scholarly journals Blue Light in Dermatology

Life ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 670
Author(s):  
Magdalena Sadowska ◽  
Joanna Narbutt ◽  
Aleksandra Lesiak
Keyword(s):  
Blue Light ◽  
Propionibacterium Acnes ◽  
Skin Diseases ◽  
Acne Vulgaris ◽  
Cellular Responses ◽  
Skin Aging ◽  
Clinical Effects ◽  
Long Term Effects ◽  
Inflammatory Skin Diseases

Phototherapy is an important method of dermatological treatments. Ultraviolet (280–400 nm) therapy is of great importance; however, there are concerns of its long-term use, as it can lead to skin aging and carcinogenesis. This review aims to evaluate the role and the mechanism of action of blue light (400–500 nm), a UV-free method. The main mediators of cellular responses to blue light are nitric oxide (NO) and reactive oxygen species (ROS). However, the detailed mechanism is still not fully understood. It was demonstrated that blue light induces an anti-inflammatory and antiproliferative effect; thus, it may be beneficial for hyperproliferative and chronic inflammatory skin diseases such as atopic dermatitis, eczema, and psoriasis. It was also found that blue light might cause the reduction of itching. It may be beneficial on hair growth and may be used in the treatment of acne vulgaris by reducing follicular colonization of Propionibacterium acnes. Further studies are needed to develop accurate protocols, as the clinical effects depend on the light parameters as well as the treatment length. There are no major adverse effects observed yet, but long-term safety should be monitored as there are no studies considering the long-term effects of blue light on the skin.

scholarly journals Can Plant Phenolic Compounds Protect the Skin from Airborne Particulate Matter?

Antioxidants ◽  
2019 ◽  
Vol 8 (9) ◽  
pp. 379 ◽  
Author(s):  
Yong Chool Boo
Keyword(s):  
Particulate Matter ◽  
Phenolic Compounds ◽  
Skin Diseases ◽  
Inflammatory Responses ◽  
Acne Vulgaris ◽  
Experimental Studies ◽  
Airborne Particulate Matter ◽  
Skin Aging ◽  
Atmospheric Environment ◽  
Airborne Particulate

The skin is directly exposed to the polluted atmospheric environment, and skin diseases, such as atopic dermatitis and acne vulgaris, can be induced or exacerbated by airborne particulate matter (PM). PM can also promote premature skin aging with its accompanying functional and morphological changes. PM-induced skin diseases and premature skin aging are largely mediated by reactive oxygen species (ROS), and the harmful effects of PM may be ameliorated by safe and effective natural antioxidants. Experimental studies have shown that the extracts and phenolic compounds derived from many plants, such as cocoa, green tea, grape, pomegranate, and some marine algae, have antioxidant and anti-inflammatory effects on PM-exposed cells. The phenolic compounds can decrease the levels of ROS in cells and/or enhance cellular antioxidant capacity and, thereby, can attenuate PM-induced oxidative damage to nucleic acids, proteins, and lipids. They also lower the levels of cytokines, chemokines, cell adhesion molecules, prostaglandins, and matrix metalloproteinases implicated in cellular inflammatory responses to PM. Although there is still much research to be done, current studies in this field suggest that plant-derived phenolic compounds may have a protective effect on skin exposed to high levels of air pollution.

scholarly journals Shedding Light on the Effects of Calorie Restriction and Its Mimetics on Skin Biology

Nutrients ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1529 ◽  
Author(s):  
Yeon Ja Choi
Keyword(s):  
Calorie Restriction ◽  
Skin Diseases ◽  
Skin Aging ◽  
Peroxisome Proliferator ◽  
Extrinsic Factors ◽  
Inflammatory Skin Diseases ◽  
Peroxisome Proliferator Activated Receptor ◽  
Beneficial Effects ◽  
Age Related ◽  
Skin Biology

During the aging process of an organism, the skin gradually loses its structural and functional characteristics. The skin becomes more fragile and vulnerable to damage, which may contribute to age-related diseases and even death. Skin aging is aggravated by the fact that the skin is in direct contact with extrinsic factors, such as ultraviolet irradiation. While calorie restriction (CR) is the most effective intervention to extend the lifespan of organisms and prevent age-related disorders, its effects on cutaneous aging and disorders are poorly understood. This review discusses the effects of CR and its alternative dietary intake on skin biology, with a focus on skin aging. CR structurally and functionally affects most of the skin and has been reported to rescue both age-related and photo-induced changes. The anti-inflammatory, anti-oxidative, stem cell maintenance, and metabolic activities of CR contribute to its beneficial effects on the skin. To the best of the author’s knowledge, the effects of fasting or a specific nutrient-restricted diet on skin aging have not been evaluated; these strategies offer benefits in wound healing and inflammatory skin diseases. In addition, well-known CR mimetics, including resveratrol, metformin, rapamycin, and peroxisome proliferator-activated receptor agonists, show CR-like prevention against skin aging. An overview of the role of CR in skin biology will provide valuable insights that would eventually lead to improvements in skin health.

scholarly journals Essential Oil and Juice from Bergamot and Sweet Orange Improve Acne Vulgaris Caused by Excessive Androgen Secretion

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Peng Sun ◽  
Liang Zhao ◽  
Nanhai Zhang ◽  
Chengtao Wang ◽  
Wei Wu ◽  
...  
Keyword(s):  
Essential Oil ◽  
Orange Juice ◽  
Sebaceous Gland ◽  
Skin Diseases ◽  
Sweet Orange ◽  
Acne Vulgaris ◽  
Large Population ◽  
High Dose ◽  
Inflammatory Skin Diseases ◽  
Functional Components

Acne vulgaris is one of the most common chronic inflammatory skin diseases. Bergamot and sweet orange are rich in nutritional and functional components, which exhibit antioxidant, anti-inflammatory, and antiapoptotic effect. The aim of this study was to evaluate the potential effect of bergamot and sweet orange (juice and essential oil) on acne vulgaris caused by excessive secretion of androgen. Eighty male golden hamsters were randomly divided into 10 groups and received low or high dose of bergamot and sweet orange juice and essential oil, physiological saline, and positive drugs for four weeks, respectively. Results showed that all interventions could improve acne vulgaris by reducing the growth rate of sebaceous gland spots, inhibiting TG accumulation, decreasing the release of inflammatory cytokines (notably reducing IL-1α levels), promoting apoptosis in the sebaceous gland, and decreasing the ratio of T/E2. Among them, bergamot and orange essential oil may have better effects (dose dependent) on alleviating acne vulgaris than the corresponding juice. In view of the large population of acne patients and the widespread use of sweet orange and bergamot, this study is likely to exert an extensive and far-reaching influence.

scholarly journals Ceramides: Where do we stand?

2021 ◽  
Vol 1 ◽  
pp. 44
Author(s):  
Nidhi Yadav ◽  
Bhushan Madke ◽  
Anupam Das
Keyword(s):  
Atopic Dermatitis ◽  
Barrier Function ◽  
Skin Diseases ◽  
Acne Vulgaris ◽  
Skin Aging ◽  
Skin Disorders ◽  
Healthy Skin ◽  
Epidermal Barrier ◽  
Inflammatory Dermatoses ◽  
Integral Component

Ceramides are an integral component of the epidermal barrier system. Alterations in ceramides levels are associated with various inflammatory dermatoses such as psoriasis, atopic dermatitis, ichthyosis, Gaucher’s disease, acne vulgaris, and skin aging. Various formulations containing ceramides have been developed so that exogenous ceramides can repair the barrier function. Herein, the authors have provided an overview of the basic anatomy, structure, functioning, and importance of ceramides and their role in healthy skin and various skin disorders. In addition, the authors review conventional and newer technologies for delivery of ceramides in various skin diseases.

The Role of Bioactive Compounds and other Metabolites from Mushrooms against Skin Disorders- A Systematic Review Assessing their Cosmeceutical and Nutricosmetic Outcomes

2020 ◽  
Vol 27 (41) ◽  
pp. 6926-6965
Author(s):  
Oludemi Taofiq ◽  
Maria Filomena Barreiro ◽  
Isabel C.F.R. Ferreira
Keyword(s):  
Systematic Review ◽  
Bioactive Compounds ◽  
Skin Diseases ◽  
Scientific Data ◽  
Inflammatory Skin Diseases ◽  
Toxicological Studies ◽  
Pros And Cons ◽  
Long Term Studies

Bioactive compounds derived from mushrooms have been shown to present promising potential as cosmeceutical or nutricosmetic ingredients. Scientific data reviewed herein showed that extracts prepared from medicinal and edible mushrooms and their individual metabolites presented antiinflammatory, antioxidant, photoprotective, antimicrobial, anti-tyrosinase, anti-elastase, and anticollagenase activities. These metabolites can be utilised as ingredients to suppress the severity of Inflammatory Skin Diseases, offer photoprotection to the skin, and correct Hyperpigmentation. However, studies regarding the molecular mechanism behind the mentioned bioactivities are still lacking. Challenges associated with the use of mushroom extracts and their associated metabolites as cosmeceutical and nutricosmetic ingredients include several steps from the fruiting bodies to the final product: extraction optimization, estimation of the efficacy and safety claims, the use of micro and nanocarriers to allow for controlled release and the pros and cons associated with the use of extracts vs individual compounds. This systematic review highlights that mushrooms contain diverse biomolecules that can be sustainably used in the development of nutricosmetic and cosmeceutical formulations. Reports regarding stability, compatibility, and safety assessment, but also toxicological studies are still needed to be considered. Furthermore, some of the constraints and limitations hindering the development of this type of ingredients still require long-term studies to achieve major breakthroughs.

Human Immunodeficiency Viruses and its effect on the Pulmonary Vascular bed

2021 ◽  
Author(s):  
Ghazwan Butrous
Keyword(s):  
Pulmonary Hypertension ◽  
Illicit Drugs ◽  
Clinical Effects ◽  
Long Term Effects ◽  
Vascular Bed ◽  
Human Immunodeficiency Viruses ◽  
Vascular Beds ◽  
The Impact ◽  
Pulmonary Vascular Bed

December. 1st 2021 is "World AIDS Day" reminding us that HIV infection is still widespread and that many of its long-term effects can be deadly. One of these complications is its effect on the pulmonary vascular beds, leading to an increase in the pulmonary pressure, causing the clinical manifestation of "pulmonary hypertension". Unfortunately, we are still far from fully understanding the prevalence, mechanics, and pathobiology of "HIV pulmonary hypertension", especially in Africa and other developing countries where HIV is still common. In addition, the impact of other factors like co-infection and illicit drugs can add and modify the effect on the pulmonary vascular bed, complicating the pathological and clinical effects of HIV. Thus, "World AIDS Day" can be an impetus to pursue further research in this area.

scholarly journals Case Report. A Case Report of Adult Acne

2016 ◽  
Vol 9 (2) ◽  
pp. 154-158
Author(s):  
Ivelina A. Yordanova ◽  
Desislava D. Tsvetanova ◽  
Diana D. Strateva ◽  
Pavlina D. Yordanova-Laleva ◽  
Dimitar K. Gospodinov
Keyword(s):  
Case Report ◽  
Sex Hormones ◽  
Skin Diseases ◽  
Acne Vulgaris ◽  
Epidemiologic Studies ◽  
Hair Follicles ◽  
Adult Onset ◽  
Inflammatory Skin Diseases ◽  
The Face ◽  
Sebum Production

Summary Acne vulgaris is among the commonest inflammatory skin diseases affecting pilosebaceous units. It occurs mainly in puberty and affects adolescents at the age of 14-19 years both females and males, in relation to sebum production of hair follicles under the action of sex hormones. Clinically the disease is presented with comedones, papules, pustules, nodules and scars in some cases. Seborrheic areas face, chest and back are affected. Recent epidemiologic studies have shown significant number of female patients aged over 25 years with acne and the term Adult onset acne (AOA)was established.The latter is manifested clinically in the lower third of the face. Primary etiological cause of AOAisahormonal imbalance, mainly hyperandrogenemia. Acase ofa25-year-old woman with adult acne and elevated levels of testosterone and prolactine is presented in this paper.

scholarly journals Contributions of peroxisome proliferator-activated receptor β/δ to skin health and disease

2013 ◽  
Vol 4 (1) ◽  
pp. 53-64 ◽  
Author(s):  
Alexandra Montagner ◽  
Walter Wahli
Keyword(s):  
Skin Diseases ◽  
Acne Vulgaris ◽  
Receptor Expression ◽  
Future Research ◽  
Low Grade ◽  
Peroxisome Proliferator ◽  
Inflammatory Skin Diseases ◽  
Skin Wound Healing ◽  
Peroxisome Proliferator Activated Receptor ◽  
Health And Disease

AbstractAmong the three peroxisome proliferator-activated receptor (PPAR) transcription factors, PPARβ/δ is the isotype with the broadest expression pattern. In fact, the expression of PPARβ/δ is ubiquitous, albeit at levels that are tightly regulated. Herein, we reviewed its multiple functions in skin health and disease. PPARβ/δ has pro-differentiating effects in keratinocytes, regulates sebocyte differentiation, and promotes hair follicle growth in healthy skin. Furthermore, we reviewed novel insights into the roles of PPARβ/δ in skin wound healing, especially in inhibiting apoptosis and in modulating keratinocyte proliferation and migration. Therefore, PPARβ/δ represents a research target for the understanding and treatment of inflammatory skin diseases, such as psoriasis and acne vulgaris. In addition, PPARβ/δ is a tumor growth modifier. Epidemiological studies have established that tumor progression may be exacerbated by chronic low-grade inflammation, a condition promoting the production of the lipids that act as modulators of PPARβ/δ activity. The action of PPARβ/δ in skin cancer is ambivalent, which might be explained by this receptor’s putative highly context-specific behavior, which depends on a combination of factors ranging from receptor expression levels to co-regulator distribution, diversity and activity of the ligands produced, and other tissue-specific conditions. Given its diverse and crucial roles in many tissues and organs, PPARβ/δ will remain a major focus of future research.

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