scholarly journals An Overview of the Pathogenesis, Transmission, Diagnosis, and Management of Endemic Human Coronaviruses: A Reflection on the Past and Present Episodes and Possible Future Outbreaks

Pathogens ◽  
2021 ◽  
Vol 10 (9) ◽  
pp. 1108
Author(s):  
Adeoye J. Kayode ◽  
Folasade O. Banji-Onisile ◽  
Ademola O. Olaniran ◽  
Anthony I. Okoh
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Management Strategies ◽  
Personal Hygiene ◽  
Species Barrier ◽  
The Past ◽  
Hygiene Practices ◽  
Human Coronaviruses ◽  
The 1960S ◽  
Reservoir Hosts ◽  
Independent Species

The outbreak of the 2019 coronavirus pandemic caught the world by surprise in late 2019 and has held it hostage for months with an increasing number of infections and deaths. Although coronavirus was first discovered in the 1960s and was known to cause respiratory infection in humans, no information was available about the epidemic pattern of the virus until the past two decades. This review addresses the pathogenesis, transmission dynamics, diagnosis, management strategies, the pattern of the past and present events, and the possibility of future outbreaks of the endemic human coronaviruses. Several studies have described bats as presumptive natural reservoirs of coronaviruses. In essence, the identification of a diverse group of similar SARS coronaviruses in bats suggests the possibility of a future epidemic due to severe acute respiratory syndrome (SARS-like) coronaviruses originating from different reservoir hosts. The study also identified a lack of vaccines to prevent human coronavirus infections in humans in the past, however, the recent breakthrough in vaccine discovery and approval for emergency use for the treatment of Severe Acute Respiratory Syndrome Coronavirus 2 is commendable. The high rates of genomic substitution and recombination due to errors in RNA replication and the potential for independent species crossing suggest the chances of an entirely new strain evolving. Therefore, rapid research efforts should be deployed for vaccination to combat the COVID-19 pandemic and prevent a possible future outbreak. More sensitization and enlightenment on the need to adopt good personal hygiene practices, social distancing, and scientific evaluation of existing medications with promising antiviral effects against SARS-CoV-2 is required. In addition, intensive investigations to unravel and validate the possible reservoirs, the intermediate host, as well as insight into the ability of the virus to break the species barrier are needed to prevent future viral spillover and possible outbreaks.

Maternal Knowledge and Practices towards Sanitation and Their Relationships with Occurrence of Diarrhoea in Children

2014 ◽  
Vol 3 (3) ◽  
pp. 206 ◽  
Author(s):  
Shriya Ankit Seksaria ◽  
Mini K Sheth
Keyword(s):  
Cross Sectional Study ◽  
Personal Hygiene ◽  
Food Hygiene ◽  
Maternal Knowledge ◽  
Cross Sectional ◽  
The Past ◽  
Hygiene Practices ◽  
Childhood Morbidity ◽  
The Mean ◽  
Structured Questionnaire

<p>Diarrhoea, a major contributor of childhood morbidity and mortality is mostly caused by poor hygiene and sanitation. Literature reveal that hygiene practices at household levels greatly affects the occurrence of diarrhoea among children. A cross sectional study was conducted to determine association between hygiene knowledge and practices of mothers with occurrence of diarrhoea in young children below 3 years in the tribal villages of Gujarat. Structured questionnaire was used to elicit information on personal hygiene (PH), food Hygiene (FH), and environmental Hygiene (EH) practices of 536 mothers with children between 6-36 months of age. Past one month diarrhoeal episodes were recorded using the recall method. The mean percent scores for FH, PH and EH practices were 77%, 88% and 80% respectively. Almost 35% children suffered from diarrhoea in the past one month of which 10 were admitted to the hospital. Diarrhoeal incidences were associated with FH and EH practices (p&lt;0.001) and not with PH practices. Improvement in the environmental and personal hygiene practices of the mothers can contribute largely in reducing the prevalence of diarrhoea among children in Chikhli taluka of Gujarat.</p>

scholarly journals Coronavirus Disease 2019 (COVID-19): Prevention and Disinfection

2020 ◽  
pp. 10-14
Author(s):  
Nabih Mohammad Lawand ◽  
Samaa Al Tabbah
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Personal Protective Equipment ◽  
Preventive Measures ◽  
Personal Hygiene ◽  
Protective Equipment ◽  
The Novel ◽  
Routine Application ◽  
Hygiene Practices ◽  
Cleaning And Disinfection ◽  
Successful Prevention

The successful prevention of spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection depends on the routine application of preventive measures taken to prevent this spread. Strategies for preventing transmission of the disease include practices such as social/physical distancing, self-quarantine and isolation when appropriate, maintaining overall good personal hygiene practices like of handwashing and protecting others from coughs and sneezes by wearing Personal Protective Equipment (PPE). Moreover, Transmission of coronavirus occurs through contaminated surfaces where it may remain viable for hours to days. It is recommended to clean visibly dirty surfaces followed by disinfection through applying surface-appropriate disinfectants. In this review, we summarized the recommendations on the prevention, cleaning, and disinfection of the novel beta-coronavirus, SARS-CoV-2, in order to help lower the chances of contracting Covid-19 and spreading it to someone else. Keywords: SARS-CoV-2; Coronavirus Disease; COVID-19, Disinfection

scholarly journals The human coronaviruses (HCoVs) and the molecular mechanisms of SARS-CoV-2 infection

2020 ◽  
Vol 99 (1) ◽  
pp. 93-106
Author(s):  
Luigi Santacroce ◽  
Ioannis A. Charitos ◽  
Domenico M. Carretta ◽  
Emanuele De Nitto ◽  
Roberto Lovero
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Respiratory Tract ◽  
Common Cold ◽  
Molecular Mechanisms ◽  
Middle Eastern ◽  
International Committee ◽  
Upper Respiratory Tract ◽  
Human Coronaviruses ◽  
The 1960S ◽  
Tract Infections

AbstractIn humans, coronaviruses can cause infections of the respiratory system, with damage of varying severity depending on the virus examined: ranging from mild-to-moderate upper respiratory tract diseases, such as the common cold, pneumonia, severe acute respiratory syndrome, kidney failure, and even death. Human coronaviruses known to date, common throughout the world, are seven. The most common—and least harmful—ones were discovered in the 1960s and cause a common cold. Others, more dangerous, identified in the early 2000s and cause more severe respiratory tract infections. Among these the SARS-CoV, isolated in 2003 and responsible for the severe acute respiratory syndrome (the so-called SARS), which appeared in China in November 2002, the coronavirus 2012 (2012-nCoV) cause of the Middle Eastern respiratory syndrome (MERS) from coronavirus, which exploded in June 2012 in Saudi Arabia, and actually SARS-CoV-2. On December 31, 2019, a new coronavirus strain was reported in Wuhan, China, identified as a new coronavirus beta strain ß-CoV from group 2B, with a genetic similarity of approximately 70% to SARS-CoV, the virus responsible of SARS. In the first half of February, the International Committee on Taxonomy of Viruses (ICTV), in charge of the designation and naming of the viruses (i.e., species, genus, family, etc.), thus definitively named the new coronavirus as SARS-CoV-2. This article highlights the main knowledge we have about the biomolecular and pathophysiologic mechanisms of SARS-CoV-2.

scholarly journals Maternal Knowledge and Practices towards Sanitation and Their Relationships with Occurrence of Diarrhoea in Children

2014 ◽  
Vol 3 (3) ◽  
pp. 206
Author(s):  
Shriya Ankit Seksaria ◽  
Mini K Sheth
Keyword(s):  
Cross Sectional Study ◽  
Personal Hygiene ◽  
Food Hygiene ◽  
Maternal Knowledge ◽  
Cross Sectional ◽  
The Past ◽  
Hygiene Practices ◽  
Childhood Morbidity ◽  
The Mean ◽  
Structured Questionnaire

<p>Diarrhoea, a major contributor of childhood morbidity and mortality is mostly caused by poor hygiene and sanitation. Literature reveal that hygiene practices at household levels greatly affects the occurrence of diarrhoea among children. A cross sectional study was conducted to determine association between hygiene knowledge and practices of mothers with occurrence of diarrhoea in young children below 3 years in the tribal villages of Gujarat. Structured questionnaire was used to elicit information on personal hygiene (PH), food Hygiene (FH), and environmental Hygiene (EH) practices of 536 mothers with children between 6-36 months of age. Past one month diarrhoeal episodes were recorded using the recall method. The mean percent scores for FH, PH and EH practices were 77%, 88% and 80% respectively. Almost 35% children suffered from diarrhoea in the past one month of which 10 were admitted to the hospital. Diarrhoeal incidences were associated with FH and EH practices (p&lt;0.001) and not with PH practices. Improvement in the environmental and personal hygiene practices of the mothers can contribute largely in reducing the prevalence of diarrhoea among children in Chikhli taluka of Gujarat.</p>

scholarly journals The Human Coronaviruses (HCoVs) and the Molecular Mechanisms of SARS-CoV-2 Infection

2020 ◽  
Author(s):  
Luigi Santacroce ◽  
Ioannis A. Charitos ◽  
Domenico M. Carretta ◽  
Emanuele De Nitto ◽  
Roberto Lovero
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Respiratory Tract ◽  
Common Cold ◽  
Molecular Mechanisms ◽  
Middle Eastern ◽  
International Committee ◽  
Upper Respiratory Tract ◽  
Human Coronaviruses ◽  
The 1960S ◽  
Tract Infections

In humans, coronaviruses can cause infections of the respiratory system, with damage of varying severity depending on the virus examined: ranging from mild or moderate upper respiratory tract diseases, such as the common cold, to pneumonia, severe acute respiratory syndrome, kidney failure and even death. Human coronaviruses known to date, common throughout the world, are seven. The most common - and least harmful - ones were discovered in the 1960s and cause a common cold. Others, more dangerous, were identified in the early 2000s and cause more severe respiratory tract infections. Among these the SARS-CoV, isolated in 2003 and responsible for the Severe Acute Respiratory Syndrome (the so-called SARS), which appeared in China in November 2002, the Coronavirus 2012 (2012-nCoV) cause of the Middle Eastern Respiratory Syndrome from Coronavirus (MERS), which exploded in June 2012 in Saudi Arabia, and actually SARS-CoV-2. On December 31, 2019, a new Coronavirus strain was reported in Wuhan, China, identified as a new Coronavirus beta strain &szlig;-CoV from Group 2B, with a genetic similarity of approximately 70% to SARS-CoV, the virus responsible. of SARS. In the first half of February, the International Committee on Taxonomy of Viruses (ICTV), in charge of the designation and naming of the viruses (i.e., species, genus, family, etc.), thus definitively named the new coronavirus as SARS-CoV-2. This article highlights the main knowledge we have about the biomolecular and pathophysiologic mechanisms of SARS-CoV-2.

Problems of Analysis of Design and Research Methods of Interaction with the Urban Environment

2020 ◽  
pp. 99-110
Author(s):  
П. В. Капустин ◽  
А. И. Гаврилов
Keyword(s):  
Urban Planning ◽  
Urban Environment ◽  
Urban Studies ◽  
Environmental Movement ◽  
The Past ◽  
Types Of Knowledge ◽  
Historical Dynamics ◽  
The 1960S ◽  
The City ◽  
Research And Design

Состояние проблемы. Проблематика городской среды заявила о себе в 1960-е годы как протест против модернистских методов урбанизма и других видов проектирования. Средовое движение не случайно тогда именовали «антипрофессиональным» - оно было направлено против устоявшихся и недейственных методов работы с городом - от исследования до управления. За прошедшие десятилетия в рамках самого средового движения и его идейных наследников наработано немало методов и приемов работы, однако они до сих не подвергались анализу как пребывающая в исторической динамике целостная совокупность инструментария, альтернативного традиционному градостроительству. Результаты. Рассмотрены особенности и проблемы анализа методологического «арсенала» средового движения и урбанистики. Методы работы с городской средой впервые структурированы по типам знания. Показана близость методов исследовательского и проектного подходов в отношении городской среды. Выводы. В ближайшее время можно ожидать появления новых синтетических знаний и частных методологий, связанных как с обострением средовой проблематики, с расширением круга средовых акторов, так и с процессом профессионализации урбанистики. Statement of the problem. The urban environment paradigm emerged in the 1960s as a protest against the modernist methods of urbanism and other types of design. It was no coincidence that the environmental movement was back then called "anti-professional" as it was directed against the established and ineffective methods of working with the city, i. e., from research to management. Over the past decades, within the framework of the environmental movement and its ideological heirs, a lot of methods and have been developed. However, they have not yet been analyzed as an integral set of tools in the historical dynamics which is an alternative to traditional urban planning. Results. The features and problems of the analysis of the methodological “arsenal” of environmental movement and urban studies are considered. The methods of working with the urban environment are first structured according to the types of knowledge. The proximity of research and design approaches in the case when the urban environment is dealt with is shown. Conclusions. In the nearest future, we can expect new synthetic knowledge and particular methodologies related to both the exacerbation of environmental problems to emerge as well as the expansion of the circle of environmental actors and the process of professionalization of urbanstics.

scholarly journals A new diatom training set for the reconstruction of past water pH in the Tatra Mountain lakes

2021 ◽  
Author(s):  
Elwira Sienkiewicz ◽  
Michał Gąsiorowski ◽  
Ladislav Hamerlík ◽  
Peter Bitušík ◽  
Joanna Stańczak
Keyword(s):  
Surface Sediments ◽  
Tatra Mountains ◽  
Training Set ◽  
Statistical Parameters ◽  
The Past ◽  
Water Ph ◽  
Inferred Ph ◽  
The 1960S ◽  
The Tatra Mountains ◽  
The Relationship

AbstractLakes located in the Polish and Slovak parts of the Tatra Mountains were included in the Tatra diatom database (POL_SLOV training set). The relationship between the diatoms and the water chemistry in the surface sediments of 33 lakes was the basis for the statistical and numerical techniques for quantitative pH reconstruction. The reconstruction of the past water pH was performed using the alpine (AL:PE) and POL_SLOV training sets to compare the reliability of the databases for the Tatra lakes. The results showed that the POL_SLOV training set had better statistical parameters (R2 higher by 0.16, RMSE and max. bias lower by 0.2 and 0.36, respectively) compared to the AL:PE training set. The better performance of the POL_SLOV training set is particularly visible in the case of Przedni Staw Polski where the curve of the inferred water pH shows an opposite trend for the period from the 1960s to 1990 compared to that based on the AL:PE dataset. The reliability of the inferred pH was confirmed by the comparison with current instrumental measurements.

scholarly journals Trauma-Induced Coagulopathy: Overview of an Emerging Medical Problem from Pathophysiology to Outcomes

Medicines ◽  
2021 ◽  
Vol 8 (4) ◽  
pp. 16
Author(s):  
Gabriele Savioli ◽  
Iride Francesca Ceresa ◽  
Luca Caneva ◽  
Sebastiano Gerosa ◽  
Giovanni Ricevuti
Keyword(s):  
Major Trauma ◽  
Management Strategies ◽  
Medical Problem ◽  
Current Evidence ◽  
Potential Drug ◽  
The Past ◽  
Trauma Induced Coagulopathy ◽  
Threatening Condition ◽  
Life Threatening ◽  
Trauma Mortality

Coagulopathy induced by major trauma is common, affecting approximately one-third of patients after trauma. It develops independently of iatrogenic, hypothermic, and dilutive causes (such as iatrogenic cause in case of fluid administration), which instead have a pejorative aspect on coagulopathy. Notwithstanding the continuous research conducted over the past decade on Trauma-Induced Coagulopathy (TIC), it remains a life-threatening condition with a significant impact on trauma mortality. We reviewed the current evidence regarding TIC diagnosis and pathophysiological mechanisms and summarized the different iterations of optimal TIC management strategies among which product resuscitation, potential drug administrations, and hemostatis-focused approaches. We have identified areas of ongoing investigation and controversy in TIC management.

scholarly journals Anti-phospholipid syndrome and COVID-19 thrombosis: connecting the dots

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Moon Ley Tung ◽  
Bryce Tan ◽  
Robin Cherian ◽  
Bharatendu Chandra
Keyword(s):  
Endothelial Dysfunction ◽  
Severe Acute Respiratory Syndrome ◽  
Potential Role ◽  
Molecular Mimicry ◽  
Thromboembolic Events ◽  
The Past ◽  
High Prevalence ◽  
Connecting The Dots ◽  
Anti Phospholipid Syndrome

Abstract As the coronavirus disease 2019 (COVID-19) pandemic, which is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is spreading rapidly worldwide, it has emerged as a leading cause of mortality, resulting in &gt;1 million deaths over the past 10 months. The pathophysiology of COVID-19 remains unclear, posing a great challenge to the medical management of patients. Recent studies have reported an unusually high prevalence of thromboembolic events in COVID-19 patients, although the mechanism remains elusive. Several studies have reported the presence of aPLs in COVID-19 patients. We have noticed similarities between COVID-19 and APS, which is an autoimmune prothrombotic disease that is often associated with an infective aetiology. Molecular mimicry and endothelial dysfunction could plausibly explain the mechanism of thrombogenesis in acquired APS. In this review, we discuss the clinicopathological similarities between COVID-19 and APS, and the potential role of therapeutic targets based on the anti-phospholipid model for COVID-19 disease.

Preventive aspect of ayurveda and yoga towards newly emerging disease COVID-19

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Ranjeet S. Sawant ◽  
Bharat D. Zinjurke ◽  
Sandeep V. Binorkar
Keyword(s):  
Public Health ◽  
Severe Acute Respiratory Syndrome ◽  
Medical Care ◽  
Supportive Therapy ◽  
Prophylactic Therapy ◽  
Current Line ◽  
Therapeutic Aspect ◽  
The Past

Abstract The ongoing coronavirus pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS CoV 2) and unique in various facets. The earlier experience from the past severe acute respiratory syndrome (SARS) epidemics seem to be insufficient and there is need for better strategies in public health and medical care. Ayurved & Yog are well known for their preventive and therapeutic aspect, but not getting utilized properly for prevention of Covid 19 crisis which may also be helpful as supportive therapy along with current line of management. This paper is aimed at unrevealing the role of Ayurved and Yoga guidelines established by Department of AYUSH for prevention from SARS-CoV-2 by providing help to improving the quality of supportive/prophylactic therapy in relation with their immunity.

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