scholarly journals Dynapenia and Low Cognition: A Cross-Sectional Association in Postmenopausal Women

2021 ◽  
Vol 10 (2) ◽  
pp. 173
Author(s):  
Julie A. Pasco ◽  
Amanda L. Stuart ◽  
Sophia X. Sui ◽  
Kara L. Holloway-Kew ◽  
Natalie K. Hyde ◽  
...  
Keyword(s):  
Muscle Strength ◽  
Mini Mental State Examination ◽  
Cross Sectional ◽  
Logistic Regression Models ◽  
Global Cognitive Function ◽  
Geelong Osteoporosis Study ◽  
Hip Abductor ◽  
Hip Flexor ◽  
State Examination ◽  
Flexor Strength

Dynapenia is a key contributor to physical frailty. Cognitive impairment and dementia accompany frailty, yet links between skeletal muscle and neurocognition are poorly understood. We examined the cross-sectional relationship between lower limb muscle strength and global cognitive function. Participants were 127 women aged 51–87 years, from the Geelong Osteoporosis Study. Peak eccentric strength of the hip-flexors and hip abductors was determined using a hand-held dynamometer, and dynapenia identified as muscle strength t-scores < −1. Cognition was assessed using the Mini-Mental State Examination (MMSE), and MMSE scores below the median were rated as low. Associations between dynapenia and low cognition were examined using logistic regression models. Hip-flexor dynapenia was detected in 38 (71.7%) women with low cognition and 36 (48.7%) with good cognition (p = 0.009); for hip abductor dynapenia, the pattern was similar (21 (39.6%) vs. 9 (12.2%); p < 0.001). While the observed difference for hip-flexor strength was attenuated after adjusting for age and height (adjusted Odds Ratio (OR) 1.95, 95%CI 0.86–4.41), low cognition was nearly 4-fold more likely in association with hip abductor dynapenia (adjusted OR 3.76, 95%CI 1.44–9.83). No other confounders were identified. Our data suggest that low strength of the hip abductors and low cognition are associated and this could be a consequence of poor muscle function contributing to cognitive decline or vice versa. As muscle weakness is responsive to physical interventions, this warrants further investigation.

scholarly journals Impairments in balance and mobility identify delirium in patients with comorbid dementia

2018 ◽  
Vol 31 (5) ◽  
pp. 749-753 ◽  
Author(s):  
Neus Gual ◽  
Sarah J. Richardson ◽  
Daniel H. J. Davis ◽  
Giuseppe Bellelli ◽  
Wolfgang Hasemann ◽  
...  
Keyword(s):  
Motor Function ◽  
Mini Mental State Examination ◽  
The Elderly ◽  
Motor Dysfunction ◽  
Cross Sectional ◽  
Dsm 5 ◽  
Hierarchical Assessment ◽  
State Examination ◽  
Rehabilitation Hospitals ◽  
Delirium Superimposed On Dementia

ABSTRACTDiagnosing delirium superimposed on dementia (DSD) remains challenging because of a lack of specific tools, though motor dysfunction in delirium has been relatively under-explored. This study aimed to use dysfunction in balance and mobility (with the Hierarchical Assessment of Balance And Mobility: HABAM) to identify DSD. This is a cross-sectional multicenter study, recruiting consecutive patients ≥70 years admitted to five acute or rehabilitation hospitals in Ireland, Italy, Portugal, and Switzerland. Delirium was diagnosed using DSM-5 criteria; dementia was determined by the Mini-Mental State Examination and the Questionnaire of Cognitive Decline in the Elderly. HABAM score was recorded at admission. Out of 114 patients (mean age ± SD = 82 ± 7; 54% female), dementia alone was present in 24.6% (n = 28), delirium alone in 18.4% (n = 21) and DSD in 27.2% (n = 31). Patients with DSD had a mean HABAM score 7 points greater than those with dementia alone (19.8 ± 8.7 vs 12.5 ± 9.5; p < 0.001); 70% of participants with DSD were correctly identified using the HABAM at a cut off of 22 (sensitivity 61%, specificity 79%, AUC = 0.76). Individuals with delirium have worse motor function than those without delirium, even in the context of comorbid dementia. Measuring motor function using the HABAM in older people at admission may help to diagnose DSD.

scholarly journals Hubungan Lama Hemodialisis dengan Fungsi Kognitif pada Pasien yang Menjalani Hemodialisis Menggunakan Metode Mini Mental State Examination Ditinjau dari Kedokteran dan Islam

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Suci Purnama ◽  
Linda Armelia
Keyword(s):  
Mental State ◽  
Mini Mental State Examination ◽  
Cross Sectional ◽  
Consecutive Sampling ◽  
State Examination

Hemodialisis merupakan terapi pengganti ginjal pada penyakit ginjal kronik. Terdapat data statistik yang berbeda untuk prevalensi gangguan kognitif di Indonesia pada pasien yang menjalani hemodialisis mulai dari 20% - 47%. Penelitian ini menggunakan analitik korelatif dengan desain cross sectional yang dilakukan pada bulan Agustus 2018 di RS Anna Medika Bekasi dengan jumlah sampel sebanyak 102 responden yang diambil dengan cara consecutive sampling. Peneliti melakukan wawancara dengan menggunakan kuisioner Mini Mental State Examination (MMSE). Analisis data dengan menggunakan uji spearman. Fungsi kognitif pasien hemodialisis berdasarkan MMSE didapatkan penurunan fungsi kognitif ringan sebanyak 56 (54,9%), penurunan fungsi kognitif sedang sebanyak 13 (12,7%) dan tidak mengalami penurunan fungsi kognitif sebanyak 33 (32,4%). Hubungan antara lama hemodialisis dengan fungsi kognitif didapatkan p=0,002. Terdapat hubungan signifikan antara lama hemodialisis dengan fungsi kognitif pada pasien hemodialisis di RS Anna Medika

scholarly journals Hubungan Usia, Jenis Kelamin dan Status Anemia dengan Fungsi Kognitif pada Lanjut Usia

2020 ◽  
Vol 7 (1) ◽  
pp. 12-17
Author(s):  
Riza Firdaus
Keyword(s):  
Mental State ◽  
Mini Mental State Examination ◽  
Chi Square ◽  
Cross Sectional ◽  
State Examination

Menurunnya fungsi kognitif sangat mempengaruhi kualitas hidup lanjut usia. Faktor yang mempengaruhi adalah faktor fisiologis, psikologis dan lingkungan. Studi ini bertujuan untuk mengetahui hubungan usia, jenis kelamin dan status anemia dengan fungsi kognitif pada lanjut usia. Desain penelitian yaitu analitik observasional dengan pendekatan cross-sectional. Penelitian ini dilakukan di Panti Wredha Wening Wardoyo Semarang. Jumlah sampel yang didapatkan sebanyak 51 orang lanjut usia dengan total sampling. Variabel dependen adalah fungsi kognitif dan variabel independen adalah usia, jenis kelamin dan status anemia. Pemeriksaan fungsi kognitif diukur dengan instrumen Mini Mental State Examination (MMSE) dan pemeriksaan status anemia menggunakan haemometer dengan metode Sahli. Analisis data yang digunakan adalah menggunakan uji Chi Square. Hasil penelitian menunjukkan usia < 75 tahun meningkatkan risiko fungsi kognitif normal (OR = 6,480; 95% CI 1,844- 22,769; p = 0,002), jenis kelamin laki – laki (OR = 2,357; 95% CI 0,688- 8,075; p = 0,167) dan anemia ringan (OR = 2,821; 95% CI 0,831- 9,577; p = 0,091). Penelitian ini menyimpulkan bahwa fungsi kognitif pada lanjut usia dipengaruhi oleh usia, jenis kelamin dan status anemia.

36 Cognitive functioning in patients aged 60 and older with chronic non- communicable diseases

2020 ◽  
Vol 91 (8) ◽  
pp. e23-e23
Author(s):  
¹Jurate Peceliuniene ◽  
²Guntis Karelis ◽  
³Irena Zukauskaite ◽  
Zane Kalnina ◽  
Diana Blagovescenska ◽  
...  
Keyword(s):  
Mini Mental State Examination ◽  
Cross Sectional Study ◽  
Communicable Diseases ◽  
Chi Square ◽  
Cross Sectional ◽  
Non Communicable Diseases ◽  
Cognitive Failures ◽  
Cognitive Failures Questionnaire ◽  
State Examination ◽  
One Way Anova

ObjectiveIt is well established that chronic non-communicable diseases (CND) are linked to early cognitive impairment (CI) before or at the beginning of the old age, bringing those patients at higher risk for dementia.The aim: to evaluate CI of aged 60 or older cognitively healthy patients visiting doctors due to different CNDMethods107 patients aged 60 or older (mean age 74 years; 44 male, 63 female; 25 were visiting general practitioner (GP), 21 – neurologist (NE), 23 – pulmonologist (PU), 38 – otorhinolaryngologist (OT)) for their CND took part in pilot cross sectional study. They filled The Cognitive Failures Questionnaire (CFQ), Subjective Cognitive Complaints (SCCs), Mini-Mental State Examination (MMSE). Results were compared using Pearson Chi-Square and one-way ANOVA.ResultsOT patients had higher CFQ results (M=30.7) comparing to all groups (GP M=24.3; NE M=22.6, PU M=18.3, p=0.001). PU patients had less problems with Forgetfulness (M=8.6), comparing to GP (M=11.4) or OT (M=12.4) groups (p=0.022). OT (M=9.3) had more problems with Distractibility comparing to PU (M=5.7) and GP (M=6.7) groups (p=0.011). OT had higher scores in False Triggering (M=7.9) comparing to GP (M=5.92), NE (M=5.8) and PU (4.8) groups (p=0.011).The cut-off point of row score 45 was overstepped in18.9% of OT group, 8% of GP group, but none in NE or PU group (p=0.026). Results of MMSE showed alike tendencies: PU patients (M=27.8) had higher results than GP (M=25.7) or OT (M=25.6) groups (p=0.029). CI was found in 39.1% of GP and 35.1% of OT, comparing to 19.0% in NE and 3.7% in PU groups (p=0.020). But groups did not differ by SCCs scores, even if 3 or more complains were found in 50.0% of GP, 52.2% of PU, 42.9% of NE and 71.1% OT groups. The only SCCs question where found differences between groups – limitation of daily activities: concerning about possible mistakes 62.5% of GP and PU groups would ask somebody’s help, while it would be done by 52.4% of NE and only 15.8% of OT group (p<0.001).ConclusionsCognitive health in elderly people with CND is not monitored well. About 2/3 of them have subjective cognitive complains (3 or more by SCCs), 1/4 would be named as having CI by MMSE, 8.5% have problems due to forgetfulness, distractibility, false triggering. Cognitive functions are predominantly impaired in OT group patients, however, they declare less need for helping them.

scholarly journals Lifetime Musical Training and Cognitive Performance in a Memory Clinic Population: A Cross-Sectional Study

2020 ◽  
pp. 102986492091863
Author(s):  
Daisy Fancourt ◽  
Katharina Geschke ◽  
Andreas Fellgiebel ◽  
Alexandra Wuttke-Linnemann
Keyword(s):  
Mental State ◽  
Mini Mental State Examination ◽  
Musical Training ◽  
Cognitive Impairments ◽  
Neuropsychological Test ◽  
Word List ◽  
Memory Clinic ◽  
Cross Sectional ◽  
Examination Score ◽  
State Examination

Background: Music training has been found to be beneficial for young and healthy participants but the associations between musical training and the cognitive functioning of elderly participants have not been reported consistently. We examined whether lifetime musical training is associated with neuropsychological performance in a memory clinic population of older patients. Methods: A total of 478 patients (54.2% female, mean age 73.70 ± 6.22, mean Mini Mental State Examination score 25 ± 3) were included in the cross-sectional analyses. All patients were referred to the memory clinic due to cognitive impairments. During the course of diagnosis, all patients underwent neuropsychological tests using the CERAD neuropsychological assessment battery. Patients provided information on whether they ever learned to play an instrument for at least five years in their life. Results: Neuropsychological test results differed based on musical training ( p = .042). Overall, there were no differences in any domains of cognitive functioning, other than that patients with musical training performed worse on word list memory ( p = .008). However, this relationship varied based on the extent of cognitive impairments. Patients who were cognitively unimpaired (Mini Mental State Examination score 27–30) and had musical training showed better word list learning, whereas patients with cognitive impairments (Mini Mental State Examination score < 27) and musical training performed worse in word list learning ( p = .042) and word list recall ( p = .045). Discussion: Overall, there was little evidence of associations between specific neuropsychological test results and musical training. Only in cognitively unimpaired patients was there evidence that musical training had beneficial associations. In patients with cognitive impairment, there were suggestions of negative associations with verbal memory. Future research should longitudinally investigate the beneficial effects of musical training in people with and without cognitive impairments.

Use of benzodiazepines and cognitive performance in primary care patients with first cognitive complaints

2017 ◽  
Vol 30 (4) ◽  
pp. 597-601 ◽  
Author(s):  
G. Grande ◽  
I. Tramacere ◽  
D. L. Vetrano ◽  
S. Pomati ◽  
C. Mariani ◽  
...  
Keyword(s):  
Primary Care ◽  
Cognitive Performance ◽  
Mini Mental State Examination ◽  
Cognitive Complaints ◽  
Logistic Regression Models ◽  
Benzodiazepine Use ◽  
Primary Care Patients ◽  
Long Acting ◽  
The Impact ◽  
State Examination

ABSTRACTThe aim of the present study is to investigate the impact of benzodiazepine use on cognitive performance in primary care patients with first cognitive complaints. The association between the exposition to benzodiazepines (short and long half-life) and cognitive performance, evaluated through the Mini Mental State Examination (MMSE), was tested through analysis of the covariance and logistic regression models. Within the 4,249 participants (mean age 77.0 ± 8.2, 66.4% women), 732 (17%) were on benzodiazepines. When compared with non-users, short- and long-acting benzodiazepine users presented overlapping adjusted MMSE mean scores (respectively, mean MMSE score: 25.3, 95%CI 25.2–25.5; 25.4, 95%CI 25.1–25.7, and 25.9, 95%CI 25.3–26.4; p = 0.156). When tested according to the logistical regression model, after adjusting for potential confounders, no association was found between short and long acting benzodiazepine use and a MMSE < 24 (respectively, OR 0.9, 95%CI 0.7–1.2; OR 0.8, 95%CI 0.7–1.3) as compared with non-users. In conclusion, according to the results of our study, benzodiazepine use seems not to impact on cognitive performance- as assessed with the MMSE- of primary care patients referring to GPs for first cognitive complaints.

scholarly journals Cognitive Functions and Cognitive Reserve in Relation to Blood Pressure Components in a Population-Based Cohort Aged 53 to 94 Years

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Nunzia Giordano ◽  
Valérie Tikhonoff ◽  
Paolo Palatini ◽  
Anna Bascelli ◽  
Giovanni Boschetti ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Neuropsychological Tests ◽  
Cognitive Reserve ◽  
Mini Mental State Examination ◽  
Population Based ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Clock Drawing Test ◽  
Drawing Test ◽  
State Examination

In 288 men and women from general population in a cross-sectional survey, all neuropsychological tests were negatively associated with age; memory and executive function were also positively related with education. The hypertensives (HT) were less efficient than the normotensives (NT) in the test of memory with interference at 10 sec (MI-10) (−33%,P=0.03), clock drawing test (CLOX) (−28%,P<0.01), and mini-mental state examination (MMSE) (−6%,P=0.02). Lower MMSE, MI-10, and CLOX were predicted by higher systolic (odds ratio, OR, 0.97,P=0.02; OR 0.98,P<0.005; OR 0.95,P<0.001) and higher pulse blood pressure (BP) (OR 0.97,P=0.02; OR 0.97,P<0.01; and 0.95,P<0.0001). The cognitive reserve index (CRI) was 6% lower in the HT (P=0.03) and was predicted by higher pulse BP (OR 0.82,P<0.001). The BP vectors of lower MMSE, MI-10, and CLOX were directed towards higher values of systolic and diastolic BP, that of low CRI towards higher systolic and lower diastolic. The label of hypertension and higher values of systolic or pulse BP are associated to worse memory and executive functions. Higher diastolic BP, although insufficient to impair cognition, strengthens this association. CRI is predicted by higher systolic BP associated to lower diastolic BP.

Sign in / Sign up

Export Citation Format

Share Document