scholarly journals Clinical Relevance of Plasma Concentrations of MBL in Accordance with IgE Levels in Children Diagnosed with Bronchial Asthma

Medicina ◽  
2020 ◽  
Vol 56 (11) ◽  
pp. 594
Author(s):  
Simona Maria Borta ◽  
Simona Dumitra ◽  
Imola Miklos ◽  
Romana Popetiu ◽  
Luminița Pilat ◽  
...  
Keyword(s):  
Bronchial Asthma ◽  
Clinical Relevance ◽  
Severe Disease ◽  
Plasma Concentrations ◽  
Control Group ◽  
Asthma Patients ◽  
Diagnostic Role ◽  
Study Population ◽  
Ige Determination ◽  
And Control

Background and objectives: Bronchial asthma is a heterogeneous, multifactorial pulmonary disease characterized by variable airway obstruction caused by chronic inflammation. Our study investigates the clinical relevance of MBL plasma levels in accordance with IgE values in children who attended a pediatric consult for respiratory symptoms with bronchial asthma. Materials and Methods: The study population consists of patients <18-years-old and included 43 patients with bronchial asthma and 64 age-matched healthy subjects as a control group. We used the ELISA Human MBL Immunoassay kit and the electrochemiluminescence immunoassay (ECLIA) kit for IgE determination. Results: Our results show significantly different distributions of patients in the bronchial asthma group and control group. The measured values were within the normal range for most controls, while the bronchial asthma patients displayed higher values of plasma MBL and IgE levels. We observed a wider heterogeneity in MBL concentrations in bronchial asthma patients when compared to the healthy age-matched controls. Our results also suggest a potential clinical usefulness of plasma MBL concentrations in accordance with IgE and eosinophil cells levels in the diagnosis of bronchial asthma, and our results may suggest a prognostic role of MBL in the evolution of asthmatic disease; however, further studies are necessary to confirm these findings. Conclusions: We can say that plasma MBL concentrations present a relative diagnostic role for bronchial asthma in pediatric patients and may suggest a more severe disease progression; however, further studies are needed to elucidate the role played by MBL in the determination and evolution of this disease.

scholarly journals Management of Psycho-Physiological aspect of Bronchial Asthma through Yogic Intervention

2019 ◽  
Vol 3 ◽  
pp. 42-48
Author(s):  
SARITA PRAJAPATI ◽  
RAKESH VARMA ◽  
AMAL K. DUTTA
Keyword(s):  
Bronchial Asthma ◽  
Stress Level ◽  
Forced Expiratory Volume ◽  
Control Group ◽  
Yoga Therapy ◽  
Therapy Program ◽  
Increasing Trend ◽  
Asthma Patients ◽  
And Control ◽  
Experimental Group

In this study eighty bronchial asthma patients were selected through accidental sampling and sample was divided into experimental group (n=40) and control group (n=40). They underwent Yoga therapy program for 60 days with an integrated set of yogic practices, including jihvamula, karnarandhra, kapalrandhra, tadasana, tiryaka tadasana, kati chakrasana and marjariasana , nadishodhan pranayama, bhastrika pranayama and Gayatri mantra. Bronchial asthmatics practiced these exercises for 45 minutes daily for 60 days. Stress level and forced expiratory volume in one second (FEV1) were assessed on all the Bronchial asthmatics, both initially and after completion of study. The obtained data were statistically analyzed through paired t-test. Subjects of experimental group showed a statistically significant decreasing trend in average stress level and increasing trend in average forced expiratory volume in one second (FEV1) after 60 days Yoga practice, while control group showed no such improvement (P>0.01).

MYCOPLASMA AND CHLAMYDIA AS ETHIOLOGICAL FACTORS OF BRONCHIAL ASTHMA IN TERMS OF ETHNOGENESIS

2013 ◽  
Vol 68 (7) ◽  
pp. 57-60
Author(s):  
O. A. Sharavii ◽  
S. V. Smirnova
Keyword(s):  
Immune Response ◽  
Chlamydia Trachomatis ◽  
Blood Serum ◽  
Bronchial Asthma ◽  
Mycoplasma Hominis ◽  
Acute Stage ◽  
Control Group ◽  
Clinical Markers ◽  
Chlamydophila Psittaci ◽  
Asthma Patients

 Aim. The study of the prevalence and clinical peculiarities of Mycoplasmosis and Chlamydiosis in patients with different pathogenic forms of bronchial asthma (BA) taking into account ethnicity of a patient. Subjects and Methods. The research covered 239 subjects – both the Europeoids and the Mongoloids in the city of Krasnoyarsk and the town of Kyzyl, all of them being BA patients of different stages, including acute stage and practically healthy. We had determined antigens Mycoplasma pneumoniae, Mycoplasma hominis, Chlamydophila pneumoniae, Chlamydophila psittaci and Chlamydia trachomatis in smears of mucosa of pharynx and antibodies to these antigens in peripheral blood serum. Results.  We found high frequency of Mycoplasmosis and Chlamydiosis in the inhabitants of Eastern Siberia, BA patients with different pathogenic forms as compared to control group. We had determined ethnic peculiarities of specific immune response: IgM to М. pneumoniae was revealed in the Europoids more frequently than in the Mongoloids, but IgM to С. pneumoniae and to C. trachomatis, C. trachomatis antigens had been revealed more often in the Mongoloids than in the Europoids. We accepted as clinical equivalents of Mycoplasmosis and Chlamydiosis diagnostics the following signs: temperature around 37C (subfebrile temperature), non-intensive but stable coughing with scanty mucous and muco-purulent sputum, dyspnea of mixed character. Conclusions. Mycoplasma and Chlamydia are meaningful etiologic factors of bronchial asthma. We have found the peculiarities of immune response depending on ethnicity of a patient (ethnic belonging). Clinical markers of Mycoplasmosis and Chlamydiosis should be taken into account in bronchial asthma in order to provide diagnostics timely as well as eradication of infection agents. Because of insufficient knowledge of problem of bronchial asthma related to contamination with Мycoplasma and Chlamydia we put the goal to study the frequency of Mycoplasmosis and Chlamydiosis occurrence in bronchial asthma patients and determine the characteristics clinical course of diseases. We defined antigens Мycoplasma pneumoniae, Мycoplasma hominis, Chlamydophila pneumoniaе, Chlamydophila psittaci, Chlamydia trachomatis in smears of oropharynx mucosa and antibodies to them in blood serum. 

scholarly journals Hepatic steatosis: a risk factor for increased COVID-19 prevalence and severity—a computed tomography study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Asmaa Ali ◽  
Mona Hasan ◽  
Shaimaa Hamed ◽  
Amir Elhamy
Keyword(s):  
Hepatic Steatosis ◽  
Severe Disease ◽  
Severe Pneumonia ◽  
Liver Disorder ◽  
Control Group ◽  
Case Group ◽  
World Population ◽  
Positive Class ◽  
The Mean ◽  
And Control

Abstract Background Around 25% of the world population was affected by the metabolic-related fatty liver disorder. Hepatic steatosis is frequently observed in conjunction with hypertension, obesity comorbidities, and diabetes. We evaluate the hepatic steatosis frequency found in chest CT exams of COVID-19-positive cases compared to non-infected controls and evaluate the related increased prevalence and severity of COVID. Results Our research includes 355 subjects, 158 with positive PCR for COVID-19 (case group) and 197 with negative PCR and negative CT chest (control group). The mean age in the positive group was 50.6 ± 16 years, and in the control, it was 41.3 ± 16 years (p < 0.001). Our study consists of 321 men (90.5%) and 34 women (9.5%). The number of males in both cases and control groups was greater. In the case group, 93% men vs. 6.9% women, while in controls, 88.3% men vs.11.6% women, p < 0.001. CT revealed normal results in 55.5% of individuals (i.e., CORADs 1) and abnormal findings in 45.5% of participants (i.e., CORADs 2–5). In abnormal scan, CO-RADs 2 was 13.92%, while CO-RADs 3–4 were 20.89% of cases. CO-RADs 5 comprised 65.19% of all cases. Approximately 42.6% of cases had severe disease (CT score ≥ 20), all of them were CO-RADs 5. The PCR-positive class had a greater prevalence of hepatic steatosis than controls (28.5% vs.12.2%, p < 0.001). CO-RADs 2 represented 11.1%, CO-RADs 3–4 represented 15.6%, and CO-RADs 5 represented 73.3% in the hepatic steatosis cases. The mean hepatic attenuation value in the case group was 46.79 ± 12.68 and in the control group 53.34 ± 10.28 (p < 0.001). When comparing patients with a higher severity score (CT score ≥ 20) to those with non-severe pneumonia, it was discovered that hepatic steatosis is more prevalent (73.2% vs. 26.8%). Conclusions Steatosis was shown to be substantially more prevalent in COVID-19-positive individuals. There is a relation among metabolic syndrome, steatosis of the liver, and obesity, as well as the COVID-19 severity.

Analysis of association between histamine receptor gene HRH1, HRH2, HRH3, HRH4 polymorphisms and asthma in children

2021 ◽  
Vol 31 (6) ◽  
pp. 729-738
Author(s):  
Olga N. Savelieva ◽  
Aleksandra S. Karunas ◽  
Yuliya Yu. Fedorova ◽  
Radik F. Gatiyatullin ◽  
Esfir I. Etkina ◽  
...  
Keyword(s):  
Gene Polymorphisms ◽  
Receptor Gene ◽  
Severe Disease ◽  
Histamine Receptor ◽  
Control Group ◽  
Republic Of Bashkortostan ◽  
Children With Asthma ◽  
Asthma Patients ◽  
Receptor Gene Polymorphisms ◽  
The Republic

Asthma is a common multifactorial disease characterized by chronic inflammation of the respiratory tract. Insufficient control of asthma symptoms significantly reduces the patient’s quality of life, leads to the risk for more severe disease and disability. It is important to research the role of gene polymorphisms encoding proteins involved in various stages of histamine metabolism, which is one of the known mediators of allergic reactions.The aim of the study was to investigate histamine receptor gene polymorphisms (HRH1, HRH2, HRH3, HRH4) in children with asthma and the control group.Methods. The study of HRH1 (rs901865), HRH2 (rs2067474), HRH3 (rs3787429), HRH4 (rs11665084) gene polymorphisms in asthma patients and healthy individuals aged 2 - 17 years of different ethnicities living in the Republic of Bashkortostan was carried out. Genotyping of polymorphisms was performed by polymerase chain reaction with fluorescence detection.Results. In Tatars, rs901865*CT genotype and rs901865*T allele of HRH1 gene were associated with asthma development and decrease in spirometry measures (MEF25). In Tatars, a statistically significant model of the interaction between HRH1 (rs901865), HRH3 (rs3787429), and HRH4 (rs11665084) gene polymorphisms that leads to the risk of asthma was established.Conclusion. The results of this study reveal certain aspects of asthma pathogenesis and suggest the possible involvement of polymorphic variants of histamine receptors genes HRH1, HRH3, HRH4 in the development of asthma.

scholarly journals UPAYA PENINGKATAN PENGETAHUAN DAN SIKAP KADER DALAM PENCEGAHAN PEMBERIAN MAKANAN PRALAKTAL PADA BAYI 0-3 HARI

2018 ◽  
Vol 10 (2) ◽  
pp. 173-178
Author(s):  
Iis Ria Fitriani
Keyword(s):  
Public Health ◽  
Health Center ◽  
Control Group ◽  
Public Health Center ◽  
Before And After ◽  
Post Test ◽  
Comparison Groups ◽  
Study Population ◽  
Knowledge And Attitude ◽  
And Control

Infant Mortality in Bengkulu Province is still high, this can be prevented through breastfeeding as a staple food in infants 0-6 months without other complementary foods because breast milk boosts immune status for infants and thus can reduce mobility and mortality rates but exclusive ASI coverage still low, this is influenced by pralactal feeding in infants 0-3 days of birth. Research Objective to increase knowledge and attitude of cadre through training as promotion effort of prevention of pralactal food in 0-3 days old baby. Quasi pre and post test experiments with comparison groups. The study population were all cadres in Talang Tinggi Public Health Center, which were 50 people in Talang Tinggi Public Health Center, Seluma District with experimental group samples were cadres who were given training by using module and control group were cadres who were trained by using lecture and question and answer method. There is an average difference of attitude and knowledge before and after intervention in the cadres given training on prevention of pralactal food in infants 0-3 days. There is an effect of training on prevention efforts of pralactal feeding using modules with cadre attitude. Puskesmas should increase the promotion of prevention of pralactal food to change cadre attitude to support program exclusive breastfeeding.

scholarly journals Constipation: an overlooked, unmanaged symptom of patients with pheochromocytoma and sympathetic paraganglioma

2015 ◽  
Vol 173 (3) ◽  
pp. 377-387 ◽  
Author(s):  
Sonali Thosani ◽  
Montserrat Ayala-Ramirez ◽  
Alejandro Román-González ◽  
Shouhao Zhou ◽  
Nirav Thosani ◽  
...  
Keyword(s):  
Symptom Improvement ◽  
Control Group ◽  
Primary Tumors ◽  
Impact On Survival ◽  
Study Population ◽  
Md Anderson ◽  
Design And Methods ◽  
And Control ◽  
Sympathetic Paraganglioma

ObjectivePheochromocytomas (PHs) and sympathetic paragangliomas (PGs) are tumors that produce catecholamines, predisposing patients to cardiovascular disease and gastrointestinal effects such as constipation. Objectives: i) determine the prevalence of constipation, its risk factors, and its impact on survival; ii) identify whether a systematic combination of fiber, water, and laxatives was effective for treatment of constipation.Design and methodsWe retrospectively studied 396 patients with PH/PG diagnosed in 2005–2014. The study population was patients with constipation as a presenting symptom; the control group was patients without constipation as a presenting symptom. The MD Anderson Symptom Inventory was used to assess constipation and quality of life.ResultsTwenty-three patients (6%) had constipation. Constipation was associated with headaches, palpitations, diaphoresis, weight loss, and excessive noradrenaline production (P<0.0001). Eighteen of these patients had non-metastatic primary tumors larger than 5 cm and/or extensive metastases. No statistically significant differences in age, sex, and genotype were noted between the study and control groups. In patients without metastases, resection of the primary tumor led to symptom disappearance. A systematic combination of fiber, water, and laxatives was associated with symptom improvement. Two patients who presented unmanaged constipation died because of sepsis from toxic megacolon.ConclusionsConstipation is a rare and potentially lethal complication in patients with PH/PGs. Severe constipation can be prevented by recognizing and treating mild symptoms.

Diagnostic Role Of MPV In Acute Appendicitis

2020 ◽  
pp. 10-13
Author(s):  
◽  
Keyword(s):  
Acute Appendicitis ◽  
Mean Platelet Volume ◽  
Pathological Diagnosis ◽  
Control Group ◽  
Healthy Children ◽  
Platelet Volume ◽  
Blood Samples ◽  
Diagnostic Role ◽  
And Control

Introduction: The aim of this study was to investigate the diagnostic role of mean platelet volume (MPV) for acute appendicitis. Methods: Patient files were retrospectively observed. MPV of 311 patients with pathological diagnosis of acute appendicitis were compared with the MPV of 314 healthy children (blood samples were taken for elective operations). SPSS (IBM SPSS Statistics for Windows, Version 20.0. Armonk, NY: IBM Corp.) was used to evaluate the results. Results: 188 of acute appendicitis were male (%60.5). Mean age of acute appendicitis group was 10.22±3.83. MPV of children with the diagnosis of acute appendicitis (8.37±0.83fL) and the control group (10.55±0.83fL). MPV values were statistically different between the acute appendicitis and control group (p<0,001). Conclusion: MPV may be used as a marker for the diagnosis of acute appendicitis, but it is not a specific biomarker for appendicitis.

The influence of injectable sodium selenite on semen characteristics and testosterone concentration in Aardi goats

2015 ◽  
Vol 49 (6) ◽  
Author(s):  
A. Hajalshaikh ◽  
M. J. Al-Hassan ◽  
H. E. Mohamed
Keyword(s):  
Body Weight ◽  
Sodium Selenite ◽  
Semen Quality ◽  
Sperm Count ◽  
Plasma Concentrations ◽  
Control Group ◽  
Progressive Motility ◽  
Group I ◽  
Semen Characteristics ◽  
And Control

The objective of this study was to test the effects of sodium selenite (SS) injection on semen characteristics and testosterone plasma concentrations in male Aardi goats. Fifteen animals were assigned into three groups; control (group I, with no supplemental SS); group II; injected intramuscular with 0.1 mg/kg SS body weight; group III injected 0.05 mg/kg SS body weight. Blood samples were collected once weekly (week 0 and four weeks after treatment) in the morning (at 8 am). Semen was collected by electro-ejaculator on a weekly basis post SS supplementation. Sperm count, motility %, progressive motility characteristic; average path velocity (VAP), straight line velocity (VSL), curvilinear velocity (VCL), straightness (STR) and linearity (LIN) were analyzed. Significant differences were found between the two treated-groups and control after week four for motility and progressive motility. After five weeks, significant differences were found between groups, for motility and progressive motility. The live % showed significant differences after five weeks between treated and control groups. After five weeks, significant differences were found between the three groups, for motility and progressive motility. The live % showed significant differences after 5 weeks between different treatments. However, VAP, VSL, VCL, STR, and LIN showed non-significant differences, suggesting that bucks might already have a good motility characteristic. No significant effects of SS supplementation on testosterone plasma levels, and the reported values were 1.28; 1.35, and 1.36 ng/ml for control; group 1, and group 2; respectively. In conclusion, SS improved reproduction in goats <italic>via</italic> the enhancement of semen quality in Aardi goats.

scholarly journals Assessing the Effectiveness of Animal Therapy on Alleviation of Anxiety in Pre-School Children

2020 ◽  
Author(s):  
Mohammad Tahan
Keyword(s):  
Control Group ◽  
Control Groups ◽  
Animal Therapy ◽  
General Anxiety ◽  
Post Test ◽  
Quasi Experimental ◽  
Study Population ◽  
Anxiety Screening ◽  
And Control ◽  
Experimental Group

Introduction: The purpose of this study was to assess the effectiveness of animal therapy in alleviation of anxiety in pre-school children.Method: The study was carried out as a quasi-experimental study with pre-test and post-test design and control group. The study population consisted of 33 anxious 5-7years old children (participated in a welfare anxiety screening plan held by Counseling Center, Tehran-Iran) between 2018 and 2019. The participants took part in the study voluntarily.The subjects were randomly divided into experimental and control groups (10 in each group). The experimental group was exposed to 8 sessions of animal therapy. The research instrument was Spence Preschool Anxiety Scale (Parent Form) and the data were analyzed on SPSS 21 software.Results: The results showed that animal therapy had a significant effect on general anxiety score after adjusting for post-test scores (f= 32.49 and p= 0.001) with the effect equal to 0.70. In addition, the effect of animal therapy on anxiety of separation (f= 5.63, p= 0.03), generalized anxiety disorder (f= 8.56, p= 0.01), social phobia (f= 14.58, p= 0.002) and specific anxiety (f= 11.63, p= 0.005) was significant with effects equal to 0.30, 0.40, 0.53, and 0.47, respectively. The results also showed that the effect of animal therapy on obsession was not significant (p&gt;0.05).Conclusion: Therefore, it can be concluded that Animal therapy is effective in alleviating anxiety in children.

scholarly journals Outcome of vaginal sildinafil in assisted reproductive technology cycles

2021 ◽  
Vol 10 (2) ◽  
pp. 575
Author(s):  
Avnika Kapoor ◽  
Garima Sharma ◽  
Rita Bakshi
Keyword(s):  
Uterine Artery ◽  
Endometrial Thickness ◽  
Study Groups ◽  
Control Group ◽  
P Value ◽  
Surrogate Mothers ◽  
Endometrial Pattern ◽  
Study Population ◽  
Pre Treatment ◽  
And Control

Background: The present study assessed the role of sildenafil in endometrial blood flow and successful pregnancy in IVF done in surrogate mothers.Methods: In the present study surrogate mothers were included. Thirty patients were randomized to receive sildenafil 25 mg thrice a day vaginally in addition to standard drugs and technique and another 30 were not given sildenafil.Results: Mean age, anthropometry, duration of infertility and pre-treatment endometrial thickness was similar in the two study groups.  After treatment completion, it was observed that the endometrial pattern in ultrasound was similar in the two study groups (p value=0.58). Heterogenic endometrial pattern was observed in 6.7% of the Sildenafil patients and 3.3% in the control patients, while echogenic pattern was seen in 10% of the sildenafil patients and 6.7% of the control patients. Similarly, endometrial thickness was 10.2±1.7 and 9.7±1.8 mm in sildenafil and control group respectively, p value=0.62. Using doppler ultrasound, uterine artery PI was significantly lower in Sildenafil group patients as compared to control group patients. Similarly, we found uterine artery RI was also significantly lower in the Sildenafil group patients as compared to control group patients. We followed the patients and found that clinical pregnancy rate was significantly higher among Sildenafil group (60%) as compared to control group (26.6%), p value<0.05.Conclusions: Vaginal sildenafil resulted in significantly higher pregnancy rates in our study population. The uterine artery PI and RI were significantly lower in patients taking sildenafil.

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