scholarly journals Osmotically Enabled Wearable Patch for Sweat Harvesting and Lactate Quantification

Micromachines ◽  
2021 ◽  
Vol 12 (12) ◽  
pp. 1513
Author(s):  
Tamoghna Saha ◽  
Jennifer Fang ◽  
Sneha Mukherjee ◽  
Charles T. Knisely ◽  
Michael D. Dickey ◽  
...  
Keyword(s):  
Human Body ◽  
Colorimetric Assay ◽  
Sweat Rate ◽  
Microfluidic Channel ◽  
External Power ◽  
Paper Microfluidic ◽  
Lactate Levels ◽  
Monitoring Devices ◽  
Sweat Lactate

Lactate is an essential biomarker for determining the health of the muscles and oxidative stress levels in the human body. However, most of the currently available sweat lactate monitoring devices require external power, cannot measure lactate under low sweat rates (such as in humans at rest), and do not provide adequate information about the relationship between sweat and blood lactate levels. Here, we discuss the on-skin operation of our recently developed wearable sweat sampling patch. The patch combines osmosis (using hydrogel discs) and capillary action (using paper microfluidic channel) for long-term sweat withdrawal and management. When subjects are at rest, the hydrogel disc can withdraw fluid from the skin via osmosis and deliver it to the paper. The lactate amount in the fluid is determined using a colorimetric assay. During active sweating (e.g., exercise), the paper can harvest sweat even in the absence of the hydrogel patch. The captured fluid contains lactate, which we quantify using a colorimetric assay. The measurements show the that the total number of moles of lactate in sweat is correlated to sweat rate. Lactate concentrations in sweat and blood correlate well only during high-intensity exercise. Hence, sweat appears to be a suitable biofluid for lactate quantification. Overall, this wearable patch holds the potential of providing a comprehensive analysis of sweat lactate trends in the human body.

First clinical experience with the wearable cardiac rhythm long-term monitoring cardioskin device

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
P Guedeney ◽  
J Silvain ◽  
F Hidden-Lucet ◽  
C Maupain ◽  
S Dinanian ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Clinical Practice ◽  
Cardiac Rhythm ◽  
Cardiac Monitoring ◽  
Funding Source ◽  
Single Center ◽  
Long Term Monitoring ◽  
Monitoring Devices ◽  
Term Monitoring

Abstract Background There are only limited options for long-term cardiac monitoring devices readily available in clinical practice for outpatients. Holter monitoring devices are limited by the uncomfort of wires and patches, the small number of leads for analysis, the quality of recordings or the monitoring duration while insertable cardiac monitors are costly and exposed to potential local complication. Purpose To describe a single center experience with a novel wearable device for cardiac rhythm monitoring. Methods The Cardioskin™ system is a patch-free, wire-free, wearable device with rechargeable batteries that provides a high quality 15-lead electrocardiogram monitoring over 1 month (Figure 1). Data are sent using a mobile application downloaded in the patient smartphone to a central Corelab where they can be interpreted by an expert and/or the prescribing physician. An alarm signal is readily available within the Cardioskin™ device, to allow patients to indicate the presence of symptoms. In this single center retrospective registry, we provide a first report of the use of this novel device in real world practice, with indication and duration of cardiac monitoring left at the physicans “discretion”. Results From January 2019 to December 2019, the Cardioskin™ system was prescribed in 60 patients for an overall median duration of 26.5 (14–32) days. The mean age of the patients was 45±12.2 years and 24 (40%) were male. Indications for cardiac monitoring were post-Stroke, palpitation, syncope and cardiomyopathy assessment in 56%, 30%, 7% and 7% of the cases, respectively. A sustained (>30 seconds) supraventricular tachycardia was detected in 4 cases, including one case of atrial fibrillation, two case of atrial tachycardia and on case of junctional tachycardia. Unsustained ventricular tachycardia and atrial fibrillation burst were detected in another 2 cases (Figure 1). There was no reported case of skin irritation by the Cardioskin™ system or abrupt interruption of the monitoring by the patients. Conclusion The Cardioskin™ system is a novel, discreet and comfortable cardiac rhythm wearable long-term monitoring device which can be used in clinical practice for broad diagnostic indications. Figure 1. Cardioskin system Funding Acknowledgement Type of funding source: Public Institution(s). Main funding source(s): ACTION coeur

Review of Recent Developments in Surface Nanocrystallization of Metallic Biomaterials

Nanoscale ◽  
2021 ◽  
Author(s):  
Srijan Acharya ◽  
Satyam Suwas ◽  
Kaushik Chatterjee
Keyword(s):  
Human Body ◽  
Surface Characteristics ◽  
Metallic Materials ◽  
Short Term ◽  
Surface Nanocrystallization ◽  
Metallic Biomaterials ◽  
Recent Developments

Metallic materials are widely used to prepare implants for both short-term and long-term use in the human body. The performance of these implants is greatly influenced by their surface characteristics,...

scholarly journals Contamination of food with cadmium and dioxins – influence on the human body

2019 ◽  
Vol 65 (3) ◽  
Author(s):  
Aleksandra Słojewska ◽  
Izabela Gutowska
Keyword(s):  
General Population ◽  
Health Effects ◽  
Human Body ◽  
Bone Mineralization ◽  
The Body ◽  
Food Sources ◽  
Hormonal Balance ◽  
Small Doses ◽  
Contaminated Food

Introduction: Food is a carrier of many pollutants nowadays. For cadmium and dioxins, it is the main source of these compounds in the general population. Hence, the aim of this work was to collect data on the health effects associated with exposure to cadmium and dioxins which get into the human body through food.Materials and methods: A literature review was conducted by searching the scientific Medline database (PubMed) and Google Scholar.Results: Health effects associated with a long-term exposure to low doses of cadmium and dioxins may be nonspecific and are rarely attributed to food sources. These may cause disorders affecting hormonal balance, kidney function, lipid metabolism, fertility, cognitive function, bone mineralization, and susceptibility to diseases and allergies. These compounds may also lead to cancer development.Conclusions: The general population faces the problem of longterm exposure to small doses of these substances due to their accumulation in the body, even if their amounts do not exceed the relevant standards. The health effects of this type of exposure may be significantly delayed and are not likely to be attributed to the consumption of contaminated food. Consumers wishing to reduce the amounts of these compounds delivered to the body should limit the consumption of grilled and smoked products, and should also opt for organic food.

scholarly journals Role of Sex Hormones at Different Physiobiological Conditions and Therapeutic Potential in MBD2 Mediated Severe Asthma

2021 ◽  
Vol 2021 ◽  
pp. 1-16
Author(s):  
Binaya Wasti ◽  
Zhifeng Chen ◽  
Yi Ke ◽  
Wen Tao Duan ◽  
Shao-Kun Liu ◽  
...  
Keyword(s):  
Severe Asthma ◽  
Sex Hormones ◽  
Human Body ◽  
Therapeutic Potential ◽  
Corticosteroid Treatment ◽  
Sex Hormone ◽  
Asthma Prevalence ◽  
Term Survival

Sex hormone has become a “hot topic” to evaluate the hormonal therapeutic potential in severe asthma. Th17 cell is one of the main influencing factors involved in the pathogenesis of severe asthma, hence also called as kernel of severe asthma, and Th17 subtype of non-T2 asthma is less responsive (resistance) to inhaled corticosteroid (ICS), so severe in nature. Methyl-CpG binding domain protein 2 (MBD2) is overexpressed and regulates the Th17 differentiation, showing the possibility of therapeutic target in treating Th17 mediated severe asthma. Sex hormone fluctuates at the different physiobiological conditions of the human body and affects the asthma pathobiology showing its role in asthma prevalence, severity, remission, and therapy. This review briefly overviews the sex hormones, their influence in asthma at the different physiobiological conditions of human body, and MBD2 severe asthma connection with the possible therapeutic potential of sex steroids in MBD2 mediated Th17 predominant severe asthma. Male sex hormone tends to show a beneficial effect and possibly downregulates the expression of Th17 cells via regulating MBD2 through a mechanism distinct from corticosteroid treatment and guides us towards discovery of new therapeutic agent, reduces the asthma-related complications, and promotes long-term survival by lowering the risk of therapy-resistant issues of old age severe asthma.

scholarly journals Screening of variety collections of sunflower and winter wheat for Cadmium low accumulation

2019 ◽  
pp. 42-46
Author(s):  
Yuanzhi Fu ◽  
Liuliu Wu ◽  
V.I. Trotsenko ◽  
H.O. Zhatova
Keyword(s):  
Winter Wheat ◽  
Human Health ◽  
Human Body ◽  
Cadmium Accumulation ◽  
Urgent Problem ◽  
Cadmium Pollution ◽  
New Varieties

Cadmium pollution in soil is a long-term and urgent problem, which directly affects the edible value of sunflower and winter wheat and may cause harm to human health. Breeding new varieties with low cadmium accumulation can effectively reduce the content of this element in seeds and fundamentally solve the risk of cadmium entering the human body through seeds and oil. In this paper, the method and significance of breeding sunflower and winter wheat with low cadmium accumulation  were discussed.

The Effect of Long-Term Aerial Exposure on Heart Rate, Ventilation, Respiratory Gas Exchange and Acid-Base Status in the Crayfish Austropotamobius Pallipes

1981 ◽  
Vol 92 (1) ◽  
pp. 109-124
Author(s):  
E. W. TAYLOR ◽  
MICHÈLE G. WHEATLY
Keyword(s):  
Heart Rate ◽  
Lactic Acid ◽  
O2 Consumption ◽  
Aerial Exposure ◽  
Acid Base ◽  
Bicarbonate Buffer ◽  
Content Difference ◽  
Acid Base Status ◽  
Lactate Levels

1. When first removed into air, crayfish showed transient increases in heart rate (fH) and scaphognathite rate (fR) which rapidly recovered to submerged levels and were unchanged for 24 h. The rate of O2 consumption(Moo2) increased from an initially low level and was then maintained for 24 h in air at the same level as in settled submerged animals. 2. There was an initial acidosis in the haemolymph which was both respiratory and metabolic due to the accumulation of CO2 and lactate. Progressive compensation by elevation of the levels of bicarbonate buffer in the haemolymph and reduction of circulating lactate levels returned pH towards submerged levels after 24 h in air. 3. Exposure to air resulted in a marked internal hypoxia with haemolymph O2, tensions, both postbranchial Pa, oo2 and prebranchial Pv, oo2, remaining low throughout the period of exposure. The oxygen content or the haemolymph was initially reduced, with a - vOO2 content difference close to zero. Within 24 h both Ca, oo2 and Cv, OO2 had returned towards their levels in submerged animals. These changes are explained by the Bohr shift on the haemocyanin consequent upon the measured pH changes. 4. After 48 h in air, MO2 and fH were significantly reduced and ventilation became intermittent. There was a slight secondary acidosis, increase in lactic acid levels and reduction in a - vO2 content difference in the haemolymph. 5. When crayfish were returned to water after 24 h in air, MOO2, fHfR were initially elevated by disturbance and there was a period of hyperventilation. In the haemolymph there was an initial slight alkalosis, and an increase in Ca, OO2 lactic acid. All variables returned to their settled submerged levels within 8 h.

Rational vitamin therapy

1982 ◽  
Vol 63 (1) ◽  
pp. 58-61
Author(s):  
I. M. Raskin ◽  
J. S. Zimmerman
Keyword(s):  
Adverse Effect ◽  
High Activity ◽  
Human Body ◽  
Complex Interaction ◽  
The Body ◽  
Scientific Development ◽  
Functional Connections ◽  
Vitamin Therapy ◽  
Excessive Intake

Free sale of vitamin preparations with high activity, insufficient scientific development of the consequences of excessive intake of vitamins, the spread of superficial knowledge about vitamins among the population have led to numerous facts of the adverse effect of certain vitamins on the human body. It turned out that unjustifiably long-term intake of large doses of one of the vitamins can cause a deficiency in the body of another vitamin, cause the development of hypovitaminosis. The complex interaction of vitamins in the human body is due to the presence, they have metabolic and functional connections.

Electrode Belt: A New Method for Long-Term Monitoring

PEDIATRICS ◽  
1979 ◽  
Vol 63 (4) ◽  
pp. 670-673
Author(s):  
Dorothy H. Kelly ◽  
Kathleen O'Connell ◽  
Daniel C. Shannon
Keyword(s):  
Heart Rate ◽  
Sleep Apnea ◽  
Electronic Monitoring ◽  
False Alarms ◽  
American Academy Of Pediatrics ◽  
Long Term Monitoring ◽  
Monitoring Devices ◽  
Term Monitoring ◽  
At Home

Infants who have experienced an episode of prolonged sleep apnea associated with cyanosis, pallor, and limpness requiring vigorous stimulation or mouth-to-mouth resuscitation to restore breathing, are at risk of experiencing a recurrence that may result in death1.2. The American Academy of Pediatrics has recommended that such infants be treated by 24-hour surveillance either in the home or in the hospital. Electronic monitoring devices "may be useful adjuncts" to such surveillance.3 Since 1973, we have monitored 270 infants at home with apnea or cardiac monitors. A major problem with monitoring infants at home has been false alarms, such as alarms for apnea when the infant is breathing, on heart rate or apnea alarms due to a loose electrode.

scholarly journals Lactate and BDNF: Key Mediators of Exercise Induced Neuroplasticity?

2020 ◽  
Vol 9 (4) ◽  
pp. 1136 ◽  
Author(s):  
Patrick Müller ◽  
Yves Duderstadt ◽  
Volkmar Lessmann ◽  
Notger G. Müller
Keyword(s):  
Physical Exercise ◽  
High Intensity ◽  
Long Term Potentiation ◽  
Potential Mediator ◽  
Term Potentiation ◽  
Lactate Levels ◽  
Exercise Induced ◽  
Lactate Infusion ◽  
Relationship Of

Accumulating evidence from animal and human studies supports the notion that physical exercise can enhance neuroplasticity and thus reduce the risk of several neurodegenerative diseases (e.g., dementia). However, the underlying neurobiological mechanisms of exercise induced neuroplasticity are still largely unknown. One potential mediator of exercise effects is the neurotrophin BDNF, which enhances neuroplasticity via different pathways (e.g., synaptogenesis, neurogenesis, long-term potentiation). Current research has shown that (i) increased peripheral lactate levels (following high intensity exercise) are associated with increased peripheral BDNF levels, (ii) lactate infusion at rest can increase peripheral and central BDNF levels and (iii) lactate plays a very complex role in the brain’s metabolism. In this review, we summarize the role and relationship of lactate and BDNF in exercise induced neuroplasticity.

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