scholarly journals A Traditional Korean Diet Alters the Expression of Circulating MicroRNAs Linked to Diabetes Mellitus in a Pilot Trial

Nutrients ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2558
Author(s):  
Phil-Kyung Shin ◽  
Myung Sunny Kim ◽  
Seon-Joo Park ◽  
Dae Young Kwon ◽  
Min Jung Kim ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Dietary Intervention ◽  
Control Diet ◽  
Pilot Trial ◽  
Diet Therapy ◽  
Diet Group ◽  
Alcoholic Fatty Liver ◽  
Circulating Micrornas ◽  
Coronary Syndrome ◽  
Metabolic Conditions

The traditional Korean diet (K-diet) is considered to be healthy and circulating microRNAs (miRs) have been proposed as useful markers or targets in diet therapy. We, therefore, investigated the metabolic influence of the K-diet by evaluating the expression of plasma and salivary miRs. Ten women aged 50 to 60 years were divided into either a K-diet or control diet (a Westernized Korean diet) group. Subjects were housed in a metabolic unit-like condition during the two-week dietary intervention. Blood and saliva samples were collected before and after the intervention, and changes in circulating miRs were screened by an miR array and validated by individual RT-qPCRs. In the K-diet group, eight plasma miRs were down-regulated by array (p < 0.05), out of which two miRs linked to diabetes mellitus, hsa-miR26a-5p and hsa-miR126-3p, were validated (p < 0.05). Among five down-regulated salivary miRs, hsa-miR-92-3p and hsa-miR-122a-5p were validated, which are associated with diabetes mellitus, acute coronary syndrome and non-alcoholic fatty liver disease. In the control diet group, validated were down-regulated plasma hsa-miR-25-3p and salivary hsa-miR-31-5p, which are associated with diabetes mellitus, adipogenesis and obesity. The K-diet may influence the metabolic conditions associated with diabetes mellitus, as evidenced by changes in circulating miRs, putative biomarkers for K-diet.

scholarly journals Circulating Extracellular MicroRNAs in Blood and Saliva Are a New Source of Biomarkers in the Assessment of Health Effects of Traditional Korean Diet (P15-003-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Sang-Woon Choi ◽  
Myung-Sunny Kim ◽  
Dae Young Kwon ◽  
Hae-Jeung Lee ◽  
Seon-Joo Park ◽  
...  
Keyword(s):  
Health Effects ◽  
Dietary Intervention ◽  
Metabolic Diseases ◽  
Statistical Significance ◽  
Diet Group ◽  
Control Group ◽  
Rt Pcr ◽  
Alcoholic Fatty Liver ◽  
Altered Expression ◽  
Increased Risk

Abstract Objectives Over the past decades current Korean diet has been rapidly modified to the Western style, which might be responsible for the increased risk of metabolic diseases in Korea, whereas the traditional Korean diet (K-diet) has been reported as metabolically and epigenetically healthy diet. MicroRNAs (miRs) are small, single-stranded, non-coding RNAs that affect posttranscriptional regulation and circulating miRs have been regarded as next generation biomarkers of many health conditions. We therefore determined whether extracellular miRs can be useful biomarkers to determine the health effects of K-diet. Methods Ten obese perimenopausal women were recruited and randomly divided into either K-diet group (n = 5) or control diet (a Westernized Korean diet) group (n = 5). Subjects were housed in a metabolic unit like condition for 2 weeks of dietary intervention. Blood and saliva samples were collected before and after the intervention and circulating miRs were extracted using Qiagen miRNeasy kit. After 84 circulating miRs were detected with miScript miRNA PCR Array, miRs with statistical significance were validated with individual RT-PCRs. Results In the K-diet group significantly down-regulated plasma miRs were hsa-miR126-3p, hsa-miR18a-5p, hsa-miR19b-3p, hsa-miR107, hsa-miR148a-3p, hsa-miR26b-5p, hsa-miR374a-5p and hsa-miR26a-5p, which are known to be associated with type 1 or 2 diabetes or non-alcoholic fatty liver disease. Among them hsa-miR126-3p (P = 0.0158) and hsa-miR26a-5p (P = 0.0348) were validated by RT-PCR. In the control group plasma hsa-miR25-3p was down-regulated and hsa-miR-148a-3p was up-regulated. Only hsa-miR-25-3p (P = 0.0407), which is known to be associated with cardiovascular disease, was validated. In the K diet group 5 saliva miRs, hsa-miR-92-3p , hsa-miR-17-3p, hsa-miR-25b-3p, hsa-miR-122a-5p and hsa-miR-193a-5p, were significantly down-regulated by the array, while only hsa-miR-92-3p (P = 0.0381) and hsa-miR-122a-5p (P = 0.0242) were validated by RT-PCR. In the control group 3 saliva miRs (hsa-miR-25-3p, hsa-miR-31-5p and hsa-miR-200a-3p) showed significantly altered expression by the array but not by RT-PCR. Conclusions Circulating miRs can be a new source of biomarkers to determine the health effects of K-diet. Funding Sources Korea Food Research Institute.

scholarly journals Can Ketogenic Diet Therapy Improve Migraine Frequency, Severity and Duration?

Healthcare ◽  
2021 ◽  
Vol 9 (9) ◽  
pp. 1105
Author(s):  
Rebecca L. Haslam ◽  
Aaron Bezzina ◽  
Jaimee Herbert ◽  
Neil Spratt ◽  
Megan E. Rollo ◽  
...  
Keyword(s):  
Side Effects ◽  
Ketogenic Diet ◽  
Dietary Intervention ◽  
Pilot Trial ◽  
Diet Therapy ◽  
Self Report ◽  
Migraine Frequency ◽  
Important Trend ◽  
History Of ◽  
Randomised Controlled

Migraine is the third most common condition worldwide and is responsible for a major clinical and economic burden. The current pilot trial investigated whether ketogenic diet therapy (KDT) is superior to an evidence-informed healthy “anti-headache” dietary pattern (AHD) in improving migraine frequency, severity and duration. A 12-week randomised controlled crossover trial consisting of the two dietary intervention periods was undertaken. Eligible participants were those with a history of migraines and who had regularly experienced episodes of moderate or mildly intense headache in the previous 4 weeks. Migraine frequency, duration and severity were assessed via self-report in the Migraine Buddy© app. Participants were asked to measure urinary ketones and side effects throughout the KDT. Twenty-six participants were enrolled, and 16 participants completed all sessions. Eleven participants completed a symptom checklist; all reported side-effects during KDT, with the most frequently reported side effect being fatigue (n = 11). All completers experienced migraine during AHD, with 14/16 experiencing migraine during KDT. Differences in migraine frequency, severity or duration between dietary intervention groups were not statistically significant. However, a clinically important trend toward lower migraine duration on KDT was noted. Further research in this area is warranted, with strategies to lower participant burden and promote adherence and retention.

scholarly journals Dietary Glycaemic Index and Type 2 Diabetes Mellitus: Potential Modulation of Gut Microbiota

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Hanusha Durganaudu ◽  
Thubasni Kunasegaran ◽  
Amutha Ramadas
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Gut Microbiota ◽  
Dietary Intervention ◽  
Current Knowledge ◽  
Diet Therapy ◽  
Glycaemic Index ◽  
Therapeutic Implications

Diet therapy is often the first-line approach in prevention and management of type 2 diabetes mellitus (T2DM). Adoption of low glycaemic index (GI) diet one of the recent dietary strategies to modulate glycaemic response in individuals with T2DM. Generally, diet has strong influence on the gut microbiota, which recently have been found to be associated with insulin resistance and the inflammatory response in diabetes. The possible modulation of the gut microbiota with dietary intervention is a topic of emerging interest, with limited evidence among T2DM population. In this review, we have narrated the available evidence and discussed the current knowledge about diet manipulation associated with dietary GI in order to shape the gut microbiota. As a conclusion, we have pointed out several key research directions that may have helpful impact on diet interventions with modulation of gut microbiota on the pathogenesis and therapeutic implications in T2DM.

scholarly journals A Traditional Korean Diet with a Low Dietary Inflammatory Index Increases Anti-Inflammatory IL-10 and Decreases Pro-Inflammatory NF-κB in a Small Dietary Intervention Study

Nutrients ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2468
Author(s):  
Phil-Kyung Shin ◽  
Seon-Joo Park ◽  
Myung Sunny Kim ◽  
Dae Young Kwon ◽  
Min Jung Kim ◽  
...  
Keyword(s):  
Dietary Intervention ◽  
Control Diet ◽  
Diet Group ◽  
Control Group ◽  
Low Grade ◽  
Dietary Inflammatory Index ◽  
Obese Women ◽  
Inflammatory Index ◽  
Animal Fat ◽  
Anti Inflammatory

Chronic low-grade inflammation may increase the risk of chronic disease, while diets rich in anti-inflammatory components may reduce it. To determine the anti-inflammatory properties of the traditional Korean diet (K-diet) that comprises high amounts of vegetables, fiber and phytochemicals, moderate amounts of legumes, and low amounts of animal fat, ten obese women aged 50–60 years were randomly assigned to the K-diet or control diet group. The control diet was a Westernized Korean diet commonly consumed in Korea, which is high in animal fat and protein. Subjects were housed in metabolic unit-like conditions during the 2-week intervention. Plasma was collected before and after the intervention to measure inflammatory cytokines using ELISA. The dietary inflammatory index (DII) was calculated based on nutrients and food intake. The DII score for the K-diet was lower than that of the control diet (−0.94 ± 1.39 vs. 1.04 ± 1.61, p < 0.001). In the K-diet group, anti-inflammatory interleukin (IL)-10 levels increased (4.45 ± 0.34 pg/mL vs. 5.94 ± 0.33 pg/mL, p = 0.0102), whereas pro-inflammatory nuclear factor kappa B (NF-κB) levels decreased (7.70 ± 0.62 pg/mL vs. 2.71 ± 0.49 pg/mL, p = 0.0015), but not in the control group. In the K-diet group, NF-κB levels negatively correlated with IL-10 levels (r = −0.794, p = 0.006). The K-diet has anti-inflammatory properties, and IL-10 and NF-κB are putative inflammatory markers for K-diet studies.

scholarly journals Effect of dietary approaches to stop hypertension diet plan on pregnancy outcome patients with gestational diabetes mellitus

2015 ◽  
Vol 10 (4) ◽  
pp. 732 ◽  
Author(s):  
Jie Yao ◽  
Lin Cong ◽  
Benli Zhu ◽  
Ting Wang
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnancy Outcomes ◽  
Control Diet ◽  
Diet Group ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
Dash Diet ◽  
Diet Plan

<p class="Abstract">The purpose of this study is to test the effects of Dietary Approaches to Stop Hypertension (DASH) diet plan on pregnancy outcomes patients with gestational diabetes mellitus. This randomized controlled clinical trial was performed among 33 women diagnosed with gestational diabetes. These patients were randomly distributed to the control group (n = 16) or DASH diet group (n = 17) for 4 weeks. Whereas 47.1% of women in the DASH diet needed to have a cesarean section, this percentage of mean gestational age in control diet was 81.3% (p&lt;0.01). Approximately 23.5% of women in the DASH diet and 75% of women in control diet needed to commence insulin therapy after intervention (p&lt;0.01). In conclusion, the effect of DASH diet improved pregnancy outcomes patients with gestational diabetes.</p><p> </p>

288: The Men's Eating and Living (Meal) Study: A Multi-Center Pilot Trial of Dietary Intervention for the Treatment of Prostate Cancer

2007 ◽  
Vol 177 (4S) ◽  
pp. 96-97
Author(s):  
J. Kellogg Parsons ◽  
Vicky Newman ◽  
James L. Mohler ◽  
John P. Pierce ◽  
Electra Paskett ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Dietary Intervention ◽  
Pilot Trial ◽  
Meal Study

Study on Vitamin D deficiency in patients of diabetes mellitus presenting with Acute Coronary syndrome in a tertiary care hospital in South India

2020 ◽  
Vol 11 (5) ◽  
pp. 49-53
Author(s):  
Archana Bhat ◽  
Arunachalam Ramachandran ◽  
Pradeep Periera ◽  
Akshatha Rao Aroor
Keyword(s):  
Diabetes Mellitus ◽  
Coronary Artery Disease ◽  
Vitamin D ◽  
Acute Coronary Syndrome ◽  
Coronary Artery ◽  
Vitamin D Deficiency ◽  
Coronary Syndrome ◽  
Vitamin D Levels ◽  
Luminal Stenosis ◽  
Artery Disease

Background: Vitamin D, a fat-soluble vitamin has its receptor present in myriad of tissues and it modulates multiple cellular processes. Vitamin D deficiency is reported to be associated with coronary artery disease. Cardiovascular disease is the leading cause of mortality worldwide. Aims and Objective: The primary outcome was to investigate if there is a correlation of 25-OH levels with the percentage of luminal stenosis, as measured with coronary angiogram. The secondary outcome was to determine the differences in angiographically proven luminal stenosis across categories of 25-OH vitamin D levels. Materials and Methods: Thirty patients with acute coronary syndrome with diabetes mellitus were included in this cross-sectional descriptive study. All patients were tested for fasting vitamin D levels, fasting blood sugar, HbA1C and serum creatinine. Detailed history of the patients was recorded. Data was analyzed by the statistical software SPSS version 19 and p value <0.05 was considered significant. Statistical tests like Chi- square, independent t test and log regression was used. Results: In this study 30 patients undergoing coronary angiography for acute coronary syndrome, Vitamin D levels showed severe deficiency in 6.7% (2) cases while mild deficiency was seen in 50% of the cases. Patients with single vessel disease on the coronary angiogram had lower mean HbA1C (9.18) levels in our study. Patients with triple vessel disease had poorly controlled mean HbA1C levels (10.42). Conclusion: In this study we did not find any significant difference between the serum Vitamin D deficiency levels with patients with angiographic severity of the coronary artery disease. Patients with poorly controlled diabetes mellitus had more severe angiographic proven coronary artery disease.

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