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PEDIATRICS ◽  
1979 ◽  
Vol 64 (1) ◽  
pp. 125-125
Author(s):  
Miles Weinberger
Keyword(s):  
State Of The Art ◽  
Review Article ◽  
Current State ◽  
Children With Asthma ◽  
Degree Of Control ◽  
Considerable Morbidity ◽  
High Degree ◽  
Changing Role ◽  
Excellent Review Article

The excellent review article by Leffert1 and the accompanying commentary by Bergner2 made important points regarding the changing role of the pediatric allergist and the broad requirements for knowledge of any physicians who are to provide specialty care for children with asthma. While the current state of the art allows a high degree of control for this disease,3 considerable morbidity from inadequately treated asthma persists. This situation is unlikely to change rapidly unless departments of pediatrics place a high priority on ensuring that the modern allergist described by Dr. Bergner is on their faculty to teach the current housestaff and provide continuing education for the practitioner; only then will most general pediatricians be able to assume the role envisioned by Dr. Leffert.

The blurring border between the police and the military

2011 ◽  
Vol 46 (3) ◽  
pp. 396-405 ◽  
Author(s):  
Tomáš Weiss
Keyword(s):  
Case Studies ◽  
State Of The Art ◽  
Review Article ◽  
Current Debate ◽  
Current State ◽  
Art And Literature ◽  
The Military ◽  
Conceptual Underpinning ◽  
Future Case

This review article reviews the current ‘state of the art’ and literature on the role of the police and military within the changing nature of internal and external security. Some scholars believe that the border between these two forces has recently begun to blur, whereas others strongly disagree. This article argues that the current debate lacks comprehensiveness and conceptual underpinning. It is suggested that definitional differences between the two forces should serve as the basis for detailed and comprehensive future case studies.

scholarly journals Geomorphometry: Today and Tomorrow

2018 ◽  
Author(s):  
John P Wilson
Keyword(s):  
Content Knowledge ◽  
State Of The Art ◽  
High Fidelity ◽  
Terrain Modeling ◽  
Actionable Knowledge ◽  
Digital Terrain ◽  
Current State ◽  
Digital Terrain Modeling ◽  
Key Innovations

This paper summarizes the current state-of-the-art in geomorphometry and describes the innovations that are close at hand and will be required to push digital terrain modeling forward in the future. These innovations will draw on concepts and methods from computer science and the spatial sciences and require greater collaboration to produce “actionable” knowledge and outcomes. The key innovations include rediscovering and using what we already know, developing new digital terrain modeling methods, clarifying and strengthening the role of theory, developing high-fidelity DEMs, developing and embracing new visualization methods, adopting new computational approaches, and making better use of provenance, credibility, and application-content knowledge.

Modular Prosthetic Design for Transtibial Child Amputees

2017 ◽  
Author(s):  
Brendan M. Hickey ◽  
Samuel T. Woo ◽  
Sally F. Shady
Keyword(s):  
Quality Of Life ◽  
Health Care ◽  
Lower Limb ◽  
State Of The Art ◽  
Insurance Coverage ◽  
Review Article ◽  
Prosthetic Design ◽  
Current State ◽  
Limb Deficiencies

Lower limb deficiencies and below knee amputations are the most common form of deficiency that may arise from disease or trauma, and returning a patient close to a normal quality-of-life requires prosthetics, which can be quite challenging. Children present even further difficulty to prosthetists and physicians than adults. Although the underlying prosthetic principles for adults are the same for children, additional considerations must be made for practicality, such as downsizing while maintaining its degree of complexity, and frequent appointments to account for the rapid growth of an adolescent. This review article will evaluate the current state-of-the-art in the field of transtibial-amputee prosthetics, review the insurance coverage a typical family would face, and suggest potential improvements to children’s biomimetic prostheses that aid in reducing the frequency of health care provider intervention.

scholarly journals Biomechanical behaviours of the bone–implant interface: a review

2019 ◽  
Vol 16 (156) ◽  
pp. 20190259 ◽  
Author(s):  
Xing Gao ◽  
Manon Fraulob ◽  
Guillaume Haïat
Keyword(s):  
Bone Tissue ◽  
Medical Devices ◽  
State Of The Art ◽  
Biomechanical Properties ◽  
Review Article ◽  
Implant Stability ◽  
Bone Implant ◽  
Current State ◽  
Mechanical Methods

In recent decades, cementless implants have been widely used in clinical practice to replace missing organs, to replace damaged or missing bone tissue or to restore joint functionality. However, there remain risks of failure which may have dramatic consequences. The success of an implant depends on its stability, which is determined by the biomechanical properties of the bone–implant interface (BII). The aim of this review article is to provide more insight on the current state of the art concerning the evolution of the biomechanical properties of the BII as a function of the implant's environment. The main characteristics of the BII and the determinants of implant stability are first introduced. Then, the different mechanical methods that have been employed to derive the macroscopic properties of the BII will be described. The experimental multi-modality approaches used to determine the microscopic biomechanical properties of periprosthetic newly formed bone tissue are also reviewed. Eventually, the influence of the implant's properties, in terms of both surface properties and biomaterials, is investigated. A better understanding of the phenomena occurring at the BII will lead to (i) medical devices that help surgeons to determine an implant's stability and (ii) an improvement in the quality of implants.

The growing role of structural mass spectrometry in the discovery and development of therapeutic antibodies

The Analyst ◽  
2018 ◽  
Vol 143 (11) ◽  
pp. 2459-2468 ◽  
Author(s):  
Yuwei Tian ◽  
Brandon T. Ruotolo
Keyword(s):  
Mass Spectrometry ◽  
State Of The Art ◽  
Therapeutic Antibodies ◽  
Critical Importance ◽  
Current State ◽  
Measurement Science ◽  
Structural Mass Spectrometry ◽  
Structural Mass

The comprehensive structural characterization of therapeutic antibodies is of critical importance for the successful discovery and development of such biopharmaceuticals, yet poses many challenges to modern measurement science. Here, we review the current state-of-the-art mass spectrometry technologies focusing on the characterization of antibody-based therapeutics.

scholarly journals Introduction to the Audiological Evaluation: Case-Based Applications to Patients with Skull Base Disease

2019 ◽  
Vol 80 (02) ◽  
pp. 111-119 ◽  
Author(s):  
Kelsey Dumanch ◽  
Gayla Poling
Keyword(s):  
Differential Diagnosis ◽  
Skull Base ◽  
Auditory Pathway ◽  
Review Article ◽  
Interdisciplinary Teams ◽  
Auditory Information ◽  
Current State ◽  
Lateral Skull Base ◽  
Case Based

Objectives To provide an introduction to the role of audiological evaluations with special reference to patients with skull base disease. Design Review article with case-based overview of the current state of the practice of diagnostic audiology through highlighting the multifaceted clinical toolbox and the value of mechanism-based audiological evaluations that contribute to otologic differential diagnosis. Setting Current state of the practice of diagnostic audiology. Main Outcome Measures Understanding of audiological evaluation results in clinical practice and value of contributions to interdisciplinary teams to identify and quantify dysfunction along the auditory pathway and its subsequent effects. Results Accurate auditory information is best captured with a test battery that consists of various assessment crosschecks and mechanism-driven assessments. Conclusion Audiologists utilize a comprehensive clinical toolbox to gather information for assessment, diagnosis, and management of numerous pathologies. This information, in conjunction with thorough medical review, provides mechanism-specific contributions to the otologic and lateral skull base differential diagnosis.

scholarly journals Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles

2011 ◽  
Vol 68 (16) ◽  
pp. 2667-2688 ◽  
Author(s):  
Bence György ◽  
Tamás G. Szabó ◽  
Mária Pásztói ◽  
Zsuzsanna Pál ◽  
Petra Misják ◽  
...  
Keyword(s):  
Extracellular Vesicles ◽  
State Of The Art ◽  
Membrane Vesicles ◽  
Current State

scholarly journals Nanoarchitectonics: Complexes and Conjugates of Platinum Drugs with Silicon Containing Nanocarriers. An Overview

2021 ◽  
Vol 22 (17) ◽  
pp. 9264
Author(s):  
Kinga Piorecka ◽  
Jan Kurjata ◽  
Wlodzimierz A. Stanczyk
Keyword(s):  
Drug Delivery ◽  
Driving Force ◽  
State Of The Art ◽  
Platinum Drugs ◽  
Research Groups ◽  
Current State ◽  
Delivery Platform ◽  
Silicon Based ◽  
Intensive Search

The development in the area of novel anticancer prodrugs (conjugates and complexes) has attracted growing attention from many research groups. The dangerous side effects of currently used anticancer drugs, including cisplatin and other platinum based drugs, as well their systemic toxicity is a driving force for intensive search and presents a safer way in delivery platform of active molecules. Silicon based nanocarriers play an important role in achieving the goal of synthesis of the more effective prodrugs. It is worth to underline that silicon based platform including silica and silsesquioxane nanocarriers offers higher stability, biocompatibility of such the materials and pro-longed release of active platinum drugs. Silicon nanomaterials themselves are well-known for improving drug delivery, being themselves non-toxic, and versatile, and tailored surface chemistry. This review summarizes the current state-of-the-art within constructs of silicon-containing nano-carriers conjugated and complexed with platinum based drugs. Contrary to a number of other reviews, it stresses the role of nano-chemistry as a primary tool in the development of novel prodrugs.

scholarly journals Host-Directed Therapies and Anti-Virulence Compounds to Address Anti-Microbial Resistant Tuberculosis Infection

2020 ◽  
Vol 10 (8) ◽  
pp. 2688 ◽  
Author(s):  
Raphael Gries ◽  
Claudia Sala ◽  
Jan Rybniker
Keyword(s):  
Immune Cells ◽  
State Of The Art ◽  
Research Community ◽  
Review Article ◽  
Drug Resistant ◽  
Resistant Tuberculosis ◽  
Current State ◽  
Major Virulence Factor ◽  
Emerging Therapies ◽  
Active Research

Despite global efforts to contain tuberculosis (TB), the disease remains a leading cause of morbidity and mortality worldwide, further exacerbated by the increased resistance to antibiotics displayed by the tubercle bacillus Mycobacterium tuberculosis. In order to treat drug-resistant TB, alternative or complementary approaches to standard anti-TB regimens are being explored. An area of active research is represented by host-directed therapies which aim to modulate the host immune response by mitigating inflammation and by promoting the antimicrobial activity of immune cells. Additionally, compounds that reduce the virulence of M. tuberculosis, for instance by targeting the major virulence factor ESX-1, are being given increased attention by the TB research community. This review article summarizes the current state of the art in the development of these emerging therapies against TB.

Cardiovascular Risk in Psoriasis: Current State of the Art

2018 ◽  
Vol 17 (1) ◽  
pp. 85-91 ◽  
Author(s):  
Giuseppe Dattilo ◽  
Francesco Borgia ◽  
Claudio Guarneri ◽  
Matteo Casale ◽  
Roberto Bitto ◽  
...  
Keyword(s):  
Risk Factor ◽  
Cardiovascular Risk ◽  
Skin Disease ◽  
Independent Risk Factor ◽  
Clinical Laboratory ◽  
State Of The Art ◽  
Mortality And Morbidity ◽  
Current State ◽  
Immune Mediated

Psoriasis (Pso) is a chronic inflammatory immune-mediated skin disease associated with several comorbidities. Despite the growing number of studies providing evidence for the link between Pso and Cardiovascular (CV) disorders, there are still many unsolved questions, dealing with the role of the skin disease as an independent risk factor for CV events, the influence of Pso severity and duration on CV damage, the presence of Psoriatic Arthritis (PsA) as a predictor of increased CV mortality and morbidity and the detection of reliable clinical, laboratory and/or instrumental parameters to stratify CV risk in psoriatic patients. Moreover, it remains to clarify if the early treatment of the dermatosis may lower CV risk. In this paper we will try to provide answers to these queries in the light of the updated data of the literature.

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