scholarly journals Blood Metabolomic Profiling Confirms and Identifies Biomarkers of Food Intake

Metabolites ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 468
Author(s):  
Julia Langenau ◽  
Kolade Oluwagbemigun ◽  
Christian Brachem ◽  
Wolfgang Lieb ◽  
Romina di Giuseppe ◽  
...  
Keyword(s):  
Linear Regression ◽  
Regression Models ◽  
Linear Regression Models ◽  
Cross Sectional ◽  
Novel Food ◽  
Dietary Biomarkers ◽  
Metabolomic Profiling ◽  
Specific Potential ◽  
Sectional Analysis ◽  
Potential Use

Metabolomics can be a tool to identify dietary biomarkers. However, reported food-metabolite associations have been inconsistent, and there is a need to explore further associations. Our aims were to confirm previously reported food-metabolite associations and to identify novel food-metabolite associations. We conducted a cross-sectional analysis of data from 849 participants (57% men) of the PopGen cohort. Dietary intake was obtained using FFQ and serum metabolites were profiled by an untargeted metabolomics approach. We conducted a systematic literature search to identify previously reported food-metabolite associations and analyzed these associations using linear regression. To identify potential novel food-metabolite associations, datasets were split into training and test datasets and linear regression models were fitted to the training datasets. Significant food-metabolite associations were evaluated in the test datasets. Models were adjusted for covariates. In the literature, we identified 82 food-metabolite associations. Of these, 44 associations were testable in our data and confirmed associations of coffee with 12 metabolites, of fish with five, of chocolate with two, of alcohol with four, and of butter, poultry and wine with one metabolite each. We did not identify novel food-metabolite associations; however, some associations were sex-specific. Potential use of some metabolites as biomarkers should consider sex differences in metabolism.

scholarly journals Isotonic quadriceps endurance is better associated with daily physical activity than quadriceps strength and power in COPD: an international multicentre cross-sectional trial

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Erik Frykholm ◽  
Sarah Gephine ◽  
Didier Saey ◽  
Arthur Lemson ◽  
Peter Klijn ◽  
...  
Keyword(s):  
Physical Activity ◽  
Linear Regression ◽  
Multiple Linear Regression ◽  
Regression Models ◽  
Sedentary Time ◽  
Quadriceps Strength ◽  
Linear Regression Models ◽  
Cross Sectional ◽  
Quadriceps Function ◽  
Multiple Linear Regression Models

AbstractKnowledge about modifiable determinants of daily physical activity (PA) in patients with chronic obstructive pulmonary disease (COPD) is crucial to design effective PA interventions. The present study aimed to determine the contribution of quadriceps strength, power and endurance to daily PA in COPD. Additionally, for quadriceps endurance, we also aimed to determine to what extent the association varies according to the mode of movement (isotonic, isometric, or isokinetic). Using a multicentre cross-sectional trial design we determined the contribution of quadriceps function to daily PA (steps, sedentary time and time spent doing moderate-to-very-vigorous physical activity [MVPA]) using bivariate and partial Pearson correlation analysis (r) and multiple linear regression models (ΔR2). Pre-determined controlling factors were sex, age, body mass index (BMI), COPD-assessment test, forced expiratory volume in one second in percent of the predicted value (FEV1pred), and distance walked on the 6-minute walk test. Eighty-one patients with COPD (mean ± SD: age 67 ± 8 years, FEV1pred 57 ± 19%, daily steps 4968 ± 3319, daily sedentary time 1016 ± 305 min, and MVPA time 83 ± 45 min) were included. Small to moderate bivariate correlations (r = .225 to .452, p < .05) were found between quadriceps function and measures of PA. The best multiple linear regression models explained 38–49% of the variance in the data. Isotonic endurance was the only muscle contributor that improved all PA models; daily steps (ΔR2 = .04 [relative improvement 13%] p = .026), daily sedentary time (ΔR2 = .07 [23%], p = .005) and MVPA-minutes (ΔR2 = .08 [20%], p = .001). Isotonic endurance was also independently associated with most PA variables, even when controlling for strength, power or isometric-isokinetic endurance properties of the muscle (r = .246 to .384, p < .05). In contrast, neither strength, power, isometric-or isokinetic endurance properties of the muscle was independently associated with PA measures when controlling for isotonic endurance (r = .037 to .219, p > .05). To conclude, strength, power, and endurance properties of the quadriceps were low to moderately associated with PA in patients with COPD. Isotonic quadriceps endurance was the only quadriceps property that was independently associated with the different measures of PA after controlling for a basic set of known determinants of PA, quadriceps strength or power, or isometric or isokinetic quadriceps endurance. Future longitudinal studies should investigate its potential as a modifiable determinant of PA.

Effect of position on intracranial pressure and compliance: a cross-sectional study including 101 patients

2021 ◽  
pp. 1-9
Author(s):  
Linda D’Antona ◽  
Claudia Louise Craven ◽  
Fion Bremner ◽  
Manjit Singh Matharu ◽  
Lewis Thorne ◽  
...  
Keyword(s):  
Intracranial Pressure ◽  
Linear Regression ◽  
Regression Models ◽  
Cross Sectional Study ◽  
Icp Monitoring ◽  
Linear Regression Models ◽  
Sectional Study ◽  
Csf Dynamics ◽  
Cross Sectional ◽  
Intracranial Compliance

OBJECTIVE A better understanding of the effect of position on intracranial pressure (ICP) and compliance is important for the development of treatment strategies that can restore normal cerebrospinal fluid (CSF) dynamics. There is limited knowledge on the effect of position on intracranial compliance. In this cross-sectional study the authors tested the association of pulse amplitude (PA) with position and the day/night cycle. Additionally, they describe the postural ICP and PA changes of patients with “normal” ICP dynamics. METHODS This single-center retrospective study included patients with suspected and/or confirmed CSF dynamics abnormalities who had been examined with elective 24-hour ICP monitoring between October 2017 and September 2019. Patients had been enrolled in a short exercise battery including four positions: supine, lumbar puncture position in the left lateral decubitus position, sitting, and standing. Each position was maintained for 2 minutes, and mean ICP and PA were calculated for each position. The 24-hour day and night median ICP and PA data were also collected. Linear regression models were used to test the correlation of PA with position and day/night cycle. All linear regressions were corrected for confounders. The postural ICP monitoring results of patients without obvious ICP dynamics abnormality were summarized. RESULTS One hundred one patients (24 males and 77 females) with a mean age of 39 ± 13years (mean ± standard deviation) were included in the study. The adjusted linear regression models demonstrated a significant association of ICP with position and day/night cycle, with upright (sitting and standing) and day ICP values lower than supine and night ICP values. The adjusted linear regression model was also significant for the association of PA with position and day/night cycle, with upright and day PA values higher than supine and night PA results. These associations were confirmed for patients with and without shunts. Patients without clear ICP dynamics abnormality had tighter control of their postural ICP changes than the other patients; however, the difference among groups was not statistically significant. CONCLUSIONS This is the largest study investigating the effect of postural changes on intracranial compliance. The results of this study suggest that PA, as well as ICP, is significantly associated with posture, increasing in upright positions compared to that while supine. Further studies will be needed to investigate the mechanism behind this association.

scholarly journals Psychiatric Disorders and Alcohol Consumption Among Low-Income African Americans:Gender Differences

2019 ◽  
Vol 9 (4) ◽  
pp. 86 ◽  
Author(s):  
Sharon Cobb ◽  
Shervin Assari
Keyword(s):  
Alcohol Consumption ◽  
Alcohol Use ◽  
Linear Regression ◽  
Low Income ◽  
Regression Models ◽  
Future Research ◽  
Linear Regression Models ◽  
Cross Sectional ◽  
Men And Women ◽  
Compulsive Disorder

Background: Although cooccurrence of nonsubstance use disorders (non-SUDs) and substance use is well-established in the literature, most of what we know in this regard is derived from studies that have recruited predominantly White sample populations. As a result, there is a gap in knowledge on this link among low-income African Americans (AAs). There is also a need to understand how low-income AA men and women differ in these associations. Objective: To study whether there is an association between number of non-SUDs and amount of alcohol consumption by AA adults, and whether this association varies between AA men and women. Methods: This cross-sectional study recruited a nonrandom sample of 150 AA adults with non-SUDs (i.e., major depression, bipolar disorders, obsessive–compulsive disorder, paranoid disorder, panic disorder, posttraumatic stress disorder (PTSD), and schizoaffective disorder). The independent variable was the number of non-SUDs. The dependent variable was the amount of alcohol consumption. Age, socioeconomic status (educational attainment and household income), and self-rated health were covariates. Gender was the moderator. Linear regression models were used to analyze the data. Results: A higher number of non-SUDs was not associated with a higher amount of alcohol use in the pooled sample of AA adults. We, however, found a significant interaction between gender and number of non-SUDs on the amount of alcohol use, suggesting a stronger effect of non-SUDs on alcohol consumption in AA men than in AA women. Gender-stratified linear regression models showed a positive association between number of non-SUDs and amount of alcohol consumption in AA men but not in AA women. Conclusion: Non-SUDs impact alcohol use of AA men but not women. Future research should test whether AA men may have a higher tendency to turn to alcohol to regulate their emotions and cope with psychological pain due to multiple non-SUDs. The results also suggest that integration of services for SUDs and non-SUDs may be more relevant to provision of mental health services for AA men than AA women.

scholarly journals The Importance of Teaching Assistant Support and Interactions in Student Engagement

2020 ◽  
Author(s):  
Denise Wilson ◽  
joanna wright ◽  
Lauren Summers
Keyword(s):  
Student Engagement ◽  
Linear Regression ◽  
Survey Data ◽  
Regression Models ◽  
Teaching Assistant ◽  
Public Institution ◽  
Linear Regression Models ◽  
Cross Sectional Survey ◽  
Student Interactions ◽  
Cross Sectional

Hierarchical linear regression models using cross-sectional survey data from over 750 students at a single large public institution were used to assess relationships between TA support, TA-student interactions, and three forms of student behavioral engagement. <br>

scholarly journals The Influence of Sitting, Standing, and Stepping Bouts on Cardiometabolic Health Markers in Older Adults

2021 ◽  
pp. 1-9
Author(s):  
Simone J.J.M. Verswijveren ◽  
Cormac Powell ◽  
Stephanie E. Chappel ◽  
Nicola D. Ridgers ◽  
Brian P. Carson ◽  
...  
Keyword(s):  
Physical Activity ◽  
Older Adults ◽  
Body Composition ◽  
Linear Regression ◽  
Regression Models ◽  
Fasting Glucose ◽  
Cardiometabolic Health ◽  
Linear Regression Models ◽  
Cross Sectional

Aside from total time spent in physical activity behaviors, how time is accumulated is important for health. This study examined associations between sitting, standing, and stepping bouts, with cardiometabolic health markers in older adults. Participants from the Mitchelstown Cohort Rescreen Study (N = 221) provided cross-sectional data on activity behaviors (assessed via an activPAL3 Micro) and cardiometabolic health. Bouts of ≥10-, ≥30-, and ≥60-min sitting, standing, and stepping were calculated. Linear regression models were fitted to examine the associations between bouts and cardiometabolic health markers. Sitting (≥10, ≥30, and ≥60 min) and standing (≥10 and ≥30 min) bouts were detrimentally associated with body composition measures, lipid markers, and fasting glucose. The effect for time spent in ≥60-min sitting and ≥30-min standing bouts was larger than shorter bouts. Fragmenting sitting with bouts of stepping may be targeted to benefit cardiometabolic health. Further insights for the role of standing need to be elicited.

Abstract 321: Central Blood Pressure Regulation in Relation to Hypertension and Adiposity in Youth

2017 ◽  
Vol 37 (suppl_1) ◽  
Author(s):  
Neil E Hultgren ◽  
Nicholas G Evanoff ◽  
Alexander M Kaizer ◽  
Kyle D Rudser ◽  
Donald R Dengel ◽  
...  
Keyword(s):  
Body Fat ◽  
Regression Models ◽  
Linear Regression Models ◽  
Hypertension Status ◽  
Cross Sectional ◽  
X Ray ◽  
Post Hoc ◽  
Sectional Analysis ◽  
The Relationship ◽  
Pearson Correlations

Introduction: The relationship between different central BP measurements with hypertension status in youth is not well documented. We hypothesized that measures of central BP would be positively associated with hypertension status in youth independent of adiposity. Methods: We recruited 149 males and 160 females for this cross-sectional analysis (mean±SD: age = 12.8±2.7; BMI percentile (%) = 78.5±27.8). Body fat % was measured by dual energy X-ray absorptiometry (DXA) and brachial BP was measured using an automated cuff to calculate systolic BP (SBP) and diastolic BP (DBP). Determined by systolic percentile, there were 238 normotensive (<90 th ), 29 pre-hypertensive (<90 th - <95 th ), and 42 hypertensive (<95 th ) individuals enrolled. Central BP was determined using the SphygmoCor MM3 system to calculate carotid-aorta SBP (caSBP) carotid-aorta DBP (caDBP) radial-aorta SBP (raSBP) and radial-aorta DBP (raDBP). Central BP measures were compared across hypertension status groups using ANCOVA, with post-hoc Tukey HSD, adjusted for age, sex, and race. Pearson correlations (unadjusted) and multiple linear regression models, examining the relationship between central BP measures with brachial BP adjusted for age, sex, race, and height, were conducted with further adjustment for body fat % (shown as β±SE). Results: raSBP, caSBP, raDBP, and caDBP were significantly different between the normotensive and hypertensive groups (all p<0.001). No statistically significant differences were found between normotensive and pre-hypertensive or between pre-hypertensive and hypertensive groups. raSBP and caSBP were correlated to SBP (r=0.59, r=0.62, respectively, p<0.001). raDBP and caDBP were correlated to DBP (r=0.58, r=0.6, respectively, p<0.001). In regression analysis, SBP was positively associated with both raSBP and caSBP (β=0.3±0.06, p<0.001) and (β=0.28±0.08, p<0.001), respectively. DBP was positively associated with raDBP and caDBP (β=0.31±0.06, p<0.001) and (β=0.31 ±0.06, p<0.001), respectively. All associations remained significant after adjustment for body fat %. Conclusion: These data suggest that central BP, regardless of measurement site, is highly associated with brachial BP and hypertension status in youth independent of adiposity.

Exposure to Organophosphate Pesticides and Menstrual Cycle Characteristics in Chinese Preconceptional Women

2019 ◽  
Vol 189 (5) ◽  
pp. 375-383 ◽  
Author(s):  
Yan Zhang ◽  
Lin Ji ◽  
Yi Hu ◽  
Lap Ah Tse ◽  
Yiwen Wang ◽  
...  
Keyword(s):  
Menstrual Cycle ◽  
Confidence Interval ◽  
Regression Models ◽  
Linear Regression Models ◽  
Cross Sectional ◽  
Logistic Regression Models ◽  
Maternity Hospitals ◽  
Diethyl Phosphate ◽  
Sectional Analysis ◽  
The Relationship

Abstract Organophosphates (OPs) are the most heavily used pesticides in China. The Chinese population, including preconceptional women, is highly exposed, yet little is known regarding the associations between OP exposure and menstruation in humans. We conducted a cross-sectional analysis in women preparing for pregnancy to investigate the relationship between biomarkers of OP exposure and menstrual cycle characteristics. From 2013 to 2015, 627 women visiting free preconception-care clinics at 2 maternity hospitals in Shanghai, China, were included. Information on menstrual cycle characteristics was obtained through questionnaires. OP exposure was assessed by measuring urine concentrations of 6 dialkylphosphate metabolites (dimethylphosphate, dimethylthiophosphate, dimethyldithiophosphate, diethylphosphate, diethylthiophosphate, and diethyldithiophosphate). The relationship between concentrations of dialkylphosphate metabolites and menstrual cycle characteristics was analyzed using multiple linear regression models and logistic regression models. Log-transformed levels of diethyl phosphate metabolites (the sum of diethylphosphate and diethylthiophosphate levels) were related to a higher risk of irregularity of menstrual cycles (adjusted odds ratio = 2.36, 95% confidence interval: 1.28, 4.34). Subjects with a higher concentration of diethyl phosphate metabolites (log-transformed) had a shorter duration of menstrual bleeding (adjusted β = −0.33, 95% confidence interval: −0.64, −0.02). The findings suggest that OP exposure may be associated with alterations in menstrual function in preconceptional women.

scholarly journals Patterns of change in cardiovascular risk assessments and ankle brachial index among Puerto Rican adults

PLoS ONE ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. e0245236
Author(s):  
Sabrina E. Noel ◽  
David J. Cornell ◽  
Xiyuan Zhang ◽  
Julia C. Mirochnick ◽  
Josiemer Mattei ◽  
...  
Keyword(s):  
Linear Regression ◽  
Puerto Rican ◽  
Mexican Americans ◽  
Regression Models ◽  
Allostatic Load ◽  
Ankle Brachial Index ◽  
Growth Mixture Modeling ◽  
Linear Regression Models ◽  
Cross Sectional

Background Puerto Rican adults have higher odds of peripheral artery disease (PAD) compared with Mexican Americans. Limited studies have examined relationships between clinical risk assessment scores and ABI measures in this population. Methods Using 2004–2015 data from the Boston Puerto Rican Health Study (BPRHS) (n = 370–583), cross-sectional, 5-y change, and patterns of change in Framingham Risk Score (FRS) and allostatic load (AL) with ankle brachial index (ABI) at 5-y follow-up were assessed among Puerto Rican adults (45–75 y). FRS and AL were calculated at baseline, 2-y and 5-y follow-up. Multivariable linear regression models were used to examine cross-sectional and 5-y changes in FRS and AL with ABI at 5-y. Latent growth mixture modeling identified trajectories of FRS and AL over 5-y, and multivariable linear regression models were used to test associations between trajectory groups at 5-y. Results Greater FRS at 5-y and increases in FRS from baseline were associated with lower ABI at 5-y (β = -0.149, P = 0.010; β = -0.171, P = 0.038, respectively). AL was not associated with ABI in cross-sectional or change analyses. Participants in low-ascending (vs. no change) FRS trajectory, and participants in moderate-ascending (vs. low-ascending) AL trajectory, had lower 5-y ABI (β = -0.025, P = 0.044; β = -0.016, P = 0.023, respectively). Conclusions FRS was a better overall predictor of ABI, compared with AL. Puerto Rican adults, an understudied population with higher FRS over 5 years, may benefit from intensive risk factor modification to reduce risk of PAD. Additional research examining relationships between FRS and AL and development of PAD is warranted.

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