scholarly journals Editorial of Special Issue “Surface-Functionalized Nanoparticles as Drug Carriers”

2019 ◽  
Vol 20 (24) ◽  
pp. 6352
Author(s):  
Buddhadev Layek ◽  
Jagdish Singh
Keyword(s):  
Drug Delivery ◽  
Clinical Trials ◽  
Biomedical Applications ◽  
Drug Carriers ◽  
Dosage Forms ◽  
Successful Therapy ◽  
Special Issue ◽  
Functionalized Nanoparticles ◽  
Therapeutic Benefits ◽  
Effective Delivery

Safe and effective delivery of therapeutics at the target site is the key to successful therapy. Nanocarriers can offer significant advantages over conventional dosage forms. Over the decades, nanoparticles have been extensively used to increase bioavailability, improve solubility and stability, reduce toxicities, and facilitate the controlled release of therapeutics. Further, nanoparticles have often been surface-functionalized with a variety of ligands to enhance circulation half-life and increase target-specificity. Although nanotechnology has shown significant therapeutic benefits for multiple biomedical applications, limited nanoparticle-based formulations have progressed to clinical trials, and only a few have reached the pharmaceutical market. This editorial is an introduction to the special issue entitled Surface-Functionalized Nanoparticles as Drug Carriers. We outline the scope of the special issue, summarize the results and conclusions of the nine articles published in this issue, and provide perspective on the application of surface-functionalized nanoparticles in the drug delivery field.

The Potential of Milk-derived Exosomes for Drug Delivery

2020 ◽  
Vol 17 ◽  
Author(s):  
Shuyuan Li ◽  
Yue Tang ◽  
Yushun Dou
Keyword(s):  
Drug Delivery ◽  
Oral Delivery ◽  
Therapeutic Potential ◽  
Current Knowledge ◽  
Biological Fluids ◽  
Drug Loading ◽  
Drug Carriers ◽  
Current Application ◽  
Therapeutic Benefits ◽  
Loading Methods

Background: Exosomes, one of the extracellular vesicles, are widely present in all biological fluids and play an important role in intercellular communication. Because of its hydrophobic lipid bilayer and aqueous hydrophilic core structure, it is considered a possible alternative to liposome drug delivery systems. Not only do they protect the cargo like liposomes during delivery, they are less toxic and better tolerated. However, due to the lack of sources and methods for obtaining enough exosomes, the therapeutic application of exosomes as drug carriers is limited. Methods: A literature search was performed using the ScienceDirect and PubMed electronic databases to obtain information from published literature on milk exosomes related to drug delivery. Results: Here, we briefly reviewed the current knowledge of exosomes, expounded the advantages of milk-derived exosomes over other delivery vectors, including a higher yield, the oral delivery characteristic and additional therapeutic benefits. The purification and drug loading methods of milk exosomes, and the current application of milk exosomes were also introduced. Conclusion: The emergence of milk-derived exosomes is expected to break through the limitations of exosomes as therapeutic carriers of drugs. We hope to raise awareness of the therapeutic potential of milk-derived exosomes as a new drug delivery system.

scholarly journals Transmucosal Absorption Enhancers in the Drug Delivery Field

Pharmaceutics ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 339 ◽  
Author(s):  
Maher ◽  
Casettari ◽  
Illum
Keyword(s):  
Drug Delivery ◽  
Clinical Trials ◽  
Drug Delivery Systems ◽  
Permeation Enhancer ◽  
Special Issue ◽  
Permeation Enhancers ◽  
Absorption Enhancers ◽  
Chemical Permeation Enhancers ◽  
Epithelial Barriers ◽  
Chemical Permeation

Drug delivery systems that safely and consistently improve transport of poorly absorbed compounds across epithelial barriers are highly sought within the drug delivery field. The use of chemical permeation enhancers is one of the simplest and widely tested approaches to improve transmucosal permeability via oral, nasal, buccal, ocular and pulmonary routes. To date, only a small number of permeation enhancers have progressed to clinical trials, and only one product that includes a permeation enhancer has reached the pharmaceutical market. This editorial is an introduction to the special issue entitled Transmucosal Absorption Enhancers in the Drug Delivery Field (https://www.mdpi.com/journal/pharmaceutics/special_issues/transmucosal_absorption_enhancers). The guest editors outline the scope of the issue, reflect on the results and the conclusions of the 19 articles published in the issue and provide an outlook on the use of permeation enhancers in the drug delivery field.

scholarly journals Membrane Technological Pathways and Inherent Structure of Bacterial Cellulose Composites for Drug Delivery

2021 ◽  
Vol 9 (1) ◽  
pp. 3
Author(s):  
Alfred Mensah ◽  
Yajun Chen ◽  
Narh Christopher ◽  
Qufu Wei
Keyword(s):  
Drug Delivery ◽  
Bacterial Cellulose ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Drug Carriers ◽  
Morphological Features ◽  
Cellulose Composites ◽  
Inherent Structure ◽  
Made In ◽  
Critical Aspects

This report summarizes efforts undertaken in the area of drug delivery, with a look at further efforts made in the area of bacterial cellulose (BC) biomedical applications in general. There are many current methodologies (past and present) for the creation of BC membrane composites custom-engineered with drug delivery functionality, with brief consideration for very close applications within the broader category of biomedicine. The most emphasis was placed on the crucial aspects that open the door to the possibility of drug delivery or the potential for use as drug carriers. Additionally, consideration has been given to laboratory explorations as well as already established BC-drug delivery systems (DDS) that are either on the market commercially or have been patented in anticipation of future commercialization. The cellulose producing strains, current synthesis and growth pathways, critical aspects and intrinsic morphological features of BC were given maximum consideration, among other crucial aspects of BC DDS.

scholarly journals Nanotechnology and Microtechnology in Drug Delivery Systems

Dose-Response ◽  
2020 ◽  
Vol 18 (2) ◽  
pp. 155932582090781 ◽  
Author(s):  
Jingyao Sun ◽  
Zhaogang Yang ◽  
Lesheng Teng
Keyword(s):  
Drug Delivery ◽  
Time Distribution ◽  
Drug Delivery Systems ◽  
Therapeutic Index ◽  
Controlled Drug Release ◽  
Drug Carriers ◽  
Delivery Systems ◽  
Polymer Materials ◽  
Special Issue ◽  
Targeting Delivery

A special issue of the journal Dose-Response entitled “Nanotechnology and Microtechnology in Drug Delivery Systems” is proposed. In pharmaceutical studies, new and existing drugs continue to be investigated for their poor specificity, solubility, therapeutic index, and immunogenicity. In order to solve these problems, drug delivery systems are essential for controlled drug release. It has been shown that the size and shape (nano- or micro-) of drug carriers can affect a drug’s circulation time, distribution, and cellular uptake. Hence, it is not surprising that nanotechnology and microtechnology have been explored as powerful tools for drug delivery in past decades. The main topics will be related to the technologies including microtechnology for the sustained release of drug, nanotechnology for the targeting delivery of drugs, new polymer materials nanotechnology, nanotechnology in drugs combination application, and so on.

scholarly journals A Critical Review of Standardization of Ayurvedic Dosage Form Kwatha - Part - II: Approaches and Outcome

2020 ◽  
Vol 11 (3) ◽  
pp. 378-386
Author(s):  
Narendra Bhatt ◽  
Manasi Deshpande ◽  
Sunetra Chaskar
Keyword(s):  
Drug Delivery ◽  
Conventional Medicine ◽  
Dosage Forms ◽  
Raw Material ◽  
New Techniques ◽  
Preparation Methods ◽  
Therapeutic Benefits ◽  
Nano Drug Delivery ◽  
Liquid Preparation ◽  
Manufacturing Technologies

A Kwatha, decoction, is one of the most used classical Ayurvedic dosage forms. It is a liquid preparation to be freshly consumed. For this preparation the raw material, mostly herbs or a group of herbs are extracted in water by boiling them for a specific time span. This is second part of the review paper on Ayurvedic Kwatha - herbal decoction to review and consider various approaches and their outcomes for the standardization. It provides information and reference data for the standardization of decoction across conventional methods and new techniques and explains how this classical process has evolved within new pharmaceutical developments. Many Ayurvedic production units appear to have adapted to newer manufacturing technologies including fermentation techniques. This paper explores the scope for application of newer technologies for the purpose of better standardization and novel product applications. Application of Kwatha's nano-drug delivery systems have a promising potential to enhance operation and resolve issues related to classical dosage forms. In order to tackle further chronic diseases, the incorporation of nano-carriers as NDDS in the conventional medicine system is necessary. This review examines the benefits of the nano-drug delivery system, its properties, its drawbacks, forms of nanoparticles, their preparation methods, and various herbal nano medicines. This review further explores how therapeutic benefits can be improved by reducing toxicity and increasing bioavailability.

Pegylated Drug Delivery Systems: From Design to Biomedical Applications

Nano LIFE ◽  
2016 ◽  
Vol 06 (03n04) ◽  
pp. 1642002 ◽  
Author(s):  
Fei Liu ◽  
Yuan Sun ◽  
Chen Kang ◽  
Hongyan Zhu
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Simple Procedure ◽  
Drug Carriers ◽  
Delivery Systems ◽  
Circulation Time ◽  
In Vivo Studies

Pegylation, as a simple procedure to attach hydrophilic polyethylene glycol (PEG) onto therapeutic molecule or drug carriers has been utilized widely to deliver small molecules, proteins and peptides. It was first reported in 1970s by Dr. Frank Davis of Rutgers University and Dr. Abuchowsky in the studies of PEG modified albumin and catalase. The significance of this method at that time was able to successfully modify the enzyme with better hydrophilicity but also keep the enzymatic activity. The employment of PEG has provided superior stability of drug delivery systems (DDS) and enhanced the circulation time in vivo. Simple conjugation of PEG chains with various molecular weights enables the possibility to regulate the properties of desired DDS and led to important contribution in targeting therapy and diagnosis. Pegylation has been reported to be able to protect peptides by shielding antigenic epitopes from reticuloendothelial (RES) clearance and avoid enzymes being recognized by immune system and avoid early degradation. In addition, utilization of PEG in DDS are reported with enhanced delivery efficiency, prolonged circulation time and improved stability, especially active enzymes and peptides drug delivery. In this paper, we will conclude current studies about Pegylated DDS and their biomedical applications from both in vitro and in vivo studies.

scholarly journals Special Issue: Biopolymers in Drug Delivery and Regenerative Medicine

Molecules ◽  
2021 ◽  
Vol 26 (3) ◽  
pp. 568
Author(s):  
Ricardo Starbird-Perez ◽  
Pasquale Del Gaudio ◽  
Carlos A. García-González
Keyword(s):  
Drug Delivery ◽  
Regenerative Medicine ◽  
Biomedical Applications ◽  
Special Issue ◽  
Novel Materials

Biopolymers and biocomposites have emerged as promising pathways to develop novel materials and substrates for biomedical applications [...]

scholarly journals MIL-53 (Al) metal-organic frameworks as potential drug carriers

2021 ◽  
Vol 2058 (1) ◽  
pp. 012015
Author(s):  
O Yu Griaznova ◽  
I V Zelepukin ◽  
G V Tikhonowski ◽  
V N Kolokolnikov ◽  
S M Deyev
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Drug Loading ◽  
High Surface ◽  
Metal Organic Frameworks ◽  
High Surface Area ◽  
Drug Carriers ◽  
Microwave Assisted Synthesis ◽  
Promising Candidate ◽  
Metal Organic

Abstract One of the challenges of the medicine is to improve the chemical stability of drugs and to prevent their premature biodegradation before reaching the therapeutic target. Various nanoparticles were used to solve this problem, but low drug loading efficiency limited their biomedical applications. Metal organic frameworks are promising candidates for drug delivery since they have extremely high surface area and regular porosity. In this study, we prepared high-crystalline MIL-53 frameworks based on aluminium and 2-aminoterephtalic acid by microwave-assisted synthesis and evaluated their properties as drug carriers. Drug loading of chemotherapeutic and diagnostic molecules of different nature riches value of 34% by particle weight, significantly higher than those of other reported solid nanoparticles. Therefore, our results make MIL-53 (Al) frameworks promising candidate for drug delivery.

scholarly journals Integration of Mesoporous Bioactive Glass Nanoparticles and Curcumin into PHBV Microspheres as Biocompatible Composite for Drug Delivery Applications

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3177
Author(s):  
Arturo E. Aguilar-Rabiela ◽  
Aldo Leal-Egaña ◽  
Qaisar Nawaz ◽  
Aldo R. Boccaccini
Keyword(s):  
Drug Delivery ◽  
Bioactive Glass ◽  
Biomedical Applications ◽  
Drug Carriers ◽  
Bioactive Glasses ◽  
Composite Microspheres ◽  
Convenient Approach ◽  
Model Drug ◽  
Mesoporous Bioactive Glass

Bioactive glasses (BGs) are being increasingly considered for biomedical applications. One convenient approach to utilize BGs in tissue engineering and drug delivery involves their combination with organic biomaterials in order to form composites with enhanced biocompatibility and biodegradability. In this work, mesoporous bioactive glass nanoparticles (MBGN) have been merged with polyhydroxyalkanoate microspheres with the purpose to develop drug carriers. The composite carriers (microspheres) were loaded with curcumin as a model drug. The toxicity and delivery rate of composite microspheres were tested in vitro, reaching a curcumin loading efficiency of over 90% and an improving of biocompatibility of different concentrations of MBGN due to its administrations through the composite. The composite microspheres were tested in terms of controlled release, biocompatibility and bioactivity. Our results demonstrate that the composite microspheres can be potentially used in biomedicine due to their dual effects: bioactivity (due to the presence of MBGN) and curcumin release capability.

scholarly journals Polyethylene Glycol Coated Magnetic Nanoparticles: Hybrid Nanofluid Formulation, Properties and Drug Delivery Prospects

Nanomaterials ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 440
Author(s):  
Rashmi Mannu ◽  
Vaithinathan Karthikeyan ◽  
Nandakumar Velu ◽  
Chandravadhana Arumugam ◽  
Vellaisamy A. L. Roy ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Polyethylene Glycol ◽  
Magnetic Nanoparticles ◽  
Drug Release ◽  
Biomedical Applications ◽  
Drug Loading ◽  
Drug Carriers ◽  
Zero Order ◽  
Fickian Diffusion ◽  
Hybrid Nanofluid

Magnetic nanoparticles (MNPs) are widely used materials for biomedical applications owing to their intriguing chemical, biological and magnetic properties. The evolution of MNP based biomedical applications (such as hyperthermia treatment and drug delivery) could be advanced using magnetic nanofluids (MNFs) designed with a biocompatible surface coating strategy. This study presents the first report on the drug loading/release capability of MNF formulated with methoxy polyethylene glycol (referred to as PEG) coated MNP in aqueous (phosphate buffer) fluid. We have selected MNPs (NiFe2O4, CoFe2O4 and Fe3O4) coated with PEG for MNF formulation and evaluated the loading/release efficacy of doxorubicin (DOX), an anticancer drug. We have presented in detail the drug loading capacity and the time-dependent cumulative drug release of DOX from PEG-coated MNPs based MNFs. Specifically, we have selected three different MNPs (NiFe2O4, CoFe2O4 and Fe3O4) coated with PEG for the MNFs and compared their variance in the loading/release efficacy of DOX, through experimental results fitting into mathematical models. DOX loading takes the order in the MNFs as CoFe2O4 > NiFe2O4 > Fe3O4. Various drug release models were suggested and evaluated for the individual MNP based NFs. While the non-Fickian diffusion (anomalous) model fits for DOX release from PEG coated CoFe2O4, PEG coated NiFe2O4 NF follows zero-order kinetics with a slow drug release rate of 1.33% of DOX per minute. On the other hand, PEG coated NiFe2O4 follows zero-order DOX release. Besides, several thermophysical properties and magnetic susceptibility of the MNFs of different concentrations have been studied by dispersing the MNPs (NiFe2O4, CoFe2O4 and Fe3O4) in the base fluid at 300 K under ultrasonication. This report on the DOX loading/release capability of MNF will set a new paradigm in view that MNF can resolve problems related to the self-heating of drug carriers during mild laser treatment with its thermal conducting properties.

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