scholarly journals Stimulation of Sulfonamides Antibacterial Drugs Activity as a Result of Complexation with Ru(III): Physicochemical and Biological Study

2021 ◽  
Vol 22 (24) ◽  
pp. 13482
Author(s):  
Paulina Spisz ◽  
Agnieszka Chylewska ◽  
Aleksandra Królicka ◽  
Sandra Ramotowska ◽  
Aleksandra Dąbrowska ◽  
...  
Keyword(s):  
Metal Ions ◽  
Biological Properties ◽  
Biological Study ◽  
Antibacterial Drugs ◽  
Anticancer Properties ◽  
Promising Solution ◽  
Pharmacological Potential ◽  
Ct Dna ◽  
Selection Of ◽  
Stimulation Of

Antibiotic resistance is a global problem, and one promising solution to overcome this issue is using metallodrugs, which are drugs containing metal ions and ligands. These complexes are superior to free ligands in various characteristics including anticancer properties and mechanism of action. The pharmacological potential of metallodrugs can be modulated by the appropriate selection of ligands and metal ions. A good example of proper coordination is the combination of sulfonamides (sulfamerazine, sulfathiazole) with a ruthenium(III) ion. This work aimed to confirm that the activity of sulfonamides antibacterial drugs is initiated and/or stimulated by their coordination to an Ru(III) ion. The study determined the structure, electrochemical profile, CT-DNA affinity, and antimicrobial as well as anticancer properties of the synthesized complexes. The results proved that Ru(III) complexes exhibited better biological properties than the free ligands.

scholarly journals Potential Anticancer Properties and Mechanisms of Action of Formononetin

2019 ◽  
Vol 2019 ◽  
pp. 1-11 ◽  
Author(s):  
Dongjun Jiang ◽  
Azhar Rasul ◽  
Rabia Batool ◽  
Iqra Sarfraz ◽  
Ghulam Hussain ◽  
...  
Keyword(s):  
Trifolium Pratense ◽  
Antioxidant Properties ◽  
Cancer Therapeutics ◽  
Biological Properties ◽  
Anticancer Properties ◽  
Biological Potential ◽  
Pharmacological Potential ◽  
Reported Data ◽  
Pharmacologically Active ◽  
Promising Source

Nature, a vast reservoir of pharmacologically active molecules, has been most promising source of drug leads for the cure of various pathological conditions. Formononetin is one of the bioactive isoflavones isolated from different plants mainly from Trifolium pratense, Glycine max, Sophora flavescens, Pycnanthus angolensis, and Astragalus membranaceus. Formononetin has been well-documented for its anti-inflammatory, anticancer, and antioxidant properties. Recently anticancer activity of formononetin is widely studied. This review aims to highlight the pharmacological potential of formononetin, thus providing an insight of its status in cancer therapeutics. Formononetin fights progression of cancer via inducing apoptosis, arresting cell cycle, and halting metastasis via targeting various pathways which are generally modulated in several cancers. Although reported data acclaims various biological properties of formononetin, further experimentation on mechanism of its action, medicinal chemistry studies, and preclinical investigations are surely needed to figure out full array of its pharmacological and biological potential.

Physiochemical properties and bioapplication of nano- and microsized hydroxy zinc phosphate particles modulated by reaction temperature

2015 ◽  
Vol 3 (7) ◽  
pp. 1301-1312 ◽  
Author(s):  
Peng Liu ◽  
Bangshang Zhu ◽  
Xiaoya Yuan ◽  
Gangsheng Tong ◽  
Yue Su ◽  
...  
Keyword(s):  
Heavy Metal ◽  
Metal Ions ◽  
Reaction Temperature ◽  
Heavy Metal Ions ◽  
Zinc Phosphate ◽  
Drug Loading ◽  
Biological Properties ◽  
Physiochemical Properties

Temperature plays an important part in determining the size, morphology, and physiochemical and biological properties of hydroxy zinc phosphate particles, which can be used in drug-loading and for the removal of heavy metal ions.

Observations On the Sexual Behaviour of Some Longicorn Beetles, Subfamily Lepturinae (Coleoptera, Cerambycidae)

Behaviour ◽  
1963 ◽  
Vol 22 (1-2) ◽  
pp. 152-166 ◽  
Author(s):  
Axel Michelsen
Keyword(s):  
Comparative Analysis ◽  
Sexual Behaviour ◽  
The State ◽  
Round Dance ◽  
Selection Of ◽  
Stimulation Of

AbstractA description is given of the sexual behaviour of 16 longicorn beetles of the subfamily Lepturinae. The following points have been investigated:- 1. Stimulation of the female performed by the male either as a "licking" or combined "licking and tapping" of the female elytra or the grasping of an antenna of the female. 2. Movements of the antennae of the male, which seem to be an expression of the "state of excitement" of the male. These movements are in principle thought to be one of the behaviour patterns originally present in the order Coleoptera. 3. A "round dance", one of the methods for the female to throw off the male after copula, is described. 4. A selection of partner according to size is described in the genus Rhagium. 5. A comparative analysis is attempted for some species and systematic conclusions of such comparisons are proposed.

scholarly journals Isolation of humic acid from oxidized lignite and complexation with metal cations

2017 ◽  
Vol 71 (4) ◽  
pp. 319-327
Author(s):  
Benjamin Catovic ◽  
Minela Sisic ◽  
Majda Srabovic ◽  
Melita Huremovic
Keyword(s):  
Humic Acid ◽  
Metal Ions ◽  
Humic Acids ◽  
Metal Binding ◽  
Base Material ◽  
Metal Cations ◽  
Biological Properties ◽  
Metal Nitrate ◽  
Chemical Difference ◽  
The Difference

Lignite is brown coal, which in its composition contains humic acids. Humic acids are produced by coal combustion, which leads to the enrichment of coal humic acids. Lignite, from the opet pit mine Sikulje, lignite ore ?Kreka?, Bosnia and Herzegovina, was fragmented and sieved to the appropriate size and used as a base material. The isolation of humic acid was carried out from pre-oxidized and dried lignite after which it was refined. Identification thus obtained humic acids was carried out by FTIR spectroscopy and its characterization of UV analysis which is determined by optical density of isolated humic acid and its complexation with metal cations. Data obtained by FTIR spectroscopic analysis of isolated humic acids show no significant structural and chemical difference in relation to the spectrum obtained for standard humic acids (Sigma Aldrich). UV analysis showed that isolated and standard humic acid have E4/E6 ratio in an appropriate range of 3?5, which indicates the presence of a large number of aliphatic structure. Based on the degree of humification was found that the isolated humic acids belong to the type B standard while humic acids belong to type A. The most important property of the humic substances is the ability to interact with the metal ions forming soluble or insoluble complexes which possess different chemical and biological properties and stability. The nature of the complex between humic acid and metal cation derived from the heterogeneous, polyelectric and polydispersive character humic acids that occurs due to the presence of a large number of functional groups. Complexation of humic acid is carried out with different concentrations of metal nitrate solutions and at different pH values. Different amounts of humic acids were used for the complexation. The amount of the free metal ions was measured with the ICP-OES methode. The data were also statistically analyzed with ANOVA. The results showed that increasing the pH reduces the concentration of metal ions adsorbed on humic acid and by increasing the concentrations and amounts of metal humic acid that power increases. On the basis of the difference in absorbance between metals and humic acids can be said that there is an interaction between the metal and the ligand and is based on absorbance values obtained can be determine the next set of metal binding to humic acids Pb>Zn>Ni>Cu.

scholarly journals Students’ Perception and Attitudes toward Faculty Image on Social Networks

2021 ◽  
pp. 63-74
Author(s):  
Milena Vukić ◽  
Snežana Milićević ◽  
Ksenija Vukić
Keyword(s):  
Social Networks ◽  
Social Media ◽  
New Technology ◽  
Common Source ◽  
Positive Perception ◽  
Promotion Strategy ◽  
Promising Solution ◽  
And Gender ◽  
Source Of Information ◽  
Selection Of

Purpose of this paper is to determine how students perceive the image of their faculty on social networks, but also to analyse their experience and attitudes towards faculty social media strategy. The research was implemented using descriptive statistic techniques, as well as non-parametric tests such as Mann-Whitney U Test, Kruskal-Wallis H Test and Spearman’s Rho. The most common source of information when it comes to enrolment to faculty is word of mouth, while social media have a signifi-cantly lower credibility. During their schooling the respondents have most confidence in the official website, and far less in social networks. Such findings signalize the necessity of creating an adequate digital marketing strategy that can significantly improve the perceived faculty image. Positive perception of the image is fundamental for understanding the process of searching for and selection of the faculty, especially since the results have shown that the students do not value highly the image their faculties have on social networks. Positive perception of faculty image mostly depends on promotion strategy on Facebook and Insta-gram, and far less on LinkedIn and Twitter. In addition, students value more the image of the faculty whose social network pro-file they follow and, in a case, when they are followed back. No correlation was found between faculty image and gender, age or average grade. Therefore, we can conclude that social networks are very important in creating positive image and thanks to new technology, they are a promising solution for differentiation from competition in digital space.

scholarly journals Fe(III)-doxycycline complexes with diimine ligands: Syntheses, characterization and biological properties

2019 ◽  
Vol 38 (1) ◽  
pp. 29
Author(s):  
Joshua A Obaleye ◽  
Olufunso Olumide Abosede
Keyword(s):  
Binding Constants ◽  
Biological Properties ◽  
Axial Position ◽  
Klebsiella Pneumonia ◽  
Ionization Mass ◽  
Polypyridyl Ligands ◽  
Diimine Ligands ◽  
Electrospray Ionization Mass Spectroscopy ◽  
Ionization Mass Spectroscopy ◽  
Ct Dna

Three new iron(III) complexes of doxycycline viz: [Fe(dox)2Cl]Cl2 (1), [Febpy(dox)Cl]Cl2 (2) and [Fephen(dox)Cl]Cl2 (3), where dox is doxycycline, bpy is 2,2ʹ-bipyridine and phen is 1,10-phenanthroline, were synthesized and characterized by elemental analysis, electronic absorption, FT-IR, and electrospray ionization mass spectroscopy. Doxycycline and the polypyridyl ligands behave as bidendate ligands; the polypyridyl ligands coordinate through the two diimine nitrogen atoms and doxycycline through enolate and diketoamide oxygen atoms of ring A in a five-coordinate system with chloride atom in the axial position. Their antibacterial and antiplasmodial activities against chloroquine-sensitive Plasmodium falciparum NF54 and their interaction with calf thymus (CT) DNA using electronic titration were investigated. The three complexes showed good activity against strains of Staphylococcus aureus and Klebsiella pneumonia. The complexes bind moderately to CT DNA with binding constants of 5.6 × 104 and 4.8 × 104 for complexes 2 and 3, respectively.

scholarly journals Separation and properties of two arylamidases from rat cardiac-muscle extracts

1977 ◽  
Vol 163 (3) ◽  
pp. 565-570 ◽  
Author(s):  
A F Bury ◽  
T Coolbear ◽  
C R Savery
Keyword(s):  
Metal Ions ◽  
Cardiac Muscle ◽  
Rat Heart ◽  
Bivalent Metal ◽  
Ph Optimum ◽  
Minor Peak ◽  
Bivalent Metal Ions ◽  
Stimulation Of

Two main arylamidase activities were separated from a particle-free supernatant of rat heart by chromatography on DEAE-Sephadex. Although both enzymes hydrolysed L-leucine 4-nitroanilide, only peak-II enzyme hydrolysed L-lysine 4-nitroanilide. A third minor peak (Ia) contained an enzyme that was active mainly on the L-lysine 4-nitroanilide. The mol.wts. of the enzymes in peaks I and II were approx. 257000 and 105000 respectively. The pH optimum was approx. pH7.0 for peak-I enzyme and 7.0-8.0 for peak-II enzyme. Both enzymes were inhibited by addition of puromycin, p-hydroxymercuribenzoate, o-phenanthroline and bivalent metal ions. Addition of dithiothreitol resulted in stimulation of both activities. Dialysis against o-phenanthroline resulted in inhibition of peak-I and -II enzymes, but after dialysis against EDTA only peak-II enzyme was inhibited.

Enhanced water stability and high CO2 storage capacity of Lewis basic sites containing zirconium metal–organic framework

2021 ◽  
Author(s):  
Selcuk Demir ◽  
Nuray Bilgin ◽  
H. Merve Cepni ◽  
Hiroyasu Furukawa ◽  
Fatih Yilmaz ◽  
...  
Keyword(s):  
Metal Ions ◽  
Storage Capacity ◽  
Metal Organic Framework ◽  
Co2 Storage ◽  
Metal Organic Frameworks ◽  
Water Stability ◽  
High Co2 ◽  
Metal Organic ◽  
Zirconium Metal ◽  
Selection Of

Metal–organic frameworks (MOFs) are an emerging class of materials employed for custom-designed purposes by judicious selection of the linker and the metal ions. Among the MOFs composed of carboxylate linkers,...

GLYCYL-RNA SYNTHETASE OF RAT LIVER: PARTIAL PURIFICATION AND EFFECTS OF SOME METAL IONS ON ITS ACTIVITY

1963 ◽  
Vol 41 (1) ◽  
pp. 1123-1133 ◽  
Author(s):  
M. J. Fraser
Keyword(s):  
Heat Treatment ◽  
Metal Ions ◽  
Ammonium Sulphate ◽  
Rat Liver ◽  
Partial Purification ◽  
Ammonium Sulphate Fractionation ◽  
Stimulation Of

Glycyl-RNA synthetase has been purified 40-fold from a 105,000 × g supernatant of an homogenate of rat liver by successive precipitation at pH = 5.0, heat treatment at 55 °C for 3.0 minutes in the presence of 1.0 mM ATP, and ammonium sulphate fractionation. The purified fractions catalyzed glycine-dependent ATP-32PP exchange. The effect of some metal ions on glycine activation was studied. Activation occurred in the presence of either Mg++or Mn++. The apparent stimulation of glycine activation by Co++was found to be an artifact.

scholarly journals Phytosynthesis of BiVO4 nanorods using Hyphaene thebaica for diverse biomedical applications

AMB Express ◽  
2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Hamza Elsayed Ahmed Mohamed ◽  
Shakeeb Afridi ◽  
Ali Talha Khalil ◽  
Tanzeel Zohra ◽  
Muhammad Masroor Alam ◽  
...  
Keyword(s):  
Zeta Potential ◽  
Radical Scavenging ◽  
Cost Effective ◽  
Biological Properties ◽  
Klebsiella Pneumonia ◽  
Anticancer Properties ◽  
Transmission Electron ◽  
Total Antioxidant ◽  
Raman Modes ◽  
Dried Fruit

AbstractBiosynthesis of bismuth vanadate (BiVO4) nanorods was performed using dried fruit extracts of Hyphaene thebaica as a cost effective reducing and stabilizing agent. XRD, DRS, FTIR, zeta potential, Raman, HR-SEM, HR-TEM, EDS and SAED were used to study the main physical properties while the biological properties were established by performing diverse assays. The zeta potential is reported as − 5.21 mV. FTIR indicated Bi–O and V–O vibrations at 640 cm−1 and 700 cm−1/1120 cm−1. Characteristic Raman modes were observed at 166 cm−1, 325 cm−1 and 787 cm−1. High resolution scanning and transmission electron micrographs revealed a rod like morphology of the BiVO4. Bacillus subtilis, Klebsiella pneumonia, Fusarium solani indicated highest susceptibility to the different doses of BiVO4 nanorods. Significant protein kinase inhibition is reported for BiVO4 nanorods which suggests their potential anticancer properties. The nanorods revealed good DPPH free radical scavenging potential (48%) at 400 µg/mL while total antioxidant capacity of 59.8 µg AAE/mg was revealed at 400 µg/mL. No antiviral activity is reported on sabin like polio virus. Overall excellent biological properties are reported. We have shown that green synthesis can replace well established processes for synthesizing BiVO4 nanorods.

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