scholarly journals Does Croton Argyrophyllus Extract Has an Effect on Muscle Damage and Lipid Peroxidation in Rats Submitted to High Intensity Strength Exercise?

2019 ◽  
Vol 16 (21) ◽  
pp. 4237 ◽  
Author(s):  
de Araújo ◽  
Aidar ◽  
Matos ◽  
Santos ◽  
Souza ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Muscle Damage ◽  
High Intensity ◽  
Recovery Process ◽  
Exercise Group ◽  
Vehicle Group ◽  
Sedentary Group ◽  
Hydroethanolic Extract ◽  
Muscular Damage

Many species of the genus Croton have been used for anti-inflammatory, antiproliferative, antidiabetic, and antitumor purposes. The objective was to evaluate the effect of a hydroethanolic extract (HEE) from the inner bark of Croton argyrophyllus (Euphorbiaceae) on muscle damage and oxidative stress in rats after high intensity exercise. The animals were divided into four groups: (i) the sedentary group (SV; n = 7), (ii) the exercise vehicle group (EV, n = 7), (iii) the sedentary group HEE (SHG; n = 7) composed of sedentary animals and treated with the hydroethanolic extract of C. argyrophyllus (200 mg/kg, v.o.), and (iv) the HEE exercise group (HEE; n = 7) composed of animals submitted to resistance exercise (RE) and treated with the hydroethanolic extract of C. argyrophyllus (200 mg/kg, v.o.). In the 2,2-Diphenyl-1-picrylhydrazyl (DPPH) test, the HEE showed lower values of inhibition potential (IP%) at 39.79% compared to gallic acid, 87.61%, and lipoperoxidation inhibition at 27.4% (100 µg/mL) or 28.6% (200 µg/mL) (p < 0.001). There was inhibition in free radicals in vivo. The HEE of C. argyrophyllus partially reduced the biomarkers of oxidative stress in muscle tissue and muscular damage (creatine kinase (CK) and Lactate Dehydrogenase (LDH)) (p < 0.05) in rats, and in this sense it can be an aid to the recovery process after exhaustive efforts.

scholarly journals Protective effect of a hydroethanolic extract from Bowdichia virgilioides on muscular damage and oxidative stress caused by strenuous resistance training in rats

2014 ◽  
Vol 11 (1) ◽  
Author(s):  
Jymmys Lopes dos Santos ◽  
Rafaela Eugênia Arce Dantas ◽  
Clésio Andrade Lima ◽  
Silvan Silva de Araújo ◽  
Elis Cristiane Valença de Almeida ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Resistance Training ◽  
Protective Effect ◽  
Hydroethanolic Extract ◽  
Muscular Damage ◽  
And Oxidative Stress

Effects of high-amount–high-intensity exercise on in vivo platelet activation: Modulation by lipid peroxidation and AGE/RAGE axis

2013 ◽  
Vol 110 (12) ◽  
pp. 1232-1240 ◽  
Author(s):  
Francesca Santilli ◽  
Natale Vazzana ◽  
Pierpaolo Iodice ◽  
Stefano Lattanzio ◽  
Rossella Liani ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Exercise Training ◽  
Platelet Activation ◽  
High Intensity ◽  
Plasma Levels ◽  
High Intensity Exercise ◽  
Similar Amount ◽  
Activation Markers

SummaryPhysical activity is associated with cardiovascular risk reduction, but the effects of exercise on platelet activation remain controversial. We investigated the effects of regular high-amount, high intensity aerobic exercise on in vivo thromboxane (TX)-dependent platelet activation and plasma levels of platelet-derived proteins, CD40L and P-selectin, and whether platelet variables changes may be related to changes in high-density lipoprotein (HDL) and in the extent of oxidative stress and oxidative stress-related inflammation, as reflected by urinary isoprostane excretion and endogenous soluble receptor for advanced glycation end-products (esRAGE), respectively. Urinary excretion of 11-dehydro-TXB2 and 8-iso-prostaglandin (PG)F2α and plasma levels of P-selectin, CD40L and esRAGE were measured before and after a eight-week standardised aerobic high-amount–high-intensity training program in 22 sedentary subjects with low-to-intermediate risk. Exercise training had a clear beneficial effect on HDL cholesterol (+10%, p=0.027) and triglyceride (-27%, p=0.008) concentration. In addition, a significant (p<0.0001) decrease in urinary 11-dehydro-TXB2 (26%), 8-iso-PGF2α (21 %), plasma P-selectin (27%), CD40L (35%) and a 61% increase in esRAGE were observed. Multiple regression analysis revealed that urinary 8-iso-PGF2α [beta=0.33, SEM=0.116, p=0.027] and esRAGE (beta=-0.30, SEM=31.3, p=0.046) were the only significant predictors of urinary 11-dehydro-TXB2 excretion rate over the training period. In conclusion, regular high-amount–high-intensity exercise training has broad beneficial effects on platelet activation markers, paralleled and possibly associated with changes in the lipoprotein profile and in markers of lipid peroxidation and AGE/RAGE axis. Our findings may help explaining why a similar amount of exercise exerts significant benefits in preventing cardiovascular events.

Endothelin receptor antagonist reverses decreased NO system in the kidney in vivo during exercise

2004 ◽  
Vol 286 (4) ◽  
pp. E609-E614 ◽  
Author(s):  
Seiji Maeda ◽  
Takashi Miyauchi ◽  
Motoyuki Iemitsu ◽  
Takumi Tanabe ◽  
Katsutoshi Goto ◽  
...  
Keyword(s):  
Blood Flow ◽  
Receptor Antagonist ◽  
Cultured Cells ◽  
Vascular Endothelial Cells ◽  
Exercise Group ◽  
Treadmill Running ◽  
No Production ◽  
Sedentary Group

Vascular endothelial cells produce endothelin (ET)-1, a potent vasoconstrictor peptide, and nitric oxide (NO), a potent vasodilator substance. There are interactions between ET-1 and NO. Exercise results in a marked decrease in renal blood flow. We previously reported that exercise causes an increase of ET-1 production in the kidney, whereas production of NO in the kidney is decreased. Furthermore, we recently revealed that the magnitude of decrease in blood flow to the kidney during exercise was significantly attenuated by the administration of the endothelin-A (ETA) receptor antagonist, strongly suggesting that endogenously increased ET-1 participates in the decrease of blood flow in the kidney during exercise. Because it was demonstrated that ET-1 depresses NO synthase (NOS) activity of cultured cells in vitro, we hypothesized that an increase of ET-1 production in kidney during exercise contributes to a decrease of NO production in kidney in vivo. We studied whether administration of the ETA receptor antagonist attenuates the decreases of NOS activity and NO production in the kidney during exercise. Rats performed treadmill running for 30 min after pretreatment with an ETA receptor antagonist (TA-0201, 0.5 mg/kg; TA-0201-treated exercise group) or vehicle (vehicle-treated exercise group). Control rats remained at rest (vehicle-treated sedentary group). Blood flow in the kidney was decreased by this exercise, but the magnitude of the decrease after pretreatment with TA-0201 was significantly smaller than that after pretreatment with vehicle. NOS activity in kidney was significantly lower in the vehicle-treated exercise group than in the vehicle-treated sedentary group, whereas that in the TA-0201-treated exercise group was significantly higher than that in the vehicle-treated exercise group. Expressions of endothelial NOS protein and NOx, the stable end product of NO, i.e., nitrite/nitrate, concentration in the kidney were significantly lower in the vehicle-treated exercise group than in the vehicle-treated sedentary group, whereas those in the TA-0201-treated exercise group were significantly higher than those in the vehicle-treated exercise group. The data suggest that increased ET-1 production in the kidney during exercise contributes to the decreases of NOS activity and NO production. Therefore, the present study provides a possibility that the exercise-induced increase in production of ET-1 in the kidney causes a decrease in blood flow in the kidney through two pathways, i.e., vasoconstrictive action and the action of attenuating NO production.

scholarly journals Purslane supplementation lowers oxidative stress, inflammatory and muscle damage biomarkers after high-intensity intermittent exercise in female runners

2021 ◽  
Vol 13 (1) ◽  
pp. 17-27
Author(s):  
ANIS CHARKHI SAHL ABAD ◽  
AMINE GRAM ◽  
RAHMAN SOORI ◽  
ALI AKBARNEJAD ◽  
FATEMEH AZIZI GHUCHAN ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Muscle Damage ◽  
High Intensity ◽  
Intermittent Exercise ◽  
Interval Exercise ◽  
Tnf Α ◽  
Healthy Female ◽  
High Intensity Interval ◽  
Treadmill Protocol ◽  
Biomarkers Of Oxidative Stress

Background: The aim of this study was to determine the effect of purslane supplementation on oxidative stress, inflammation and muscle damage biomarkers after completing high-intensity interval exercise (HIIE). Methods: Nine healthy female runners completed a HIIE treadmill protocol comprising 1 min at 100% of the peak treadmill velocity attained in a preliminary exhaustive incremental treadmill test, interspersed by 1 min of passive recovery, until they had run for 2.5 km. Athletes repeated this test following 10 days of supplementation with 1000 mg per day of purslane. Results: At baseline (i.e., absence of purslane supplementation) the HIIE protocol increased 9-HODE (p < 0.001), 13-HODE (p < 0.001), IL-17 (p < 0.001), TNF-α (p < 0.001), and LDH (p < 0.001). After purslane consumption, resting 9-HODE, 13-HODE, IL-17, TNF-α, and LDH were lowered (p < 0.001) and IL-10 was increased (p < 0.001) compared to before purslane supplementation. After purslane consumption and following the HIIE protocol, the responses of these biomarkers were lower compared to baseline (p < 0.001). Conclusion: Ten days of purslane supplementation blunted the perturbation to biomarkers of oxidative stress, inflammation and muscle damage in female runners completing a HIIE protocol.

scholarly journals Tanshinone IIA Attenuates Contrast-Induced Nephropathy via Nrf2 Activation in Rats

2018 ◽  
Vol 46 (6) ◽  
pp. 2616-2623 ◽  
Author(s):  
Rulian Liang ◽  
Qing Zhao ◽  
Guihua Jian ◽  
Dongsheng Cheng ◽  
Niansong Wang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Tanshinone Iia ◽  
Vehicle Group ◽  
Renal Tubular Cell ◽  
Contrast Induced Nephropathy ◽  
Renal Tubular ◽  
Hk2 Cells ◽  
And Oxidative Stress

Background/Aims: Tanshinone IIA is a chemical compound extracted from Salvia miltiorrhiza Bunge, a perennial plant also known as red sage used in traditional Chinese medicine. Tanshinone IIA has been shown to protect against various organ injuries. In this study, we hypothesized that Tanshinone IIA could play an anti-oxidative role in contrast-induced nephropathy (CIN) through enhancing Nrf2/ARE activation. Methods: To test whether Tanshinone IIA can attenuate CIN, oxidative stress, and apoptosis, we utilized two models: an in vivo Sprague-Dawley rat model of ioversol-induced CIN and an in vitro cell model of oxidative stress in which HK2 cells, a human renal tubular cell line, are treated with hydrogen peroxide (H2O2). Rats were randomly assigned to 4 groups (n = 6 per group): control group, ioversol group (ioversol-induced CIN), vehicle group (ioversol-induced CIN rats pretreated with vehicle), and Tanshinone IIA group (ioversol-induced CIN rats pretreated with 25mg/kg Tanshinone IIA). Renal functions, renal injuries and apoptosis were evaluated by using serum creatinine, histological scoring, and TUNEL staning respectively. Malondialdehyde, 8-hydroxy-2’ –deoxyguanosine, and intracellular reactive oxygen species were used for oxidative stress assessment. Levels of Nrf2 and heme oxygenase-1 (HO-1) were measured in vivo and in vitro. Results: Tanshinone IIA attenuated renal tubular necrosis, apoptosis and oxidative stress in rats and oxidative stress in HK2 cells. Furthermore, Tanshinone IIA activated Nrf2, and up-regulated HO-1 expression in vivo and in vitro, resulting in a reduction in oxidative stress. Conclusion: Tanshinone IIA may protect against CIN through enhancing Nrf2/ARE activation.

scholarly journals THE CONSUMPTION OF FRUITS AS A POTENTIAL ALTERNATIVE TO ACCELERATE THE RECOVERY PROCESS AFTER HIGH INTENSITY EXERCISE

2020 ◽  
Vol 20 (39) ◽  
pp. 41-48
Author(s):  
Sonja Skinner ◽  
Madison Wade ◽  
Courtney Iacobacci ◽  
Roderick Hutcherson ◽  
Julia Matzenbacher dos Santos
Keyword(s):  
Muscle Damage ◽  
High Intensity ◽  
Recovery Process ◽  
The Body ◽  
High Intensity Exercise ◽  
Blue Color ◽  
Positive Effects ◽  
Potential Alternative ◽  
Post Exercise Recovery ◽  
Glycogen Stores

A prevalent desire in the sports world is the acceleration of post-exercise recovery; therefore, many studies have examined the use of dietary supplements before, during, and after exercise to determine the positive effects on athletes as a catalyst for recovery. Overall, studies have found that adaptations to regular exercise promotes advantageous reactions in the body to boost the immune system, prevent dyslipidemia and muscle loss, and increase bone density. However, exercise at an increased intensity or duration usually performed under competitive settings can deplete glycogen stores, increase lactic acid, form an excess amount of reactive oxygen species (ROS), increase tissue damage, and decrease immunologic function. This review incorporated studies that tested the use of fruits as a strategy to attenuate the period by which the body buffers the increase in acidity and inflammation, scavenge ROS and to regenerate muscle damage after high intensity exercise. Therefore, the effect of fruit intake rich in vitamins and those containing polyphenolic ring-based flavonoids and carbohydrates was discussed. Nutrient supplementation can enhance recovery after high intensity exercise, particularly fruits of red-blue color such as cherries and blueberries seem to decrease oxidative stress, inflammation, and muscle damage. In summary, each fruit has specific targets to offset body regeneration, avoid over training, and improve overall performance.

scholarly journals PENGARUH EXERCISE INTENSITAS TINGGI TERHADAP KETEBALAN ENDOMETRIUM MENCIT (MUS MUSCULUS)

2021 ◽  
Vol 3 (1) ◽  
pp. 24
Author(s):  
Aizah Ari Setyana Yuli ◽  
Gadis Meinar Sari ◽  
Ashon Sa’adi
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
High Intensity ◽  
Endometrial Thickness ◽  
Reactive Oxygen ◽  
Exercise Group ◽  
High Intensity Exercise ◽  
Control Group ◽  
Oxygen Species ◽  
Group Data

Abstrak Latar Belakang : Exercise dapat menyebabkan terbentuknya reactive oxygen species (ROS). Ketidakseimbangan antara antioksidan endogen dan ROS dapat menyebabkan stres oksidatif. Stres oksidatif dapat menyebabkan infertilitas pada wanita melalui berbagai mekanisme. Endometrium yang tidak sempurna karena ROS tidak dapat mendukung embrio dan perkembangannya. Penelitian ini bertujuan untuk menganalisa perbedaan ketebalan endometrium pada mencit yang exercise intensitas tinggi. Metode : Penelitian ini true experimental dengan rancangan randomized posttest only design. Besar sampel adalah 7 ekor tiap kelompok, yang terdiri dari 2 kelompok. Kelompok kontrol dan  kelompok exercise intensitas tinggi. Data yang didapatkan adalah ketebalan endometrium mencit. Hasil : hasil uji mann-whitney menunjukkan hasil yang signifikan dengan P=0,006. Kesimpulan : exercise intensitas tinggi dapat mempengaruhi ketebalan endometrium.. Abstract Background: Reactive Oxygen Species (ROS) is formed by exercise. Oxidative stress is caused by an imbalance between endogenous antioxidants and ROS. Oxidative stress  causes infertility in women through mechanisms. Because of  ROS, endometrium can not support the embryo and its development. This research aim to analyze different of endometrial thickness mice with high intensity exercise. Methods: This research is true experimental researh with randomized posttest only design. The sample size is 7 female mice each group, devided into 2 groups. The control group, and the high-intensity exercise group. Data obtained from mice endometrial thickness Results: mann-whitney  gave significant result at level p=0.006. Conclusion: high intensity exercise can effect the thickness of the endometrium.

scholarly journals Magnolin Protects against Contrast-Induced Nephropathy in Rats via Antioxidation and Antiapoptosis

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Feng Wang ◽  
Guangyuan Zhang ◽  
Yang Zhou ◽  
Dingkun Gui ◽  
Junhui Li ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Model ◽  
Vehicle Group ◽  
Control Group ◽  
Contrast Induced Nephropathy ◽  
Tubular Necrosis ◽  
Renal Tubular ◽  
Group Control Group

Background. Magnolin is the major active ingredient of the herbMagnolia fargesiiwhich has anti-inflammatory and antioxidative effects. Oxidative stress and apoptosis are involved in the pathogenesis of contrast-induced nephropathy (CIN). We hypothesize that Magnolin could protect against CIN through antioxidative and antiapoptotic properties.Methods. To test whether Magnolin could attenuate CIN, oxidative stress and apoptosis,in vivoandin vitro, we utilized a rat model of ioversol-induced CIN and a cell model of oxidative stress in which HK2 cells were treated with H2O2. Rats were assigned to 4 groups (n=6per group): control group, ioversol group (ioversol-induced CIN), vehicle group (CIN rats pretreated with vehicle), and Magnolin group (CIN rats pretreated with 1 mg/kg Magnolin).Results. The results showed that magnolin ameliorated the renal tubular necrosis, apoptosis, and the deterioration of renal function (P<0.05). Furthermore, Magnolin reduced the renal oxidative stress, suppressed caspase-3 activity, and increased Bcl-2 expressionin vivoandin vitro.Conclusion. Magnolin might protect CIN in rats through antioxidation and antiapoptosis.

Estrogen and Gender Effects on Muscle Damage, Inflammation, and Oxidative Stress

2000 ◽  
Vol 25 (4) ◽  
pp. 274-287 ◽  
Author(s):  
Peter M. Tiidus
Keyword(s):  
Oxidative Stress ◽  
Gender Differences ◽  
Creatine Kinase ◽  
Vitamin E ◽  
Vitamin C ◽  
Muscle Damage ◽  
Antioxidant Properties ◽  
Gender Effects ◽  
Gender Based

Information suggests that there may be gender-based differences in skeletal muscle responses to damaging exercise. Evidence demonstrates that estrogen has strong antioxidant properties and may be an important factor in maintaining postexercise membrane stability and limiting creatine kinase (CK) leakage from damaged muscle in female animals. Research demonstrates effects of estrogen and possible gender differences in other morphological and biochemical indices of postexercise muscle damage and leukocyte invasion. Nevertheless, there are conflicting findings suggesting that in some in vivo exercise models, estrogen administration has limited ability to affect exercise-induced oxidative stress and muscle damage and max cause loss of tissue vitamin C. Gender differences appear to exist in tissue levels of other important antioxidants such as vitamin E and glutathione. More research is needed to fully define the potential for estrogen to influence postexercise muscle damage and the inflammatory response and to determine the mechanisms by which it may operate. Key words: exercise, neutrophils, creatine kinase, vitamin E, vitamin C

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