scholarly journals A Critical Review of Standardization of Ayurvedic Dosage Form Kwatha - Part - II: Approaches and Outcome

2020 ◽  
Vol 11 (3) ◽  
pp. 378-386
Author(s):  
Narendra Bhatt ◽  
Manasi Deshpande ◽  
Sunetra Chaskar
Keyword(s):  
Drug Delivery ◽  
Conventional Medicine ◽  
Dosage Forms ◽  
Raw Material ◽  
New Techniques ◽  
Preparation Methods ◽  
Therapeutic Benefits ◽  
Nano Drug Delivery ◽  
Liquid Preparation ◽  
Manufacturing Technologies

A Kwatha, decoction, is one of the most used classical Ayurvedic dosage forms. It is a liquid preparation to be freshly consumed. For this preparation the raw material, mostly herbs or a group of herbs are extracted in water by boiling them for a specific time span. This is second part of the review paper on Ayurvedic Kwatha - herbal decoction to review and consider various approaches and their outcomes for the standardization. It provides information and reference data for the standardization of decoction across conventional methods and new techniques and explains how this classical process has evolved within new pharmaceutical developments. Many Ayurvedic production units appear to have adapted to newer manufacturing technologies including fermentation techniques. This paper explores the scope for application of newer technologies for the purpose of better standardization and novel product applications. Application of Kwatha's nano-drug delivery systems have a promising potential to enhance operation and resolve issues related to classical dosage forms. In order to tackle further chronic diseases, the incorporation of nano-carriers as NDDS in the conventional medicine system is necessary. This review examines the benefits of the nano-drug delivery system, its properties, its drawbacks, forms of nanoparticles, their preparation methods, and various herbal nano medicines. This review further explores how therapeutic benefits can be improved by reducing toxicity and increasing bioavailability.

scholarly journals Methodologies to Isolate and Purify Clinical Grade Extracellular Vesicles for Medical Applications

Cells ◽  
2022 ◽  
Vol 11 (2) ◽  
pp. 186
Author(s):  
Asma Akbar ◽  
Farzaneh Malekian ◽  
Neda Baghban ◽  
Sai Priyanka Kodam ◽  
Mujib Ullah
Keyword(s):  
Drug Delivery ◽  
Extracellular Vesicles ◽  
Medical Applications ◽  
Clinical Use ◽  
Clinical Grade ◽  
Isolation And Purification ◽  
The Past ◽  
Therapeutic Benefits ◽  
Nano Drug Delivery ◽  
Purification Methods

The use of extracellular vesicles (EV) in nano drug delivery has been demonstrated in many previous studies. In this study, we discuss the sources of extracellular vesicles, including plant, salivary and urinary sources which are easily available but less sought after compared with blood and tissue. Extensive research in the past decade has established that the breadth of EV applications is wide. However, the efforts on standardizing the isolation and purification methods have not brought us to a point that can match the potential of extracellular vesicles for clinical use. The standardization can open doors for many researchers and clinicians alike to experiment with the proposed clinical uses with lesser concerns regarding untraceable side effects. It can make it easier to identify the mechanism of therapeutic benefits and to track the mechanism of any unforeseen effects observed.

scholarly journals A REVIEW ON PHARMACEUTICAL MINI TABLETS: NEW MODALITY TO ORAL DRUG DELIVERY

2020 ◽  
pp. 8-12
Author(s):  
NAVEEN TAJ S
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Oral Drug Delivery ◽  
Dosage Forms ◽  
Oral Dosage ◽  
Oral Drug ◽  
Solid Dosage ◽  
Therapeutic Benefits ◽  
Solid Oral Dosage Form

The purpose of any selected drug delivery system (DDS) is to deliver drug to target site and to get the desired drug concentration for effective therapy. The main purpose of designing controlled or sustained DDS is to decrease the frequency of dosing and maximizing its efficiency by confining the area of action of the drug to a selected region. It is well-identified that solid oral dosage form, particularly tablets, is the most satisfactory form of delivering medication. In addition, some new variations are emerging such as mini tabs which offer more formulation flexibility. Oral controlled release DDS are classified into two categories like single unit dosage forms which include tablets, capsules, and multiple-unit dosage forms include pellets, granules, or mini tablets. Mini tablets are a new development in solid dosage forms and more beneficial and great substitute for granules and pellets. Mini tablets defined as tablets which are having diameter <3 mm and promising patient friendly drug delivery system and more acceptable in small children’s and old age people as they are easy to swallow and offer therapeutic benefits such as manufactured relatively easy, dose and formulation flexibility, combination release pattern, coating, and less solvent requirement. Dose dumping and local irritation can be avoided using mini tablets. This review highlights the various advantages of mini tablets, manufacturing processes, formulation possibilities, and their challenges.

scholarly journals Editorial of Special Issue “Surface-Functionalized Nanoparticles as Drug Carriers”

2019 ◽  
Vol 20 (24) ◽  
pp. 6352
Author(s):  
Buddhadev Layek ◽  
Jagdish Singh
Keyword(s):  
Drug Delivery ◽  
Clinical Trials ◽  
Biomedical Applications ◽  
Drug Carriers ◽  
Dosage Forms ◽  
Successful Therapy ◽  
Special Issue ◽  
Functionalized Nanoparticles ◽  
Therapeutic Benefits ◽  
Effective Delivery

Safe and effective delivery of therapeutics at the target site is the key to successful therapy. Nanocarriers can offer significant advantages over conventional dosage forms. Over the decades, nanoparticles have been extensively used to increase bioavailability, improve solubility and stability, reduce toxicities, and facilitate the controlled release of therapeutics. Further, nanoparticles have often been surface-functionalized with a variety of ligands to enhance circulation half-life and increase target-specificity. Although nanotechnology has shown significant therapeutic benefits for multiple biomedical applications, limited nanoparticle-based formulations have progressed to clinical trials, and only a few have reached the pharmaceutical market. This editorial is an introduction to the special issue entitled Surface-Functionalized Nanoparticles as Drug Carriers. We outline the scope of the special issue, summarize the results and conclusions of the nine articles published in this issue, and provide perspective on the application of surface-functionalized nanoparticles in the drug delivery field.

A Review on Emerging Floating Drug Delivery System

2016 ◽  
Vol 6 (4) ◽  
Author(s):  
Christe Mary M ◽  
Sasikumar Swamiappan
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Stomach Contents ◽  
Gastric Fluid ◽  
Dosage Forms ◽  
Gastric Residence Time ◽  
Advantages And Disadvantages ◽  
Floating Drug Delivery ◽  
Floating Drug Delivery System

Presently, various approaches have been exploited in the prolongation of gastric residence time which includes floating drug delivery system (FDDS), swelling and expanding systems, bio-adhesive systems, modified shape systems and high density systems. Among various methods, floating drug delivery system is considered to be a predominant method. Gastric emptying of dosage forms is an extremely varying process and ability to extend and control the emptying time is a valuable resource for the dosage forms. This FDDS is having the ability to provides a solution for this purpose. The FDDS is a bulk density system lower than the gastric fluid, so that the rest will float on the stomach contents for a prolonged period of time and allowing the drug to release slowly at a desired rate from the system and intensifies the bio-availability of the drug having narrow absorption window. The main intension of writing this review on floating drug delivery system is to study the mechanism of flotation to acheive the gastric retention and to discuss briefly about the background of FDDS, advantages and disadvantages, application of FDDS and factors affecting the gastric retension time.

A Review on Fast Dissolving Tablet

2017 ◽  
Vol 8 (03) ◽  
Author(s):  
Sagar T. Malsane ◽  
Smita S. Aher ◽  
R. B. Saudagar
Keyword(s):  
Drug Delivery ◽  
Patient Compliance ◽  
Research Area ◽  
Oral Route ◽  
Dosage Forms ◽  
The Novel ◽  
The Past ◽  
Orally Disintegrating Tablets ◽  
Novel Drug ◽  
Experience Difficulty

Oral route is presently the gold standard in the pharmaceutical industry where it is regarded as the safest, most economical and most convenient method of drug delivery resulting in highest patient compliance. Over the past three decades, orally disintegrating tablets (FDTs) have gained considerable attention due to patient compliance. Usually, elderly people experience difficulty in swallowing the conventional dosage forms like tablets, capsules, solutions and suspensions because of tremors of extremities and dysphagia. In some cases such as motion sickness, sudden episodes of allergic attack or coughing, and an unavailability of water, swallowing conventional tablets may be difficult. One such problem can be solved in the novel drug delivery system by formulating “Fast dissolving tablets” (FDTs) which disintegrates or dissolves rapidly without water within few seconds in the mouth due to the action of superdisintegrant or maximizing pore structure in the formulation. The review describes the various formulation aspects, superdisintegrants employed and technologies developed for FDTs, along with various excipients, evaluation tests, marketed formulation and drugs used in this research area.

Recent Advances of Mesoporous Silica Based Multifunctional Nano Drug Delivery Systems

2013 ◽  
Vol 40 (10) ◽  
pp. 1014
Author(s):  
Xiao-Hong HAO ◽  
Cui-Miao ZHANG ◽  
Xiao-Long LIU ◽  
Xing-Jie LIANG ◽  
Guang JIA ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Recent Advances ◽  
Nano Drug Delivery

Hydrogels: A Versatile Drug Delivery Carrier Systems

1970 ◽  
Vol 5 (3) ◽  
pp. 1745-1756
Author(s):  
L H Baldaniya ◽  
Sarkhejiya N A
Keyword(s):  
Drug Delivery ◽  
Protein Delivery ◽  
Structural Integrity ◽  
Healing Process ◽  
Polymer Chains ◽  
Wound Healing Process ◽  
Aqueous Environment ◽  
Preparation Methods ◽  
Control Drug

Hydrogels are the material of choice for many applications in regenerative medicine due to their unique properties including biocompatibility, flexible methods of synthesis, range of constituents, and desirable physical characteristics. Hydrogel (also called Aquagel) is a network of polymer chains that are hydrophilic, sometimes found as a colloidal gel in which water is the dispersion medium. Hydrogels are highly absorbent (contain ~99.9% water), natural or synthetic polymers. Hydrogel also possess a degree of flexibility very similar to natural tissue, due to its significant water content. It can serve as scaffolds that provide structural integrity to tissue constructs, control drug and protein delivery to tissues and cultures. Also serve as adhesives or barriers between tissue and material surfaces. The positive effect of hydrogels on wounds and enhanced wound healing process has been proven. Hydrogels provide a warm, moist environment for wound that makes it heal faster in addition to its useful mucoadhesive properties. Moreover, hydrogels can be used as carriers for liposomes containing variety of drugs, such as antimicrobial drugs. Hydrogels are water swollen polymer matrices, with a tendency to imbibe water when placed in aqueous environment. This ability to swell, under biological conditions, makes it an ideal material for use in drug delivery and immobilization of proteins, peptides, and other biological compounds. Hydrogels have been extensively investigated for use as constructs to engineer tissues in vitro. This review describes the properties, classification, preparation methods, applications, various monomer used in formulation and development of hydrogel products.

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