Targeted Delivery of Drugs and Genes Using Polymer Nanocarriers for Cancer Therapy

Cancer is one of the primary causes of worldwide human deaths. Most cancer patients receive chemotherapy and radiotherapy, but these treatments are usually only partially efficacious and lead to a variety of serious side effects. Therefore, it is necessary to develop new therapeutic strategies. The emergence of nanotechnology has had a profound impact on general clinical treatment. The application of nanotechnology has facilitated the development of nano-drug delivery systems (NDDSs) that are highly tumor selective and allow for the slow release of active anticancer drugs. In recent years, vehicles such as liposomes, dendrimers and polymer nanomaterials have been considered promising carriers for tumor-specific drug delivery, reducing toxicity and improving biocompatibility. Among them, polymer nanoparticles (NPs) are one of the most innovative methods of non-invasive drug delivery. Here, we review the application of polymer NPs in drug delivery, gene therapy, and early diagnostics for cancer therapy.

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The Smart Dual-Stimuli Responsive Nanoparticles for Controlled AntiTumor Drug Release and Cancer Therapy

Anti-Cancer Agents in Medicinal Chemistry ◽

10.2174/1871520620666200924110418 ◽

2020 ◽

Vol 20 ◽

Author(s):

Feng Wu ◽

Fei Qiu ◽

Siew Anthony Wai-Keong ◽

Yong Diao

Keyword(s):

Drug Delivery ◽

Cancer Therapy ◽

Drug Release ◽

Targeted Delivery ◽

Relevant Information ◽

Therapeutic Effects ◽

Stimuli Responsive ◽

Control Effect ◽

Chemotherapy Drugs ◽

Excellent Control

Background: In recent years, the emergence of stimuli-responsive nanoparticles makes drug delivery more efficient. As an intelligent and effective targeted delivery platform, it can reduce the side effects generated during drug transportation while enhancing the treatment efficacy. The stimuli-responsive nanoparticles can respond to different stimuli at corresponding times and locations to deliver and release their drugs and associated therapeutic effects. Objective: This review aims to inform researchers on the latest advances in the application of dual-stimuli responsive nanoparticles in precise drug delivery, with special attention to their design, drug release properties, and therapeutic effects. Syntheses of nanoparticles with simultaneous or sequential responses to two or more stimuli (pH-redox, pH-light, redoxlight, temperature-magnetic, pH-redox-temperature, redox-enzyme-light, etc.) and the applications of such responsivity properties for drugs control and release have become a hot topic of recent research. Methods: A database of relevant information for the production of this review was sourced, screened and analyzed from Pubmed, Web of Science, SciFinder by searching for the following keywords: “dual-stimuli responsive”, “controlled release”, “cancer therapy”, “synergistic treatment”. Results: Notably, the nanoparticles with dual-stimuli responsive function have an excellent control effect on drug delivery and release, playing a crucial part in the treatment of tumors. They can improve the encapsulation and delivery efficiency of hydrophobic chemotherapy drugs, combine chemo-photothermal therapies, apply imaging function in the diagnosis of tumors and even conduct multi-drugs delivery to overcome multi-drugs resistance (MDR). Conclusion: With the development of smart dual-stimuli responsive nanoparticles, cancer treatment methods will become more diverse and effective. All the stimuli-responsive nanoparticles functionalities exhibited their characteristics individually within the single nanosystem.

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Stimuli-Responsive Nano-Drug Delivery Systems for Cancer Therapy

Nanotechnology in the Life Sciences - Green Nanoparticles ◽

10.1007/978-3-030-39246-8_6 ◽

2020 ◽

pp. 151-162

Author(s):

Sauraj ◽

Anuj Kumar ◽

Bijender Kumar ◽

Ruchir Priyadarshi ◽

Chhavi Sharma ◽

...

Keyword(s):

Drug Delivery ◽

Cancer Therapy ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Stimuli Responsive ◽

Nano Drug Delivery

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Active targeting of nanoparticles: An innovative technology for drug delivery in cancer therapeutics

Journal of Drug Delivery and Therapeutics ◽

10.22270/jddt.v9i1-s.2356 ◽

2019 ◽

Vol 9 (1-s) ◽

pp. 408-415 ◽

Cited By ~ 1

Author(s):

Rupalben Kaushalkumar Jani ◽

Gohil Krupa

Keyword(s):

Drug Delivery ◽

Cell Proliferation ◽

Cancer Therapy ◽

Targeted Delivery ◽

Cancer Therapeutics ◽

Active Targeting ◽

Innovative Technology ◽

Cross Linking ◽

Uncontrolled Cell Proliferation ◽

Insight Into

In nanomedicines, currently a wide array of reported nanoparticle systems is being explored by targeting schemes which suggests great potential of targeted delivery to revolutionize cancer therapeutics. This review gives insight into recent challenges in modification of nanoparticle systems for enhanced cancer therapy acknowledged by researchers to date and also outlines different major targeting strategies of nanoparticle systems that have been utilized for the delivery of therapeutics or imaging agents, targeting ligand and cross-linking agent to cancer which was divided into three sections: 1) Angiogenesis associated targeting, 2) Uncontrolled cell proliferation targeting and 3) Tumor cell targeting. Keywords: nanoparticles, tumor cells, active targeting, targeting strategies, targeting ligands

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Multiplexed Non-invasive in vivo Imaging to Assess Metabolism and Receptor Engagement in Tumor Xenografts

10.1101/758383 ◽

2019 ◽

Author(s):

Alena Rudkouskaya ◽

Nattawut Sinsuebphon ◽

Marien Ochoa ◽

Joe E. Mazurkiewicz ◽

Xavier Intes ◽

...

Keyword(s):

Drug Delivery ◽

Targeted Delivery ◽

Near Infrared ◽

Metabolic Response ◽

Imaging Modalities ◽

Wide Field ◽

Receptor Ligand ◽

Non Invasive ◽

Intracellular Drug Delivery

AbstractFollowing an ever-increased focus on personalized medicine, there is a continuing need to develop preclinical molecular imaging modalities to guide the development and optimization of targeted therapies. To date, non-invasive quantitative imaging modalities that can comprehensively assess simultaneous cellular drug delivery efficacy and therapeutic response are lacking. In this regard, Near-Infrared (NIR) Macroscopic Fluorescence Lifetime Förster Resonance Energy Transfer (MFLI-FRET) imaging offers a unique method to robustly quantify receptor-ligand engagement in vivo and subsequent intracellular internalization, which is critical to assess the delivery efficacy of targeted therapeutics. However, implementation of multiplexing optical imaging with FRET in vivo is challenging to achieve due to spectral crowding and cross-contamination. Herein, we report on a strategy that relies on a dark quencher that enables simultaneous assessment of receptor-ligand engagement and tumor metabolism in intact live mice. First, we establish that IRDye QC-1 (QC-1) is an effective NIR dark acceptor for the FRET-induced quenching of donor Alexa Fluor 700 (AF700) using in vitro NIR FLI microscopy and in vivo wide-field MFLI imaging. Second, we report on simultaneous in vivo imaging of the metabolic probe IRDye 800CW 2-deoxyglucose (2-DG) and MFLI-FRET imaging of NIR-labeled transferrin FRET pair (Tf-AF700/Tf-QC-1) uptake in tumors. Such multiplexed imaging revealed an inverse relationship between 2-DG uptake and Tf intracellular delivery, suggesting that 2-DG signal may predict the efficacy of intracellular targeted delivery. Overall, our methodology enables for the first time simultaneous non-invasive monitoring of intracellular drug delivery and metabolic response in preclinical studies.

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Surface functionalisation of poly-APO-b-polyol ester cross-linked copolymers as core–shell nanoparticles for targeted breast cancer therapy

Scientific Reports ◽

10.1038/s41598-020-78601-x ◽

2020 ◽

Vol 10 (1) ◽

Author(s):

Rida Tajau ◽

Rosiah Rohani ◽

Siti Selina Abdul Hamid ◽

Zainah Adam ◽

Siti Najila Mohd Janib ◽

...

Keyword(s):

Breast Cancer ◽

Drug Delivery ◽

Cancer Therapy ◽

Targeted Delivery ◽

Particle Diameter ◽

Core Shell ◽

Breast Cancer Therapy ◽

Polyol Ester ◽

Apo B ◽

Chemical Structures

AbstractPolymeric nanoparticles (NPs) are commonly used as nanocarriers for drug delivery, whereby their sizes can be altered for a more efficient delivery of therapeutic active agents with better efficacy. In this work, cross-linked copolymers acted as core–shell NPs from acrylated palm olein (APO) with polyol ester were synthesized via gamma radiation-induced reversible addition-fragmentation chain transfer (RAFT) polymerisation. The particle diameter of the copolymerised poly(APO-b-polyol ester) core–shell NPs was found to be less than 300 nm, have a low molecular weight (MW) of around 24 kDa, and showed a controlled MW distribution of a narrow polydispersity index (PDI) of 1.01. These properties were particularly crucial for further use in designing targeted NPs, with inclusion of peptide for the targeted delivery of paclitaxel. Moreover, the characterisation of the synthesised NPs using Fourier Transform-Infrared (FTIR) and Neutron Magnetic Resonance (NMR) analyses confirmed the possession of biodegradable hydrolysed ester in its chemical structures. Therefore, it can be concluded that the synthesised NPs produced may potentially contribute to better development of a nano-structured drug delivery system for breast cancer therapy.

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Therapeutic strategies and nano-drug delivery applications in management of ageing Alzheimer’s disease

Drug Delivery ◽

10.1080/10717544.2018.1428243 ◽

2018 ◽

Vol 25 (1) ◽

pp. 307-320 ◽

Cited By ~ 52

Author(s):

Govindarajan Karthivashan ◽

Palanivel Ganesan ◽

Shin-Young Park ◽

Joon-Soo Kim ◽

Dong-Kug Choi

Keyword(s):

Alzheimer’S Disease ◽

Drug Delivery ◽

Alzheimer's Disease ◽

Therapeutic Strategies ◽

Nano Drug Delivery ◽

Drug Delivery Applications

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A mitochondria-targeted delivery system of doxorubicin and evodiamine for the treatment of metastatic breast cancer

RSC Advances ◽

10.1039/c9ra07096f ◽

2019 ◽

Vol 9 (63) ◽

pp. 37067-37078

Author(s):

Xiaoyan Tan ◽

Yanlin Zhou ◽

Li Shen ◽

Han Jia ◽

Xiaorong Tan

Keyword(s):

Breast Cancer ◽

Drug Delivery ◽

Metastatic Breast Cancer ◽

Therapeutic Effect ◽

Delivery System ◽

Targeted Delivery ◽

Drug Delivery Systems ◽

Metastatic Breast ◽

Nano Drug Delivery ◽

Targeted Delivery System

For mitochondria-targeted nano-drug delivery systems against cancer, effectively targeting and releasing the drug into mitochondria are the keys to improve the therapeutic effect.

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