scholarly journals The Prospective Use of Brazilian Marine Macroalgae in Schistosomiasis Control

Marine Drugs ◽  
2021 ◽  
Vol 19 (5) ◽  
pp. 234
Author(s):  
Erika M. Stein ◽  
Sara G. Tajú ◽  
Patrícia A. Miyasato ◽  
Rafaela P. de Freitas ◽  
Lenita de F. Tallarico ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Marine Algae ◽  
Pearson Correlation ◽  
Marine Macroalgae ◽  
Parasitic Disease ◽  
Isolation And Identification ◽  
Promising Alternative ◽  
Schistosomiasis Control ◽  
Lead Compounds ◽  
Correlation Tests

Schistosomiasis is a parasitic disease that affects more than 250 million people. The treatment is limited to praziquantel and the control of the intermediate host with the highly toxic molluscicidal niclosamide. Marine algae are a poorly explored and promising alternative that can provide lead compounds, and the use of multivariate analysis could contribute to quicker discovery. As part of our search for new natural compounds with which to control schistosomiasis, we screened 45 crude extracts obtained from 37 Brazilian seaweed species for their molluscicidal activity against Biomphalaria glabrata embryos and schistosomicidal activities against Schistosoma mansoni. Two sets of extracts were taxonomically grouped for metabolomic analysis. The extracts were analyzed by GC–MS, and the data were subjected to Pattern Hunter and Pearson correlation tests. Overall, 22 species (60%) showed activity in at least one of the two models. Multivariate analysis pointed towards 3 hits against B. glabrata veliger embryos in the Laurencia/Laurenciella set, 5 hits against B. glabrata blastula embryos, and 31 against S. mansoni in the Ochrophyta set. Preliminary annotations suggested some compounds such as triquinane alcohols, prenylated guaianes, dichotomanes, and xenianes. Despite the putative identification, this work presents potential candidates and can guide future isolation and identification.

Validation of a Belgian Prediction Model for Patient Encounters at Football Mass Gatherings

2021 ◽  
pp. 1-6
Author(s):  
Kris Spaepen ◽  
Door Lauwaert ◽  
Leonard Kaufman ◽  
Winne AP Haenen ◽  
Ives Hubloue
Keyword(s):  
Pearson Correlation ◽  
First Aid ◽  
Rank Test ◽  
Mean Deviation ◽  
Mass Gatherings ◽  
Actual Patient ◽  
Significant Difference ◽  
Correlation Tests ◽  
The Mean ◽  
Patient Presentation

Abstract Background: To validate the Belgian Plan Risk Manifestations (PRIMA) model, actual patient presentation rates (PPRs) from Belgium’s largest football stadium were compared with predictions provided by existing models and the Belgian PRIMA model. Methods: Actual patient presentations gathered from 41 football games (2010-2019) played at the King Baudouin Stadium (Brussels, Belgium) were compared with predictions by existing models and the PRIMA model. All attendees who sought medical help from in-event health services (IEHS) in the stadium or called 1-1-2 within the closed perimeter around the stadium were included. Data were analyzed by ANOVA, Pearson correlation tests, and Wilcoxon singed-rank test. Results: A total of 1,630,549 people attended the matches, with 626 people needing first aid. Both the PRIMA and the Hartman model over-estimated the number of patient encounters for each occasion. The Arbon model under-estimated patient encounters for 9.75% (95% CI, 0.49-19.01) of the events. When comparing deviations in predictions between the PRIMA model to the other models, there was a significant difference in the mean deviation (Arbon: Z = −5.566, P <.001, r = −.61; Hartman: Z = −4.245, P <.001, r = .47). Conclusion: When comparing the predicted patient encounters, only the Arbon model under-predicted patient presentations, but the Hartman and the PRIMA models consistently over-predicted. Because of continuous over-prediction, the PRIMA model showed significant differences in mean deviation of predicted PPR. The results of this study suggest that the PRIMA model can be used during planning for domestic and international football matches played at the King Baudouin Stadium, but more data and further research are needed.

scholarly journals Correlation of birth weight with other anthropometric variables in detection of low birth weight (LBW) babies

2012 ◽  
Vol 17 (1) ◽  
pp. 29-32 ◽  
Author(s):  
Reema Afroza Alia ◽  
MA Mannan ◽  
Kanij Fatema ◽  
Fahmida Begum ◽  
Russel Siddique
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Observational Study ◽  
Pearson Correlation ◽  
Calf Circumference ◽  
Cross Sectional ◽  
Low Birth Weight Babies ◽  
Chi Squared ◽  
Correlation Tests ◽  
Level Of Significance

Objective: To assess the correlation of birth weight with other anthropometric variables and their appropriateness in prediction and detection of low birth weight babies. Methodology: It was a hospital-based cross-sectional observational study, conducted over 100 newborn babies within 24 hours of their birth. Birth weight and other anthropometric variables were recorded and analyzed with statistical package for social science (SPSS-17) and Student’s t-test, Chi-squared (?2), ANOVA and Pearson correlation tests were done to test the hypothesis and level of significance was set as p <0.05. Result: All the anthropometric variables were well correlated with birth-weight, irrespective of gestational age (p<0.01). The highest correlation was found with chest circumference (r = 0.962), while the lowest correlation was observed with calf circumference (r 0.923). Conclusion: All anthropometric variables except calf circumference can be considered as appropriate indicators for identifying neonates require special attention and intervention for low birth weight (LBW) where weighing machine or facilities for ultrasonography is not readily available. DOI: http://dx.doi.org/10.3329/jdnmch.v17i1.12189 J. Dhaka National Med. Coll. Hos. 2011; 17 (01): 29-32

scholarly journals Sustainability and Competitiveness of Thailand’s Natural Rubber Industry in Times of Global Economic Flux

2017 ◽  
Vol 14 (1) ◽  
pp. 169
Author(s):  
Palapan Kampan
Keyword(s):  
Natural Rubber ◽  
Positive Relationship ◽  
New Technologies ◽  
Pearson Correlation ◽  
The United States ◽  
Bivariate Correlation ◽  
Synthetic Rubber ◽  
Reinforcing Factors ◽  
Strong Positive Relationship ◽  
Correlation Tests

This study assesses economic, legal, and environmental conditions that Thai rubber farmers face, and evaluates actions they can take to increase incomes. Statistical analyses determine relationships between prices of oil, natural and synthetic rubber. Pearson correlation tests found a strong positive relationship (r = 0.887) between the price of Brent crude and Thai ribbed smoked sheets, and a moderate positive relationship between price changes in Brent and synthetic rubber (r = 0.648). Regression analysis showed Brent oil price is a good predictor of natural rubber prices. Moderate to strong positive relationships were also found between natural rubber price and gross domestic product of Japan, China, and the United States. Criminal antitrust behavior in rubber industries appeared to interfere with normal pricing in rubber markets. No significant bivariate correlation was found between rainfall in Thailand and natural rubber price, production, or export although flooding and other environmental issues clearly affected rubber farms. A survey of options showed Thai rubber farmers can improve livelihoods best through collective purchase and use of new technologies, and by integrating into downstream supply chain industries. At very least, farmers are urged to abandon monocrop methods and supplement incomes with fruit, fish, livestock, or pigs. stment budget, 2) architectural Aesthetic, and 3) utilization. Additionally, background of the interviewees is one of reinforcing factors for decision on universal design investment.

scholarly journals MULTIVARIATE ANALYSIS APPLIED AT THE SCHOOL OF THE UBERLAND-AMERICAN FIELD OF CONSUMER UNDERGROUND WATER QUALITY

2019 ◽  
Vol 16 (32) ◽  
pp. 833-847
Author(s):  
M. S. MEDEIROS ◽  
A. C. GOULART ◽  
I. S. PACHECO ◽  
F. A. AMARAL ◽  
S. C. CANOBRE
Keyword(s):  
Multivariate Analysis ◽  
Rural Areas ◽  
Pearson Correlation ◽  
Microbiological Quality ◽  
Well Being ◽  
Underground Water ◽  
Septic Tank ◽  
Human Consumption ◽  
Sources Of Pollution ◽  
Artesian Wells

The decrease of the water available for human consumption is directly related to the unregulated and unconscious action from the man himself. In rural areas, this depreciation is related to inappropriate conditions of artesian wells that capture the water (old wells and poorly sealed) and which are usually close to sources of pollution, such as septic tanks and animal grazing. In this context, the objective of the present work was to evaluate the physico-chemical and microbiological quality of underground water samples made available for consumption in three schools in the field next to the municipality of Uberlândia-MG. Methodologically, the data were statistically processed by means of descriptive and multivariate analysis (Pearson correlation coefficient). All schools are supplied by an artesian well, being carried out simplified treatment (chlorination mechanism of chemical treatment). In only one of the schools was identified the presence of a septic tank sewage collection system. Of samples evaluated, all were at odds with the standards laid down in annex XX of the Consolidation Ordinance No. 5 of the Ministry of health (old law 2,914/2011) in at least one of the parameters evaluated. Therefore, the results reflect the possibility of biological contamination of the water by grazing areas located in the region close to the wells, as well as the need for emerging measures, such as regular cleaning and maintenance of storage systems and distribution of the water consumed in the institutions.

scholarly journals Fucosterol of Marine Macroalgae: Bioactivity, Safety and Toxicity on Organism

Marine Drugs ◽  
2021 ◽  
Vol 19 (10) ◽  
pp. 545
Author(s):  
Maria Dyah Nur Meinita ◽  
Dicky Harwanto ◽  
Gabriel Tirtawijaya ◽  
Bertoka Fajar Surya Perwira Negara ◽  
Jae-Hak Sohn ◽  
...  
Keyword(s):  
Cell Lines ◽  
Marine Algae ◽  
Animal Cell ◽  
Biological Activities ◽  
Clinical Stage ◽  
Bioactive Compound ◽  
Marine Macroalgae ◽  
Pharmaceutical Industries ◽  
Safety And Toxicity ◽  
Meta Analyses

Fucosterol (24-ethylidene cholesterol) is a bioactive compound belonging to the sterol group that can be isolated from marine algae. Fucosterol of marine algae exhibits various biological activities including anti-osteoarthritic, anticancer, anti-inflammatory, anti-photoaging, immunomodulatory, hepatoprotective, anti-neurological, antioxidant, algicidal, anti-obesity, and antimicrobial. Numerous studies on fucosterol, mainly focusing on the quantification and characterization of the chemical structure, bioactivities, and health benefits of fucosterol, have been published. However, there is no comprehensive review on safety and toxicity levels of fucosterol of marine algae. This review aims to discuss the bioactivities, safety, and toxicity of fucosterol comprehensively, which is important for the application and development of fucosterol as a bioactive compound in nutraceutical and pharmaceutical industries. We used four online databases to search for literature on fucosterol published between 2002 and 2020. We identified, screened, selected, and analyzed the literature using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses method and identified 43 studies for review. Despite the potential applications of fucosterol, we identified the need to fill certain related research gaps. Fucosterol exhibited low toxicity in animal cell lines, human cell lines, and animals. However, studies on the safety and toxicity of fucosterol at the clinical stage, which are required before fucosterol is developed for the industry, are lacking.

Isolation and Identification of Native Auxins in Marine Algae

1972 ◽  
Vol 36 (12) ◽  
pp. 2259-2260 ◽  
Author(s):  
Hiroshi Abe ◽  
Masaaki Uchiyama ◽  
Rokuro Sato
Keyword(s):  
Marine Algae ◽  
Isolation And Identification

754 STEEP RAMP TEST: AN ALTERNATIVE TO ASSESS PHYSICAL FITNESS BEFORE OESOPHAGECTOMY IN CANCER PATIENTS

2021 ◽  
Vol 34 (Supplement_1) ◽  
Author(s):  
David Crull ◽  
I Mekenkamp ◽  
G M F Ruinemans ◽  
M J Det ◽  
E A Kouwenhoven
Keyword(s):  
Physical Fitness ◽  
Cancer Patients ◽  
Oesophageal Cancer ◽  
Perioperative Complications ◽  
Pearson Correlation ◽  
Intraclass Correlation ◽  
Cardiopulmonary Exercise Test ◽  
Promising Alternative ◽  
Ramp Test ◽  
The Difference

Abstract   Oesophagectomy patients are at high risk of perioperative complications. An important predictor for a complication is inadequate preoperative physical fitness. Cardiopulmonary Exercise Test (CPET) is the golden standard for measuring VO₂ max. The Steep Ramp Test (SRT) is an alternative with a lower patient burden and cost, but provides an estimation of VO₂ max. The aim was to determine whether SRT is an adequate alternative for CPET to determine preoperative fitness in oesophageal cancer patients. Methods The population consisted of 113 oesophageal cancer patients of a single centre that have performed CPET and SRT within a timeframe of two weeks. The agreement between SRT and CPET was analysed using a t-test, the Pearson correlation, the Intraclass Correlation Coefficient (ICC) and the Bland-Altmann analysis. A CPET-measured VO₂ max of 17 mL/kg/min was the set threshold for adequate operative fitness, based on current literature. Results The mean difference between the CPET and SRT was 2.77 mL/kg/min (95% CI, 2.14–3.41). The Pearson correlation was 0.792 (P &lt; 0.001). The ICC was 0.879 (95% CI, 0.825–0.917). In 93 (82.3%) patients, SRT was higher than the CPET. The limits of agreement (LOA) for the Bland-Altmann were − 3.89 − +9.44. Thirty-one (27.4%) patients performed better on SRT than the set threshold plus the upper LOA. Twenty-three patients scored inadequate on CPET, of whom 14 patients (60.9%) SRT was sufficient. Conclusion VO₂ max as estimated by SRT differs from the VO₂ max as measured by CPET. In patients that are well above the threshold of adequate preoperative fitness, the difference is of clinical irrelevance. In conclusion: SRT is a promising alternative to CPET for determining preoperative physical fitness, it might render CPET obsolete for fit individuals which leads to a lower burden for the patient and substantial cost reduction.

scholarly journals Biological Markers Predictive of Invasive Recurrence in DCIS

2008 ◽  
Vol 2 ◽  
pp. 117955490800200 ◽  
Author(s):  
Sharon Nofech-Mozes ◽  
Jacqueline Spayne ◽  
Eileen Rakovitch ◽  
Harriette J Kahn ◽  
Arun Seth ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Biological Markers ◽  
Pearson Correlation ◽  
Univariate Analysis ◽  
Breast Conserving Surgery ◽  
Invasive Disease ◽  
Current Approach ◽  
Time To Recurrence ◽  
Pathologic Features ◽  
Increased Risk

DCIS is a heterogeneous group of non-invasive cancers of the breast characterized by various degrees of differentiation and unpredictable propensity for transformation into invasive carcinoma. We examined the expression and prognostic value of 9 biological markers with a potential role in tumor progression in 133 patients with pure DCIS treated with breast conserving surgery alone, between 1982–2000. Histology was reviewed and immunohistochemical staining was performed. Pearson correlation coefficient was used to determine the associations between markers and histopathological features. Univariate and multivariate analysis examined associations between time to recurrence and clinico-pathologic features and biological markers. Median age at diagnosis was 55 years (25–85). With a median follow up of 8.91 years, 41/133 patients recurred (21 as invasive recurrence). In this cohort 13.5% had low, 43% intermediate and 42% high nuclear grade. Comedo necrosis was found in 65% of cases. Expression of ER (62.4%), PR (55.6%), HER2/neu (31.6%), MIB1 (39.8%), p53 (22.6%), p21 (39.8%), Cyclin D1 (95.5%) calgranulin (20.5%), psoriasin (12%), was found in DCIS. HER2/neu was overexpressed in 45% that recurred as DCIS and 42.9% that recurred as invasive cancer, and only in 26.1% in cases that never recurred. On univariate analysis, HER2/neu overexpression was the only marker associated with an increased risk for any recurrence (p = 0.044). The hazard ratio for recurrence for HER2/neu positive DCIS was 1.927 (confidence interval 1.016–3.653) compared to HER2 negative DCIS. On multivariate analysis, HER2/neu overexpression remained the only independent variable significantly associated with any recurrence (p = 0.014) and with invasive recurrence (p = 0.044). This data suggest that HER2/neu testing may become an important parameter in the management of DCIS and the treatment of cases with positive HER2/neu status could be modified accordingly, similar to the current approach for HER2/neu positive invasive disease.

The role of sunshine in suicide: an explanatory model for the suicide peak in spring

2011 ◽  
Vol 26 (S2) ◽  
pp. 1652-1652
Author(s):  
B. Vyssoki ◽  
G. Sonneck ◽  
N. Praschak-Rieder ◽  
S. Kasper ◽  
M. Willeit ◽  
...  
Keyword(s):  
Statistical Analysis ◽  
Suicidal Behavior ◽  
Seasonal Pattern ◽  
Pearson Correlation ◽  
Central Institute ◽  
Sunshine Hours ◽  
Correlation Tests ◽  
Vulnerable Subjects ◽  
Image Position

IntroductionIt is known from previous studies that suicide follows a seasonal pattern with a peak in spring.ObjectivesAnalyze whether suicidal behavior is associated with the increase in the duration of sunshine in spring.AimsTo investigate the effect of number of sunshine hours per month on suicide rates in Austria between 1996–2006.MethodsSuicide data, differentiated by month of suicide, gender, and method of suicide (violent vs. non-violent methods), were provided by Statistics Austria. Data on the average number of sunshine hours per month were provided by the Austrian Central Institute for Meteorology. For statistical analysis ANOVA tests and Pearson correlation tests were used.ResultsSuicide frequencies were highest between March and May, lowest between November and January (df = 11, F = 5.2, p < .0001). The average number of sunshine hours per month was significantly correlated with the number of suicides among both genders r = .43 (p < .0001), violent methods (r = .48; p < .0001) but not with nonviolent methods (r = .03; p = .707).ConclusionsLight, possibly through interaction with melatonin, norepinephrine and serotonin, may improve motivation and drive first while mood improves at a later point in time. Thereby, a rapid increase in sunshine in spring might increase suicidal tendencies in vulnerable subjects.Fig. 1[Suicides and sunshine hours in Austria,1996-2006]

Paricalcitol and Peritoneal Protein Loss in Peritoneal Dialysis: A Double-Center Study

2018 ◽  
Vol 46 (2) ◽  
pp. 103-110 ◽  
Author(s):  
Teresa Jerónimo ◽  
Anabela Malho Guedes ◽  
Gloria del Peso ◽  
Ana Paula Silva ◽  
Rafael Selgas ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Multivariate Analysis ◽  
Peritoneal Dialysis ◽  
Pearson Correlation ◽  
Pearson Correlation Coefficient ◽  
Protein Loss ◽  
Student’S T ◽  
The Relationship ◽  
Center Study ◽  
Student’S T Test

Background/Aims: Peritoneal protein loss (PPL) is associated with cardiovascular disease and mortality in peritoneal dialysis (PD). Controversial results have been published about the effect of paricalcitol in PPL among PD patients. This study intends to analyze the relationship between paricalcitol and PPL in PD. Methods: In a retrospective study, prevalent PD patients were divided into 2 groups: “with paricalcitol” and “without paricalcitol”. X2-test, Student’s t test, Pearson correlation coefficient and Logistic Regression analysis were applied. Results: Eighty-two patients were included. PPL was lower among patients medicated with paricalcitol (5.17 ± 1.71 vs. 6.79 ± 2.10 g/24 h, p = 0.0001). In multivariate analysis, paricalcitol and dialysate/plasma ratio of creatinine (D/P creatinine) were independently related to PPL (OR 4.270 [1.437–12.684], p = 0.009 and OR 0.205 [0.064–0.659], p = 0.008, respectively), adjusted for diabetes. Conclusion: Paricalcitol and D/P creatinine were independently related to PPL. Paricalcitol may have an effect on PPL in PD patients

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