scholarly journals Rapamycin: Drug Repurposing in SARS-CoV-2 Infection

2021 ◽  
Vol 14 (3) ◽  
pp. 217
Author(s):  
Jiri Patocka ◽  
Kamil Kuca ◽  
Patrik Oleksak ◽  
Eugenie Nepovimova ◽  
Martin Valis ◽  
...  
Keyword(s):  
Literature Review ◽  
Human Health ◽  
World Economy ◽  
Web Of Science ◽  
Drug Repurposing ◽  
Final Analysis ◽  
High Rate ◽  
Suitable Candidate ◽  
Promising Strategy ◽  
The World

Since December 2019, SARS-CoV-2 (COVID-19) has been a worldwide pandemic with enormous consequences for human health and the world economy. Remdesivir is the only drug in the world that has been approved for the treating of COVID-19. This drug, as well as vaccination, still has uncertain effectiveness. Drug repurposing could be a promising strategy how to find an appropriate molecule: rapamycin could be one of them. The authors performed a systematic literature review of available studies on the research describing rapamycin in association with COVID-19 infection. Only peer-reviewed English-written articles from the world’s acknowledged databases Web of Science, PubMed, Springer and Scopus were involved. Five articles were eventually included in the final analysis. The findings indicate that rapamycin seems to be a suitable candidate for drug repurposing. In addition, it may represent a better candidate for COVID-19 therapy than commonly tested antivirals. It is also likely that its efficiency will not be reduced by the high rate of viral RNA mutation.

scholarly journals The competitiveness of Czech agrarian trade within the context of the global crisis

2013 ◽  
Vol 59 (No. 4) ◽  
pp. 183-193 ◽  
Author(s):  
L. Smutka ◽  
J. Burianová
Keyword(s):  
Czech Republic ◽  
World Trade ◽  
World Economy ◽  
Agricultural Trade ◽  
High Rate ◽  
The Czech Republic ◽  
The World ◽  
Territorial Structure ◽  
Merchandise Trade ◽  
Very High

World trade underwent a significant shock within the recent years, which caused a decline in the world economy primarily in the year 2009. Within the following years (2010 and 2011), the high rate of growth from the years preceding the crisis could not be restored. The crisis had an impact on all segments of the merchandise trade, whereby the trade in agricultural and food products was affected the least by the crisis. In the case of the Czech Republic, the crisis of the global and national economy was reflected in the case of agricultural trade primarily by the way of a decline in the rate of the growth of export, which was very high in the period prior to the crisis. As far as the territorial structure and commodity structure of agricultural trade is concerned, their development in the years 2008–2011 was not affected in any largely significant manner. In relation to the main objective of this article, which was to identify the effects of the crisis on the competitiveness of Czech agricultural trade, it may be stated that the crisis itself did not worsen the competitiveness of agricultural trade in any significant manner.  

scholarly journals The role of social media in e-Government: systematic literature review and case of Jordan

2020 ◽  
Vol 338 ◽  
pp. 363-379
Author(s):  
Nemer Aburumman ◽  
Róbert Szilágyi
Keyword(s):  
Social Media ◽  
Literature Review ◽  
Systematic Literature Review ◽  
Web Of Science ◽  
The World ◽  
Social Media Platforms ◽  
Main Determinants ◽  
Governmental Institutions ◽  
Use Of Social Media

Social media has become a new revolution in communications and most governments around the world use these platforms as two-way communication between them and the citizens. The Jordanian government started using these platforms early, so this paper came to examine the Jordanian's practice on these platforms. The paper use two way of analysis, the first one was a systematic literature review in the largest two databases (Scopus and Web of Science). After the literature has been analysed and the paper found the best practices for governments around the world, three main determinants were identified for any government to start the use of social media (presence, up to date information and interaction). The most popular Jordanian's social platforms (Facebook, Twitter, and YouTube) have been selected to start the analyses and 52 Jordanian governmental institutions (all the 25 ministries and 27 institutions belong to the prime ministry) have been analysed. After the institutions' websites and their pages or accounts on social media platforms scanned and analysed, most of the institutions have fulfilled the first two criteria (presence) and 77% shows that they have appearances on social media and (up to date information) 67% of the institutions regularly updated their information. But for the last criteria (interaction) we have found that the institutions still need to improve their interactions with the citizens since the results showed only 38% of these institutions have interaction on their pages or accounts on social media.

scholarly journals Coronavirus: A Scientometric Study with Special Reference to Web of Science

2020 ◽  
Vol 8 (1) ◽  
pp. 213-217
Author(s):  
L Radha
Keyword(s):  
Special Reference ◽  
World Economy ◽  
Web Of Science ◽  
Research Output ◽  
Scientific Publication ◽  
Research Publication ◽  
The World ◽  
The Common ◽  
Scientometric Study ◽  
The Web

Scientometrics study is one of the most efficient methods of quantitative evaluation of the scientific publication. Coronaviruses are one of the common viruses affect the human and animals some time. There is 7 type of corona already in existence, but the recent Coronavirus called novel corona (Covid19) which spreads among human rapidly. This study is to know the recent research publication of Coronavirus from the web of science, especially after December 2019, where the real spreads started and impact the world economy due to lock down. The data for this study is retrieved from the web of science for the year of 2018, 2019, and 2020 (till March). This study is an attempt to know the publication pattern, year-wise growth of publications, country-wise research output, and top-cited paper. Also, this paper is focusing on the research output of China and Wuhan University in the publications and the Wuhan University’s participation in this research publication during the period.

scholarly journals A Review of Potential Antiviral Drugs and Vaccines to Treat COVID-19

2020 ◽  
Vol 14 (suppl 1) ◽  
pp. 765-774
Author(s):  
Sanjeet Singh ◽  
Jayaram R.
Keyword(s):  
Health Care Workers ◽  
Social Life ◽  
Patient Monitoring ◽  
Web Of Science ◽  
Drug Repurposing ◽  
Patient Handling ◽  
Care Workers ◽  
The World ◽  
Muscle Ache

Coronavirus disease 19 (COVID-19) is a challenge to the whole humanity. COVID-19 was first reported in China and rigorous researches are going on for developing vaccine for the pandemic. This review was prepared by following PRISMA guidelines and used the resources from the Web of Science and PubMed. This research focuses on the niches of symptoms and vaccines for COVID-19. The research for vaccine involves research for new vaccine and drug repurposing. Out of various drug repurposing options, Remdesivir, and Favipiravir, Chloroquine and Lopinavir/Ritonavir were found to be the popular ones for treating COVID-19 patients across the world. Even though there are concerns regarding asymptotic patients, the most dominant symptoms of COVID-19 are fever and cough, followed by Dyspnoea and muscle ache. This review concludes that the COVID-19 related research should focus on developing immunity vaccines, and repurposing of drugs. Research on the problems of quarantine life, patient monitoring, and usage of information technology in facing COVID-19 will improve the quality of patient handling during the pandemic. The research on the effectiveness of various models of lockdown and regulation of social life during lockdown periods, improving the safety of health care workers in the workplace will definitely help the governments in their fight against COVID-19.

scholarly journals Social support for the elderly with HIV/Aids: an integrative review

2019 ◽  
Vol 22 (2) ◽  
Author(s):  
Marcelo Caetano de Azevedo Tavares ◽  
Márcia Carréra Campos Leal ◽  
Ana Paula de Oliveira Marques ◽  
Rogério Dubosselard Zimmermann
Keyword(s):  
Quality Of Life ◽  
Social Support ◽  
Literature Review ◽  
Chronic Condition ◽  
Web Of Science ◽  
Final Analysis ◽  
The Elderly ◽  
Elderly Persons ◽  
Hiv Aids

Abstract Objective: The present integrative literature review aimed to verify the scientific knowledge produced about social support for elderly persons with HIV/Aids. Method: A search was carried out in the Lilacs, Medline, Scopus and Web of Science databases for studies published in the last ten years. The final analysis consisted of seven articles. Results: It was found that social support is extremely important in the life of the elderly with HIV/Aids, and a real need for this support was identified. Such support can both contribute to quality of life in many ways, as well as impair the care of those who live with the disease, as the diagnosis, treatment and the entire stigma surrounding this chronic condition directly influence the type and quality of support provided. Conclusion: It is hoped that the results of this review will contribute to are flection on health practices for the elderly with HIV/Aids.

Repurposing Glyburide as Antileishmanial Agent to Fight Against Leishmaniasis

2019 ◽  
Vol 26 (5) ◽  
pp. 371-376 ◽  
Author(s):  
Abdur Rub ◽  
Kamal Shaker ◽  
Mohammad Kashif ◽  
Mohd Arish ◽  
Abdul Aziz Bin Dukhyil ◽  
...  
Keyword(s):  
Leishmania Donovani ◽  
Culture Media ◽  
Drug Repurposing ◽  
Parasite Growth ◽  
High Rate ◽  
Mammalian Host ◽  
Dependent Manner ◽  
The World

Background: Leishmaniasis is caused by a protozoan parasite, Leishmania. It is common in more than 98 countries throughout the world. Due to insufficient availability of antileishmanial chemotherapeutics, it is an urgent need to search for new molecules which have better efficacy, low toxicity and are available at low cost. Objectives: There is a high rate of diabetic cases throughout the world that is why we planned to test the antileishmanial activity of glyburide, an effective sugar lowering drug used for the treatment of diabetes. In this study, glyburide showed a significant decrease in the parasite growth and survival in vitro in a dose-dependent manner. Methods: Anti-leishmanial activity of glyburide was checked by culturing Leishmania donovani promastigotes in the presence of glyburide in a dose and time dependent manner. Docking study against Leishmania donovani-Trypanothione synthetase (LdTrySyn) protein was performed using Autodock Vina tool. Results: Growth reversibility assay shows that growth of treated parasite was not reversed when transferred to fresh culture media after 7 days. Moreover, docking studies show efficient interactions of glyburide with key residues in the catalytic site of Leishmania donovani- Trypanothione synthetase (LdTrySyn), a very important leishmanial enzyme involved in parasite’s survival by detoxification of Nitric Oxide (NO) species, generated by the mammalian host as a defense molecule. Thus this study proves that the drug-repurposing is a beneficial strategy for identification of new and potent antileishmanial molecules. Conclusion: The results suggest that glyburide binds to LdTrySyn and inhibits its activity which further leads to the altered parasite morphology and inhibition of parasite growth. Glyburide may also be used in combination with other anti-leishmanial drugs to potentiate the response of the chemotherapy. Overall this study provides information about combination therapy as well as a single drug treatment for the infected patients suffering from diabetes. This study also provides raw information for further in vivo disease model studies to confirm the hypothesis.

scholarly journals Relation Between Physical Activities and Built Environment: A Literature Review

2014 ◽  
Vol 7 ◽  
pp. 91-98
Author(s):  
Md Masud Parves Rana ◽  
Xiaolu Zhou
Keyword(s):  
Physical Activity ◽  
Literature Review ◽  
Built Environment ◽  
Physical Inactivity ◽  
Physical Activities ◽  
Neighborhood Environment ◽  
High Rate ◽  
Observational Measures ◽  
Perceived Environment ◽  
The World

Physical inactivity has been a leading factor of chronic diseases and high rate of mortality in the world. Despite the fact, only a small portion of people are able to meet up the recommended physical activities. However, there are handful studies suggest that built environment may provide stimulus or barriers to people’s participation in physical activities. Drawing upon this context, this paper aims to review articles regarding ‘built environment and physical activity’ focusing on characteristics of built environment which are particularly helpful in improving neighborhood environment, and to catch the attention to physical activities, such as walking, and cycling. It also critically reviews the measures of built environment, and finds three measures viz. (i) perceived environment measures, (ii) observational measures, and (iii) GIS-based measures. The article argues that integrated measures of built environment might be helpful to reduce limitations of individual measures and to understand the reasons of less participation in physical activities. It also suggests some practical interventions for improvement of built environment which is essentially inevitable to persuade physical activities. DOI: http://dx.doi.org/10.3329/jles.v7i0.20127 J. Life Earth Sci., Vol. 7: 91-98, 2012

scholarly journals The Many Faces of Grief: A Systematic Literature Review of Grief During the COVID-19 Pandemic

2021 ◽  
pp. 105413732110380
Author(s):  
Ritesh M. Kumar
Keyword(s):  
Literature Review ◽  
Systematic Literature Review ◽  
Web Of Science ◽  
Qualitative Synthesis ◽  
Prolonged Grief ◽  
Extant Literature ◽  
Grief Process ◽  
The World ◽  
The Many ◽  
Ecological Grief

Coronavirus disease 2019 (COVID-19) pandemic has halted life all around the world. The disease, along with quarantine, social distancing, unemployment, and displacement, has led to myriad losses. There is a rising concern for the epidemic of grief that can result from these multiple losses. The present study aimed to investigate how grief is understood and discussed in the extant literature during the COVID pandemic. A systematic literature review was conducted using PsycArticles, Web of Science, and Scopus databases. The qualitative synthesis of 33 articles indicates that grief can be manifested at various levels such as grief for self, relational grief, collective grief, and ecological grief. Another theme emphasizes some of the factors that could intensify the grief process leading to prolonged grief disorder. A third theme relates to the focus of grief processes as experienced by individuals in different developmental periods from childhood to senescence. The study contributes theoretically by expanding our perception and understanding of varied forms of grief.

Scientometric and patent researchof technological directions in the field of protection and restoration of land ecosystems using “Web of science” and “Derwent innovation” platforms

2021 ◽  
pp. 62-72
Author(s):  
N. V. Berezniak ◽  
N. I. Shabranska
Keyword(s):  
Web Of Science ◽  
Terrestrial Ecosystems ◽  
Publication Activity ◽  
High Rate ◽  
Scientometric Analysis ◽  
Patent Activity ◽  
Patent Classification ◽  
The World ◽  
International Data ◽  
Number Of Citations

The results of scientometric and patent research aime date stablishing the most promising technological trends for making forecasts for 2021–2030 are described. The study is focused on the achievement of Ukraine’s Sustainable Development Goal 15 “Protection and restoration of terrestrial ecosystems”. There search was conducted using the international platforms “Web of Science” (WoS) and “Derwent Innovation”. The period under study is 2011–2019. The results of a scientometric analysis of world and domestic publication activity, as well as the dynamics of citations for a selected array of publications are presented. The publication activity of the countries of the world and Ukraine, as well as of world and domestic companies, institutions, higher educational institutions, carrying out scientific and technical activities, has been established. The analysis of the dynamics of citations and determination of the growth rate of the number of citations (2019/2015, %) by key words / technological areas, which belong to the global technological trends in the field of protection and restoration of terrestrial ecosystems, were carried out. The top-10 technological are as that are the most promising for predictive research have been identified. The results of the analysis of the dynamics and rates of patenting in the world and in Ukraine in this area are presented. The analysis was carried out on the basis of the codes of the International Patent Classification using the international data base “Derwent Innovation”. The patent activity of the main countries of the world and Ukraine, as well as leading world and domestic patent holders, has been established. The patent research was carried out on keywords / technology areas that relate to global technology trends in the named area. The analysis of the dynamics and rates of patenting (2019/2015, %) was carried out. A selection of technological areas with a high rate of patent activity and placement of landscape maps on blue and green zones was carried out. To conduct predictive studies, the most promising, promising and mid-promising technological directions in the field of protection and restoration of terrestrial ecosystems have been identified.

scholarly journals The Two Weapons against Bacterial Biofilms: Detection and Treatment

Antibiotics ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 1482
Author(s):  
Adriana Cruz ◽  
Manuel Condinho ◽  
Beatriz Carvalho ◽  
Cecília M. Arraiano ◽  
Vânia Pobre ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Human Health ◽  
Human Body ◽  
Biofilm Formation ◽  
World Economy ◽  
Antimicrobial Agents ◽  
Bacterial Biofilms ◽  
The World ◽  
Microbial Infections ◽  
Biofilm Infection

Bacterial biofilms are defined as complex aggregates of bacteria that grow attached to surfaces or are associated with interfaces. Bacteria within biofilms are embedded in a self-produced extracellular matrix made of polysaccharides, nucleic acids, and proteins. It is recognized that bacterial biofilms are responsible for the majority of microbial infections that occur in the human body, and that biofilm-related infections are extremely difficult to treat. This is related with the fact that microbial cells in biofilms exhibit increased resistance levels to antibiotics in comparison with planktonic (free-floating) cells. In the last years, the introduction into the market of novel compounds that can overcome the resistance to antimicrobial agents associated with biofilm infection has slowed down. If this situation is not altered, millions of lives are at risk, and this will also strongly affect the world economy. As such, research into the identification and eradication of biofilms is important for the future of human health. In this sense, this article provides an overview of techniques developed to detect and imaging biofilms as well as recent strategies that can be applied to treat biofilms during the several biofilm formation steps.

Sign in / Sign up

Export Citation Format

Share Document