area under the curve of 2 hours postprandial plasma glucose (PG-AUC) was calculated. The effect of the intervention was evaluated by general linear model. Results Six subjects in group AB and One in BA voluntarily withdrew before the first period of intervention and other 38 subjects completed the whole intervention. Consumption of 90 mL SBFP for 35 days (n = 38) resulted in a reduction of 0.13 ± 0.56 mmol/L (P = 0.173) on FPG in subjects with IGR, but the placebo intervention (n = 38) resulted in an increase of 0.12 ± 0.47 mmol/L (P = 0.122), and the difference in intervention was statistically significant (P = 0.045). The PG-AUC increased by 0.22 ± 1.02 h mmol/L (P = 0.184) and 0.07 ± 1.38 h mmol/L (P = 0.755), respectively, while no significant difference was observed (P = 0.871). During the wash-out period, the FPG changed with a decrease of 0.28 ± 0.61 mmol/L in the SBFP group (group AB, P = 0.080) but an increase of 0.16 ± 0.82 mmol/L in the placebo group (group BA, P = 0.373), and the effect was significantly different (P = 0.043). No significant difference was found for PG-AUC. Conclusions Daily consumption of 90 mL SBFP for 35 days played a positive role in reducing the FPG in people with IGR, and it might still be effective within 28 days after discontinued use. Funding Sources The National Natural Science Foundation of China (No. 81773420).

scholarly journals Effect of Sea Buckthorn on Plasma Glucose in Individuals with Impaired Glucose Regulation: A Two-Stage Randomized Crossover Intervention Study

Foods ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 804
Author(s):  
Zhongxia Ren ◽  
Huiting Gong ◽  
Ai Zhao ◽  
Jian Zhang ◽  
Chenlu Yang ◽  
...  
Keyword(s):  
Plasma Glucose ◽  
Mixed Model ◽  
Sea Buckthorn ◽  
Wilcoxon Test ◽  
Glucose Regulation ◽  
Impaired Glucose Regulation ◽  
Dietary Intakes ◽  
Blood Samples ◽  
Postprandial Plasma Glucose ◽  
Significant Difference

Sea buckthorn (SB) has been indicated to have hypoglycemic potential, but its effects on glucose in people with impaired glucose regulation (IGR) are still unclear. This work presents a randomized, double-blinded, two-way crossover study. A total of 38 subjects with IGR completed the intervention of consuming sea buckthorn fruit puree (SBFP, 90 mL/day, five weeks), washing out (four weeks), and then consuming placebo (90 mL/day, five weeks) or in reverse order. In our methodology, a unified questionnaire was used to gather information on physical activity and dietary intakes, and physical examinations were performed to measure blood pressure, height, and weight. Fasting blood samples were collected to detect the fasting plasma glucose (FPG) and glycated serum protein (GSP). To calculate the area under the curve of 2 h postprandial plasma glucose (2 h PG-AUC), blood samples at t = 30, 60, and 120 min were also collected and analyzed. Effects of the intervention were evaluated by paired-sample Wilcoxon test and mixed model analyses. Our results show that the FPG in subjects with IGR decreased by a median reduction of 0.14 mmol/L after five weeks’ consumption of SBFP, but increased by a median of 0.07 mmol/L after placebo intervention, and the comparison of these two interventions was statistically significant (p = 0.045). During the wash-out period, a similar difference was observed as the FPG decreased in the group that received SBFP intervention first, but increased in another group (p = 0.043). Both SBFP and placebo significantly raised GSP during the intervention period, but lowered it in the wash-out period (p < 0.05), while no significant difference was found between the two interventions. The 2 h PG-AUC remained relatively stable throughout the study. Our results indicated that consumption of SBFP for five weeks showed a slight downward trend on FPG in subjects with IGR.

scholarly journals Effects of Fermented Milk Containing Lacticaseibacillus paracasei Strain Shirota on Constipation in Patients with Depression: A Randomized, Double-Blind, Placebo-Controlled Trial

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2238
Author(s):  
Xiaomei Zhang ◽  
Shanbin Chen ◽  
Ming Zhang ◽  
Fazheng Ren ◽  
Yimei Ren ◽  
...  
Keyword(s):  
Mental Illness ◽  
Placebo Group ◽  
Rating Scale ◽  
Controlled Trial ◽  
Fermented Milk ◽  
Daily Consumption ◽  
Double Blind ◽  
Tnf Α ◽  
Significant Difference ◽  
Factor Α

Probiotics have been shown to benefit patients with constipation and depression, but whether they specifically alleviate constipation in patients with depression remains unclear. The aim of this study was to investigate the effect of Lacticaseibacillus paracasei strain Shirota (LcS), formerly Lactobacillus casei strain Shirota, on constipation in patients with depression with specific etiology and gut microbiota and on depressive regimens. Eighty-two patients with constipation were recruited. The subjects consumed 100 mL of a LcS beverage (108 CFU/mL) or placebo every day for 9 weeks. After ingesting beverages for this period, we observed no significant differences in the total patient constipation-symptom (PAC-SYM) scores in the LcS group when compared with the placebo group. However, symptoms/scores in item 7 (rectal tearing or bleeding after a bowel movement) and items 8–12 (stool symptom subscale) were more alleviated in the LcS group than in the placebo group. The Beck Depression Index (BDI) and Hamilton Depression Rating Scale (HAMD) scores were all significantly decreased, and the degree of depression was significantly improved in both the placebo and LcS groups (p < 0.05), but there was no significant difference between the groups. The LcS intervention increased the beneficial Adlercreutzia, Megasphaera and Veillonella levels and decreased the bacterial levels related to mental illness, such as Rikenellaceae_RC9_gut_group, Sutterella and Oscillibacter. Additionally, the interleukin (IL)-1β, IL-6, and tumor necrosis factor-α (TNF-α) levels were significantly decreased in both the placebo and LcS groups (p < 0.05). In particular, the IL-6 levels were significantly lower in the LcS group than the placebo group after the ingestion period (p < 0.05). In conclusion, the daily consumption of LcS for 9 weeks appeared to relieve constipation and improve the potentially depressive symptoms in patients with depression and significantly decrease the IL-6 levels. In addition, the LcS supplementation also appeared to regulate the intestinal microbiota related to mental illness.

scholarly journals California Strawberry Consumption Alters Gut Microbiome in Healthy Participants: A Pilot Study

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1561-1561
Author(s):  
Susanne Henning ◽  
Jieping Yang ◽  
Shih Lung Woo ◽  
Ru-Po Li ◽  
Jianjun Huang ◽  
...  
Keyword(s):  
High Performance ◽  
Lithocholic Acid ◽  
Colorimetric Assay ◽  
Fecal Microbiota ◽  
Daily Consumption ◽  
Double Blind ◽  
Alpha And Beta Diversity ◽  
Rdna Sequencing ◽  
Significant Difference ◽  
Fecal Cholesterol

Abstract Objectives Based on the polyphenol and fiber content of strawberries (SB), it was our hypothesis that daily consumption of California strawberries will lead to changes in the composition of the intestinal microbiota, and concentration of fecal cholesterol and bile acid (BA) microbial metabolites. Methods We performed a randomized, double blind, parallel design intervention study. 28 healthy adults were randomized to either daily consumption of 26 g of SB powder (2 servings of fresh SB) or placebo (PL) powder for 4 wks. Stool samples were collected at baseline (BL), 4 and 6 wks (2 wks no SB/PL). Fecal microbiota was analyzed by 16S rDNA sequencing of the V4 region; fecal cholesterol, coprostanol, cholestanol, cholic acid (primary BA), chenodeoxycholic acid (primary BA), deoxycholic acid (2ndBA), lithocholic acid (2ndBA) by gas chromatography, serum cholesterol, triglyceride by colorimetric assay and serum pelargonidin glucuronide (PG) by high performance liquid chromatography. Results Serum PG, a SB anthocyanin, was found in all participants in the SB group. Two participants in the PL group showed serum PG and were excluded from the analyses. Daily SB increased the abundance of Christensenellaceae, Bifidobacteriaceae, Verrucomicrobiaceae and multiple members of the Lachnospiraceae, Ruminococcaceae family, and decreased significantly Alcaligenaceae/Sutterella comparing BL to wk4. Comparing the change from BL to wk4 between the SB and PL group, we found increased abundance of Alcaligenaceae/Sutterella and several members of the Clostridia class including Lachnopsiraceae and Ruminococcaceae and a decrease in Clostridiaceae. Comparing wk 4 to wk 6, we observed a reversal of Clostridiales/Christensenellaceae, Verrucomicrobiaceae, and Alcaligenaceae/Sutterella. No effects on alpha and beta diversity were observed. No significant difference in serum and fecal cholesterol, BA and bacterial metabolites was observed between SB and PL groups. Five participants did not form coprostanol. Comparing coprostanol producers to non-producers at baseline showed that most differences were observed in the Lachnospiraceae, Ruminococcaceae and Bacteroidaceae families. Conclusions SB consumption altered the gut microbiota, which was partially reversed after 2 wks of customary diet without SB. Funding Sources California Strawberry Commission.

scholarly journals Randomized, Double-Blinded, Double-Dummy, Active-Controlled, and Multiple-Dose Clinical Study Comparing the Efficacy and Safety of Mulberry Twig (Ramulus Mori, Sangzhi) Alkaloid Tablet and Acarbose in Individuals with Type 2 Diabetes Mellitus

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Mengyi Li ◽  
Xuemin Huang ◽  
Hui Ye ◽  
Yao Chen ◽  
Jing Yu ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Clinical Trial ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Efficacy And Safety ◽  
Postprandial Plasma Glucose ◽  
Glucose Levels ◽  
Fasting Plasma ◽  
Significant Difference

Aims. To evaluate the efficacy and safety of mulberry twig alkaloid (SZ-A) tablet compared with acarbose in patients with type 2 diabetes.Methods. This clinical trial enrolled 38 patients who were randomized into two groups (SZ-A: 23; acarbose: 15) and were treated for 24 weeks. Patients and clinical trial staffs were masked to treatment assignment throughout the study. The primary outcome measures were glycated hemoglobin (HbA1c) and 1-hour and 2-hour postprandial and fasting plasma glucose levels from baseline to the end of treatment. Analysis included all patients who completed this study.Results. By the end of this study, HbA1c level in SZ-A group was decreased from baseline significantly (P<0.001). No significant difference was found when compared with acarbose group (P=0.652). Similarly, 1-hour and 2-hour postprandial plasma glucose levels in SZ-A group were decreased from baseline statistically (P<0.05), without any significant differences compared with acarbose group (P=0.748and 0.558, resp.). The fasting plasma glucose levels were not significantly changed in both groups. One of 23 patients in SZ-A group (4.76%) and 5 of 15 patients in acarbose group (33.33%) suffered from gastrointestinal adverse events.Conclusions. Compared with acarbose, SZ-A tablet was effective and safe in glycemic control in patients with type 2 diabetes.

scholarly journals A Doubled-Blind, Crossover-RCT in T2DM for Evaluating Hypoglycemic Effect of P. indicus, M. charantia, P. vulgaris and A. paniculata in Central Java

2016 ◽  
Vol 16 (3) ◽  
pp. 108 ◽  
Author(s):  
Mahalul Azam ◽  
Charles Ong Saerang ◽  
Sri Ratna Rahayu ◽  
Fitri Indrawati ◽  
Irwan Budiono ◽  
...  
Keyword(s):  
Combination Treatment ◽  
Plasma Glucose ◽  
Study Data ◽  
Double Blind ◽  
Postprandial Plasma Glucose ◽  
Central Java ◽  
Time Treatment ◽  
Lower Plasma Glucose ◽  
Student’S T

This study investigated whether mixture extract of <em>Pterocarpus indicus, Momordica charantia, Phaseolus vulgaris</em> and <em>Andrographis paniculata</em> could lower plasma glucose in Type 2 Diabetes Mellitus (T2DM) patients. 43 T2DM patients, consist of 10 male and 33 female patients participated in this possitive-controlled, double-blind, and crossover clinical study with administration of either mixture extract (22 mg/kg BW) or glibenclamide 5 mg daily in breakfast time. Treatment of extract or glibenclamide was administered for a month, then medication was changed after a week of washout period and finally combination therapy was administered after wash out period as well. The efficacy of mixture extracts was measured by using Fasting Plasma Glucose (FPG) and two-hour Postprandial Plasma Glucose (PPG). Forty-one subjects completed the study. Data was analyzed using SPSS 19 with Student's t test, and p&lt;0.05 was considered significant. FPG level significantly decreased 16.07 mg/dl after extract, 43.34 mg/dl after glibenclamide and 50.16 mg/dl after combination treatment. Two-hour PPG level decreased 25.88 mg/dl after extract, 66.61 after glibenclamide and 58.93 after combination treatment. We concluded that extract administration could lower FPG and PPG although not as good as glibenclamide treatment did and combination treatment was the best to lower FPG.

scholarly journals Efficacy and Safety of Ginkgo Biloba Pills for Coronary Heart Disease with Impaired Glucose Regulation: Study Protocol for a Series of N-of-1 Randomized, Double-Blind, Placebo-Controlled Trials

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Mingyue Sun ◽  
Lulu Chai ◽  
Fang Lu ◽  
Yang Zhao ◽  
Qingna Li ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Cardiovascular Diseases ◽  
Ginkgo Biloba ◽  
Glucose Regulation ◽  
Single Subject ◽  
Impaired Glucose Regulation ◽  
Double Blind ◽  
Double Blind Placebo

Background. Coronary heart disease has become a serious challenge to China with its high prevalence and mortality. The impaired glucose regulation is prevalent in patients with cardiovascular disease. However, there are few drugs that interfere early with impaired glucose regulation. Ginkgo biloba extract not only is a commonly used drug for cardiovascular diseases, but also has a significant effect in reducing blood sugar. Therefore, this study used a single-case randomized controlled trial to explore the efficacy of Ginkgo biloba pills in the treatment of coronary heart disease patients with impaired glucose regulation. Methods/Design. This is a randomized, double-blind, placebo-controlled, three-period crossover trial for a single subject. A total of 12 subjects will be recruited in this trial. The trial is divided into three cycles, and one cycle has two treatment periods. Ginkgo biloba pills and placebo will be randomized during the treatment period. The test period will last for 58 weeks and subjects will take 48 weeks. Subjects will be selected by the researcher strictly in accordance with the inclusion and exclusion criteria. Discussion. Ginkgo biloba preparations are widely used in cardiovascular diseases both at home and abroad due to their definite curative effect, few side effects, various dosage forms, and convenient and safe use. Diabetes mellitus is a high-risk factor for the occurrence of cardiovascular disease. Therefore, it is of great significance to control the impaired glucose regulation and slow down the development of diabetes and reduce the incidence and mortality of cardiovascular diseases. This trial is registered with ClinicalTrials.gov (ID: NCT03483779).

scholarly journals Effectiveness and safety of Bifidobacterium and berberine in human hyperglycemia and their regulatory effect on the gut microbiota: a multi-center, double-blind, randomized, parallel-controlled study

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Jie Ming ◽  
Xinwen Yu ◽  
Xiaoqiang Xu ◽  
Li Wang ◽  
Chao Ding ◽  
...  
Keyword(s):  
Placebo Group ◽  
Gut Microbiota ◽  
Plasma Glucose ◽  
Least Square ◽  
Hypoglycemic Effect ◽  
Controlled Study ◽  
Primary Analysis ◽  
Double Blind ◽  
Postprandial Plasma Glucose ◽  
And Function

Abstract Background Berberine and Bifidobacterium have been reported to improve glucose tolerance in people with hyperglycemia or other metabolic disorders. This study aimed to assess the hypoglycemic effect and the regulation of the gut microbiota caused by berberine and Bifidobacterium and the possible additive benefits of their combination. Methods This was an 18-week, multi-center, randomized, double-blind, parallel-controlled study of patients newly diagnosed with hyperglycemia. After a 2-week run-in period, 300 participants were randomly assigned to the following four groups for 16 weeks of treatment: berberine (Be), Bifidobacterium (Bi), berberine and Bifidobacterium (BB), and placebo group. The primary efficacy endpoint was the absolute value of fasting plasma glucose (FPG) compared with baseline after 16 weeks of treatment. Results Between October 2015 and April 2018, a total of 297 participants were included in the primary analysis. Significant reductions of FPG were observed in the Be and BB groups compared with the placebo group, with a least square (LS) mean difference of − 0.50, 95% CI [− 0.85, − 0.15] mmol/L, and − 0.55, 95% CI [− 0.91, − 0.20] mmol/L, respectively. The Be and BB groups also showed significant reductions in 2-h postprandial plasma glucose. A pronounced decrease in HbA1c occurred in the BB group compared to the placebo group. Moreover, compared with the Bi and placebo groups, the Be and BB groups had more changes in the gut microbiota from the baseline. Conclusions Berberine could regulate the structure and function of the human gut microbiota, and Bifidobacterium has the potential to enhance the hypoglycemic effect of berberine. These findings provide new insights into the hypoglycemic potential of berberine and Bifidobacterium. Trial registration ClinicalTrials.gov, NCT03330184. Retrospectively registered on 18 October 2017

scholarly journals Effects of lifestyle intervention and meal replacement on glycaemic and body-weight control in Chinese subjects with impaired glucose regulation: a 1-year randomised controlled trial

2012 ◽  
Vol 109 (3) ◽  
pp. 487-492 ◽  
Author(s):  
Dan-Feng Xu ◽  
Jian-Qin Sun ◽  
Min Chen ◽  
Yan-Qiu Chen ◽  
Hua Xie ◽  
...  
Keyword(s):  
Weight Loss ◽  
Body Weight ◽  
Lifestyle Intervention ◽  
Plasma Glucose ◽  
Intervention Group ◽  
Body Weight Loss ◽  
Glucose Regulation ◽  
Control Group ◽  
Impaired Glucose Regulation ◽  
Meal Replacement

The purpose of the present study was to evaluate the impact of a lifestyle intervention programme, combined with a daily low-glycaemic index meal replacement, on body-weight and glycaemic control in subjects with impaired glucose regulation (IGR). Subjects with IGR were randomly assigned to an intervention group (n 46) and a control group (n 42). Both groups received health counselling at baseline. The intervention group also received a daily meal replacement and intensive lifestyle intervention to promote healthy eating habits during the first 3 months of the study, and follow-up visits performed monthly until the end of the 1-year study. Outcome measurements included changes in plasma glucose, glycated Hb (HbA1c), plasma lipids, body weight, blood pressure and body composition (such as body fat mass and visceral fat area). The results showed that body-weight loss after 1 year was significant in the intervention group compared with the control group ( − 1·8 (sem 0·35) v.− 0·6 (sem 0·40) 2·5 kg, P< 0·05). The 2 h plasma glucose concentration decreased 1·24 mmol/l in the intervention group and increased 0·85 mmol/l in the control group (P< 0·05) compared with their baseline, respectively. A 5 kg body-weight loss at 1 year was associated with a decrease of 1·49 mmol/l in 2 h plasma glucose (P< 0·01). The incidence of normal glucose regulation (NGR) in the two groups was significantly different (P= 0·001). In conclusion, the combination of regular contact, lifestyle advice and meal replacement is beneficial in promoting IGR to NGR.

Effects of daidzein and genistein on markers of cardiovascular disease risk among women with impaired glucose regulation: A double-blind, randomized, placebo-controlled trial

2021 ◽  
Author(s):  
Yanbin Ye ◽  
Kai-yin He ◽  
Wan-lin Li ◽  
Shu-yu Zhuo ◽  
Yu M. Chen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Soy Protein ◽  
Disease Risk ◽  
Controlled Trial ◽  
Cardiovascular Disease Risk ◽  
Soy Isoflavones ◽  
Glucose Regulation ◽  
Impaired Glucose Regulation ◽  
Double Blind

Background and objective: Soy protein and soy isoflavones have been suggested to be associated with improved cardiovascular risk factors (e.g., lipid profiles and uric acid (UA)), but few studies have...

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