scholarly journals Clinical Efficacy of Brown Seaweeds Ascophyllum nodosum and Fucus vesiculosus in the Prevention or Delay Progression of the Metabolic Syndrome: A Review of Clinical Trials

Molecules ◽  
2021 ◽  
Vol 26 (3) ◽  
pp. 714
Author(s):  
Enver Keleszade ◽  
Michael Patterson ◽  
Steven Trangmar ◽  
Kieran J. Guinan ◽  
Adele Costabile
Keyword(s):  
Metabolic Syndrome ◽  
Clinical Trials ◽  
Brown Seaweed ◽  
Public Health Problem ◽  
Ascophyllum Nodosum ◽  
Fucus Vesiculosus ◽  
Total Phenolic ◽  
World Population ◽  
Brown Seaweeds ◽  
The Metabolic Syndrome

Metabolic syndrome (MetS) is a global public health problem affecting nearly 25.9% of the world population characterised by a cluster of disorders dominated by abdominal obesity, high blood pressure, high fasting plasma glucose, hypertriacylglycerolaemia and low HDL-cholesterol. In recent years, marine organisms, especially seaweeds, have been highlighted as potential natural sources of bioactive compounds and useful metabolites, with many biological and physiological activities to be used in functional foods or in human nutraceuticals for the management of MetS and related disorders. Of the three groups of seaweeds, brown seaweeds are known to contain more bioactive components than either red and green seaweeds. Among the different brown seaweed species, Ascophyllum nodosum and Fucus vesiculosus have the highest antioxidant values and highest total phenolic content. However, the evidence base relies mainly on cell line and small animal models, with few studies to date involving humans. This review intends to provide an overview of the potential of brown seaweed extracts Ascophyllum nodosum and Fucus vesiculosus for the management and prevention of MetS and related conditions, based on the available evidence obtained from clinical trials.

scholarly journals Effectiveness of Ascophyllum nodosum and Fucus vesiculosus on Metabolic Syndrome Components: A Real-World, Observational Study

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Antonio Nicolucci ◽  
Maria Chiara Rossi ◽  
Massimiliano Petrelli
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Body Weight ◽  
Blood Glucose ◽  
Waist Circumference ◽  
Real World ◽  
Fasting Blood Glucose ◽  
Ascophyllum Nodosum ◽  
Fucus Vesiculosus ◽  
The Metabolic Syndrome

Introduction. Gdue is a nutraceutical obtained from the association of two marine algae, Ascophyllum nodosum and Fucus vesiculosus, in addition to chromium picolinate, which could be useful for the treatment of dysglycemia, overweight, and the other components of the metabolic syndrome. The aim of the study was to assess the real-world effectiveness and safety of Gdue when administered to subjects with one or more components of the metabolic syndrome. Methods. A longitudinal, retrospective, observational study, conducted among primary care physicians, nutritionists, and specialists from various disciplines. The impact of 180 days of administration of Gdue was assessed on body weight, waist circumference, fasting blood glucose, HbA1c, lipid profile, and blood pressure levels. The likelihood of experiencing a first major cardiovascular event over ten years was estimated using Italian risk charts. General linear models for repeated measures were applied to assess changes in the parameters of interest during the follow-up. Results are expressed as estimated marginal means with their 95% confidence interval. Results. Overall, 505 patients were enrolled by 282 physicians. After 6 months of treatment with Gdue, body weight was reduced on average by 7.3 kg (-8.0; -6.6), waist circumference by 7.5 cm (-8.2; -6.8), fasting blood glucose by 16.3 mg/dL (-17.8; -14.7), HbA1c by 0.55% (-0.62; -0.49), systolic and diastolic blood pressure by 7.1 mmHg (-8.3; -6.0) and 4.2 mmHg (-5.0; -3.5), respectively, LDL cholesterol by 18.2 mg/dL (-21.2; -15.3), and triglycerides by 39 mg/dL (-45; -32). HDL cholesterol was significantly increased by 2.9 mg/dL (0.7; 5.0). The 10-year risk of cardiovascular events significantly decreased by 1.8%, corresponding to a relative risk reduction of 27.7%. Conclusion. Our real-world study shows that 6 months of treatment with Gdue have an impact on all the components of the metabolic syndrome, thus offering the potential for decreasing the cardiovascular risk associated with metabolic syndrome.

scholarly journals The Metabolic Syndrome and Mind-Body Therapies: A Systematic Review

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Joel G. Anderson ◽  
Ann Gill Taylor
Keyword(s):  
Systematic Review ◽  
Metabolic Syndrome ◽  
Clinical Trials ◽  
Tai Chi ◽  
Clinical Trial Data ◽  
Clinical Effectiveness ◽  
The Metabolic Syndrome ◽  
Worldwide Population ◽  
Increased Risk

The metabolic syndrome, affecting a substantial and increasing percentage of the worldwide population, is comprised of a cluster of symptoms associated with increased risk of type 2 diabetes, cardiovascular disease, and other chronic conditions. Mind-body modalities based on Eastern philosophy, such as yoga, tai chi, qigong, and meditation, have become increasingly popular worldwide. These complementary therapies have many reported benefits for improving symptoms and physiological measures associated with the metabolic syndrome. However, clinical trial data concerning the effectiveness of these practices on the syndrome as a whole have not been evaluated using a systematic and synthesizing approach. A systematic review was conducted to critically evaluate the data from clinical trials examining the efficacy of mind-body therapies as supportive care modalities for management of the metabolic syndrome. Three clinical trials addressing the use of mind-body therapies for management of the metabolic syndrome were identified. Findings from the studies reviewed support the potential clinical effectiveness of mind-body practices in improving indices of the metabolic syndrome.

scholarly journals Association between Dietary Habits, Shift Work, and the Metabolic Syndrome: The Korea Nurses’ Health Study

2020 ◽  
Vol 17 (20) ◽  
pp. 7697
Author(s):  
Heeja Jung ◽  
Hyunju Dan ◽  
Yanghee Pang ◽  
Bohye Kim ◽  
Hyunseon Jeong ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Shift Work ◽  
Dietary Habits ◽  
Public Health Problem ◽  
Health Study ◽  
Calorie Intake ◽  
Important Public Health Problem ◽  
Family History Of Diabetes ◽  
The Metabolic Syndrome ◽  
Factors Influencing

Metabolic syndrome (MetS) is an important public health problem, and unhealthy dietary habits and shift work are considered major factors that increase the prevalence of MetS. The purpose of this study was to examine whether dietary habits, alcohol drinking, and shift-working were associated with development of MetS in shift-working female nurses. This study analyzed cross-sectional survey data from the Korea Nurses’ Health Study (KNHS). Of the 1638 nurses, 403 participants were selected based on the propensity score matching method (PSM). These participants had either no or more than three MetS determinant factors. Analysis was conducted by using multivariable logistic regression to confirm the factors influencing MetS. The prevalence of MetS in this group (1638 participants) was 5.6% (92 participants). Consumption of over 50% of daily calorie intake after 7 p.m., consumption of carbonated drinks, family history of diabetes, and non-shift work were significant factors influencing MetS. Nurses are one of the at-risk groups for unhealthy dietary habits due to the nature of their work. Therefore, nurse managers should include regular dietary education for nurses and continue their policy efforts to resolve health problems that may arise in connection with nurses’ work.

scholarly journals Effect of menopausal hormone therapy on components of the metabolic syndrome

2016 ◽  
Vol 11 (1) ◽  
pp. 33-43 ◽  
Author(s):  
Dragana Lovre ◽  
Sarah H. Lindsey ◽  
Franck Mauvais-Jarvis
Keyword(s):  
Metabolic Syndrome ◽  
Hormone Therapy ◽  
Visceral Obesity ◽  
Menopausal Hormone Therapy ◽  
World Population ◽  
Metabolic Function ◽  
Metabolic Dysfunction ◽  
The Metabolic Syndrome ◽  
The World

The world population is aging, and women will spend an increasing share of their lives in a postmenopausal state that predisposes to metabolic dysfunction. Thus, the prevalence of metabolic syndrome (MetS) in women is likely to increase dramatically. This article summarizes the effects of menopause in predisposing to components of MetS including visceral obesity, dyslipidemia, type 2 diabetes (T2D) and hypertension (HTN). We also summarize the effects of menopausal hormone therapy (MHT) in reversing these metabolic alterations and discuss therapeutic advances of novel menopausal treatment on metabolic function.

scholarly journals A perspective on vegetarian dietary patterns and risk of metabolic syndrome

2015 ◽  
Vol 113 (S2) ◽  
pp. S136-S143 ◽  
Author(s):  
Joan Sabaté ◽  
Michelle Wien
Keyword(s):  
Metabolic Syndrome ◽  
Dietary Patterns ◽  
Dietary Pattern ◽  
Public Health Problem ◽  
Current Evidence ◽  
Case Control Studies ◽  
Important Public Health Problem ◽  
Cross Sectional ◽  
The Metabolic Syndrome ◽  
The Usa

The vegetarian dietary pattern is traditionally a plant-based diet that includes fruits, vegetables, cereals, legumes, nuts, vegetable oils, soya, and possibly dairy products and/or eggs. Vegetarians and other populations who follow a plant-based dietary pattern enjoy longevity. Specifically, vegetarian dietary patterns have been associated with a lower risk for developing IHD, type 2 diabetes, hypertension, specific cancers, lower all-cause mortality and reduction in cause-specific mortality. The prevalence of the metabolic syndrome (MetS) in the USA is approximately 20 % and is currently increasing in developing countries in line with the obesity epidemic. The health care costs associated with the MetS are on a magnitude of 1·6 overall compared with healthy individuals, which makes it an important public health problem. Current evidence from several cross-sectional and case–control studies shows an association between consumption of a vegetarian dietary pattern and a reduced prevalence or risk of developing the MetS. There is a need for further research to be conducted, particularly prospective cohort studies to evaluate the effect of vegetarian dietary patterns on reducing the incidence of the MetS and, clinical trials should be designed to explore vegetarian dietary patterns for the reversal of the MetS in high-risk populations. This research could contribute to reduce the societal and economic burdens associated with the disorder.

scholarly journals Prevalence of Metabolic Syndrome and of Cardiovascular Risk Factors

2018 ◽  
Vol 15 (5) ◽  
pp. 35-42
Author(s):  
Manta Andrei ◽  
Maștaleru Alexandra ◽  
Oancea Andra ◽  
Anghel Razvan Constantin ◽  
Roca Mihai ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Public Health Problem ◽  
Left Ventricular ◽  
Lifestyle Changes ◽  
Therapeutic Success ◽  
The Metabolic Syndrome ◽  
Group 2 ◽  
Group 1

AbstractObesity, a component of the metabolic syndrome, is a rising public health problem, continuously increasing in the European countries. The therapeutic success of the patient with metabolic syndrome requires a multidisciplinary approach to lifestyle changes, weight loss, continuous and dynamic dietary improvement, sedentary reduction, normalization of blood pressure, glycemia and lipid parameters. We performed a retrospective study that was conducted in the Clinical Rehabilitation Hospital in Iasi, with 4627 patients that were admitted in the Cardiovascular Rehabilitation Clinic from January 2011 to December 2015 with the diagnosis of metabolic syndrome according to WHO definition (Group 1) or with other comorbidities (Group 2). In the first group were included 1064 patients diagnosed with metabolic syndrome. This group has predominantly smoking female patients. Also, in group 1 were diagnosed more patients with left ventricular hypertrophy and coronary heart disease compared to group 2. Most of the patients with inflammatory syndrome were included in the group without metabolic syndrome (group 2). The results of our study confirm that metabolic syndrome is a cluster of abnormalities whose evolution determines the development of coronary heart disease. All this would advocate for treating metabolic syndrome as the primary method of preventing cardiovascular disease.

scholarly journals Effects of Acute Dietary Polyphenols and Post-Meal Physical Activity on Postprandial Metabolism in Adults with Features of the Metabolic Syndrome

Nutrients ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 1120 ◽  
Author(s):  
Dustin W Davis ◽  
James W Navalta ◽  
Graham R McGinnis ◽  
Reimund Serafica ◽  
Kenneth Izuora ◽  
...  
Keyword(s):  
Physical Activity ◽  
Metabolic Syndrome ◽  
Clinical Trials ◽  
Oxidative Damage ◽  
Virgin Olive Oil ◽  
Postprandial Glucose ◽  
Stair Climbing ◽  
Dietary Polyphenols ◽  
The Metabolic Syndrome ◽  
Freeze Dried

Approximately 22% of U.S. adults and 25% of adults globally have metabolic syndrome (MetS). Key features, such as dysglycemia and dyslipidemia, predict type 2 diabetes, cardiovascular disease, premature disability, and death. Acute supplementation of dietary polyphenols and post-meal physical activity hold promise in improving postprandial dysmetabolism. To our knowledge, no published review has described the effects of either intervention on postprandial glucose, insulin, lipids, and markers of oxidative damage and inflammation in adults with features of MetS. Thus, we conducted this review of controlled clinical trials that provided dietary polyphenols from oils, fruits, teas, and legumes during a dietary challenge, or implemented walking, cycling, and stair climbing and descending after a dietary challenge. Clinical trials were identified using ClinicalTrials.gov, PubMed, and Google Scholar and were published between 2000 and 2019. Dietary polyphenols from extra virgin olive oil, grapes, blackcurrants, strawberries, black tea, and black beans improved postprandial glucose, insulin, and markers of oxidative damage and inflammation, but results were not consistent among clinical trials. Freeze-dried strawberry powder distinctly improved postprandial insulin and markers of oxidative damage and inflammation. Post-meal physical activity attenuated postprandial glucose, but effects on postprandial lipids and markers of oxidative damage and inflammation were inconclusive. Consuming dietary polyphenols with a meal and completing physical activity after a meal may mitigate postprandial dysmetabolism in adults with features of MetS.

scholarly journals Fucus vesiculosus and Ascophyllum nodosum Ameliorate Liver Function by Reducing Diet-Induced Steatosis in Rats

Marine Drugs ◽  
2020 ◽  
Vol 18 (1) ◽  
pp. 62 ◽  
Author(s):  
Daniela Gabbia ◽  
Miriam Saponaro ◽  
Samantha Sarcognato ◽  
Maria Guido ◽  
Nicola Ferri ◽  
...  
Keyword(s):  
Ascophyllum Nodosum ◽  
Fucus Vesiculosus ◽  
In Vivo Studies ◽  
Brown Seaweeds ◽  
Nonalcoholic Fatty Liver ◽  
Obesity And Diabetes ◽  
Ancient Times ◽  
Lipid Parameters

The Asian coastal communities have used the brown seaweeds Fucus vesiculosus and Ascophyllum nodosum since ancient times. Recently, some in vitro and in vivo studies have demonstrated their abilities in reducing risk factors for metabolic syndrome. Here, we analyzed the protective effect of a phytocomplex extracted from these seaweeds on the deposition of fat in the liver after the administration of a high-fat diet (HFD) to rats for five weeks. The administration of F. vesiculosus and A. nodosum led to significant reductions in microvescicular steatosis and plasma biochemical and lipid parameters, such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), total and conjugated bilirubin, and triglycerides. Furthermore, the postprandial glycemic peak was delayed and significantly reduced (p < 0.01) by the algal extract administration. In conclusion, this extract is effective in reducing microvescicular steatosis and improving glycemic control, thereby lowering the risk of nonalcoholic fatty liver disease, obesity, and diabetes, diseases related to the consumption of fat and sugar-enriched diets.

scholarly journals The Brown Algae Fucus vesiculosus and Ascophyllum nodosum Reduce Metabolic Syndrome Risk Factors: A Clinical Study

2018 ◽  
Vol 13 (12) ◽  
pp. 1934578X1801301 ◽  
Author(s):  
Sara De Martin ◽  
Daniela Gabbia ◽  
Maria Carrara ◽  
Nicola Ferri
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Blood Glucose ◽  
Waist Circumference ◽  
Fasting Blood Glucose ◽  
Ascophyllum Nodosum ◽  
Fucus Vesiculosus ◽  
Homa Index ◽  
Insulin Levels ◽  
Glucose Levels

Fucus vesiculosus and Ascophyllum nodosum have been traditionally used for the treatment of obesity and several gastrointestinal diseases. We have recently demonstrated that the phytocomplex obtained from these algae (Gdue™) controls postprandial glucose levels in a mouse model of steatohepatitis, a condition often associated with obesity and type 2 diabetes mellitus. We analyzed the effect of Gdue™ on HOMA index, waist circumference, fasting blood glucose and insulin levels in overweight or obese subjects. Waist circumference decreased significantly after 6 months of treatment (112 ± 17 at t0 vs 105 ± 13 cm after 6 months of treatment; p<0.0001). Both blood glucose and insulin levels were significantly reduced after 6 months of treatment with Gdue™ (110 ± 15 at t0 vs 98 ± 15 mg/dL after 6 months for glucose; p<0.0001; 22.6 ± 9.5 at t0 vs 17.8 ± 8.6 μU/mL after 6 months for insulin; p<0.05). Accordingly, HOMA index decreased significantly (6.103 ± 2.548 at t0 vs 4.419 ± 2.382 after 6 months; p<0.01), suggesting an improvement of insulin sensitivity status. This phytocomplex represents a useful dietary supplement for controlling relevant metabolic syndrome risk factors, such as waist circumference, fasting insulin and glucose levels.

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