scholarly journals From Far West to East: Joining the Molecular Architecture of Imidazole-like Ligands in HO-1 Complexes

2021 ◽  
Vol 14 (12) ◽  
pp. 1289
Author(s):  
Giuseppe Floresta ◽  
Antonino Nicolò Fallica ◽  
Vincenzo Patamia ◽  
Valeria Sorrenti ◽  
Khaled Greish ◽  
...  
Keyword(s):  
Biological Activity ◽  
Clinical Outcomes ◽  
Molecular Architecture ◽  
Synthetic Pathway ◽  
Classical Structure ◽  
Starting Point ◽  
Further Development

HO-1 overexpression has been reported in several cases/types of human malignancies. Unfortunately, poor clinical outcomes are reported in most of these cases, and the inhibition of HO-1 is considered a valuable and proven anticancer approach. To identify novel hit compounds suitable as HO-1 inhibitors, we report here a fragment-based approach where ligand joining experiments were used. The two most important parts of the classical structure of the HO-1 inhibitors were used as a starting point, and 1000 novel compounds were generated and then virtually evaluated by structure and ligand-based approaches. The joining experiments led us to a novel series of indole-based compounds. A synthetic pathway for eight selected molecules was designed, and the compounds were synthesized. The biological activity revealed that some molecules reach the micromolar activity, whereas molecule 4d inhibits the HO-1 with an IC50 of 1.03 μM. This study suggested that our joining approach was successful, and a novel hit compound was generated. These results are ongoing for further development.

scholarly journals A NEW CONCEPTUAL MODEL FOR THE DEVELOPMENT OF PROCESS TECHNOLOGY IN PROCESS INDUSTRY: A POINT OF DEPARTURE FOR THE TRANSFORMATION OF THE "PROCESS DEVELOPMENT PROCESS" INTO A FORMAL WORK PROCESS?

2000 ◽  
Vol 04 (03) ◽  
pp. 319-346 ◽  
Author(s):  
THOMAS LAGER
Keyword(s):  
Conceptual Model ◽  
Development Process ◽  
Process Development ◽  
Process Industry ◽  
Process Technology ◽  
Work Process ◽  
Starting Point ◽  
Three Phase ◽  
Further Development ◽  
A Company

In an exploratory survey to R&D managers in different sectors of European Process Industry, the importance and present use of a formal work process for process development has been studied. A new conceptual three-phase model for the "process development process", including the identification of production needs, process development and transfer of results to production, was also tested. The results show that only 44% of the companies in the study presently use a formal work process for process development, but the need for such a process is considered to be high. Good support was given for the new conceptual model as a starting point for further development of a company-specific "process development process".

V. M. ZHIRMUNSKY AS A FOLKLORIST. ORIGIN AND DEVELOPMENT OF THE COMPARATIVE HISTORICAL TYPOLOGY METHODS

2020 ◽  
Vol 3 (4) ◽  
pp. 108-128
Author(s):  
Anna I. Kovalevskaya ◽  
Keyword(s):  
Literary Theory ◽  
Social Reality ◽  
Literary Studies ◽  
Basic Principles ◽  
Historical Method ◽  
Successful Search ◽  
Starting Point ◽  
High Regard ◽  
Main Ideas ◽  
Further Development

The article considers the main stages in formation of the method for the comparative historical typology the first steps of which were made by A.N. Veselovsky in the second half of the 19 th century. For example, the point elaborated upon in “Historical Poetics” concerning consequential evolution of genres and poetic forms that reflect social reality became the starting point for the further development of that method. Work in this direction was continued later on by V.M. Zhirmunsky. At the beginning of his career in academia he dwelled upon the issues of literary theory and – while keeping “Historical Poetics” in high regard – continued Veselovsky’s work in the field of literary studies. However, turning to folklore material, he managed to develop the basic principles of the comparative historical method: first of all, he had analysed and systematised the extensive epic material, what allowed him to reveal in the folklore work the national and the general, for the successful search and analysis of which the method was necessary. The author analysis of the works of Zhirmunsky, that contain his main ideas, and considers not only his suggestions on how to work with folk material, and also the features of the comparative typological method, as well as the development of Zhirmunsky’s ideas in the works of his students, followers and scientists who came to a similar result on their own (for example, V.Ya. Propp) and influenced further refinement of the methods of comparative typology.

scholarly journals THE DEVELOPMENT OF SPORTS IN UKRAINE AND ABROAD

2020 ◽  
Vol 33 (20) ◽  
pp. 42-46
Author(s):  
A.M. Kulish ◽  
V.V. Turpitko
Keyword(s):  
Middle Ages ◽  
Olympic Games ◽  
Great Influence ◽  
Ancient Greece ◽  
Ancient Egypt ◽  
Physical Culture ◽  
Ancient India ◽  
Starting Point ◽  
Set Up ◽  
Further Development

Sport has always served to establish peace, to help different peoples of the world to study each other’s culture, to create conditions for the humane resolution of conflicts, to be an opportunity to express their talents. Therefore, he never fell out of sight of society. In this work, the authors present the formation and development of sports in Ukraine and abroad. The main features of the primitive community were identified. It is determined that the invention of the chariot for the physical culture of the states: Babylon, Ancient Egypt, Mesopotamia, Ancient India, China, Persia became the starting point for the further development of sports in this region. It has been found that ancient Greece made a significant contribution to the development of sports. After all, it was the basis of the main principles of modern professional sport. Attention is drawn to the Olympic Games that took place in Ancient Greece: their appearance, conditions, prohibition, and revival Pierre de Coubertin. Further new competitions (Paralympic Games, Olympic Games, etc.) were added to them. It is revealed that international organizations and institutions have been set up to control such competitions. The authors found that religion had a great influence on the formation of physical culture during the Middle Ages and during the Renaissance. Trends in the development of modern sport and the factors that influence it was found out. As a result, it was concluded that sports are currently in the process of transformation. Therefore, the authors indicate what has the greatest influence on the formation and continued existence of sports. The main stages of the formation of physical culture in Ukraine were analyzed. It is also established that Ukraine has built a domestic sport in accordance with world experience in this field. Keywords: sports, physical culture, Olympics, doping, consolidating function.

scholarly journals The new international legal order and new states in the Balkans

2006 ◽  
Vol 58 (3) ◽  
pp. 272-293 ◽  
Author(s):  
Dusko Dimitrijevic
Keyword(s):  
International Law ◽  
Essential Role ◽  
Legal Order ◽  
State Behavior ◽  
The Balkans ◽  
Starting Point ◽  
New States ◽  
International Legal Order ◽  
The One ◽  
Further Development

In this study the author attaches a great importance to the theoretical examination of the concept of the New International Legal Order that was embodied in the last decades of the 20th century. The starting point for that reflection is the dissolution of the SFR Yugoslavia that illustrates one of the fundamental legal precedents. Reminding that the basic principle for the post-modern State behavior must be the one that includes minimal disturbance of the existing international legal relations, the author stresses that "the Yugoslav case" was customized in the way to respond to the new reality where the principle of effectiveness played an essential role in valuation of the statehood. It could also be one of the greatest catalysts for all further 'development rules' of international law.

scholarly journals Transportation Hub-Kumanovo

2017 ◽  
Vol 2017 ◽  
pp. 6
Author(s):  
Mihajlo Zinoski ◽  
Igor Medarski ◽  
Stefani Solarska
Keyword(s):  
Rail Transport ◽  
City Centre ◽  
Way Of Life ◽  
Downtown Area ◽  
Starting Point ◽  
Bus Station ◽  
New City ◽  
Bus Service ◽  
The City ◽  
Further Development

The modern way of life is conditioned by fast transportation. This, in turn, requires integration of many additional contents that opens the opportunity to the passengers for quick access to their target-food, accommodation, entertainment, communication. The distance of the existing railway station (3.7 km from the city centre) makes it hardly accessible to the population, therefore it is neglected and the rail traffic in the city of Kumanovo is minimized. On the other hand, the bus station has a good location, but the building is in poor condition, which impedes the functioning of the city and intercity bus service. Adjacent to the existing bus station, a segment of the railroad from the proposed "Corridor 8" transits, which opens the question of the importance of rail transport and its impact in the further development of the city. These considerations clearly indicate the need to establish an integrated transport hub, whose proposed location touches the downtown area, but is still in the zone between the city and the suburbia, which includes adjoining contents such as: retail, hospitality and culture, which will help achieve the goal of the transportation hub as a starting point of development of a new city nucleus, a new point in the city.

French Influences on Germany’s Commercial Courts in the Nineteenth Century

2020 ◽  
Vol 88 (3-4) ◽  
pp. 469-494
Author(s):  
Thomas Vogl
Keyword(s):  
Nineteenth Century ◽  
Eighteenth Century ◽  
Modern Literature ◽  
French Law ◽  
Present Contribution ◽  
Legal Situation ◽  
Starting Point ◽  
State Of Research ◽  
Further Development ◽  
Commercial Courts

Summary The present contribution explores the extent of influence which French law had on the development of Germany’s commercial courts in the nineteenth century. Modern literature describes this influence as marginal, yet without further proof. The author takes this state of research as a starting point to compare the Napoleonic legislation on commercial courts with the German commercial court systems of the nineteenth century. However, the present contribution will start with an overview of the German legal situation at the end of the eighteenth century. This is followed by an examination of whether French law was transferred to Germany during the French occupation of large parts of Germany at the beginning of the nineteenth century. Against this background it is possible to fully analyse the influence which French law had on the further development of German commercial courts.

scholarly journals Capturing the value of peer support: measuring recovery-oriented services

2019 ◽  
Vol 18 (3) ◽  
pp. 180-187
Author(s):  
Stacey L. Barrenger ◽  
Victoria Stanhope ◽  
Emma Miller
Keyword(s):  
Clinical Outcomes ◽  
Peer Support ◽  
Support Services ◽  
Outcome Measurement ◽  
Evidence Base ◽  
Content Type ◽  
Evaluation Approach ◽  
The People ◽  
Starting Point ◽  
Peer Support Services

Purpose The purpose of this paper is to examine the gap between recovery-oriented processes and clinical outcomes in peer support, an exemplar of recovery-oriented services, and offer suggestions for bridging this gap. Design/methodology/approach This viewpoint is a brief review of literature on peer support services and gaps in outcome measurement towards building an evidence base for recovery-oriented services. Findings Clinical outcomes like hospitalizations or symptoms remain a focus of research, practice and policy in recovery-oriented services and contribute to a mixed evidence base for peer support services, in which recovery-oriented outcomes like empowerment, self-efficacy and hopefulness have more evidentiary support. One approach is to identify the theoretical underpinnings of peer support services and the corresponding change mechanisms in models that would make these recovery-oriented outcomes mediators or process outcomes. A better starting point is to consider which outcomes are valued by the people who use services and develop an evaluation approach according to those stated goals. User driven measurement approaches and more participatory types of research can improve both the quality and impact of health and mental health services. Originality/value This viewpoint provides a brief review of peer support services and the challenges of outcome measurement in establishing an evidence base and recommends user driven measurement as a starting point in evaluation of recovery-oriented services.

scholarly journals A systematic review on organizational empowerment

2019 ◽  
Vol 27 (5) ◽  
pp. 1336-1361
Author(s):  
Linda Rothman ◽  
Frans De Vijlder ◽  
René Schalk ◽  
Martine Van Regenmortel
Keyword(s):  
Systematic Review ◽  
Web Of Science ◽  
Service Organizations ◽  
Future Research ◽  
Content Type ◽  
Starting Point ◽  
Broad Concept ◽  
Organizational Empowerment ◽  
Further Development ◽  
Practical Implications

Purpose This paper aims to present a systematic review on organizational empowerment (OE) using Peterson and Zimmerman´s model (2004) as a starting point. The aim is to further conceptualize OE, discover how the components in the model influence each other and identify recommendations for future research. Design/methodology/approach All articles that cited the OE model, published in 2004 by Peterson and Zimmerman, have been systematically reviewed. In total, 37 studies of 410, found in Google Scholar and Web of Science, are included in the review. Findings The review revealed that intra-, inter- and extra-organizational empowerment affect each other and that evidence for the processes and outcomes on intra-organizational empowerment have increased, but there is limited additional evidence for the other two components. Research limitations/implications Literature was searched in two databases, focusing on the OE model. A search using other databases on OE as a broad concept might provide additional sources. Practical implications Findings are relevant for professionals, leaders in human service organizations, educators and researchers. Practice can be improved by applying the knowledge; educators can use the results in their program and researchers may use the findings for the further development of OE. Originality/value Since the OE model was presented in 2004, no systematic review has been performed. Therefore, this review contributes to the further conceptualization of OE.

Capturing Process Knowledge for Multi-Channel Information Systems

2012 ◽  
Vol 3 (1) ◽  
pp. 78-98 ◽  
Author(s):  
Shang Gao ◽  
John Krogstie
Keyword(s):  
Early Stage ◽  
Process Models ◽  
System Support ◽  
Knowledge Capture ◽  
Process Knowledge ◽  
Starting Point ◽  
Channel Information ◽  
Further Development ◽  
Goal Models

In this paper, a case study is used to evaluate the business process characterizing modeling (BPCM) language. The BPCM-framework is meant to guide both business stakeholders and model developers during model-based development. The focus of the approach is the use of BPCM as a starting point for capturing process knowledge when planning and developing information system support. Based on information within the BPCM models, goal models and process models can be developed and used for further development of the BPCM model. The approach in this paper is evaluated using a case study related to the arrangement of a conference series. Through the case study, the authors have confirmed the potential usability and usefulness of BPCM for early stage knowledge capture, getting input for further improvement of the approach.

scholarly journals Assessment of Industry 4.0 Maturity Models by Design Principles

2020 ◽  
Vol 12 (23) ◽  
pp. 9927
Author(s):  
Dinara Dikhanbayeva ◽  
Sabit Shaikholla ◽  
Zhanybek Suleiman ◽  
Ali Turkyilmaz
Keyword(s):  
Development Strategy ◽  
Industry 4.0 ◽  
Industrial Revolution ◽  
Design Principles ◽  
Maturity Models ◽  
Digital Revolution ◽  
Starting Point ◽  
Traditional Manufacturing ◽  
Globalized World ◽  
Further Development

The fourth industrial revolution and accompanying digital transformation has progressed dramatically in recent years. The new digital revolution, mostly known as Industry 4.0, introduces impressive changes in the way enterprises and organizations are operating in a globalized world and altering the well-established lifestyle of a society. Therefore, it is of utmost importance to identify the current capabilities of companies in the context of Industry 4.0. Current literature on Industry 4.0 maturity and assessment models underlies the importance of a proper development strategy with exact steps to perform. Design principles address the issue of systematizing the measurable and attainable steps for further development. The present study contributes towards the identification of the research gap in the presence of core Industry 4.0 design principles during the development of maturity models. The analysis of 12 chosen maturity models by eight core design principles was provided. This research can serve as a starting point for the development of a complex strategic roadmap and thereby to provide a successful transition from traditional manufacturing into Industry 4.0.

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