scholarly journals The Role of Resveratrol in Human Male Fertility

Molecules ◽  
2021 ◽  
Vol 26 (9) ◽  
pp. 2495
Author(s):  
Laura M. Mongioì ◽  
Sarah Perelli ◽  
Rosita A. Condorelli ◽  
Federica Barbagallo ◽  
Andrea Crafa ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Cardiovascular Diseases ◽  
Human Health ◽  
Male Fertility ◽  
Red Wine ◽  
Clinical Aspects ◽  
Beneficial Effects ◽  
Human Male ◽  
The Relationship

Resveratrol (RSV) (3,4′,5 trihydroxystilbene) is a natural non-flavonoid polyphenol widely present in the Mediterranean diet. In particular, RSV is found in grapes, peanuts, berries, and red wine. Many beneficial effects of this molecule on human health have been reported. In fact, it improves some clinical aspects of various diseases, such as obesity, tumors, hypertension, Alzheimer’s disease, stroke, cardiovascular diseases, and diabetes mellitus. However, little is known about the relationship between this compound and male fertility and the few available results are often controversial. Therefore, this review evaluated the effects of RSV on human male fertility and the mechanisms through which this polyphenol could act on human spermatozoa.

scholarly journals Irisin: A New Code Uncover the Relationship of Skeletal Muscle and Cardiovascular Health During Exercise

2021 ◽  
Vol 12 ◽  
Author(s):  
Chunlian Ma ◽  
Haichao Ding ◽  
Yuting Deng ◽  
Hua Liu ◽  
Xiaoling Xiong ◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Cardiovascular Health ◽  
Therapeutic Agent ◽  
Current Knowledge ◽  
Positive Role ◽  
Beneficial Effects ◽  
Relationship Of ◽  
Near Future ◽  
The Relationship

Exercise not only produces beneficial effects on muscle itself via various molecular pathways, but also mediates the interaction between muscles and other organs in an autocrine/paracrine manner through myokines, which plays a positive role in maintaining overall health. Irisin, an exercise-derived myokine, has been found involved in the regulation of some cardiovascular diseases. However, the relationship between irisin and cardiovascular health is not fully elucidated and there are some divergences on the regulation of irisin by exercise. In this review, we present the current knowledge on the origin and physiology of irisin, describe the regulation of irisin by acute and chronic exercises, and discuss the divergences of the related research results. Importantly, we discuss the role of irisin as a biomarker in the diagnosis of cardiovascular diseases and describe its treatment and molecular mechanism in some cardiovascular diseases. It is expected that irisin will be used as a therapeutic agent to combat cardiovascular diseases or other disorders caused by inactivity in the near future.

Diabetic neuropathy: Epidemiological, pathogenetic, and clinical aspects with special emphasis on type 2 diabetes mellitus

1983 ◽  
Vol 104 (4_Suppl) ◽  
pp. S89-S94
Author(s):  
E. Matikainen ◽  
J. Juntunen
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Peripheral Neuropathy ◽  
Diabetic Control ◽  
Clinical Aspects ◽  
Type 2 Diabetics ◽  
Insulin Dependent

ABSTRACT. Peripheral neuropathy is a frequent complication of diabetes mellitus. Alterations of the peripheral nervous system in diabetics have been studied in numerous investigations. There are many factors known to participate in the development of this complication, e.g. the age of the patient, duration of the diabetes, quality of the diabetic control etc. The role of different types of diabetes in development of neuropathy is still largely unclear since investigations on this aspect are few. It seems, however, that peripheral neuropathy in type 2 (non-insulin dependent) diabetes is common but often mild. The differential diagnosis of the peripheral neuropathy in type 2 diabetics is more difficult than in type 1 (insulin dependent) diabetics, since these patients tend to be older and also may have other concomitant disorders. In this paper the clinical features and pathogenetic mechanisms of neuropathy in type 2 diabetes are briefly discussed.

scholarly journals Peran Faktor-faktor Psikologis terhadap Depresi pada Pasien Diabetes Mellitus Tipe 2

2014 ◽  
Vol 41 (2) ◽  
pp. 241
Author(s):  
Jenita DT Donsu ◽  
M Noor Rochman Hadjam ◽  
Ahmad Husain Asdie ◽  
Rahmat Hidayat
Keyword(s):  
Diabetes Mellitus ◽  
Social Support ◽  
Psychological Factors ◽  
Self Esteem ◽  
Mediating Effect ◽  
The Other ◽  
Negative Coefficient ◽  
Other Hand ◽  
The Relationship

Depression has strong relationship with diabetes mellitus and the aspect of psychology has influence toward the diabetes patient as control. This research aimed to find out the role of psychological factors in dealing with depression suffered by patient of DM-2 and to see the dynamics of both direct and indirect relationship of psychological factors toward the depression of DM-2 patient. The main model is a model that can bring effect of mediation between social support and depression caused by DM-2. Optimism can provide mediating effect of the relationship between social support and self-esteem. Resilience can provide mediating effect of the relationship between social support and self-esteem. Similarly, self-esteem acts as the mediator of the relationship between optimism and resilience toward the depression of DM-2 patient. The result of estimation parameter test showed the direct relationship between social support toward optimism (0.717), resilience (0.811), self-esteem (0.269) and depression (-0.210) and the direct role to depression (-0.397). The higher social support and self-esteem will cause the higher optimism and resilience. On the other hand, the role of self-esteem showed negative coefficient. On the other hand, the role of self-esteem to depression showed a negative coefficient is, the higher self-esteem will be followed by the decrease of depression in patient with DM-2. Keywords: depression, optimism, resilience, self-esteem, social support, DM-2

Microbiote et probiotiques : impact en santé humaine

2010 ◽  
Vol 56 (8) ◽  
pp. 611-650 ◽  
Author(s):  
Sophie Coudeyras ◽  
Christiane Forestier
Keyword(s):  
Lactic Acid ◽  
Human Health ◽  
Health Benefit ◽  
Therapeutic Strategies ◽  
Beneficial Effects ◽  
Mucous Membranes ◽  
Genus Lactobacillus ◽  
Human Flora ◽  
Constant Improvement

All accessible mucous membranes of the human body are colonized by an abundant and diversified microbial flora called microbiota. Recent studies have shown that these microorganisms, long regarded as purely commensal, have essential beneficial effects on human health. Thus, numerous human ailments are linked to dysbiosis; that is, imbalances in the microflora composition. The administration of probiotic microorganisms could, in some situations, provide substantial relief from such disorders. These live microorganisms, which, according to the definition, confer a health benefit to the host when administered in adequate amounts, are often derived from human flora and belong mostly to lactic acid bacteria, in particular to the genus Lactobacillus . The constant improvement of knowledge of the role of human microbiota and the growing popularity of probiotics are now opening the door to new prophylactic and therapeutic strategies in human health.

Hypothyroidism and cardiovascular system

2016 ◽  
Vol 94 (7) ◽  
pp. 497-503 ◽  
Author(s):  
A. F. Verbovoy ◽  
Lyudmila A. Sharonova ◽  
O. V. Kosareva ◽  
N. I. Verbovaya ◽  
Yu. A. Dolgikh
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Cardiovascular Diseases ◽  
Vitamin D3 ◽  
Thyroid Dysfunction ◽  
Myocardial Remodeling ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
The Relationship

The article presents data on the relationship between thyroid dysfunction and cardiovascular diseases. The role of dyslipidemia, adipokines (adiponectin, leptin, resistin), C-reactive protein, deficiency of vitamin D3 in the development of cardiovascular disease in hypothyroidism is discussed. The article describes characteristics of myocardial remodeling, its dysfunction and their correlation with risk factors of cardiovascular diseases in patients with hypothyroidism.

Drugs and Drug Policy

2011 ◽  
Author(s):  
Mark A.R. Kleiman ◽  
Jonathan P. Caulkins ◽  
Angela Hawken
Keyword(s):  
Drug Policy ◽  
Illicit Trade ◽  
Beneficial Effects ◽  
Control Drug ◽  
The Subject ◽  
Drugs And Crime ◽  
The Relationship ◽  
Drug Free ◽  
The Brain

While there have always been norms and customs around the use of drugs, explicit public policies--regulations, taxes, and prohibitions--designed to control drug abuse are a more recent phenomenon. Those policies sometimes have terrible side-effects: most prominently the development of criminal enterprises dealing in forbidden (or untaxed) drugs and the use of the profits of drug-dealing to finance insurgency and terrorism. Neither a drug-free world nor a world of free drugs seems to be on offer, leaving citizens and officials to face the age-old problem: What are we going to do about drugs? In Drugs and Drug Policy, three noted authorities survey the subject with exceptional clarity, in this addition to the acclaimed series, What Everyone Needs to Know. They begin by, defining "drugs, " examining how they work in the brain, discussing the nature of addiction, and exploring the damage they do to users. The book moves on to policy, answering questions about legalization, the role of criminal prohibitions, and the relative legal tolerance for alcohol and tobacco. The authors then dissect the illicit trade, from street dealers to the flow of money to the effect of catching kingpins, and show the precise nature of the relationship between drugs and crime. They examine treatment, both its effectiveness and the role of public policy, and discuss the beneficial effects of some abusable substances. Finally they move outward to look at the role of drugs in our foreign policy, their relationship to terrorism, and the ugly politics that surround the issue. Crisp, clear, and comprehensive, this is a handy and up-to-date overview of one of the most pressing topics in today's world.

Diet and Brain Health: Which Role for Polyphenols?

2018 ◽  
Vol 24 (2) ◽  
pp. 227-238 ◽  
Author(s):  
Vanessa Castelli ◽  
Davide Grassi ◽  
Raffaella Bocale ◽  
Michele d'Angelo ◽  
Andrea Antonosante ◽  
...  
Keyword(s):  
Cognitive Performance ◽  
Brain Aging ◽  
Experimental Studies ◽  
Brain Health ◽  
Lifestyle Modifications ◽  
Dietary Polyphenols ◽  
Beneficial Effects ◽  
The Central Nervous System ◽  
The Relationship

Background: The aging of western societies is leading to a dramatic increase in the prevalence of chronic conditions, threatening the health status and then the sustainability of our healthcare systems. In particular, dementia is being increasingly recognized as a public health priority, given its enormous socioeconomic burdens further amplified by the absence of treatments really effective in improving the clinical course of the disease. Methods: The question of whether some degree of cognitive deterioration is an inevitable part of aging or should be considered as a pathological pre-stage of dementia is currently debated. This is a field in need of research because accelerated brain aging as well as further decline in cognition might be preventable in the early stages of cognitive impairment. Herein, we discuss evidence from clinical and experimental studies on the role of polyphenols in preserving cognitive performance across life. Results: In recent years, the possibility of favorably influencing the cognitive trajectory through promotion of lifestyle modifications has been increasingly investigated. In particular, the relationship between nutritional habits and brain health has attracted special attention. Dietary polyphenols exhibit a strong potential to promote brain due to their efficacy in protecting neurons against oxidative stress-induced injury, suppressing neuroinflammation and in ameliorating cardiovascular risk factor control and cardiovascular function thus counteracting neurotoxicity and neurodegeneration. Conclusion: Emerging evidence suggest that dietary polyphenols, in particular flavonoids, may exert beneficial effects on the central nervous system thus representing a potential tool to preserve cognitive performance throught senescence.

scholarly journals The role of nonesterified fatty acids in pathogenesis of cardiovascular diseases

2010 ◽  
Vol 16 (1) ◽  
pp. 93-103 ◽  
Author(s):  
M. V. Tsvetkova ◽  
V. N. Khirmanov ◽  
N. N. Zybina
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Fatty Acids ◽  
Type 2 Diabetes Mellitus ◽  
Adipose Tissue ◽  
Risk Factor ◽  
Cardiovascular Diseases ◽  
Sudden Death

The paper reviews publications concerned the role of nonesterifi ed fatty acids (NEFA) in pathogenesis of cardiovascular diseases. NEFAs are four and more carbons chain length carbonic acids and they are presented in free form (nonesterifi ed) in human body. Plasma NEFAs are produced by the adipose tissue triglyceride lipolysis, another source are lipoproteins such as chylomicrons, very low density lipoproteins and intermediate density lipoproteins. Elevated NEFA concentrations in plasma are the risk factor of cardiovascular diseases and type 2 diabetes mellitus and the independent risk factor of hypertension and sudden death. NEFA plasma concentration is elevated in atherosclerosis, acute myocardial infarction, diabetes mellitus, obesity, hypertension, and often in metabolic syndrome. A probable cause of NEFAs accumulation in plasma may be overeating and low physical activity, which result in increase of adipose tissue mass, lipolysis intensifi cation and elevation of NEFAs concentration in plasma. The role of elevated plasma NEFA concentration in a number of conditions (abdominal obesity, atherogenic dyslipidemia, insulin resistance, type 2 diabetes mellitus, endothelial dysfunction, vascular infl ammation, atherosclerosis, hypertension, ischemic heart disease, rhythm disturbances, sudden death) and possible ways of their correction are discussed.

scholarly journals Cardiovascular diseases in diabetic patients

2010 ◽  
Vol 1 (1) ◽  
pp. 46-50
Author(s):  
I. Y Yarek-Martynova ◽  
M. V Shestakova
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Cardiovascular Diseases ◽  
Cerebrovascular Diseases ◽  
Diabetic Patients ◽  
Metabolic Disturbances ◽  
Lower Extremity Ischemia ◽  
Traditional Risk Factors ◽  
Extremity Ischemia

The review pays attention to a considerable rise in the incidence of diabetes mellitus (DM) and to its association with cardiovascular diseases (CVD) and events. It is noted that these events may be present much earlier than DM is diagnosed. The paper also discusses in detail a role of hyperglycemia, postprandial one in particular, hyperinsulinemia, insulin resistance, endothelial dysfunction, impaired blood rheological properties, lipid metabolic disturbances, and genetic and traditional risk factors in the development of atherosclerosis, coronary heart disease, chronic heart failure, cerebrovascular diseases, and lower extremity ischemia in DM.

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