scholarly journals The Effect of Submaximal Exercise Followed by Short-Term Cold-Water Immersion on the Inflammatory State in Healthy Recreational Athletes: A Cross-Over Study

2021 ◽  
Vol 10 (18) ◽  
pp. 4239
Author(s):  
Marta Pawłowska ◽  
Celestyna Mila-Kierzenkowska ◽  
Tomasz Boraczyński ◽  
Michał Boraczyński ◽  
Karolina Szewczyk-Golec ◽  
...  
Keyword(s):  
Lysosomal Enzymes ◽  
Room Temperature ◽  
Transforming Growth Factor ◽  
Cold Water ◽  
Water Immersion ◽  
Interleukin 10 ◽  
Cold Water Immersion ◽  
Recreational Athletes ◽  
Tnf Α ◽  
Inflammatory State

Cold-water immersion (CWI) after exercise is a method used by sportsmen to improve recovery. The aim of the study was to assess the effect of a 3 min CWI on the inflammatory state by measuring levels of interleukin 6 (IL-6), interleukin 10 (IL-10), tumor necrosis factor α (TNF-α), and transforming growth factor β1 (TGF-β1), and activities of α1-antitrypsin (AAT) and lysosomal enzymes, including arylsulfatase (ASA), acid phosphatase (AcP), and cathepsin D (CTS D), in the blood of healthy recreational athletes. Male volunteers (n = 22, age 25 ± 4.8 yr) performed a 30 min submaximal aerobic exercise, followed by a 20 min rest at room temperature (RT-REST) or a 20 min rest at room temperature with an initial 3 min 8 °C water bath (CWI-REST). Blood samples were taken at baseline, immediately after exercise, and after 20 min of recovery. The IL-6, IL-10, and TNF-α levels and the AAT activity increased significantly immediately after exercise. The IL-6 level was significantly higher after CWI-REST than after RT-REST. No changes in the activities of the lysosomal enzymes were observed. The effect of a 3 min CWI on the level of inflammatory markers during post-exercise recovery was limited. Thus, it might be considered as a widely available method of regeneration for recreational athletes.

β-Hydroxy-β-methylbutyrate (HMB)-free acid attenuates circulating TNF-α and TNFR1 expression postresistance exercise

2013 ◽  
Vol 115 (8) ◽  
pp. 1173-1182 ◽  
Author(s):  
Jeremy R. Townsend ◽  
Maren S. Fragala ◽  
Adam R. Jajtner ◽  
Adam M. Gonzalez ◽  
Adam J. Wells ◽  
...  
Keyword(s):  
Recovery Time ◽  
Cold Water ◽  
Free Acid ◽  
Water Immersion ◽  
Exercise Bout ◽  
Cold Water Immersion ◽  
Intense Exercise ◽  
Exercise Protocol ◽  
Percent Change ◽  
Tnf Α

The purpose of this study was to examine the effect of β-hydroxy-β-methylbutyrate-free acid (HMB-FA) and cold-water immersion (CWI) on circulating concentrations of TNF-α and monocyte TNF-α receptor 1 (TNFR1) expression. Forty resistance-trained men (22.3 ± 2.4 yr) were randomized into four groups [placebo (PL), HMB-FA, CWI, and HMB-FA-CWI] and performed an acute, intense exercise protocol (four sets of up to 10 repetitions of the squat, dead lift, and split squat). Participants also performed four sets of up to 10 repetitions of the squat at 24 and 48 h following the initial exercise bout. Blood was sampled before exercise (PRE), immediately postexercise (IP), and 30 min, 24 h, and 48 h postexercise (30P, 24P, and 48P, respectively). Circulating TNF-α was assayed, and TNFR1 expression on CD14+ monocytes was measured by flow cytometry. The exercise protocol significantly elevated TNF-α in only PL ( P = 0.006) and CWI ( P = 0.045) IP. Mean percent changes show that TNF-α significantly increased from PRE to IP for only PL and CWI groups ( P < 0.05), whereas the percent change of TNF-α for HMB-FA and HMB-FA-CWI was not significant. TNFR1 expression was elevated in PL ( P = 0.023) and CWI ( P = 0.02) at 30P compared with PRE, whereas both HMB-FA-treated groups did not increase significantly. In conclusion, HMB-FA attenuated circulating TNF-α IP and TNFR1 expression during recovery compared with PL and CWI. HMB-FA supplementation may attenuate the initial immune response to intense exercise, which may reduce recovery time following intense exercise.

scholarly journals The effect of cold-water immersion after eccentric exercise on oxidative and inflammatory responses in skeletal muscle

2021 ◽  
Vol 43 (2) ◽  
pp. 230-239
Author(s):  
Tohid Hemmatzade Bedovli ◽  
Maryam Nourshahi ◽  
Rana Fayaz Milani ◽  
Siavash Parvarde
Keyword(s):  
Skeletal Muscle ◽  
Eccentric Exercise ◽  
Inflammatory Responses ◽  
Cold Water ◽  
Ischemia Reperfusion ◽  
Water Immersion ◽  
Cold Water Immersion ◽  
Repeated Measure ◽  
Tnf Α ◽  
Normal Water

Background: Oxidative stress and inflammation increase after eccentric exercise. Cold-water immersion after exercise is common among athletes to accelerate recovery. Therefore, the purpose of this study was to investigate the effect of cold-water immersion after eccentric exercise on the oxidative and inflammatory responses in skeletal muscle. Methods: One hundred male Wistar rats (weight 285.11 ± 41.65) were randomly divided into control, eccentric exercise, eccentric exercise + normal water, and eccentric exercise + cold water groups. Half, 24, 48, 72, and 168 hours after eccentric exercise, EDL muscle was removed in sterile conditions. The eccentric exercise involves 90 minutes of interval running on the treadmill at a speed of 16 m/min and a -16-degree slope. Muscle reactive oxygen species (ROS) and tumor necrosis factor-alpha (TNF-α) levels were measured by DCFDA and immunohistochemical staining. Kolmogorov-Smirnov for normality test and repeated measure ANOVA and Tukey’s post-Hoc tests for compare groups were used with a significance level of P≤0.05. Results: After eccentric exercise, ROS and TNF-α levels significantly (P<0.05) increased in the three experimental groups. The peak of ROS increase in the eccentric exercise, eccentric exercise + normal water, and eccentric exercise + cold water groups were recorded significantly (P<0.001) half, 48, and 72 hours after eccentric exercise, respectively. Also, the peak of TNF-α increase was significantly higher in the eccentric exercise and eccentric exercise + normal water groups were at 48 hours and in the eccentric exercise + cold water groups was at 72 hours after eccentric exercise (P<0.001). Conclusion: Immersion in cold water causes an increase and delays the peak of ROS and TNF-α after eccentric exercise, which is probably related to ischemia-reperfusion injury. Therefore, after unaccustomed, eccentric, and damaging exercise, immersion in cold water is not recommended.

Influencia del masaje ZNAR y la inmersión en agua fría en el proceso inflamatorio, Creatin Kinasa y percepción al dolor muscular en jugadores de voleibol (Influence of ZNAR massage and cold water immersion on the inflammatory process, Creatine Kinase and

Retos ◽  
2021 ◽  
Vol 44 ◽  
pp. 95-102
Author(s):  
Zeltzin Nereyda Alonso Ramos ◽  
Blanca Rocío Rangel Colmenero ◽  
Myriam Zarai García Dávila ◽  
Gerardo Enrique Muñoz Maldonado ◽  
José Raul Hoyos Flores ◽  
...  
Keyword(s):  
Creatine Kinase ◽  
Muscle Damage ◽  
Muscle Pain ◽  
Inflammatory Process ◽  
Cold Water ◽  
Water Immersion ◽  
Cold Water Immersion ◽  
Control Group ◽  
Necrosis Factor Alpha ◽  
Tnf Α

  Las estrategias que aminoren el dolor, la inflamación y el daño muscular provocados por la actividad física de alta intensidad en atletas son de interés en la recuperación deportiva, por lo que el objetivo del estudio fue conocer el efecto del masaje ZNAR y la inmersión en agua fría a 10° sobre el proceso inflamatorio a través de la interleucina 6 (IL-6), interleucina 10 (IL-10), el factor de necrosis tumoral Alpha (TNF-α), el daño muscular mediante la Creatin Kinasa (CK) y la percepción al dolor muscular a través de la escala visual análoga de dolor (EVA) en jugadores de voleibol. Participaron 19 atletas divididos en un grupo control y un grupo experimental, sometidos a dos protocolos de recuperación (masaje ZNAR e inmersión en agua fría) posterior a un test de inducción a la fatiga. Se cuantifico la IL-6, IL-10, TNF, CK y EVA. Los resultados mostraron cambios significativos (p < .05) en las tomas de recuperación en el comportamiento del proceso inflamatorio, la CK y la percepción al dolor muscular con ambos métodos de recuperación. Conclusión, el Masaje ZNAR favorece a la recuperación de la IL-6 y la IL-10 además de la disminución de la CK y la percepción al dolor muscular.  Abstract: The strategies that reduce pain, inflammation and muscle damage caused by high intensity activity in athletes are of interest in sports recovery, the objective of the study was to know the effect of ZNAR massage and cold water immersion at 10 ° on the inflammatory process through interleukin 6 (IL-6), interleukin 10 (IL-10), tumor necrosis factor Alpha (TNF-α), muscle damage through Creatine Kinase (CK) and the perception of muscle pain through the visual analoge scale (VAS) in volleyball players. 19 athletes were divided into a control group and an experimental group, submitted to two recovery protocols (ZNAR massage and cold water immersion) after a fatigue induction test. IL-6, IL-10, TNF, CK and EVA were quantified. The results showed significant changes (p < .05) in the recovery shots in the behavior of the inflammatory process, the CK and the perception of muscle pain with both recovery methods. Conclusion, the ZNAR Massage favors the recovery of IL-6 and IL-10 in addition to the decrease in CK and the perception of muscle pain

Estimation of heat flow from hands of Eskimos by calorimetry

1961 ◽  
Vol 16 (4) ◽  
pp. 617-623 ◽  
Author(s):  
J. A. Hildes ◽  
Laurence Irving ◽  
J. S. Hart
Keyword(s):  
Heat Flow ◽  
Inverse Relationship ◽  
Room Temperature ◽  
Cold Water ◽  
Water Immersion ◽  
Heat Content ◽  
Cold Water Immersion ◽  
Statistical Comparison ◽  
Hand Size ◽  
Hand Volume

Heat flow from hands immersed in cold water was studied in nine Eskimo and four white subjects. To assess the loss of heat from the hand circulation, the change in heat content of the hand during cold water immersion was first calculated from derived average hand temperatures. After 30 min cold water immersion, average hand temperatures were found to be approximately 6.5 C higher than the water. Derived values for circulatory heat loss averaged 15,564 cal for the Eskimos and 13,815 cal for the white subjects when the room temperature was 25 ± 2 C, and 11,167 cal and 10,610 cal, respectively, when the room temperature was 15 ± 2 C. However, an inverse relationship between hand volume and heat flow per 100 ml hand was found, and when considered on this basis no difference could be made out between the two groups although the number of subjects was too small for statistical comparison. The possibility that differences reported in the literature between groups of subjects are related to differences in hand size is discussed. Submitted on January 23, 1961

scholarly journals Recovery following Rugby Union matches: effects of cold water immersion on markers of fatigue and damage

2019 ◽  
Vol 44 (5) ◽  
pp. 546-556
Author(s):  
Renan Felipe Hartmann Nunes ◽  
Rob Duffield ◽  
Fábio Yuzo Nakamura ◽  
Ewertton de Souza Bezerra ◽  
Raphael Luiz Sakugawa ◽  
...  
Keyword(s):  
Perceived Exertion ◽  
Cold Water ◽  
Water Immersion ◽  
Cold Water Immersion ◽  
Rating Of Perceived Exertion ◽  
Peak Power Output ◽  
Necrosis Factor Alpha ◽  
Markers Of Inflammation ◽  
Tnf Α ◽  
Rugby Players

We investigated the effect of postmatch cold-water immersion (CWI) on markers of muscle damage, neuromuscular fatigue, and perceptual responses within 72 h after a rugby match. Twenty-two professional male rugby players were randomized into CWI (10 °C/10 min; n = 11) or control (CON: 30 min seated; n = 11) groups. Activity profile from Global Positioning Satellite systems and postmatch rating of perceived exertion were measured to determined match load. Biochemical (tumor necrosis factor alpha (TNF-α), interleukin-6), neuromuscular performance (squat (SJ) and countermovement jumps (CMJ), peak power output (PPO), rate of force development (RFD), stiffness, 10- and 30-m sprint time, and perceptual markers (soreness, perceived recovery) were obtained before and immediately after the match, and then at 30 min, 24 h, 48 h, and 72 h after the match. Magnitude-based inference and Cohen’s effect size (ES) were used to analyze change over time and between groups. Thus, the higher/beneficial, similar/trivial, or lower/harmful differences were evaluated as follows: <1%, almost certainly not; 1% to 5%, very unlikely; 5% to 25%, unlikely; 25% to 75%, possible; 75% to 95%, likely; 95% to 99%, very likely; >99%, almost certainly. Changes were unclear for the match loads, sprint times, and perceptual markers between groups. Higher %ΔSJ at 24 h (very likely (ES = 0.75)) and in %ΔPPO_SJ at 48 h (likely (ES = 0.51)) were observed in CWI than in CON. Values in %ΔRDF_CMJ were higher immediately after (likely (ES = 0.83)), 30 min after (very likely (ES = 0.97)), and 24 h after the match (likely (ES = 0.93)) in CWI than in CON. Furthermore, %Δlog TNF-α were lower in the CWI group than in the CON group immediately after (almost certainly (ES = −0.76)), 24 h after (very likely (ES = −1.09)), and 72 h after the match (likely (ES = −0.51)), and in Δstiffness_SJ at 30 min after (likely (ES = −0.67)) and 48 h after the match (very likely (ES = −0.97)). Also, different within-groups effects throughout postmatch were reported. Implementing postmatch CWI-based strategies improved the recovery of markers of inflammation and fatigue in rugby players, despite no change in markers of speed or perceptual recovery.

Patient Involvement in Treatment Decision Making Can Help or Hinder Placebo Analgesia

2014 ◽  
Vol 222 (3) ◽  
pp. 165-170 ◽  
Author(s):  
Andrew L. Geers ◽  
Jason P. Rose ◽  
Stephanie L. Fowler ◽  
Jill A. Brown
Keyword(s):  
Patient Involvement ◽  
Cold Water ◽  
Prior Experience ◽  
Water Immersion ◽  
Treatment Decision ◽  
Cold Water Immersion ◽  
Not Given ◽  
Placebo Analgesia ◽  
Treatment Decision Making ◽  
Immersion Experience

Experiments have found that choosing between placebo analgesics can reduce pain more than being assigned a placebo analgesic. Because earlier research has shown prior experience moderates choice effects in other contexts, we tested whether prior experience with a pain stimulus moderates this placebo-choice association. Before a cold water pain task, participants were either told that an inert cream would reduce their pain or they were not told this information. Additionally, participants chose between one of two inert creams for the task or they were not given choice. Importantly, we also measured prior experience with cold water immersion. Individuals with prior cold water immersion experience tended to display greater placebo analgesia when given choice, whereas participants without this experience tended to display greater placebo analgesia without choice. Prior stimulus experience appears to moderate the effect of choice on placebo analgesia.

Thermoregulatory responses to cold water at different times of day

1999 ◽  
Vol 87 (1) ◽  
pp. 243-246 ◽  
Author(s):  
John W. Castellani ◽  
Andrew J. Young ◽  
James E. Kain ◽  
Michael N. Sawka
Keyword(s):  
Cold Water ◽  
Water Immersion ◽  
Early Morning ◽  
Cold Water Immersion ◽  
Time Of Day ◽  
Mean Skin Temperature ◽  
Mean Body Temperature ◽  
Metabolic Heat ◽  
Body Temperature Change ◽  
The Mean

This study examined how time of day affects thermoregulation during cold-water immersion (CWI). It was hypothesized that the shivering and vasoconstrictor responses to CWI would differ at 0700 vs. 1500 because of lower initial core temperatures (Tcore) at 0700. Nine men were immersed (20°C, 2 h) at 0700 and 1500 on 2 days. No differences ( P > 0.05) between times were observed for metabolic heat production (M˙, 150 W ⋅ m−2), heat flow (250 W ⋅ m−2), mean skin temperature (T sk, 21°C), and the mean body temperature-change in M˙(ΔM˙) relationship. Rectal temperature (Tre) was higher ( P < 0.05) before (Δ = 0.4°C) and throughout CWI during 1500. The change in Tre was greater ( P < 0.05) at 1500 (−1.4°C) vs. 0700 (−1.2°C), likely because of the higher Tre-T skgradient (0.3°C) at 1500. These data indicate that shivering and vasoconstriction are not affected by time of day. These observations raise the possibility that CWI may increase the risk of hypothermia in the early morning because of a lower initial Tcore.

scholarly journals Recovery strategies implemented by sport support staff of elite rugby players in South Africa

2009 ◽  
Vol 65 (1) ◽  
Author(s):  
D.V. Van Wyk ◽  
M.I. Lambert
Keyword(s):  
Cold Water ◽  
Water Immersion ◽  
Total Duration ◽  
Cold Water Immersion ◽  
Support Staff ◽  
Medical Support ◽  
Cross Sectional ◽  
Study Results ◽  
Recovery Strategies ◽  
Rugby Players

Objective: The main aim of this study was to determine strategies used toaccelerate recovery of elite rugby players after training and matches, asused by medical support staff of rugby teams in South A frica. A  secondaryaim was to focus on specifics of implementing ice/cold water immersion asrecovery strategy. Design: A  Questionnaire-based cross sectional descriptive survey was used.Setting and Participants: Most (n=58) of the medical support staff ofrugby teams (doctors, physiotherapists, biokineticists and fitness trainers)who attended the inaugural Rugby Medical A ssociation conference linked to the South A frican Sports MedicineA ssociation Conference in Pretoria (14-16th November, 2007) participated in the study. Results: Recovery strategies were utilized mostly after matches. Stretching and ice/cold water immersion were utilized the most (83%). More biokineticists and fitness trainers advocated the usage of stretching than their counter-parts (medical doctors and physiotherapists). Ice/Cold water immersion and A ctive Recovery were the top two ratedstrategies. A  summary of the details around implementation of ice/cold water therapy is shown (mean) as utilized bythe subjects: (i) The time to immersion after matches was 12±9 min; (ii) The total duration of one immersion sessionwas 6±6 min; (iii) 3 immersion sessions per average training week was utilized by subjects; (iv) The average water temperature was 10±3 ºC.; (v) Ice cubes were used most frequently to cool water for immersion sessions, and(vi) plastic drums were mostly used as the container for water. Conclusion: In this survey the representative group of support staff provided insight to which strategies are utilizedin South A frican elite rugby teams to accelerate recovery of players after training and/or matches.

scholarly journals Cold-water immersion following sprint interval training does not alter endurance signaling pathways or training adaptations in human skeletal muscle

2017 ◽  
Vol 313 (4) ◽  
pp. R372-R384 ◽  
Author(s):  
James R. Broatch ◽  
Aaron Petersen ◽  
David J. Bishop
Keyword(s):  
Mitochondrial Biogenesis ◽  
Molecular Mechanisms ◽  
Cold Water ◽  
P53 Protein ◽  
Water Immersion ◽  
Interval Training ◽  
Cold Water Immersion ◽  
Peroxisome Proliferator ◽  
Sprint Interval Training ◽  
Single Session

We investigated the underlying molecular mechanisms by which postexercise cold-water immersion (CWI) may alter key markers of mitochondrial biogenesis following both a single session and 6 wk of sprint interval training (SIT). Nineteen men performed a single SIT session, followed by one of two 15-min recovery conditions: cold-water immersion (10°C) or a passive room temperature control (23°C). Sixteen of these participants also completed 6 wk of SIT, each session followed immediately by their designated recovery condition. Four muscle biopsies were obtained in total, three during the single SIT session (preexercise, postrecovery, and 3 h postrecovery) and one 48 h after the last SIT session. After a single SIT session, phosphorylated (p-)AMPK, p-p38 MAPK, p-p53, and peroxisome proliferator-activated receptor-γ coactivator-1α ( PGC-1α) mRNA were all increased ( P < 0.05). Postexercise CWI had no effect on these responses. Consistent with the lack of a response after a single session, regular postexercise CWI had no effect on PGC-1α or p53 protein content. Six weeks of SIT increased peak aerobic power, maximal oxygen consumption, maximal uncoupled respiration (complexes I and II), and 2-km time trial performance ( P < 0.05). However, regular CWI had no effect on changes in these markers, consistent with the lack of response in the markers of mitochondrial biogenesis. Although these observations suggest that CWI is not detrimental to endurance adaptations following 6 wk of SIT, they question whether postexercise CWI is an effective strategy to promote mitochondrial biogenesis and improvements in endurance performance.

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