scholarly journals Assessment of Glycemic Response to Model Breakfasts Varying in Glycemic Index (GI) in 5–7-Year-Old School Children

Nutrients ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 4246
Author(s):  
Sandra I. Sünram-Lea ◽  
Gertrude Gentile-Rapinett ◽  
Katherine Macé ◽  
Andreas Rytz
Keyword(s):  
Energy Release ◽  
Cognitive Performance ◽  
School Children ◽  
Glycemic Index ◽  
Glucose Monitoring ◽  
Area Under The Curve ◽  
Healthy Children ◽  
Glycemic Response ◽  
Open Label ◽  
Skimmed Milk

Reduced Glycemic Index (GI) of breakfast has been linked to improved cognitive performance in both children and adult populations across the morning. However, few studies have profiled the post-prandial glycemic response (PPGR) in younger children. The aim of this study was to assess PPGR to breakfast interventions differing in GI in healthy children aged 5–7 years. Eleven subjects completed an open-label, randomized, cross-over trial, receiving three equicaloric test beverages (260 kcal) consisting of 125 mL semi-skimmed milk and 50 g sugar (either glucose, sucrose, or isomaltulose). On a fourth occasion, the sucrose beverage was delivered as intermittent supply. PPGR was measured over 180 min using Continuous Glucose Monitoring (CGM). The incremental area under the curve (3h-iAUC) was highest for the glucose beverage, followed by intermittent sucrose (−21%, p = 0.288), sucrose (−27%, p = 0.139), and isomaltulose (−48%, p = 0.018). The isomaltulose beverage induced the smallest Cmax (7.8 mmol/L vs. >9.2 mmol/L for others) and the longest duration with moderate glucose level, between baseline value and 7.8 mmol/L (150 vs. <115 min for others). These results confirm that substituting mid-high GI sugars (e.g., sucrose and glucose) with low GI sugars (e.g., isomaltulose) during breakfast are a viable strategy for sustained energy release and glycemic response during the morning even in younger children.

Glycemic and Insulinemic Response to Selected Snack Bars in Trained Versus Sedentary Individuals

2010 ◽  
Vol 20 (1) ◽  
pp. 27-33 ◽  
Author(s):  
Willeke Trompers ◽  
Tracy L Perry ◽  
Meredith C Rose ◽  
Nancy J. Rehrer
Keyword(s):  
Glycemic Index ◽  
Significant Interaction ◽  
Glucose Solution ◽  
Area Under The Curve ◽  
Glycemic Response ◽  
Reference Solution ◽  
Blood Samples ◽  
The Mean ◽  
Insulinemic Response ◽  
Training State

The purpose of this study was to determine whether glycemic index (GI) is influenced by training state. Participants were tested in a randomized order: twice with a reference solution containing 50 g glucose and once each with 2 commercially available snack bars (Griffin’s Fruitli bar and Peak Fuel’s Summit bar) containing 50 g available carbohydrate. Eleven of the participants (6 men and 5 women, M ± SD age 20.8 ± 2.0 yr) were endurance trained (ET; VO2max 57.5 ± 8.4 ml · kg−1 · min−1), and 9 participants (2 men and 7 women, M ± SD age 22.4 ± 1.8 yr) were sedentary (SE; VO2max 43.7 ± 9.1 ml · kg−1 · min−1). After an overnight fast, participants consumed either the glucose solution or snack bar, with blood samples taken before eating and at 15, 30, 45, 60, 90, and 120 min after eating began. The mean incremental area under the curve (IAUC) of the glucose reference was 31% lower (95% CI 3–52%, p = .03), and the Fruitli bar 38% lower (95% CI 0–61%, p = .05) in ET than in SE participants. There was a trend for the IAUC for the Summit bar to be 35% lower in ET than in SE participants (95% CI –7% to 61% p = .09). There was no significant interaction between training state and test food. The GIs of the Fruitli and Summit bars was not significantly different between ET and SE participants (p = .65 and .54, respectively). ET participants had a lower glycemic response than SE participants; however, training state did not influence GI.

Evaluating Thrombin Inhibition in Alzheimer’s Disease (The BEACON Trial): Protocol for a Pilot Study (Preprint)

2019 ◽  
Author(s):  
Cláudia Yang Santos ◽  
Christine Getter ◽  
John Stoukides ◽  
Brian Ott ◽  
Stephen Salloway ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Pilot Study ◽  
Cognitive Performance ◽  
Thrombin Inhibitor ◽  
Placebo Control ◽  
Open Label ◽  
Double Blind ◽  
Thrombin Inhibition ◽  
Approved Drugs

BACKGROUND The precise mechanisms whereby cardiovascular risk factors increase the risk of Alzheimer’s disease (AD) have not been delineated. We reported that microvessels isolated from AD brains overexpress a diverse array of neurotoxic and inflammatory proteins, which is consistent with the process of vascular activation. In pre-clinical studies using AD animal models we showed that a vascular activation inhibitor reduced vascular-derived neuroinflammation and improved cognitive performance. Thrombin is a key mediator of cerebrovascular activation in AD. OBJECTIVE This study aims to investigate the safety and potential efficacy of the direct thrombin inhibitor dabigatran, in patients with mild cognitive impairment (MCI) or mild AD to decrease vascular-derived neuroinflammation and improve cognitive performance. METHODS Participants will be enrolled then evaluated quarterly throughout the 24-month study. This is a 24-month randomized-control, double-blind, placebo-controlled, multicenter, delayed-start, pilot study evaluating thrombin inhibition in people with biomarker-confirmed MCI probably due to AD or mild AD. 40 - 60 participants will be recruited between 50 - 85 years old. In the initial 9-months of study, either dabigatran or placebo will be orally administered to patients at a dose of 150 mg per day. After 9 months of the placebo-control (Phase I), the placebo arm will cross-over to an active, open-label (Phase II) where all patients will be treated with a 150 mg daily dose of dabigatran orally for an additional 12 months. A 3-month non-treatment follow-up period will assess duration of effects. RESULTS Beginning in July 2019, and concluding in August 2022, this study is expected to publish final results in January 2023. CONCLUSIONS BEACON is a first-in-kind randomized clinical trial targeting thrombin activation in AD therapeutics. This trial will stimulate translational investigations of an FDA-approved drugs in a newly defined therapeutic areas. CLINICALTRIAL Clinicaltrials.gov NCT03752294

scholarly journals Nutritional status of school children living in Northern part of Sri Lanka

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
M. G. Sathiadas ◽  
Annieston Antonyraja ◽  
Arunath Viswalingam ◽  
Kasthuri Thangaraja ◽  
V. P. Wickramasinghe
Keyword(s):  
Sri Lanka ◽  
Nutritional Status ◽  
School Children ◽  
Household Income ◽  
Maternal Education ◽  
Overweight And Obesity ◽  
Growth Spurt ◽  
Healthy Children ◽  
Important Indicator ◽  
Height For Age

Abstract Background Nutritional status is an important indicator for measuring quality of life in children. A region that is recovering from war will face many problems related to nutrition. Very few studies have addressed the nutritional problems in school children. This study was undertaken to identify the prevalence of wasting, stunting and obesity among school children from Northern Sri Lanka and associated socio-demographic factors. Methods A community based cross-sectional study was carried out using multistage stratified proportionate cluster among healthy children attending schools in the Northern part of the country. Height and weight were measured, and Body Mass Index (BMI) calculated [weight (kg)/Height (m) 2]. BMI-for-age z-score (BAZ) and Height for age Z (HAZ) scores were determined and WHO growth references were used to categorise the nutritional status. Correlation between various nutritional problems with Maternal education, household income, number of family members and the residential area was assessed. Results A total of 1012 children were recruited, and the mean age and standard deviation were 11.12±1.77 yrs. Girls in the age ranges of 9–14 were heavier and taller when compared to the boys compatible with the pubertal growth spurt. Stunting based on the height for age was seen in 10.9% of boys and 11.8% of girls. Wasting based on BMI for age WHO standard (WHO 2007) was seen in 30.6% of boys and 29.1% of the girls. The prevalence of overweight was 11% and Obesity was 6.3% of the population. Obesity was predominantly seen in boys (4.2%) and it was significantly higher when compared to the girls (2.1%) (p < 0.001). Obesity in older boys (> 10 years) was significantly more than the younger ones (p < 0.01). Maternal education and family income had a significant impact on the prevalence of wasting, stunting and obesity whereas the family size contributed to the wasting and obesity (p< 0.001). Conclusion Findings suggest that stunting, wasting, overweight and obesity are prevalent among 6–16-year-old leading to concerns in public health. The nutritional status significantly varies according to the geographical location, maternal education and the household income.

Second-meal effect: low-glycemic-index foods eaten at dinner improve subsequent breakfast glycemic response

1988 ◽  
Vol 48 (4) ◽  
pp. 1041-1047 ◽  
Author(s):  
T M Wolever ◽  
D J Jenkins ◽  
A M Ocana ◽  
V A Rao ◽  
G R Collier
Keyword(s):  
Glycemic Index ◽  
Glycemic Response ◽  
Meal Effect ◽  
Low Glycemic Index

Relation of home chaos to cognitive performance and behavioral adjustment of Pakistani primary school children

2011 ◽  
Vol 35 (6) ◽  
pp. 507-516 ◽  
Author(s):  
Syeda Shamama-tus-Sabah ◽  
Nighat Gilani ◽  
Theodore D. Wachs
Keyword(s):  
Primary School ◽  
Cognitive Performance ◽  
School Children ◽  
Behavioral Problems ◽  
Behavioral Assessment ◽  
Developed Countries ◽  
Assessment System ◽  
Primary School Children ◽  
Raven's Standard Progressive Matrices ◽  
Home Chaos

Recent findings from Western developed countries have linked home chaos to children’s cognitive performance and behavioral problems. In the present paper we test whether the same pattern of associations can be replicated in a non-Western developing country. Our sample was 203 Pakistani primary school children. To assess home chaos the Confusion, Hubbub, and Order Scale (CHAOS) was translated into Urdu and administered to mothers. Children were assessed using the parent and teachers rating forms of the Behavioral Assessment System for Children and the Raven's Standard Progressive Matrices. Home chaos was not related to children’s cognitive performance. However, replicating previous findings from Western developed countries, greater home chaos uniquely predicted higher levels of internalizing and externalizing behavioral problems as well as lower levels of adaptive behavior in Pakistani children, as rated by both mothers and teachers.

scholarly journals Continuous glucose monitoring use and glucose variability in pre-school children with type 1 diabetes

2019 ◽  
Vol 147 ◽  
pp. 76-80 ◽  
Author(s):  
Klemen Dovc ◽  
Kevin Cargnelutti ◽  
Anze Sturm ◽  
Julij Selb ◽  
Natasa Bratina ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Continuous Glucose Monitoring ◽  
School Children ◽  
Glucose Monitoring ◽  
Glucose Variability

scholarly journals Nutrient content changes from steaming or soaking timothy-alfalfa hay: effects on feed preferences and acute glycemic response in Standardbred racehorses1

2019 ◽  
Vol 97 (10) ◽  
pp. 4199-4207
Author(s):  
Tiana G Owens ◽  
Madeline Barnes ◽  
Vanessa M Gargano ◽  
Louise Julien ◽  
Wilfredo D Mansilla ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Area Under The Curve ◽  
Nutrient Content ◽  
Dust Particles ◽  
Glycemic Response ◽  
Nutrient Losses ◽  
Time To Peak ◽  
Alfalfa Hay ◽  
Average Blood Glucose ◽  
Standardbred Racehorses

Abstract Soaking hay and steaming hay are strategies that are used to reduce respirable dust particles for horses but may result in variable nutrient losses, including nonstructural carbohydrates (NSC) and minerals. Since these losses have not been quantified in Canadian hay yet, the first aim of this study was to identify nutrient losses from first-cut timothy-alfalfa hay grown in southern Ontario, Canada, after soaking for 30 min or steaming for 60 min. It is uncertain whether horses prefer hay when it is dry, soaked, or steamed. To address this, 13 Standardbred racehorses were offered 2 of these hays side by side for 30 min on 6 consecutive occasions until all possible combinations had been offered. Quantity of hay eaten was determined and horses were video recorded during feedings to assess time spent eating and investigating hay. Additionally, consumption of feeds with differing NSC levels has been observed to influence glycemic response in horses; however, this has not been measured in horses consuming steamed hay before and the results from soaked hay studies have been inconclusive. As such, the final aim of this study was to examine acute glycemic response in horses after being fed dry, soaked, and steamed hays. Blood glucose was measured every 30 min from 9 Standardbred racehorses for 6 h following a meal of 0.5% of their body weight of treatment hay on a dry matter basis (DMB). Soaked, but not steamed, hay had lower concentrations of soluble protein, NSC, and potassium in contrast to the same dry hay (P < 0.05). Peak glucose, average blood glucose, total area under the curve, and time to peak did not differ among treatments (P > 0.05). We conclude that acute glycemic response of racehorses was not influenced by soaking or steaming hay. Horses also consumed less soaked hay (DMB) than dry or steamed hay (P < 0.05) and spent less time eating soaked hay than dry or steamed hay (P < 0.05).

Glycemic Index Versus Glycemic Response: Nonsynonymous terms

Diabetes Care ◽  
1992 ◽  
Vol 15 (10) ◽  
pp. 1436-1437 ◽  
Author(s):  
T. M. S. Wolever
Keyword(s):  
Glycemic Index ◽  
Glycemic Response
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