scholarly journals The 10-Year Study of the Impact of Particulate Matters on Mortality in Two Transit Cities in North-Eastern Poland (PL-PARTICLES)

2020 ◽  
Vol 9 (11) ◽  
pp. 3445
Author(s):  
Łukasz Kuźma ◽  
Emil Julian Dąbrowski ◽  
Anna Kurasz ◽  
Hanna Bachórzewska-Gajewska ◽  
Sławomir Dobrzycki
Keyword(s):  
Air Pollution ◽  
Cardiovascular Mortality ◽  
Odds Ratio ◽  
Crossover Design ◽  
Particulate Matters ◽  
Short Term ◽  
Respiratory Mortality ◽  
Case Crossover ◽  
North Eastern ◽  
The Impact

The detrimental influence of air pollution on mortality has been established in a series of studies. The majority of them were conducted in large, highly polluted cities—there is a lack of studies from small, relatively clean regions. The aim was to analyze the short-term impact of particulate matters (PMs) on mortality in north-eastern Poland. Time-stratified case-crossover design was performed for mortality in years 2008–2017. Daily concentrations of PM2.5 (28.4 µg/m3, interquartile range (IQR) = 25.2) vs. (12.6 µg/m3, IQR = 9.0) and PM10 (29.0 µg/m3, IQR = 18.0) vs. (21.7 µg/m3, IQR = 14.5) were higher in Łomża than Suwałki (p < 0.001). Impact of PM2.5 on mortality was recorded in Łomża (odds ratio (OR) for IQR increase 1.061, 1.017–1.105, p = 0.06, lag 0) and Suwałki (OR for IQR increase 1.044, 1.001–1.089, p = 0.004, lag 0). PM10 had an impact on mortality in Łomża (OR for IQR increase 1.028, 1.000–1.058, p = 0.049, lag 1). Cardiovascular mortality was affected by increase of PM2.5 in Łomża (1.086, 1.020–1.156, p = 0.01) and Suwałki (1.085, 1.005–1.171, p = 0.04). PM2.5 had an influence on respiratory mortality in Łomża (1.163, 1.021–1.380, p = 0.03, lag 1). In the whole studied region, despite differences in the air quality, the influence of PMs on mortality was observed.

scholarly journals Short-term effect of fine particulate matter and ozone on non-accidental mortality and respiratory mortality in Lishui district, China

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yuqi Chen ◽  
Zhigang Jiao ◽  
Ping Chen ◽  
Lijun Fan ◽  
Xudan Zhou ◽  
...  
Keyword(s):  
Air Pollution ◽  
Elderly People ◽  
Fine Particulate Matter ◽  
Middle Aged ◽  
Short Term ◽  
Respiratory Mortality ◽  
Population Attributable Fractions ◽  
Fine Particulate ◽  
Attributable Fractions ◽  
The Impact

Abstract Background In recent years, air pollution has become an imminent problem in China. Few studies have investigated the impact of air pollution on the mortality of the middle-aged and elderly people. Therefore, this study aims to evaluate the impact of PM2.5 (fine particulate matter) and O3 (ozone) on non-accidental mortality and respiratory mortality of the middle-aged and elderly people in Lishui District of Nanjing and provide the evidence for potential prevention and control measures of air pollution. Method Using daily mortality and atmospheric monitoring data from 2015 to 2019, we applied a generalized additive model with time-series analysis to evaluate the association of PM2.5 and O3 exposure with daily non-accidental mortality and respiratory mortality in Lishui District. Using the population attributable fractions to estimate the death burden caused by short-term exposure to O3 and PM2.5。. Result For every 10 μg/m3 increase in PM2.5, non-accidental mortality increased 0.94% with 95% confidence interval (CI) between 0.05 and 1.83%, and PM2.5 had a more profound impact on females than males. For every 10 μg/m3 increase in O3, respiratory mortality increased 1.35% (95% CI: 0.05, 2.66%) and O3 had a more profound impact on males than females. Compared with the single pollutant model, impact of the two-pollutant model on non-accidental mortality and respiratory mortality slightly decreased. In summer and winter as opposed to the other seasons, O3 had a more obvious impact on non-accidental mortality. The population attributable fractions of non-accidental mortality were 0.84% (95% CI:0.00, 1.63%) for PM2.5 and respiratory mortality were 0.14% (95% CI:0.01, 0.26%) for O3. For every 10 μg/m3 decrease in PM2.5, 122 (95% CI: 6, 237) non-accidental deaths could be avoided. For every 10 μg/m3 decrease in O3, 10 (95% CI: 1, 38) respiratory deaths could be avoided. Conclusion PM2.5 and O3 could significantly increase the risk of non-accidental and respiratory mortality in the middle-aged and elderly people in Lishui District of Nanjing. Exposed to air pollutants, men were more susceptible to O3 damage, and women were more susceptible to PM2.5 damage. Reduction of PM2.5 and O3 concentration in the air may have the potential to avoid considerable loss of lives.

scholarly journals Assessing short-term risk of ischemic stroke in relation to all prescribed medications

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Imre Janszky ◽  
Ioannis Vardaxis ◽  
Bo Henry Lindqvist ◽  
Jens Wilhelm Horn ◽  
Ben Michael Brumpton ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Odds Ratio ◽  
Crossover Design ◽  
Lasso Regression ◽  
Short Term ◽  
Case Crossover ◽  
Increased Risk ◽  
Follow Up Studies ◽  
Prescription Databases

AbstractWe examined the short-term risk of stroke associated with drugs prescribed in Norway or Sweden in a comprehensive, hypothesis-free manner using comprehensive nation-wide data. We identified 27,680 and 92,561 cases with a first ischemic stroke via the patient- and the cause-of-death registers in Norway (2004–2014) and Sweden (2005–2014), respectively, and linked these data to prescription databases. A case-crossover design was used that compares the drugs dispensed within 1 to 14 days before the date of ischemic stroke occurrence with those dispensed 29 to 42 days before the index event. A Bolasso approach, a version of the Lasso regression algorithm, was used to select drugs that acutely either increase or decrease the apparent risk of ischemic stroke. Application of the Bolasso regression algorithm selected 19 drugs which were associated with increased risk for ischemic stroke and 11 drugs with decreased risk in both countries. Morphine in combination with antispasmodics was associated with a particularly high risk of stroke (odds ratio 7.09, 95% confidence intervals 4.81–10.47). Several potentially intriguing associations, both within and across pharmacological classes, merit further investigation in focused, follow-up studies.

scholarly journals Association between air pollution and case-specific mortality in north-eastern part of Poland. Case crossover study with 4,500,000 person-years of follow-up

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
L Kuzma ◽  
A Kurasz ◽  
E J Dabrowski ◽  
M Swieczkowski ◽  
S Dobrzycki ◽  
...  
Keyword(s):  
Air Pollution ◽  
Warm Season ◽  
Cold Season ◽  
Funding Sources ◽  
Case Crossover ◽  
North Eastern ◽  
The Impact ◽  
Related Mortality ◽  
Cvd Mortality

Abstract Background Recent studies have reported associations between air pollution and daily mortality. The majority of them are conducted in highly polluted areas. Taking into consideration the scarce number of surveys from cities with moderate air quality we decided to conduct a study in this type of region. Purpose To assess the short-term impact of air pollution on cardiovascular (CVD), coronary artery-related (CAD), and cerebrovascular-related (CbVD) mortality. Methods The analysis with almost 4,500,000 person-years of follow-up with a time-stratified case-crossover design was performed. Results are reported as odds ratio (OR) associated with an increase in interquartile range (IQR). Results The analysed region was inhabited by almost 500,000 residents. From 2008 to 2017 in Bialystok, Lomza, and Suwalki we recorded 49,573 deaths – 34,005, 8,082, 7,486, respectively. The median daily concentrations of PM10 (23.8 μg/m3, IQR=16.9) was the highest in Lomza, Median daily concentration of PM2.5 was the highest in Bialystok (16.2 μg/m3, IQR=15.9). In the case of Suwalki, daily median PM2.5 concentration was 9.8 μg/m3 (IQR=8.7), and PM10 – 18.0 μg/m3 (IQR=14.3). The IQR increase in PM2.5 (OR 1.036, 95% CI 1.016–1.056, P&lt;0.001) and PM10 concentration (OR 1.034, 95% CI 1.015–1.053, P&lt;0.001) was associated with increased CVD mortality on lag 0 and this effect persisted on following days. The effects of PMs were more expressed in association with CAD-related mortality (OR for PM2.5 = 1.045, 95% CI 1.012–1.080, P=0.008), (OR for PM10 = 1.044, 95% CI 1.010–1.078, P=0.011) and CbVD mortality (OR for PM2.5 = 1.046, 95% CI 1.013–1.080, P=0.006), (OR=1.041 for PM10, 95% CI 1.002–1.082, P=0.038). Additionally, IQR increase in NO2 concentration was associated with increased CAD-related mortality at lag 0–1 (OR=1.055, 95% CI 1.004–1.108, P=0.032). The highest OR for PMs was noted in Suwalki compared to Bialystok and Lomza. The trend was noted regardless of the cause of death from lag 0 to lag 0–3. In a comparison of seasons, we noted higher CVD mortality OR in the cold season for PM10 in Suwalki (P=0.047) and Bialystok (p=0.001). However, the impact of NO2 (P=0.02) and PM10 (P=0.03) on CAD related mortality was higher in the warm season. Conclusions The impact of air pollution on CVD mortality is also observed in moderately polluted areas. PMs and NO2 had the greatest impact on CAD-related mortality. Differences in effect size and seasonality may depend on the source of air pollution. FUNDunding Acknowledgement Type of funding sources: None.

scholarly journals The Relationship Between Short-Term Exposure To Air Pollution With Hospitalization and Mortality of Cardiovascular (CVD) and Respiratory Diseases in Shahrekord, Iran

2021 ◽  
Author(s):  
Abdolkazem Neisi ◽  
Maryam Dastoorpoor ◽  
Gholamreza Godarzi ◽  
Abdolmajid Fadaei ◽  
Kambiz Ahmadi Angali ◽  
...  
Keyword(s):  
Air Pollution ◽  
Cardiovascular Mortality ◽  
Hospital Admissions ◽  
Total Mortality ◽  
Short Term ◽  
Respiratory Mortality ◽  
Risk Of Death ◽  
Short Term Exposure ◽  
The Relationship ◽  
Respiratory Death

Abstract Background and objectives: Air pollution has been widely considered as an important factor in causing heart disease, respiratory disease, and death. This study sought to determine the relationship between short-term exposure to air pollutants and hospital admissions, cardiovascular and respiratory deaths and total mortality rate in Shahrekord, Iran.Procedure: This is a time series and ecological research. We collected data on hospital admissions and cardiovascular mortality and total mortality from 2012 to 2018. The study used the quasi-Poisson regression combined with linear distributed lag models, adjusted for trend, seasonality, temperature, relative humidity, weekdays and holidays.Results: Our results show a direct and significant statistical relationship between: O3 exposure in lag4 for total mortality, PM10 exposure in lag1 for total mortality and in lag4 and lag1 for respiratory death, PM2.5 exposure for total cardiovascular admissions in lag5, respiratory mortality in lag4, total respiratory admissions in lag3, NO2 exposure to respiratory mortality in lag1, and cardiovascular mortality in lag0, increased risk of death and pathogenesis.The results show a statistically significant inverse relationship between: NO and total admissions in lag3 and for respiratory mortality in lag1 between PM2.5 and cardiovascular mortality in lag1, NO with respiratory mortality in lag1 and cardiovascular admissions in lag3, NO2 with cardiovascular admissions in lag1 and NOX with respiratory death in lag0, which reduces the risk of death and pathogenesis.Conclusion: Air pollution has a significant relationship with the number of hospital admissions and mortality in Shahrekord, Iran.

scholarly journals Short-Term Effects of “Polish Smog” on Cardiovascular Mortality in the Green Lungs of Poland: A Case-Crossover Study with 4,500,000 Person-Years (PL-PARTICLES Study)

Atmosphere ◽  
2021 ◽  
Vol 12 (10) ◽  
pp. 1270
Author(s):  
Łukasz Kuźma ◽  
Anna Kurasz ◽  
Emil Julian Dąbrowski ◽  
Sławomir Dobrzycki ◽  
Hanna Bachórzewska-Gajewska
Keyword(s):  
Air Pollution ◽  
Cardiovascular Mortality ◽  
Cold Season ◽  
Pollution Level ◽  
Short Term ◽  
Coronary Syndrome ◽  
Adverse Health ◽  
Case Crossover ◽  
Related Mortality ◽  
Cvd Mortality

Previous studies conducted in highly polluted areas have reported associations between air pollution and daily mortality. The Green Lungs of Poland are characterized by unique natural features and a moderate pollution level. We aimed to assess the short-term impact of air pollution on cardiovascular (CVD)-, acute coronary syndrome (ACS)-, and cerebrovascular-related (CbVD) mortality. An analysis with 4,500,000 person-years and a time-stratified case-crossover design was performed. The interquartile range increase in the PM2.5 (OR 1.036, 95% CI 1.016–1.056, p < 0.001) and PM10 concentration (OR 1.034, 95% CI 1.015–1.053, p < 0.001) was associated with increased CVD mortality on lag 0, and this effect persisted on the following days. The effects of PMs were expressed more in association with ACS-related mortality (PM2.5-OR = 1.045, 95% CI 1.012–1.080, p = 0.01; PM10-OR = 1.044, 95% CI 1.010–1.078, p = 0.01) and CbVD mortality (PM10-OR = 1.099, 95% CI 1.019–1.343, p = 0.02). We also noted a higher CVD mortality OR in the cold season for PM10 in cities with area-source domination: Białystok (p = 0.001) and Suwałki (p = 0.047). The short-term impact of PMs on cardiovascular mortality is also observed in moderately polluted areas. This adverse health effect was more apparent in CbVD- and ACS-related mortality, and in the cold season. Further research focusing on the adverse health effects of “Polish smog” is sorely needed.

scholarly journals Short Term Exposure to Air Pollution and Mortality in the US: A Case-Crossover Analysis

2021 ◽  
Author(s):  
Rongqi Liu ◽  
Yaguang Wei ◽  
Xinye Qiu ◽  
Anna Kosheleva ◽  
Joel D. Schwartz
Keyword(s):  
Air Pollution ◽  
Moving Average ◽  
Conditional Logistic Regression ◽  
Fine Particulate Matter ◽  
Short Term ◽  
Us States ◽  
Respiratory Mortality ◽  
Case Crossover ◽  
Short Term Exposure ◽  
All Cause Mortality

Abstract Background: Studies examining the association of short-term air pollution exposure and daily deaths have typically been limited to cities and used citywide averages for exposure. This study aims to estimate the associations between short-term exposures to fine particulate matter (PM2.5), ozone (O3), and nitrogen dioxide (NO2) and all-cause and cause-specific mortality in multiple US states including rural areas.Methods: We conducted a time-stratified case-crossover study examining the entire population of seven US states from 2000-2015, with over 3 million non-accidental deaths. Daily predictions of PM2.5, O3, and NO2 at 1x1 km grid cells across the contiguous US were linked to mortality based on census track and residential address. For each pollutant, we used conditional logistic regression to quantify the association between exposure and the relative risk of mortality conditioning on meteorological variables and other pollutants. Results: A 10 μg/m3 increase in PM2.5 exposure at the moving average of lag 0-1 day and 10 ppb increase in NO2 exposure at lag 0-3 day were significantly associated with a 0.67% (95%CI: 0.34-1.01%) and 0.20% (95%CI: 0.00-0.39%) increase in the risk of all-cause mortality, respectively. A marginally significant association for mortality was observed with each 10 ppb increase in O3 exposure at lag 0-3 day. The adverse effects of PM2.5 on all-cause mortality persisted when restricting the analysis at lower levels.. PM2.5 was also significantly associated with respiratory mortality and cardiovascular mortality. Conclusions: Short-term exposure to PM2.5 and NO2 is associated with increased risks for all-cause mortality. Our findings delivered evidence that risks of death persisted at levels below currently permissible.

scholarly journals Short-term effect of PM 2.5 and O3 on non-accidental mortality and respiratory mortality in Lishui District , China

2021 ◽  
Author(s):  
Yuqi Chen ◽  
Zhigang Jiao ◽  
Ping Chen ◽  
Lijun Fan ◽  
XuDan Zhou ◽  
...  
Keyword(s):  
Air Pollution ◽  
Elderly People ◽  
Additive Model ◽  
Scientific Basis ◽  
Control Measures ◽  
Middle Aged ◽  
Short Term ◽  
Respiratory Mortality ◽  
Short Term Exposure ◽  
The Impact

Abstract Background In recent years, air pollution has become an imminent problem in China. Few studies have investigated the impact of air pollution on the mortality of middle-aged and elderly people. Therefore, this study aims to evaluate the impact of PM2.5 and O3 on non-accidental mortality and respiratory mortality of the middle-aged and elderly in Lishui district of China and provide the scientific basis for the prevention and control measures of air pollution. Method: Using daily mortality and atmospheric monitoring data from 2015 to 2019, we applied a generalized additive model with time-series analysis to study the association of PM2.5 and O3 exposure with daily non-accidental mortality and respiratory mortality in Lishui district of China. Using attributable risk to estimate the death burden attributable to short-term exposure to O3 and PM2.5。 Result PM2.5 and O3 were associated with non-accidental and respiratory mortality. For every 10µg/m3 increased in PM2.5, non-accidental mortality increased 0.94% (95%CI: 0.05%-1.83%), and PM2.5 had a more significant impact on women. For every 10µg/m3 increased in O3, respiratory mortality increased 1.35% (95%CI: 0.05%-2.66%). and O3 had a more significant impact on men. Compared with single pollutant model, the impact of the two-pollutant model on non-accidental mortality and respiratory mortality slightly decreased. Besides, in summer and winter, O3 had a more obvious impact on non-accidental mortality. The Population Attributable Fractions of non-accidental mortality were 0.839% (95%CI:0.004–1.626%) for PM2.5 and the PAF of respiratory mortality were 0.135% (95%CI:0.005–0.263%) for O3. Conclusion PM2.5 and O3 could significantly increase the risk of non-accidental and respiratory mortality in middle-aged and elderly people in Lishui district, China. Exposing to air pollutants, men were more susceptible to O3 damage, and women were more susceptible to PM2.5 damage.

scholarly journals The Impact of Short-Term Exposure to Air Pollution on the Exhaled Breath of Healthy Adults

Sensors ◽  
2021 ◽  
Vol 21 (7) ◽  
pp. 2518
Author(s):  
Ariana Lammers ◽  
Anne H. Neerincx ◽  
Susanne J. H. Vijverberg ◽  
Cristina Longo ◽  
Nicole A. H. Janssen ◽  
...  
Keyword(s):  
Air Pollution ◽  
Ambient Air ◽  
Healthy Adults ◽  
Partial Least Square ◽  
Exhaled Breath ◽  
Short Term ◽  
Post Exposure ◽  
Short Term Exposure ◽  
Validation Set ◽  
The Impact

Environmental factors, such as air pollution, can affect the composition of exhaled breath, and should be well understood before biomarkers in exhaled breath can be used in clinical practice. Our objective was to investigate whether short-term exposures to air pollution can be detected in the exhaled breath profile of healthy adults. In this study, 20 healthy young adults were exposed 2–4 times to the ambient air near a major airport and two highways. Before and after each 5 h exposure, exhaled breath was analyzed using an electronic nose (eNose) consisting of seven different cross-reactive metal-oxide sensors. The discrimination between pre and post-exposure was investigated with multilevel partial least square discriminant analysis (PLSDA), followed by linear discriminant and receiver operating characteristic (ROC) analysis, for all data (71 visits), and for a training (51 visits) and validation set (20 visits). Using all eNose measurements and the training set, discrimination between pre and post-exposure resulted in an area under the ROC curve of 0.83 (95% CI = 0.76–0.89) and 0.84 (95% CI = 0.75–0.92), whereas it decreased to 0.66 (95% CI = 0.48–0.84) in the validation set. Short-term exposure to high levels of air pollution potentially influences the exhaled breath profiles of healthy adults, however, the effects may be minimal for regular daily exposures.

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