scholarly journals Influence of Aqueous Solubility-Enhancing Excipients on the Microstructural Characteristics of Furosemide-Loaded Electrospun Nanofibers

Pharmaceutics ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 385
Author(s):  
Andrea Kovács ◽  
Adrienn Kazsoki ◽  
Balázs Démuth ◽  
Bernadett Szirányi ◽  
János Madarász ◽  
...  
Keyword(s):  
Electrospun Nanofibers ◽  
Microstructural Characterization ◽  
Aqueous Solubility ◽  
Morphological Characterization ◽  
Diameter Distribution ◽  
Microstructural Characteristics ◽  
Sem Images ◽  
Positron Annihilation Lifetime ◽  
Normal Diameter ◽  
Solubility Enhancers

Electrospun nanofibers were prepared from furosemide-containing hydroxypropyl cellulose and poly(vinylpyrrolidone) aqueous solutions using different solubility enhancers. In one case, a solubilizer, triethanolamine, was applied, while in the other case a pH-modifier, sodium hydroxide, was applied. Scanning electron microscopy (SEM) was carried out for morphological characterization of the fibers. The SEM images indicated similar mean diameter size of the two fibrous formulations. However, in contrast to the NaOH-containing fibers of normal diameter distribution, the triethanolamine-containing fibers showed approximately normal diameter distribution, possibly due to their plasticizing effect and the consequent slightly ribbon-like morphology. Attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR), powder X-ray diffraction (XRD) and positron annihilation lifetime spectroscopy (PALS) were applied for microstructural characterization. The FTIR measurements confirmed that furosemide salt was formed in both cases. There was no sign of any crystallinity based on the XRD measurements. However, the PALS highlighted the differences in the average o-Ps lifetime values and distributions of the furosemide-loaded fibrous formulations. The two types of electrospun nanofibrous formulations containing amorphous furosemide salt showed similar macrostructures but different microstructural characteristics depending on the type of solubility enhancers, which lead to altered storage stability.

scholarly journals Fast Dissolving Electrospun Nanofibers Fabricated from Jelly Fig Polysaccharide/Pullulan for Drug Delivery Applications

Polymers ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 241
Author(s):  
Thangavel Ponrasu ◽  
Bei-Hsin Chen ◽  
Tzung-Han Chou ◽  
Jia-Jiuan Wu ◽  
Yu-Shen Cheng
Keyword(s):  
Drug Delivery ◽  
Water Vapor Permeability ◽  
Electrospun Nanofibers ◽  
Average Diameter ◽  
Xrd Analysis ◽  
Water Soluble ◽  
Vapor Permeability ◽  
Uv Spectrum ◽  
Sem Images ◽  
Triton X

The fast-dissolving drug delivery systems (FDDDSs) are developed as nanofibers using food-grade water-soluble hydrophilic biopolymers that can disintegrate fast in the oral cavity and deliver drugs. Jelly fig polysaccharide (JFP) and pullulan were blended to prepare fast-dissolving nanofiber by electrospinning. The continuous and uniform nanofibers were produced from the solution of 1% (w/w) JFP, 12% (w/w) pullulan, and 1 wt% Triton X-305. The SEM images confirmed that the prepared nanofibers exhibited uniform morphology with an average diameter of 144 ± 19 nm. The inclusion of JFP in pullulan was confirmed by TGA and FTIR studies. XRD analysis revealed that the increased crystallinity of JFP/pullulan nanofiber was observed due to the formation of intermolecular hydrogen bonds. The tensile strength and water vapor permeability of the JFP/pullulan nanofiber membrane were also enhanced considerably compared to pullulan nanofiber. The JFP/pullulan nanofibers loaded with hydrophobic model drugs like ampicillin and dexamethasone were rapidly dissolved in water within 60 s and release the encapsulants dispersive into the surrounding. The antibacterial activity, fast disintegration properties of the JFP/pullulan nanofiber were also confirmed by the zone of inhibition and UV spectrum studies. Hence, JFP/pullulan nanofibers could be a promising carrier to encapsulate hydrophobic drugs for fast-dissolving/disintegrating delivery applications.

Microstructure of Recycled Gypsum Plaster by SEM

2014 ◽  
Vol 912-914 ◽  
pp. 243-246 ◽  
Author(s):  
Gladis Camarini ◽  
Sayonara M.M. Pinheiro
Keyword(s):  
Microstructural Characterization ◽  
Building Construction ◽  
Microstructural Characteristics ◽  
Construction Waste ◽  
Gypsum Plaster ◽  
Recycled Gypsum

Gypsum waste from building constructions is a material which can contaminate the soil and groundwater if is disposed directly in the soil or landfill without any control. In Brazil, these wastes are considered a recycle and/or recovery material, but the research of gypsum plaster recycling are very few at this moment. In this way, this work presents the microstructural characterization of two types of recycled plaster. The recycled plaster was produced by a grinding and calcination the building construction waste. Microstructural characteristics were evaluated by SEM observations. The results show similarities between crystals of recycled and commercial plasters.

Effect of Solution Conductivity on the Morphology of Bubble-Electrospun Nanofibers

2011 ◽  
Vol 332-334 ◽  
pp. 1003-1006 ◽  
Author(s):  
Rui Rui Yang ◽  
Ji Huan He ◽  
Jian Yong Yu
Keyword(s):  
Mass Fraction ◽  
Smooth Surface ◽  
Electrospun Nanofibers ◽  
Diameter Distribution ◽  
Electrical Conductivities ◽  
Mean Diameter ◽  
Solution Conductivity

In this paper, we have bubble-electrospun PLA nanofibers to analyze and investigate the effect of different electrical conductivities by adding different amounts of LiCl into the PLA/DMF solutions on the morphology and diameter of the nanofibers. As a result, it is found that when the mass fraction of LiCl is 0.5%, we can obtain the smallest mean diameter of bubble-electrospun nanofibers with more smooth surface and uniform fineness. Moreover, both improving and reducing LiCl concentration brings on coarse nanofibers surface and poor diameter distribution.

scholarly journals TWO-STEP CROSSLINKING OF PVP/GEL NANOFIBERS

2021 ◽  
Vol 2021 ◽  
pp. 164-170
Author(s):  
H.K. Güler ◽  
F.C. Çallıoğlu
Keyword(s):  
Fiber Diameter ◽  
Experimental Studies ◽  
Water Soluble ◽  
Diameter Distribution ◽  
Sem Images ◽  
Crosslinking Process ◽  
Different Temperatures ◽  
Ft Ir ◽  
Ir Analysis ◽  
Gel Polymers

In this study, it was achieved that crosslinking of PVP/GEL nanofibers with two-steps. Crosslinking is a process highly important for water-soluble polymers in terms of application areas and mechanical properties. Firstly, crosslinking of PVP polymers experimental studies were carried out via heat treatment at different temperatures and times. Then, GEL polymers were crosslinked with GTA vapour at different times. Morphological analysis was carried out via SEM images and chemical characteristics were determined via FT-IR analysis. Moreover, after the crosslinking process, SD and WL values were calculated. All results showed that before crosslinking of SEM images, nanofibers were smooth, fine and without beads. The average fiber diameter is 196 nm and the fiber diameter distribution is quite uniform. After crosslinking of SEM images, it is expected that all nanowebs will turn from fibrous surfaces to membranous. Generally, SD and WL values decrease with crosslinking time increase. According to all of the SEM images, SD and WL values, optimum conditions were determined for PVP as 4 hours at 180oC and for GEL as 24 hours. Lastly, the presence of PVP and GEL polymers in the nanofiber structure was verified chemically with FT-IR analysis.

scholarly journals A Sulfur Copolymers (SDIB)/Polybenzoxazines (PBz) Polymer Blend for Electrospinning of Nanofibers

Nanomaterials ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. 1526 ◽  
Author(s):  
Ronaldo P. Parreño ◽  
Ying-Ling Liu ◽  
Arnel B. Beltran
Keyword(s):  
Polymer Blend ◽  
Single Phase ◽  
Fiber Diameter ◽  
Electrospinning Process ◽  
Diameter Distribution ◽  
Sem Images ◽  
Water Contact ◽  
Fixed Concentration ◽  
New Material ◽  
Nanofiber Mats

This study demonstrated the processability of sulfur copolymers (SDIB) into polymer blend with polybenzoxazines (PBz) and their compatibility with the electrospinning process. Synthesis of SDIB was conducted via inverse vulcanization using elemental sulfur (S8). Polymer blends produced by simply mixing with varying concentration of SDIB (5 and 10 wt%) and fixed concentration of PBz (10 wt%) exhibited homogeneity and a single-phase structure capable of forming nanofibers. Nanofiber mats were characterized to determine the blending effect on the microstructure and final properties. Fiber diameter increased and exhibited non-uniform, broader fiber diameter distribution with increased SDIB. Microstructures of mats based on SEM images showed the occurrence of partial aggregation and conglutination with each fiber. Incorporation of SDIB were confirmed from EDX which was in agreement with the amount of SDIB relative to the sulfur peak in the spectra. Spectroscopy further confirmed that SDIB did not affect the chemistry of PBz but the presence of special interaction benefited miscibility. Two distinct glass transition temperatures of 97 °C and 280 °C indicated that new material was produced from the blend while the water contact angle of the fibers was reduced from 130° to 82° which became quite hydrophilic. Blending of SDIB with component polymer proved that its processability can be further explored for optimal spinnability of nanofibers for desired applications.

Fabrication of Polyacrylonitrile Nanofiber Membranes Functionalized With Metal Organic Framework for CO2 Capturing

2015 ◽  
Author(s):  
Wahiduzzaman ◽  
Mujibur Khan ◽  
Saheem Absar ◽  
Spencer Harp ◽  
Kyle Edwards ◽  
...  
Keyword(s):  
Gas Adsorption ◽  
Metal Organic Framework ◽  
Fiber Surface ◽  
Precursor Solution ◽  
Electrospun Nanofibers ◽  
Primary Component ◽  
Secondary Process ◽  
Sem Images ◽  
Filter System ◽  
Metal Organic

Crystalline particles known as Metal Organic Frameworks (MOF’s) are known for their large surface area and high adsorption and storage capacity for CO2 gas. Electrospun nanofibers are considered as ideal substrates for synthesizing the MOF particles on the fiber surface. In this project, Polyacrylonitrile (PAN) and a Cu-based MOF known as HKUST-1 were selected as substrate fibers and adsorbent particles respectively. A precursor solution of PAN polymer hybridized with HKUST-1 particles dissolved in Dimehtylformamide (DMF) is used as the primary component solution for electrospinning. SEM images of the electrospun fibers showed small MOF particles formation into the fiber structure. A secondary solvothermal process of MOF particles growing on the fibers was then executed to increase the amount of MOF particles for effectual gas adsorption. The secondary process consists of multiple growth cycles and SEM images showed uniform distribution of porous MOF particles of 2–3μm in size on the fiber surface. EDS report of the fiber confirmed the presence of MOF particles through identification of characteristic Copper elemental peaks of HKUST-1. Thermogravitmetric analysis (TGA) of HKUST-1 doped PAN fiber displayed 32% of total weight loss between 180°C and 350°C thus proving the as-synthesized MOF particles are thermally stable within the mentioned temperature range. A comparative IR spectroscopic result between the gas-treated and gas-untreated fiber samples showed the presence of characteristic peak in the vicinity of 2300 and 2400cm−1 which corroborates the assertion of adsorption of CO2 on the system. Further step involved is to investigate the gas adsorption capacity of the filter system in an experimental test bench. Non-dispersive Infrared (NDIR) CO2 sensors will be used at the gas inlet and outlet parts to measure the concentration of CO2 and determine the amount of gas uptake by the filter system.

Nanocomposite Multilayer Fibrous Membrane for Sustained Drug Release

2014 ◽  
Vol 894 ◽  
pp. 364-368 ◽  
Author(s):  
Ahmed Hassanin ◽  
Ahmed A. El-Moneim ◽  
Mohamed Ghaniem ◽  
Hassan Nageh
Keyword(s):  
Drug Release ◽  
Outer Layer ◽  
Biomedical Application ◽  
Drug Carrier ◽  
Electrospun Nanofibers ◽  
Drug Release Profile ◽  
Sustained Drug Release ◽  
Sem Images ◽  
Fibrous Membranes ◽  
The Many

Building on the success of the many earlier studies on electrospun nanofibers technique which provide a non woven web to the order of nanometers introducing superior properties such as large surface area, superior mechanical properties and ease of implementation in many fields of applications, elctrospun nanofibers became an important issue for many researchers in various fields. Using elctrospun fibers as a drug carrier, is showing a huge promising potential for the future of biomedical application. Our work in this research is focusing on engineering a system to control the drug release profile rate especially for wound dressing. Nanocomposite multilayer fibrous membranes, using electrospinning method, have been developed for drug release in form of sandwich structure of three layers. Inner layer which is kept Polycaprolactane (PCL) loaded with drug. The two outer layers have been changed with different blend ratios between Chitosan (Cs) and PCL as follow [0%:100% Cs:PCL, 30%:70% Cs:PCL, 50%:50% Cs:PCL, 70%:30% Cs:PCL]. The results showed that the release rate has been affected dramatically by the outer layer composition. SEM images showed changing in the morphology due to the different in the composition of outer layer.

Preparation of Polyurethane (PU)/ Polyaniline (PANI) Compound Nanofiber via Electrospinning

2011 ◽  
Vol 332-334 ◽  
pp. 1352-1356
Author(s):  
Li Wei Liu ◽  
Wei Min Kang ◽  
Bo Wen Cheng
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Electrospun Nanofibers ◽  
Total Solid ◽  
Solution Concentration ◽  
Solid Content ◽  
Diameter Distribution ◽  
Mass Ratio ◽  
Total Solid Content ◽  
Scanning Electron

In this paper polyurethane (PU) / polyaniline (PANI) nanofibers were successfully prepared via electrospinning with N, N-dimethylformamide (DMF) and tetrahydrofuran (THF) mixture (1:2 mass ratio). The morphology, diameter and structure of the electrospun nanofibers were examined by scanning electron microscopy (SEM) and the diameter distribution of nanofibers was measured by Image-Pro Plus. Results indicate that the morphology, diameter and uniformity of the fibers were influenced by solution concentration, applied voltage, capillary–screen distance and flow rate greatly, and the finer and uniform nanofibers were electrospun from total solid content of the spinning solutions at 8 wt. %, PU and PANI with ratio of 10/1 (w/w), the spinning voltage at 35 kV, the collecting distance at 15 cm and the extruding speed at 6 ml/h.

Structural Transformations of Boron Nitride Powders Obtained by Mechanical Milling Process

2009 ◽  
Vol 68 ◽  
pp. 101-108
Author(s):  
Rodrigo A. Esparza ◽  
J. Ayala ◽  
C. Ángeles-Chávez ◽  
G. Rosas ◽  
Ramiro Pérez
Keyword(s):  
Boron Nitride ◽  
Microstructural Characterization ◽  
Structural Transformations ◽  
Milling Process ◽  
X Ray Diffraction ◽  
Microstructural Characteristics ◽  
X Ray ◽  
Diffraction Patterns ◽  
Milled Powders

Mechanical milled powders of boron nitride were obtained. The microstructural characterization of these milled powders was carried out using X-ray diffraction technique. Insights on the nature of the crystalline phases obtained in these milled powders were obtained between comparisons of theoretical and experimental X-ray diffraction patterns. Observations on the phase transformations have been carried out using calorimetry and thermogravity experiments. Morphological and microstructural characteristics of nanocrystals are obtained using SEM and HRTEM instruments.

scholarly journals Green formulation and characterization of Fe nanoparticles containing Calendula ‎extract and investigation of the antioxidant, cytotoxicity and anti-human ‎cholangiocarcinoma properties

2021 ◽  
Author(s):  
Jisen Zhao ◽  
Yang Yu ◽  
Wang Yan ◽  
Shujie Cheng
Keyword(s):  
Cell Lines ◽  
Metallic Nanoparticles ◽  
Medical Diagnostics ◽  
Morphological Characterization ◽  
Sem Images ◽  
Integrative Research ◽  
Vis Spectroscopy ◽  
Cholangiocarcinoma Cell ◽  
Ft Ir

IntroductionOne of the simplest nanostructures that is widely used in industry today is metallic nanoparticles. Metallic ‎nanoparticles can bind non-destructively to single-stranded DNA, which are important in medical diagnostics. ‎Cancer nanotechnology developed a new area of integrative research in biology, chemistry, engineering, and ‎medicine, and is concerned with major advances in cancer diagnosis, prevention and treatment ‎Material and methods‎ In the recent study, the structural and morphological characterization of bio‐synthesized FeNPs@Calendula ‎arvensis was performed by FT-IR and UV-vis spectroscopy, scanning electron microscopy (SEM) that SEM ‎images have exhibited an equal and uniform spherical morphology in size of 30.13 nm. ‎ResultsIn the antioxidant test, the IC50 of FeNPs@Calendula arvensis and BHT against DPPH free radicals were 117 ‎and 88 µg/mL, respectively. In the anticancer test, the treated cells with FeNPs@Calendula arvensis were ‎assessed by MTT assay for 48h about the anti-human cholangiocarcinoma and ‎ cytotoxicity properties on normal ‎‎(HUVEC) and cholangiocarcinoma ‎ carcinoma cell lines i.e., HCM-CSHL-0174-C22, CCLP-1, and QBC939. ‎The IC50 of FeNPs@Calendula arvensis were 196, 237, and 278 µg/mL against HCM-CSHL-0174-C22, ‎CCLP-1, and QBC939‎ cell lines, respectively. The viability of cholangiocarcinoma cell line reduced dose-‎dependently in the presence of FeNPs@Calendula arvensis.‎ConclusionsIt appears that the anti-human cholangiocarcinoma effect of FeNPs@Calendula arvensis is due to their ‎antioxidant effects.‎

Sign in / Sign up

Export Citation Format

Share Document