scholarly journals Ultrasound and Microbubbles Enhance Uptake of Doxorubicin in Murine Kidneys

Pharmaceutics ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2038
Author(s):  
Oystein Eikrem ◽  
Spiros Kotopoulis ◽  
Mihaela Popa ◽  
Mireia Mayoral Safont ◽  
Kjell Ove Fossan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Negative Impact ◽  
Drug Uptake ◽  
Low Intensity ◽  
Actual Contribution ◽  
Uptake Studies ◽  
Pass Through ◽  
The Individual ◽  
Acoustic Output ◽  
The Impact

The use of ultrasound and microbubble-enhanced drug delivery, commonly referred to as sonoporation, has reached numerous clinical trials and has shown favourable results. Nevertheless, the microbubbles and acoustic path also pass through healthy tissues. To date, the majority of studies have focused on the impact to diseased tissues and rarely evaluated the impact on healthy and collateral tissue. The aim of this study was to test the effect and feasibility of low-intensity sonoporation on healthy kidneys in a mouse model. In our work here, we used a clinical diagnostic ultrasound system (GE Vivid E9) with a C1-5 ultrasound transducer combined with a software modification for 20-µs-long pulses to induce the ultrasound-guided drug delivery of doxorubicin (DOX) in mice kidneys in combination with SonoVue® and Sonazoid™ microbubbles. The acoustic output settings were within the commonly used diagnostic ranges. Sonoporation with SonoVue® resulted in a significant decrease in weight vs. DOX alone (p = 0.0004) in the first nine days, whilst all other comparisons were not significant. Ultrasound alone resulted in a 381% increase in DOX uptake vs. DOX alone (p = 0.0004), whilst SonoVue® (p = 0.0001) and Sonazoid™ (p < 0.0001) further increased the uptake nine days after treatment (419% and 493%, respectively). No long-standing damage was observed in the kidneys via histology. In future sonoporation and drug uptake studies, we therefore suggest including an “ultrasound alone” group to verify the actual contribution of the individual components of the procedure on the drug uptake and to perform collateral damage studies to ensure there is no negative impact of low-intensity sonoporation on healthy tissues.

scholarly journals Flight Simulator’s Energy Consumption Depending on the Conditions of the Air Operation

Energies ◽  
2022 ◽  
Vol 15 (2) ◽  
pp. 580
Author(s):  
Michał Gołębiewski ◽  
Marta Galant-Gołębiewska ◽  
Remigiusz Jasiński
Keyword(s):  
Energy Consumption ◽  
Natural Environment ◽  
Negative Impact ◽  
Weather Conditions ◽  
Civil Aviation ◽  
Flight Simulator ◽  
Motion Platform ◽  
Simulator Motion ◽  
The Individual ◽  
The Impact

Protection of the natural environment is a key activity driving development in the transport discipline today. The use of simulators to train civil aviation pilots provides an excellent opportunity to maintain the balance between efficiency and limit the negative impact of transport on the environment. Therefore, we decided to determine the impact of selected simulations of air operations on energy consumption. The aim of the research was to determine the energy consumption of the flight simulator depending on the type of flight operation and configuration used. We also decided to compare the obtained result with the energy consumption of an aircraft of a similar class, performing a similar aviation operation and other means of transport. In order to obtain the results, a research plan was proposed consisting of 12 scenarios differing in the simulated aircraft model, weather conditions and the use of the simulator motion platform. In each of the scenarios, energy consumption was measured, taking into account the individual components of the simulator. The research showed that the use of a flight simulator has a much smaller negative impact on the natural environment than flying in a traditional plane. Use of a motion platform indicated a change in energy consumption of approximately 40% (in general, flight simulator configuration can change energy consumption by up to 50%). The deterioration of weather conditions during the simulation caused an increase in energy consumption of 14% when motion was disabled and 18% when motion was enabled. Energy consumption in the initial stages of pilot training can be reduced by 97% by using flight simulators compared to aircraft training.

scholarly journals THE PREVALENCE OF BODY DYSMORPHIC DISORDER WITH A TENDENCY TO ANOREXIA NERVOSA IN ADOLESCENTS

2021 ◽  
Vol 1 (1) ◽  
pp. 12-15
Author(s):  
Diona Wahyuni ◽  
Keyword(s):  
Anorexia Nervosa ◽  
Body Dysmorphic Disorder ◽  
Negative Impact ◽  
Eating Behaviour ◽  
Daily Functioning ◽  
Epidemiological Surveys ◽  
Body Image Disorders ◽  
Medical Emergencies ◽  
The Individual ◽  
The Impact

Background: Anorexia nervosa (AN) and body dysmorphic disorder (BDD) are severe body image disorders that severely interfere with the daily functioning of the individual. They are separate but overlapping nosologically entities. There is a study on the tendency of wrong eating behaviour in adolescents with specifications for anorexia nervosa in Jakarta 11.6% and there is also a study at High School in Jakarta 88.5% of adolescents experience wrong eating behaviour with the specifications of anorexia nervosa. And the two largest epidemiological surveys regarding BDD, there were 2.5% women and 2.2% men. With a fairly high number of these two events, this has the potential to have a negative impact on someone’s health. This study aims to discuss the impact of anorexia nervosa. Methods: The researcher used several literature and scientific journals, which was based on 15 journals and literature, discussing a tendency to anorexia nervosa with the incidence of Body Dysmorphic Disorder and its medical emergencies. Conclusion: There is a correlation of anorexia nervosa among teenager especially girl teenage

It's all in the past: how do colonial legacies between host and home countries affect the expatriate experience?

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Christopher Richardson
Keyword(s):  
Cultural Values ◽  
Negative Impact ◽  
Research Field ◽  
Content Type ◽  
Colonial Legacy ◽  
The Past ◽  
Host Country Nationals ◽  
Practical Experiences ◽  
The Individual ◽  
The Impact

PurposeWithin the expatriation subset of the wider IB literature, the focus of research has been on contemporary contextual factors. The purpose of this paper is to link the present to the past by investigating how the individual expatriate experience may be affected by a colonial legacy between host and home countries.Design/methodology/approachGiven the exploratory nature of this study, a qualitative interview-based approach eliciting thick, detailed descriptions of the practical experiences of seven Japanese expatriate managers working in Malaysia was adopted. These were supplemented by additional interviews with three host-country nationals who work alongside some of the expatriates. The data were analysed through a two-stage coding process.FindingsThe expatriate respondents were largely unanimous in their view that the colonial past between the two countries had no negative impact on their experiences in Malaysia, and the Malaysian interviewees corroborated this. On the contrary, the majority of the expatriates actually spoke positively about their experiences. This was especially true for expatriates in both the tourism and education/research field whose work was linked in some way to the period of Japanese occupation.Research limitations/implicationsThe small, single-context nature of the investigation limits generalisation. There are also many particularities in this study (the nature of Japanese-Malaysian postcolonial relations, cultural values of the Malaysians and Japanese, and so on) that are perhaps not easily relatable to other contexts. Having said this, qualitative research is not always geared towards generalisability but rather towards contextual intricacies and nuances.Originality/valueWhile most of the extant literature on expatriation has examined largely contemporary factors, this paper explores the impact of more historical events on the expatriate experience. Although such events may seem distant from an expatriate's current activities, this study suggests that in certain circumstances, they may have a lingering effect.

Trust, Ethnicity and Integrity in East Africa: Experimental Evidence from Kenya and Tanzania

2017 ◽  
Vol 2 (1) ◽  
pp. 88-123 ◽  
Author(s):  
Dominic Burbidge ◽  
Nic Cheeseman
Keyword(s):  
Ethnic Diversity ◽  
Negative Impact ◽  
Common Knowledge ◽  
Individual Level ◽  
Trust Games ◽  
Negative Effect ◽  
Experimental Games ◽  
The Individual ◽  
The Impact ◽  
First Time

AbstractPolitical economy comparisons of Kenya and Tanzania have often found the political salience of ethnicity to be far higher in the former than the latter, with a negative impact on intercommunal trust. This difference has tended to be explained on the basis of the different kinds of leadership that the two countries experienced after independence. However, these findings have typically been demonstrated using aggregate or survey data. This paper assesses the salience of ethnicity at the individual level for the first time, deploying monetized two-round trust games in urban Kenya and Tanzania. The experimental games isolate the comparative impact of common knowledge of ethnicity and integrity among a quasi-random selection of 486 citizens. Verifying previous findings, we observe higher levels of trust and trustworthiness in Tanzania as compared with Kenya. Further, in comparison with Kenya, any shared knowledge of ethnic identities in Tanzania leads players to transfer fewer resources, while common knowledge that both players are “honest” led to higher transfers there than in Kenya. These results provide robust evidence of higher levels of trust in Tanzania, and of the negative effect in that country of common knowledge of ethnicity on levels of cooperation. The findings demonstrate the way in which political context can shape the impact of ethnic diversity, and encourage further experimental research that looks at the intersubjective dynamics of social cooperation.

scholarly journals Structure of the Assemblages of Spiders in Mediterranean Pear Orchards and the Effect of Intensity of Spraying

Insects ◽  
2020 ◽  
Vol 11 (9) ◽  
pp. 553 ◽  
Author(s):  
Luis de Pedro ◽  
María Carmen Ortín-Angulo ◽  
Jesús Miñano ◽  
Elena López-Gallego ◽  
Juan Antonio Sanchez
Keyword(s):  
Negative Impact ◽  
Southern Spain ◽  
Low Intensity ◽  
Population Reduction ◽  
Pear Trees ◽  
Hunting Mode ◽  
The Impact ◽  
Predatory Arthropods

Spiders are key predatory arthropods that are negatively affected by spraying pesticides in orchards. The aim of this research was to determine the structure of the community of spiders in pear orchards and the impact of the intensity of spraying. The study was carried out over three years in four pear orchards in southern Spain; two of them were conducted by ourselves with no or low-intensity spraying of insecticides, and two under the criteria of technicians (conventional). Spiders were sampled on pear trees by the beating method. The orchards hosted a rich community of spiders belonging to 13 different families and 51 genera. However, the genera Philodromus, Oxyopes, Cheiracanthium, Icius, and Neoscona accounted for 72% of the captures. Spiders were more abundant and had a higher richness of genera in the low-intensity spraying than in conventional orchards. Philodromidae, Salticidae, and Cheiracanthiidae experienced a significant population reduction in conventional orchards, while Araneidae, Linyphiidae, and Thomisidae were not significantly affected by the intensity of spraying. The wandering hunting mode could explain the negative impact on Philodromidae, Salticidae, and Cheiracanthiidae but does not explain the lack of effect on Oxyopidae and Thomisidae. No significant effect was found on any family of web builders.

FOUR DECADES OF POVERTY AND CONSUMPTION IN CHINA

2020 ◽  
Vol 65 (supp01) ◽  
pp. 117-138
Author(s):  
JINXIAN WANG ◽  
CHEN WANG ◽  
YAN ZHANG
Keyword(s):  
Economic Growth ◽  
Income Distribution ◽  
Negative Impact ◽  
Poverty Index ◽  
Domestic Consumption ◽  
Individual Level ◽  
Provincial Level ◽  
The Individual ◽  
The Impact ◽  
Empirical Analyses

Since 2010, China’s miraculous growth has come to a halt and has shown steady deceleration. To re-accelerate economic growth, stimulating domestic consumption is a crucial way with fighting poverty as the key step. This paper attempts to explore the impact of poverty on resident consumption in China over the last four decades. Based on provincial data, we first simulate income distribution at the individual level and provide moderate poverty profiles at the provincial level. The empirical analyses are then conducted to gauge the poverty impacts using the estimated poverty index. Results show that (1) moderate poverty has decreased sharply in China, with the best achievement in Beijing, Shanghai and Guangdong; (2) moderate poverty exerts a significantly negative impact on resident consumption; and (3) when poverty increases, resident consumption on household equipment decreases the most, while resident consumption on food, transportation, and telecommunication decreases the least.

scholarly journals The Impact of COVID-19 on the Dietary Habits of Middle-Class Population in Mulund, Mumbai, India

2020 ◽  
Author(s):  
Vidhi Mehta
Keyword(s):  
Dietary Habits ◽  
Preventive Measures ◽  
Negative Impact ◽  
Health Sector ◽  
Eating Patterns ◽  
Early Implementation ◽  
The Usa ◽  
The Individual ◽  
The Impact

In India, the SARS-CoV-2 COVID-19 pandemic has grown to 112,359 cases and 3,435 deaths as per 21st May, 2020. The severe acute respiratory syndrome (SARS) affected the world with 4,893,186 cases and 323,256 deaths as of 21st May, 2020. The WHO declared the outbreak as a public health emergency of international concern on 30th January, 2020 and it was declared as a pandemic in March 2020. Clinical studies conducted on hospitalized cases show that the onset of COVID-19 is associated with symptoms commonly associated with viral pneumonia, most commonly fever, cough/sore throat and myalgia/fatigue. COVID-19 world pandemic imposed a new set of challenges for the individual to maintain a healthy diet. When compared to the USA, India is currently facing lesser cases of the pandemic because of early implementation of the preventive measures such as a lockdown. Because of the lockdown imposed, India has and is facing a downfall in every aspect, such as the economy, the agriculture, the health sector, the IT and management sectors and also tourism. This in turn, will have a negative impact on the quality of life and economy in India. The present paper aims to find out the impact of COVID-19 pandemic on the health sector and is based on the results obtained from a survey about the eating patterns of participants from Mulund, Mumbai, India. It was seen that the mental stress caused due to the pandemic had an effect on the dietary behaviors of the participants.

scholarly journals Identifying causes and potential consequences of financial fraud

2019 ◽  
pp. 47-56
Author(s):  
Tetiana Kizyma ◽  
Andrii Kizyma
Keyword(s):  
Social Relations ◽  
Negative Impact ◽  
Research Literature ◽  
Effective Control ◽  
Economic Losses ◽  
Financial Fraud ◽  
Fraud Triangle ◽  
The Individual ◽  
Global Threat ◽  
The Impact

Introduction. The article claims that due to the rapid growth of financial relations, advancement of globalization processes, the impact of IT and the Internet on financial performance, the number of economic crimes in Ukraine has increased recently, especially financial fraud offences. The authors provide evidence that fraudulent schemes have targeted not only public and private finance, but all social relations. Purpose. Therefore, the aim of the paper is to address financial fraud as a global threat and identify its causes and potential consequences. Methods. For addressing the causes and effects of financial fraud, the following general research methods are used: analysis, synthesis, induction, deduction, abstraction and grouping. Results. It should be noted that the problem of financial fraud has not received sufficient attention in domestic research literature and practice. The paper presents the leading causes of financial fraud, which include economic, moral and psychological causes as well as regulatory, infrastructural and organizational ones. Financial fraud has a negative impact on the national economy and the welfare of citizens, and therefore leads to the multimillion losses. In order to identify consequences of financial fraud, a combination two types of evaluating such consequences is suggested: quantitative (involves the calculation of pecuniary damage, economic losses and lost economic profit due to fraud offences, and qualitative (logically explains circumstances of financial fraud, risks of losing corporate reputation, image and investment attractiveness). There are three major reasons why financial fraud occurs, which constitute the so-called fraud triangle: the opportunity to commit fraud; the pressure on the individual or the motivation behind the crime; the ability to rationalize the fraud. Therefore, the most important tasks for state bodies, economic entities and individuals include neutralizing the factors which lead to financial fraud and exercising effective control over the prevention of fraud offences in social and economic areas in general, and in financial area in particular. Discussion. Further studies should focus on a comprehensive analysis of the most common types of financial fraud, which take place in Ukraine. The authors argue that this will lead to establishing a set of policies aimed at reducing this negative phenomenon.

Changes in Import Pricing Behaviour: Evidence for Germany

2011 ◽  
Vol 231 (4) ◽  
Author(s):  
Kerstin Stahn
Keyword(s):  
Import Price ◽  
Commodity Prices ◽  
Pricing To Market ◽  
Product Categories ◽  
Individual Product ◽  
Long Run ◽  
Consumer Prices ◽  
Pass Through ◽  
The Individual ◽  
The Impact

SummarySince changes in import prices feed into consumer prices and thus might affect monetary policy decisions, policymakers need to establish whether or not German importers’ long-run pricing behaviour has changed. Of particular interest are any shifts in the importance of cost pass-through and pricing-to-market for import pricing in Germany that may have ocurred since the 1990s. We analyse pricing in single equations for 11 product categories because the factors influencing the pricing behaviour, eg competitive pressure,may well have developed differently on the individual product markets. The Saikkonen (1991) approach is applied to test the import price levels for changes in the impact of their determinants. After aggregating the findings for the individual product categories, we find that, on the whole, pricing-to-market has increased, whereas cost pass-through via foreign costs and exchange rates is lower, but not via commodity prices.

scholarly journals Opportunities for the integration of the Ukrainian industry into global value chains

2018 ◽  
pp. 65-74 ◽  
Author(s):  
Оksana Kushnirenko ◽  
Olga Zarudna
Keyword(s):  
Production Systems ◽  
Negative Impact ◽  
Value Added ◽  
Global Value Chains ◽  
Value Chains ◽  
Manufacturing Companies ◽  
Production Networks ◽  
Processing Industry ◽  
Pass Through ◽  
The Impact

Relevance of the research topic is due to the impact of globalization which had brought an increasing number of more and more products pass through global value-added chains to reach the end users. That  has led to new forms of transnational production,  that gives new opportunities for Ukrainian producers. Formulation of the problem. The utilizing the opportunities and mitigating the negative impact of the liberalization of foreign trade makes new requirements  for production oriented businesses in a more open and competitive international environment. The development of global production systems provides opportunities for participating in global value chains, that opens up new opportunities for the industry of Ukraine and requires further scientific researches. Analysis of recent research and publications. There are various dimensions to the development of global value chains of industry that need to be taken into account. The most important of these are P.Marsh, R.Kaplinski and Morris, K.Schwab, R.Rajk, D.Rodrik, E.Rajnert, S.Veber, P Labasta, G. Dzerffi, Geets VM, Vishnevsky AS, Deineko LV, Kizim NA, Kvasha TK, Lyashenko VI, Musina LA, Pyatnitsky VT, Sidenko V.R. and others. Selection of unexplored parts of the general problem. In the context of increasing influence of integration processes on the development of international trade and production, the problem of choosing the most effective ways of integration into global value chains for the processing industry of Ukraine as a reliable supplier of products with a higher degree of processing remains insufficiently studied. Setting the task, the purpose of the study. The objective of the article is to analyze the features of the formation of value added chains and ways of integrating them into the processing industry of Ukraine as a reliable supplier of products with a higher degree of processing. The purpose of the study is developing the proposals for possible constructive ways of promoting the integration of Ukrainian processing industry into global value-added chains. Method or methodology for conducting research. This paper used of general scientific: abstract-logical, induction and deduction, systemic approach; analysis, and synthesis and special scientific research methods: statistical comparisons, grouping, sampling; structure-functional analysis, expert judgments. Presentation of the main material (results of work).The existing approaches to the definition of the notion of value added chains are disclosed and their grouping is carried out on significant grounds; The features and modern trends in the development of global value chains in the processing industry are explored; The opportunities and the existing risks have been identified in the chain of value added for the developing countries; and substantiated practical recommendations for choosing the most effective ways of integration into global value chains for the processing industry of Ukraine as a reliable supplier of products with a higher degree of processing. The field of application of results. The results of this research can be applied in the process of formation and implementation of Ukraine's integration industrial policy. Conclusions according to the article. In the article authors was made in  assessment of the integration of Ukrainian manufacturing companies into global value chains. The adoption of effective tools and instruments for encouraging the entry of Ukraine's processing industry into global value chains provides for the creation of effective policies and institutions, aimed at eliminating restrictions in the the Ukrainian producers integration into international production networks. 

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