scholarly journals Angioedema Coexisting Chronic Spontaneous Urticaria Negatively Influences Patients’ Sense of Coherence, What Results in Susceptibility to Anxiety Symptoms Occurrence

2021 ◽  
Vol 10 (13) ◽  
pp. 2852
Author(s):  
Karina Badura-Brzoza ◽  
Zenon Brzoza
Keyword(s):  
Sense Of Coherence ◽  
Anxiety Symptoms ◽  
Chronic Spontaneous Urticaria ◽  
Patient Anxiety ◽  
Specific Group ◽  
Coping With Stress ◽  
Urticaria Activity Score ◽  
T Values ◽  
Susceptibility Patterns ◽  
Assessment Questionnaire

Background: Angioedema coexisting chronic spontaneous urticaria (CSU) is proved to result in patient anxiety occurrence, but the mechanisms and susceptibility patterns are unknown. Sense of coherence (SOC) is one of methods of coping with stress and is defined as a person’s general orientation toward life. We decided to assess SOC disturbances in CSU patients in the context of possible angioedema association. Methods: The study comprised 71 CSU subjects. To analyze disease activity, the Urticaria Activity Score seven-day assessment questionnaire (UAS7) was used. For anxiety assessment, the STAI questionnaire was used. The SOC-29 questionnaire, consisting of questions related to comprehensibility (SOC-C), manageability (SOC-M), and meaningfulness (SOC-Mf), was used to analyze SOC parameters (SOC-T). Results: In patients with coexisting angioedema, we observed statistically significantly lower values of SOC-Mf and SOC-T in comparison to the wheals only group. In the angioedema group, we noticed significant negative correlations between SOC-M and SOC-Mf, as well as SOC-T values and anxiety. In the wheals only group, we proved statistically significant correlations between SOC-Mf and SOC-T and anxiety assessed as a state. Conclusions: It is necessary to identify CSU patients manifesting angioedema as they are more likely to have impaired SOC. Lower SOC in this specific group of patients can be related to anxiety symptoms occurrence and should probably be an indication for psychological support.

Sense of coherence and resilience for coping with stress in the group of juveniles referred to probation centres by family courts

2020 ◽  
Vol 65 (1) ◽  
pp. 134-159
Author(s):  
Karol Konaszewski ◽  
Łukasz Kwadrans
Keyword(s):  
Negative Affect ◽  
Sense Of Coherence ◽  
Coping Styles ◽  
Management Strategies ◽  
Probation Officers ◽  
Life Questionnaire ◽  
Coping With Stress ◽  
Family Courts ◽  
Resilience Scale ◽  
Motivational Aspect

The aim of this study was to analyse the relationship between the sense of coherence and resilience and the styles of stress coping and to determine which of the studied variables (comprehensibility; manageability; meaningfulness; optimistic attitude and energy; perseverance and determination in action; sense of humour and openness to new experiences; personal competences and tolerance of negative affect) was more important in predicting coping styles with stressful situations in the group of juveniles who had been referred to probation centres. Participants in this study were 210 juveniles from probation centres. The following research tools were used in the research: A. Antonovsky’s Orientation to Life Questionnaire, Resilience Scale by N. Ogińska-Bulik and Z. Juczyński, and Coping Inventory for Stressful Situations by N. S. Enlder and J. D. A. Parker. The research results show that sense of coherence and resilience play a predictive function for the style which focuses on the task, emotions, avoidance and strategy related to engaging in substitute activities and seeking contact with people. Building (by probation officers) the sense of coherence and resilience among juveniles involves better understanding of the surrounding world and the stimuli which come from it, understanding internal signals and increasing the sense of manageability and comprehensibility, enhancing the ability to use the own and the environmental resources as well as working on the sense of meaningfulness, i.e. the motivational aspect of functioning. Supporting components of resilience (optimistic attitude and energy; perseverance and determination in action; sense of humour and openness to new experiences; personal competences and tolerance of negative affect) through psychoeducational activities (in probation centres) enables better understanding of the own self and, consequently, using stress management strategies aimed at finding a positive solution to a particular situation.

PERSONAL RESOURCES IN COPING WITH STRESS AMONG PARAMEDICS PART 1

2017 ◽  
Vol 186 (4) ◽  
pp. 138-155
Author(s):  
Marzena NETCZUK-GWOŹDZIEWICZ
Keyword(s):  
Sense Of Coherence ◽  
Personal Resources ◽  
Coping With Stress ◽  
Ways Of Coping ◽  
Personal Resource ◽  
Ability To Act ◽  
The Subject ◽  
The Individual ◽  
Coherence Level

The concept of personal resources is used in health psychology in reference to all the factors that help in coping with stress. Moos and Schafer define personal resource as: ‘relatively stable personal and social factors, which influence the way the individual tries to tackle life crises and stress transactions’. Many researchers count the following as important personal resources: social support, ways of coping with stress, self-esteem and self-efficacy, sense of coherence, level of optimism, ability to act assertively, locus of control. Paramedics can be associated with jobs requiring above-average level of both health and psychological costs. Thus, determination of the relation between the sense of coherence and ways of coping with stress will be the subject of this project.

scholarly journals Combination therapy of omalizumab with house dust mite immunotherapy in chronic spontaneous urticaria associated with sensitization to dust mites-case series

2021 ◽  
pp. 469-472
Author(s):  
P C Kathuria ◽  
Manisha Rai
Keyword(s):  
Combination Therapy ◽  
Disease Control ◽  
House Dust ◽  
House Dust Mite ◽  
Immunoglobulin E ◽  
Combined Therapy ◽  
Case Series ◽  
Chronic Spontaneous Urticaria ◽  
Dust Mite ◽  
Urticaria Activity Score

Chronic spontaneous urticaria (CSU) is a heterogeneous disorder with recurrent pruritic wheals and/or angioedema. The anti-immunoglobulin E (omalizumab) is used in CSU patients resistant to four-fold second-generation anti-histamines. Most clinical trials have experienced relapse after stopping omalizumab treatment. Here, we present a case series of five cases of chronic atopic urticarial concomitant allergic rhinitis and asthma which have shown immunologically significant positivity to Dermatophagoides pteronyssinus and Dermatophagoides farinae. Disease control was achieved (Urticaria Activity Score 7 <6) in four cases by combination therapy of omalizumab with house dust mite (HDM) Allergen Immunotherapy (AIT) and remained sustained for three years on follow-up even after discontinuation of AIT for one year. We hypothesize that this combined therapy may contribute to enhanced clinical efficacy, safety, and faster achievement of disease control in CSU.

scholarly journals COVID-19 Disease Leading to Chronic Spontaneous Urticaria Exacerbation: A Romanian Retrospective Study

Healthcare ◽  
2021 ◽  
Vol 9 (9) ◽  
pp. 1144
Author(s):  
Ioana Adriana Muntean ◽  
Irena Pintea ◽  
Ioana Corina Bocsan ◽  
Carmen Teodora Dobrican ◽  
Diana Deleanu
Keyword(s):  
Inflammatory Markers ◽  
Clinical Presentation ◽  
Significant Proportion ◽  
Case Series ◽  
Treated Group ◽  
Severe Form ◽  
Chronic Spontaneous Urticaria ◽  
Retrospective Case ◽  
Markers Of Inflammation ◽  
Urticaria Activity Score

(1) Background: The COVID-19 pandemic has resulted in the exacerbation of various chronic diseases. Due to the potential impact of SARS-CoV-2 on mast cells, we aimed to analyze the relevance of COVID-19 disease on chronic spontaneous urticaria (CSU) clinical presentation and biological profile. (2) Methods: This study is a retrospective case series of patients with CSU diagnosed and treated in the Allergy Department of the Professor Doctor Octavian Fodor RIGH, (Cluj-Napoca, Romania). Patients were assessed for disease activity and level of control with the weekly urticaria activity score and the visual analogue scale. Results were correlated with COVID-19 severity and with nonspecific markers of inflammation during and after the SARS-CoV-2 infection. (3) Results: SARS-CoV-2 impacted a significant proportion (33%) of the CSU patients, of which 71% developed a moderate-severe form of COVID-19. Most of the patients (68%) had moderate-severe forms of CSU and 65% took AH1 treatment (one dose, two-fold dose or four-fold dose). The rest of them (35%) received the second-line treatment (40.3% Omalizumab, 53% Prednisolone and 4.8% Cyclosporine). In Omalizumab treated group of UCS patients we observed that COVID-19 disease was not severe. We established a positive correlation between the severity of the infection and that of the CSU clinical presentation, with most bothersome symptoms of urticaria being experienced by moderate to severe COVID-19 CSU patients (47%). Inflammatory markers were positively correlated (p = 0.01) with a more severe clinical profile of CSU, in accordance with our hypothesis that the level of inflammation triggered by COVID-19 disease has a role in CSU exacerbation. The non-specific inflammatory markers, such as CRP, were positively associated with the UAS7 score (R2 = 0.363; p = 0.001). An increased rate of exacerbation of CSU was observed in moderate-severe COVID-19 infection. 4) Conclusions: COVID-19 disease can result in the exacerbation of chronic spontaneous urticaria, more likely in moderate to severe forms of infection.

scholarly journals Personal resources in coping with stress among paramedics part 2

2018 ◽  
Vol 187 (1) ◽  
pp. 92-104
Author(s):  
Marzena Netczuk-Gwozdziewicz
Keyword(s):  
Sense Of Coherence ◽  
Theoretical Basis ◽  
Important Variable ◽  
Stressful Events ◽  
Coping With Stress ◽  
Critical Situation ◽  
And Coping ◽  
Task Oriented ◽  
High Sense ◽  
Or Task

The purpose of this project was to determine the relationships between the sense of coherence and paramedics’ coping with stress styles. Owning such resources as high sense of coherence or task-oriented coping with stress style does not imply triggering them in encountering a critical situation. However, if triggered, they become an important variable acting as an intermediary between stressful events and coping. Two concepts serve as a theoretical basis: R. Lazarus’ transactional theory of stress and Antonovsky’s salutogenic theory.

The Real-Life Effectiveness and Safety of Omalizumab Updosing in Patients With Chronic Spontaneous Urticaria

2019 ◽  
Vol 23 (5) ◽  
pp. 496-500 ◽  
Author(s):  
Andac Salman ◽  
Elif Comert
Keyword(s):  
Real Life ◽  
Complete Response ◽  
Response To Therapy ◽  
Chronic Spontaneous Urticaria ◽  
Life Effectiveness ◽  
The Mean ◽  
Group 2 ◽  
Urticaria Activity Score ◽  
Higher Doses ◽  
Group 1

Background: Omalizumab is a third-line treatment for chronic spontaneous urticaria (CSU). Studies investigating the use of higher doses of omalizumab in patients unresponsive to regular doses are limited. Objectives: This study aims to investigate the effectiveness and safety of omalizumab 450 mg in CSU. Methods: A retrospective cohort study was conducted. The response to therapy was evaluated using the Urticaria Activity Score over 7 days (UAS7) and the Urticaria Control Test (UCT). Patients showing complete response (CR) (UAS7: 0-1) to omalizumab 300 mg (Group 1) and patients receiving at least 3 doses of omalizumab 450 mg (Group 2) between 2016 and 2018 were included. Results: A total of 72 patients (Group 1: 59; Group 2: 13) were included. In Group 2, the mean UAS7 score decreased from 18.6 to 5.1 and the mean UCT score increased from 8.6 to 12 after a mean 4.3 courses of 450 mg omalizumab treatment. Of the 13 patients in Group 2, 6 had CR and 3 had good disease control (UAS7: 2-6). The rate of patients with low baseline IgE levels (< 43 IU/mL) was significantly higher in Group 2. Conclusions: Higher doses of omalizumab are effective and safe in patients with CSU that is unresponsive to omalizumab 300 mg. Lower baseline total IgE levels might be used as a predictor of nonresponse to omalizumab and the need for higher doses.

Safety and clinical efficacy of bilastine in reduction of pruritus in patients with chronic spontaneous urticaria

2021 ◽  
pp. 28-32
Author(s):  
A.Ye. Bogomolov
Keyword(s):  
Standard Deviation ◽  
Clinical Efficacy ◽  
Activity Index ◽  
Randomized Study ◽  
Initial Therapy ◽  
Chronic Spontaneous Urticaria ◽  
Double Dose ◽  
Analog Scale ◽  
The Mean ◽  
Urticaria Activity Score

Objective — to evaluate the efficacy/safety of bilastine in relieving pruritus in patients with chronic spontaneous urticaria. Materials and methods. This prospective randomized study included 50 adult patients aged 18 to 59 years with chronic spontaneous urticaria and pruritus with an intensity of more than 4 points by the visual analog scale of pruritus assessment in the last 3 days and more than 16 points by the Urticaria activity score 7 (UAS7) which assessed chronic urticaria intensity for the last week.Patients received bilastine orally at a dose of 20 mg once a day for 8 weeks. Patients who did not respond to therapy within the first 2 weeks subsequently received bilastine at a dose of 40 mg per day (two 20 mg tablets) till the end of the study (for 6 weeks). Results and discussion. The mean age of patients was 39.61 years with standard deviation (SD) of 12.33 years. In the group of patients who responded positively to the initial therapy, within 8 weeks, the pruritus intensity scoring level decreased significantly to 0.46 (95 % CI: 0.14—0.78) points (p < 0.05). The patients who received a double dose of bilastine also revealed a decrease in the intensity of pruritus and on average on the 8th week of treatment had 0.48 (95 % CI: 0.26—0.70) points (p < 0.05).The study reported 14 adverse events (AE) that occurred during bilastine treatment in 10 (23.8 %) patients. All of them were classified as mild and the most common was headache, registered in 12 (85.7 %) cases. No moderate or severe AEs were reported during the study. Conclusions. 8 week treatment with bilastine has demonstrated proven clinical efficacy both in reducing the urticaria activity index according to UAS7 and in reducing the intensity of pruritus in the absence of moderate and severe AEs. Patients who did not respond to starting therapy after doubling the bilastine dose also significantly decreased the urticaria activity index according to UAS7 and reduced the intensity of pruritus. At the same time, increasing the dose of the drug did not lead to an increase in the frequency of AEs.

Social and personal resources and adaptive and non-adaptive strategies for coping with stress in a group of socially maladjusted youths

2019 ◽  
pp. 147737081989597
Author(s):  
Karol Konaszewski ◽  
Małgorzata Niesiobędzka ◽  
Marcin Kolemba
Keyword(s):  
Family Support ◽  
Sense Of Coherence ◽  
Adaptive Strategies ◽  
Adaptive Strategy ◽  
Personal Resources ◽  
Coping With Stress ◽  
Socially Maladjusted ◽  
Relationship Of ◽  
The Impact ◽  
The Relationship

This article is the result of an empirical research project analysing the relationship between the resources of socially maladjusted youth and their strategies for coping with stress. The research was focused on non-formal functional support from family members and two types of personal resources – resilience and a sense of coherence – in forming tendencies to take advantage of adaptive and non-adaptive strategies for coping with stress. The research participants consisted of young, socially maladjusted people who have been directed to attendance centres, youth sociotherapy centres, and youth educational centres all over Poland ( N = 468). Structural equation modelling was used to verify the basic hypotheses. The observed data confirmed most of the assumptions. The sense of family support was positively related to an adaptive strategy and, contrary to expectations, to a non-adaptive strategy. The family support experienced not only had a direct impact on intensifying adaptive and non-adaptive strategies but also influenced coping with the use of personal resources. The impact of family resources on resilience and the sense of coherence were similar, but the relationship of a sense of coherence was weaker than the relationship of resilience with an adaptive strategy. Resilience turned out to be the strongest predictor of an adaptive strategy. The relationship between resilience and a non-adaptive strategy was insignificant, but a sense of coherence worked in favour of planning, positively reinterpreting the situation and actively undertaking actions focused on the problem, and at the same time lowered the tendency to release emotions and self-blame.

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