scholarly journals Occult Pathologic Findings in Reduction Mammaplasty in 5781 Patients—An International Multicenter Study

2020 ◽  
Vol 9 (7) ◽  
pp. 2223
Author(s):  
Britta Kuehlmann ◽  
Florian D. Vogl ◽  
Tomas Kempny ◽  
Gabriel Djedovic ◽  
Georg M. Huemer ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Histopathological Examination ◽  
Reduction Mammaplasty ◽  
Developed Countries ◽  
Preoperative Imaging ◽  
Breast Size ◽  
Tissue Samples ◽  
International Multicenter Study ◽  
Tissue Specimens

Breast cancer is among the most commonly diagnosed cancers in the world, affecting one in eight women in their lifetimes. The disease places a substantial burden on healthcare systems in developed countries and often requires surgical correction. In spite of this, much of the breast cancer pathophysiology remains unknown, allowing for the cancer to develop to later stages prior to detection. Many women undergo reduction mammaplasties (RM) to adjust breast size, with over 500,000 operations being performed annually. Tissue samples from such procedures have drawn interest recently, with studies attempting to garner a better understanding of breast cancer’s development. A number of samples have revealed nascent cancer developments that were previously undetected and unexpected. Investigating these so-called “occult” findings of cancer in otherwise healthy patients may provide further insight regarding risk factors and countermeasures. Here, we detail occult findings of cancer in reduction mammaplasty samples provided from a cohort of over 5000 patients from 16 different institutions in Europe. Although the majority of our resected breast tissue specimens were benign, our findings indicate that there is a continued need for histopathological examination. As a result, our study suggests that preoperative imaging should be routinely performed in patients scheduled for RM, especially those with risk factors of breast cancer, to identify and enable a primary oncologic approach.

scholarly journals Hospital visitors as controls in case-control studies

2001 ◽  
Vol 35 (5) ◽  
pp. 436-442 ◽  
Author(s):  
Gulnar Azevedo S Mendonça ◽  
José Eluf-Neto
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Family History ◽  
Case Control ◽  
Breast Size ◽  
Case Control Studies ◽  
Family History Of Cancer ◽  
History Of ◽  
Incident Cases ◽  
History Of Cancer

OBJECTIVE: Selecting controls is one of the most difficult tasks in the design of case-control studies. Hospital controls may be inadequate and random controls drawn from the base population may be unavailable. The aim was to assess the use of hospital visitors as controls in a case-control study on the association of organochlorinated compounds and other risk factors for breast cancer conducted in the main hospital of the "Instituto Nacional de Câncer" -- INCA (National Cancer Institute) in Rio de Janeiro (Brazil). METHODS: The study included 177 incident cases and 377 controls recruited among female visitors. Three different models of control group composition were compared: Model 1, with all selected visitors; Model 2, excluding women visiting relatives with breast cancer; and Model 3, excluding all women visiting relatives with any type of cancer. Odds ratios (OR) and 95% confidence intervals were calculated to test the associations. RESULTS: Age-adjusted OR for breast cancer associated with risk factors other than family history of cancer, except smoking and breast size, were similar in the three models. Regarding family history of all cancers, except for breast cancer, there was a decreased risk in Models 1 and 2, while in Model 3 there was an increased risk, but not statistically significant. Family history of breast cancer was a risk factor in Models 2 and 3, but no association was found in Model 1. In multivariate analysis a significant risk of breast cancer was found when there was a family history of breast cancer in Models 2 and 3 but not in Model 1. CONCLUSIONS: These results indicate that while investigating risk factors unrelated to family history of cancer, the use of hospital visitors as controls may be a valid and feasible alternative.

scholarly journals Faktor Resiko Yang Berhubungan Dengan Kejadian Kanker Payudara Di Ruang Edelweis RSUD Ulin Banjarmasin

2019 ◽  
pp. 99-110
Author(s):  
Ika Avrilina Haryono ◽  
Adriana Palimbo ◽  
Difa Okti Al Kautsar
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Multiple Regression ◽  
Contraceptive Use ◽  
Developed Countries ◽  
Hormonal Contraceptive ◽  
Chi Square ◽  
Cross Sectional ◽  
Chi Square Test ◽  
History Of

ABSTRAKLatar Belakang : Kanker payudara merupakan salah satu penyebab kematian utama pada wanita di dunia. Sejauh ini, kanker payudara paling sering diderita oleh wanita dengan perkiraan 43,3% juta kasus kanker baru yang didiagnosis pada tahun 2012. Angka kejadian kanker payudara bervariasi secara global dimana terjadi peningkatan insiden di negara berkembang tetapi cenderung menurun dinegara maju, dengan kasus pada negara berkembang (883.000 kasus) negara maju (794.000 kasus). Tujuan: Menganalisis faktor resiko yang berhubungan dengan kejadian kanker payudara meliputi faktor umur, umur pertama menstruasi, menopause, umur pertama kali menikah, riwayat penggunaan kontrasepsi hormonal, riwayat pemberian ASI, da riwayat kanker payudara pada keluarga.Metode: Penelitian ini adalah penelitian kuantitatif menggunakan metode survey analitik dengan rancangan cross sectional. Populasi dalam penelitian ini berjumlah 760 orang dengan sampel 88 orang. Teknik pengumpulan data primer, teknik analisa data yang digunakan adalah uji chi square dan uji regresi berganda.Hasil: Hasil Uji Chi Square menunjukan bahwa terdapat hubungan signifikan antara umur (p=0.000) dan penggunaan kontrasepsi hormonal (p=0.002) dengan hasil uji regresi berganda (p-value0.05) menunjukan bahwa tidak ada pengaruh faktor risiko terhadap kejadian kanker payudara.Simpulan: Ada hubungan antara umur dan riwayat penggunaan kontrasepsi hormonal dengan kejadian kanker payudara. Tidak ada pengaruh faktor resiko terhadap kejadian kanker payudara. Kata Kunci: kanker payudara, riwayat penggunaan kontrasepsi hormonal, umur Risk Factors Related to Breast Cancer IncidenceIn the Edelweis Room of Ulin Hospital Banjarmasin AbstractBackground: Breast cancer is one of the leading causes of death in women in the world. So far, breast cancer most often affects women with an estimated 43.3% of new cancer cases diagnosed in 2012. The incidence of breast cancer varies globally where there is an increase in incidents in developing countries but tends to decrease in developed countries, with cases in the country developing (883,000 cases) developed countries (794,000 cases).Objective: Analyzing risk factors associated with breast cancer events include age, age at first menstruation, menopause, age at first marriage, history of use of hormonal contraception, history of breastfeeding, and history of breast cancer in the family.Method: This study is a quantitative study using analytical survey method with cross sectional design. The population in this study amounted to 760 people with a sample of 88 people. Primary data collection techniques, data analysis techniques used are chi square test and multiple regression test.Results: Chi Square test results showed that there was a significant relationship between age (p = 0,000) and hormonal contraceptive use (p = 0.002) with the results of multiple regression tests (p-value 0.05) indicating that there was no effect of risk factors on breast cancer incidence.Conclusion: There is a relationship between age and history of hormonal contraceptive use with the incidence of breast cancer. There is no effect of risk factors on the incidence of breast cancer. Keywords: breast cancer, history of hormonal contraceptive use, age

scholarly journals Assessment of Expression of Homeobox A5 in Endometrial Cancer on the mRNA and Protein Level

2020 ◽  
Vol 21 (7) ◽  
pp. 635-641
Author(s):  
Konrad Dziobek ◽  
Marcin Oplawski ◽  
Nikola Zmarzły ◽  
Beniamin O. Gabarek ◽  
Robert Kiełbasiński ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Histopathological Examination ◽  
Gynecological Cancer ◽  
Mrna Level ◽  
Developed Countries ◽  
Cancer Tissue ◽  
Tissue Samples ◽  
Protein Levels ◽  
Glandular Cells ◽  
The Developed Countries

Background: Endometrial cancer is one of the most common gynecological cancer in the developed countries and occurs mainly in postmenopausal women. Angiogenesis is important for cancer formation as it provides nutrients for growing tumor mass. Most tumors do not show detectable Homeobox A5 (HOXA5 level), suggesting its potential role as a cancer suppressor. It was demonstrated that HOXA5 is involved in the progression of various types of cancer and the loss of its expression correlates with higher pathological grade and poorer outcome. Objective: The aim of the study was to evaluate HOXA5 expression at transcriptome and protein levels. Material and methods: The study enrolled 45 women diagnosed with endometrial cancer and 15 without neoplastic changes. The histopathological examination allowed us to divide cancer tissue samples according to the degree of histological differentiation: G1, 17; G2, 15; G3, 13. The expression of the HOXA5 protein was determined by immunohistochemistry. Microarray and RT-qPCR techniques were used to assess HOXA5 expression at the mRNA level. Results: The reaction to the HOXA5 protein was only visible in glandular cells in G1 endometrial cancer and was lower compared to the control. In grades 2 and 3, reactions were noted at the limit of the method’s sensitivity. In addition, reduced HOXA5 expression was observed at the transcriptome level. Conclusion: HOXA5 may become a potential complementary molecular marker, allowing early detection of neoplastic changes in the endometrium. It also seems that detection of HOXA5 at the mRNA and protein levels may be helpful in improving the accuracy of diagnosis and planning effective oncological therapy.

scholarly journals Breast Cancer Detection by Preoperative Imaging in Reduction Mammaplasty Patients: A Single Center Study of 918 Patients

2017 ◽  
Vol 41 (8) ◽  
pp. 2013-2019 ◽  
Author(s):  
Päivi A. Merkkola-von Schantz ◽  
Susanna M. C. Kauhanen ◽  
Tiina A. Jahkola ◽  
Leena A. Krogerus ◽  
Katja S. Hukkinen
Keyword(s):  
Breast Cancer ◽  
Cancer Detection ◽  
Reduction Mammaplasty ◽  
Breast Cancer Detection ◽  
Preoperative Imaging ◽  
Single Center ◽  
Single Center Study ◽  
Center Study

scholarly journals Risk factors associated with carcinoma breast: a case control study

2017 ◽  
Vol 4 (9) ◽  
pp. 3136 ◽  
Author(s):  
Palachandra A. ◽  
Ishwaraprasad G. D. ◽  
Sreelatha C. Y. ◽  
Sumana M.
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Case Control Study ◽  
Tertiary Care ◽  
Reproductive Factors ◽  
Developed Countries ◽  
Case Control ◽  
Age At Menarche ◽  
Care Hospital ◽  
Control Study

Background: The burden of breast cancer is increasing in both developed and developing countries; the peak occurrence of breast cancer in developed countries is above the age of 50 whereas in India it is above the age of 40. Reproductive factors contribute most to the development of breast cancer. Nulliparity, more age at first live birth and no breastfeeding are major reproductive risk factors for breast cancer in the developed countries. The role of reproductive factors in the development of breast cancer in Indian population is different as compared with that seen in the western population. Objective of this study was to find out some of the various risk factors of breast cancer among patients attending the tertiary care hospital in Hassan.Methods: The case control study was conducted at surgery wards of Sri Chamarajendra district hospital which is a teaching hospital. The calculated number of cases was 110, including 110 controls total 220 individuals were included in the study. A case was defined as any female patient histopathologically confirmed to have breast cancer.Results: The maximum cases (38%) were between 51 to 60 years of age group. Age at menarche, age at first child birth, age at marriage and age at menopause reported significant risk for breast cancer.Conclusions: Information, education and communication activities regarding these risk factors, early signs and symptoms of breast carcinoma, and breast self‑examination should be imparted to the women to create awareness about this fatal disease.

scholarly journals Variable Transcriptional Activity of Endogenous Retroviruses in Human Breast Cancer

2007 ◽  
Vol 82 (4) ◽  
pp. 1808-1818 ◽  
Author(s):  
Oliver Frank ◽  
Caroline Verbeke ◽  
Norbert Schwarz ◽  
Jens Mayer ◽  
Alice Fabarius ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mammary Gland ◽  
Human Breast Cancer ◽  
Endogenous Retroviruses ◽  
Human Breast ◽  
Single Class ◽  
Tissue Samples ◽  
Mammary Gland Tissue ◽  
Tumor Virus ◽  
Tissue Specimens

ABSTRACT Human endogenous retroviruses (HERVs) account for up to 9% of the human genome and include more than 800 elements related to betaretroviruses. While mouse mammary tumor virus (MMTV) is the accepted etiological agent of mammary tumors in mice, the role of retroviral elements in human breast cancer remains elusive. Here, we performed a comprehensive microarray-based analysis of overall retroviral transcriptional activities in 46 mammary gland tissue specimens representing pairs of nonmalignant and tumor samples from 23 patients. An analysis of nonmalignant tissue samples revealed a distinct, mammary gland-specific HERV expression profile that consists of 18 constitutively active HERV taxa. For corresponding tumor samples, a general trend toward lower levels of HERV transcription was observed, suggesting common regulatory mechanisms. In various subsets of patients, however, increased transcript levels of single class I HERV families (HERV-T, HERV-E, and HERV-F) and several class II families, including HML-6, were detected. An analysis of transcribed HML-6 sequences revealed either the activation of some or the increased activity of several proviral loci. No evidence for MMTV or human MMTV-like virus transcripts was found, indicating that transcriptionally active, MMTV analogous, exogenous viruses were not present in the breast cancer samples analyzed.

scholarly journals Breast Cancer among Pakistani Women in Referral Hospitals: An Overview of Risk Factors

2010 ◽  
Vol 4 (1) ◽  
pp. 1-3 ◽  
Author(s):  
Maria Shabbir Saria ◽  
Masoom Raza Mirza ◽  
Lubna Habib ◽  
Muhammad Zubair
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Breast Carcinoma ◽  
Histopathological Examination ◽  
Oral Contraceptive Pill ◽  
Early Menarche ◽  
Referral Hospitals ◽  
Group A ◽  
Post Menopausal ◽  
Group B

The aim of this study was to determine the significance of various reproductive risk factors amongstPakistani women suffering from breast carcinoma. This observational study was carried out fromMarch 2007 to February 2009 at three hospitals. The women who presented with breast swellingwith or without discharge from nipple were included in the study. The diagnosis of breast cancer wasconfirmed by histopathological examination. A questionnaire included history and various reproductiverisk factors. The study patients were divided into two groups by their menopausal history – premenopausaland post-menopausal as ‘group A’ and ‘group B’, respectively. A total of 70 patients hadthe diagnosis of breast cancer. Of them, 32 were in group A and 38 in group B. Regarding agedistribution, 49% were found in ≥51 years of age and 29% in the age group 30 – 40 years. The meanage at menarche was 13.3 years in group A and 12.4 years in group B. Nulliparity was seen in12.5% cases in group A and 5.26% in group B. History of first full term pregnancy (FFTP) belowthe age of 20 was present in majority of cases in both groups though higher in group B. Breast cancerin post-menopausal women was exclusively found among those who had early menarche (<=11years) and was more frequent among those who had FFTP below 20 years of age compared with thepre-menopausal group (88% vs. 66%). The study showed higher frequency of breast cancer in postmenopausalwomen having early menarche and also more frequent among those with early FFTP.Parity, breast feeding, oral contraceptive pill use were not related to breast cancer.Ibrahim Med. Coll. J. 2010; 4(1): 1-3Indexing Words: Breast carcinoma; risk factors; genetics.DOI: 10.3329/imcj.v4i1.5926

scholarly journals Risk Factors of Breast Cancer based on Case-Control Study in Women of Child-Bearing Age (WEBA) at Gambiran Hospital Kediri

2021 ◽  
Vol 8 (3) ◽  
pp. 386-392
Author(s):  
Nurita Nilasari Bunga Kharisma Arifiana Putri ◽  
Eko Sri Wulaningtyas
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Developed Countries ◽  
Case Control ◽  
The Body ◽  
High Rate ◽  
P Value ◽  
Control Analysis ◽  
Breast Cancer Patients ◽  
History Of

Breast cancer is a type of cancer that starts in the breast tissue and spreads throughout the body. Every year more than 185,000 women are diagnosed with breast cancer. This incidence is increasing in developed countries (Kemenkes RI, 2015). In Indonesia, a high rate of breast cancer, especially in Kediri, makes breast cancer the number one position of cancer in women, followed by cervical cancer. Based on research by Harrianto et al. at Dr. Cipto Mangunkusumo Hospital in the Journal of Public Health 8 (2) (2013) 121-126, breast cancer risk factors include a family history of breast cancer patients (15.79%), early menarche (8.77%), nullipara (7.02 %), and long-term use of pills containing estrogen (42.11%). In addition, there are also incidences of breast cancer, namely late menopause, history of breastfeeding, and obesity. From the description above, the purpose of this study is to determine and analyze the risk factors for breast cancer based on a case-control analysis in women at Gambiran Hospital, Kediri. This study uses data collection sheets and field studies, then processed for hypothesis testing so that the objectives of this research can be carried out. This study indicates a significant relationship between the risk factors for a breast cancer history with a p-value of 0.0000 OR 9.837. For women who have families with cancer should be aware of the onset of breast cancer. If they have reached puberty, it is recommended for early detection (screening test) through breast self-examination (BSE), IVA method, and mammography testing.

Correlation between toxic organochlorine pesticides and breast cancer

2017 ◽  
Vol 36 (12) ◽  
pp. 1326-1334 ◽  
Author(s):  
SA Eldakroory ◽  
DA El Morsi ◽  
RH Abdel-Rahman ◽  
S Roshdy ◽  
MS Gouida ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Organochlorine Pesticides ◽  
Negative Correlation ◽  
Tumor Tissue ◽  
Cell Lymphoma ◽  
Environmental Pollutants ◽  
B Cell Lymphoma ◽  
Tissue Samples ◽  
Tissue Specimens

Organochlorines (OCs) are common environmental pollutants that have been linked to cancer. This work aims to assess the role of OCs as a risk factor for breast cancer and to evaluate the cellular changes induced by exposure to such environmental contaminants. The study included 70 cancer patients subjected to thorough history taking and routine investigations. Samples from tumor and normal adjacent tissue were taken to measure OCs’ levels and to perform molecular analysis (some oncogenic and apoptotic markers) by flow cytometry. There were significantly higher concentrations of methoxychlor, dichloro-diphenyl-trichloroethane (DDT), hexa-chlorobenzene (HCB), and chlordane in tumor tissue samples compared to the surrounding normal tissue. There was a positive statistically significant correlation between G2m and dichloro-diphenyl-dichloroethane, DDT, and methoxychlor. There was also a negative correlation between propidium iodide (PI) and heptachlor as well as between PI, B-cell lymphoma 2, and methoxychlor. Annexin showed a negative correlation with HCB and methoxychlor. In conclusion, the higher level of organochlorine pesticides in the tissue specimens of breast cancer and the resultant molecular dysfunction highlight a possible association. Further research is warranted to elucidate the other possible mechanisms involved in the process of carcinogenesis.

scholarly journals Measuring knowledge and practice in relation to breast cancer screening in mothers in Pakistan

2017 ◽  
Vol 6 (2) ◽  
pp. 81
Author(s):  
Sharmeen Amin ◽  
Zafeer Ahmed Yazdani ◽  
Ankush Jha ◽  
Deepika Sriram ◽  
Hinozia Merchant ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Risk Factor ◽  
Signs And Symptoms ◽  
Developed Countries ◽  
Breast Diseases ◽  
P Value ◽  
Screening Methods ◽  
Early Screening ◽  
Cross Sectional

Background: Breast cancer is a major health burden mainly in the developed countries but its rates are also increasing in the developing countries. With such increasing rates of breast cancer it is imperative that the general population is aware of its risk factors, early screening methods and the preventive measures that can be undertaken before its development.Objective: To assess the awareness of breast-self-examination (BSE) & screening among the mothers belonging to different socioeconomic groups in Karachi, Pakistan. To assess the awareness of breast lump & its relation with breast cancer in mothers.Methods: This is a cross sectional research study constituting on a sample size of 284 people. The data was collected using a self administered questionnaire which was designed after detailed literature review. The date was collected from all 5 districts of Karachi, Pakistan. The duration of data collection was from April 2013 to November 2013. The data was analyzed using spss 19 with a 95% confidence interval and a 5% margin of error. A p-value of .05 or less was considered significant.Results: The results showed that most of the women (81%) have sufficient general knowledge about breast cancer and its outcomes but the awareness regarding the risk factors was limited. Only 38% were aware that old age is a risk factor, 34.9% knew that null parity is a risk factor while 57.7% believed that trauma to the breast, for example child hitting the breast, cause breast disease. The women were only partially aware of the screening methods available, only 53.2% of women knew how to self-examine their breast and 69% of them were not aware of the fact that mammography is the basic screening procedure. Results are similar for knowledge about signs and symptoms and only 46.8% were aware that bloody discharge and inward retraction of nipple may be due to breast cancer. Despite the limited current awareness about the breast diseases most women (82.4%) showed interest in learning more information about breast diseases and how might they be prevented.Conclusions: The study concluded that though the mothers were aware of breast cancer they still require sufficient knowledge regarding its risks, methods of screening and means to prevent it. In accordance with this need more initiatives should be undertaken to spread more awareness regarding this through media or other useful sources. But increasing awareness alone cannot deliver the desired results and there is a parallel need to increase the facilities and to make them accessible for all. Steps should also be undertaken to educate the women about their misconceptions regarding breast cancer and to make them free from unnecessary barriers as many women do not seek clinical advice due to these barriers.

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