scholarly journals Evaluation of Anti-Inflammatory Effect of Moringa oleifera Lam. and Cyanthillium cinereum (Less) H. Rob. Lozenges in Volunteer Smokers

Plants ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1336
Author(s):  
Thitiya Luetragoon ◽  
Rungnapa Pankla Sranujit ◽  
Chanai Noysang ◽  
Yordhathai Thongsri ◽  
Pachuen Potup ◽  
...  
Keyword(s):  
Oral Health ◽  
Moringa Oleifera ◽  
Group Iii ◽  
Percentage Decrease ◽  
Group I ◽  
Oral Inflammation ◽  
Anti Inflammatory ◽  
Group Ii ◽  
Moringa Oleifera Lam ◽  
Inflammatory Effect

Smokers have high plaque accumulation that initiates gingival inflammation and progresses to periodontitis. Thus, oral hygiene to control microbial plaque formation is an effective method of preventing gingivitis. Medicinal plants such as Moringa oleifera Lam. (MO) and Cyanthillium cinereum (Less.) H. Rob. (CC) have an anti-inflammatory effect that might improve oral health in smokers. This study evaluated the effect of MO leaf and CC extracts using MO lozenges and a combination of MO + CC lozenges on oral inflammation and gingivitis in volunteer smokers. Lozenges consisting of MO and CC extracts were developed and studied in vivo. The results showed that lozenges significantly reduced oral inflammation and gingivitis in volunteers. The gingival index (GI) of group III (MO + CC lozenges) significantly decreased, while the percentage decrease of oral inflammation in group II (MO lozenges) was significantly higher than the other groups. The percentage decrease of GI values in group II (MO lozenges) and group III (MO + CC lozenges) were significantly higher than the placebo group I. Our findings indicated that MO and MO + CC lozenges reduced oral inflammation and gingivitis and showed potential to improve oral health in smokers.

scholarly journals Anti-Inflammatory Effect of Ethanolic Extract of Carica Papaya Leaves and Indomethacin in Cotton Pellet Induced Granuloma in Animal Model

2019 ◽  
Vol 6 (1) ◽  
pp. 2-5 ◽  
Author(s):  
Afroza Sultana ◽  
Rumana Afroz ◽  
Onayza Yasmeen ◽  
Muqbula Tasrin Aktar ◽  
Md Abdullah Yusuf
Keyword(s):  
Animal Model ◽  
Carica Papaya ◽  
Ethanolic Extract ◽  
Granuloma Formation ◽  
Rat Paw Edema ◽  
Group I ◽  
Cotton Pellet ◽  
Anti Inflammatory ◽  
Group Ii ◽  
Inflammatory Effect

Background: Anti-inflammatory effect can be exerted by Carica papaya. Objective: The purpose of the present study was to see the anti-inflammatory effect of ethanolic extract of Carica papaya leaves and indomethacin in carrageenan induced rat paw edema animal model. Methodology: This was an animal study carried out in the Department of Pharmacology at Dhaka Medical College, Dhaka, Bangladesh during the period from July 2014 to June 2015 for a period of one (01) year. The leaves of Carica Papaya collected from Botanical garden, Mirpur, Dhaka, Bangladesh. The animals were divided into four groups. The animals were divided into four groups. In all the animals granuloma were induced by implantation of autoclaved cotton pellet on the 1st day and they treated as follows: Group I were served as control that was received normal saline. Group II were received ethanolic extract of Carica Papaya leaves. Group III were received ethanolic extract of Carica Papaya leaves. Group IV were received indomethacin. On the 15th day animals were anesthetized, implanted pellets were dissected out, dried at hit air oven and the final weights were measured. Result: The experiment was carried out on 48 Long Evan Norwegian rats. Rats were divided in 4 groups of six animals each. The mean increase of weight of cotton pellet was 48.06±1.02, 24.48±0.36, 22.42±0.56 and 18.02±0.43 in group I, II, III and IV respectively. The inhibition of granuloma formation was 49.06%, 53.35% and 62.51% in group II, III and IV respectively. Conclusion: In conclusion the ethanolic extract of Carica Papaya leaves has effects on cotton pellet induced granuloma formation in experimental rat. Journal of Current and Advance Medical Research 2019;6(1):2-5

scholarly journals Impact of dentures on oral health-related quality of life

2016 ◽  
Vol 69 (7-8) ◽  
pp. 203-211 ◽  
Author(s):  
Sanja Gnjato
Keyword(s):  
Quality Of Life ◽  
Oral Health ◽  
Research Study ◽  
Life Quality ◽  
Quality Parameters ◽  
Group Iii ◽  
Group I ◽  
Health Quality ◽  
Group Ii

Introduction. Stomatoprothetic dentures are one of the factors of oral health and life quality of people of all ages. The aim of the paper is to make a connection between the oral health quality and quality of life on one side and the type of denture on the other. Material and Methods. This research study was conducted on the sample of 360 patients singled out in three numerically identical groups as follows: group I - patients treated with fixed dentures, group II - patients treated with mobile dentures, and group III - patients treated with both fixed and mobile dentures. The oral health quality was observed via five parameters: anamnestic data, symptoms of ill-functioning of basic functions in stomatogenic system (chewing and speech), extra oral examination, intraoral examination, and dental abilities. For some oral health quality parameters, the index of quality was determined. Results. Analyses of our three target groups of patients indicated that the patients from group I (treated with fixed dentures) suffered the least negative effects in line with the observed parameters; they are followed by patients from group III (combined dentures) and patients from group II (mobile dentures), respectively. Conclusion. Our research study showed that some oral health parameters have different impacts on health and life quality in patients treated with different stomatoprosthetic dentures.

scholarly journals ANTIINFLAMMATION ACTIVITY ETHANOL EXTRACT OF MARBOSI-BOSI LEAVES (Tarenna polycarpa (Miq.) Koord.Ex Valeton) ON WHITE RAT IN CARRAGEENAN INDUCED PAW INFLAMMATION

2018 ◽  
Vol 6 (3) ◽  
pp. 1-4
Author(s):  
Haris Munandarnst ◽  
Marline N
Keyword(s):  
Diclofenac Sodium ◽  
Ethanol Extract ◽  
Positive Control ◽  
Negative Control ◽  
Inflammatory Activity ◽  
Group Iii ◽  
Rat Paw Edema ◽  
Group I ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Traditionally, (Tarenna polycarpa (Miq.) Koord Ex Valeton as known as marbosi-bosi which commonly found in Sibolga, North Sumatera, Indonesia has been used as antidiabetes, cholesterol, anti-inflammatory and antibacterial. Tarenna species has been found its activities as antimicrobial, anti-oxidant and anti-inflammatory activity. The aim of this study was to investigate the anti inflammatory effect ethanol extract of marbosi-bosi leaves (Tarenna polycarpa (Miq.) Koord Ex Valeton in terms of decreased edema volume of male white rat in 1% carrageenan-induced and also to determine the effective dose of extract to decrease the volume of rat paw edema Ethanol extract of marbosi-bosi (Tarenna polycarpa (Miq.) Koord Ex Valeton was obtained by maceration. The antiinflammatory activity test was divided into 5 groups. The Group I (negative control) was given CMC 0.5%, Group II (positive control) was given diclofenac sodium 2,25 mg / kg BW, while Group III, IV and V were  given marbosi-bosi leaf extract at a dose of 50, 100 and 200 mg/kgBW respectively.  Each rat was induced by 1% carrageenan subplantar injection. Examination of antiinflammatory effect was measured by using digital plethysmometer at minute of 30 to minute of 360. The data were analyzed statistically using ANOVA (analysis of variance).The results showed that negative control did not show anti-inflammatory effect had significant differences with other treatment groups. In conclusion, ethanol extract marbosi-bosi (Tarenna polycarpa (Miq.) Koord Ex Valeton has an effective anti-inflammatory activity at a dose of 100 mg / kgBW.

scholarly journals GAMBARAN HISTOPATOLOGIK LAMBUNG TIKUS WISTAR SETELAH DIINDUKSI DENGAN ASPIRIN

2013 ◽  
Vol 5 (1) ◽  
Author(s):  
Poppy M Lintong ◽  
Lily L. Loho ◽  
Herman Anggran
Keyword(s):  
Lamina Propria ◽  
Food Pellet ◽  
Wistar Rat ◽  
Control Group ◽  
Group Iii ◽  
Group I ◽  
Microscopic Features ◽  
Anti Inflammatory ◽  
Group Ii ◽  
Normal Stomach

Abstract: Aspirin is one of the non-steroid-anti-inflammatory drugs. Its pharmacodynamic effects are as an analgesic, antipyretic, anti-inflammatory, anti-thrombotic, and uricosuric agent. The side effects of aspirin are on the respiratory tract, the gastrointestinal tract, blood, metabolic processes, endocrine functions, pregnancy, hypersensitivity, and drug interaction. The purpose of this study was to evaluate the macroscopic and microscopic features of wistar rat stomachs after the administration of aspirin. This was an experimental study, using nine wistar rats divided into three groups equally. Group I, the control group, was given a food pellet only. Group II was given the pellet, added with aspirin 21 mg daily for 10 days. Group I and Group II were terminated on day 11. Group III was given the pellet, added with aspirin 21 mg/day for 10 days, and was terminated on day 14. All the wistar rat stomachs were examined macroscopically and microscopically. The results showed that the control group had a macroscopically normal stomach architecture, and the mucosa layers and rugae were intact and looked pinkish white. The groups treated with aspirin still showed normal stomach architecture, and the mucosa layers and rugae were intact but looked more palid than that of the control group. Microscopically, the stomach walls of the control group were normal, but groups treated with aspirin for 10 days revealed edema of the lamina propria, dilatation of capillaries; and predominantly neutrophilic infiltration in the lamina propria. Ceasing of aspirin administration showed a resolution of the inflammatory process, marked by diminished infiltration of PMN cells and tisuue edema. Conclusion: Aspirin treatment of 21 mg a day for 10 days revealed histopathologically acute gastritis of the wistar rat stomach walls. The inflammatory reaction was diminished after the cessation of aspirin. Keywords: aspirin, histopathology, stomach.   Abstrak: Aspirin tergolong obat anti-inflamasi non-steroid (AINS) yang secara farmakodinamika mempunyai efek analgesik, anti-piretik, anti-inflamasi, anti-trombotik, dan urikosurik, namun mempunyai efek samping pada saluran  cerna terutama lambung. Penelitian ini bertujuan untuk mendapatkan gambaran histopatologik (makroskopik dan mikroskopik) lambung tikus Wistar setelah pemberian aspirin. Penelitian ini bersifat eksperimental dengan menggunakan sampel sembilan ekor tikus Wistar yang dibagi atas tiga kelompok. Kelompok I (kontrol) terdiri dari tiga ekor tikus yang diberi pelet biasa dan air minum. Kelompok II terdiri dari tiga ekor tikus yang diberi pelet biasa, air minum, dan aspirin dosis 21 mg/hari  selama 10 hari. Pada hari ke-11 kelompok I dan II diterminasi. Kelompok III terdiri dari tiga ekor tikus yang diberikan pelet biasa, air minum, dan aspirin dosis 21 mg/hari selama 10 hari, kemudian aspirin dihentikan dan tikus diterminasi pada hari ke-14. Setelah diterminasi, kelompok I-III diotopsi, diambil organ lambungnya, kemudian dilakukan pemeriksaan histopatologik. Hasil penelitian memperlihatkan makroskopik mukosa lambung tampak lebih pucat sedangkan mikroskopik menunjukkan tanda-tanda radang akut. Penghentian pemberian aspirin diikuti dengan resolusi reaksi inflamasi yang ditandai oleh penurunan infiltrasi sel-sel radang PMN dan edema jaringan. Sinpulan: Pemberian aspirin 21 mg/hari selama 10 hari mengakibatkan terjadinya gambaran histopatologik gastritis akut pada lambung tikus Wistar. Reaksi inflamasi menurun setelah penghentian pemberian aspirin. Kata kunci: aspirin, histopatologi, lambung.

scholarly journals APPLICATION OF OBJECTIVE AND SUBJECTIVE EVALUATION METHODS FOR MASTICATORY FUNCTION IN PATIENTS WITH MANDIBULAR OVERDENTURES

2020 ◽  
pp. 21-28
Author(s):  
R.R. Bratus-Hrynkiv ◽  
A.Yu. Kordiiak
Keyword(s):  
Oral Health ◽  
Health Indicators ◽  
Group Iii ◽  
Masticatory Function ◽  
Video Registration ◽  
Masticatory Efficiency ◽  
Group I ◽  
Interview Survey ◽  
Group Ii ◽  
Oral Health Indicators

Appropriate chewing function is an important indicator of oral health, and masticatory efficiency assessment is one of the most objective methods of prosthetic treatment quality control. In the globe dental practice, static and dynamic chewing tests are still considered to be the main methods of masticatory function assessment. Thus, there is an extension of functionally-oriented clinical investigations base, which actualizes the importance of this work. The aim of the work was to evaluate the masticatory function of patients that use mandibular overdentures by studying the results of physiological masticatory test and self-assessment indicators of dental health associated with the use of dentures. Materials and methods. The clinical trials were carried out in two stages. At the first stage upon informed consent an examination of 20 student volunteers aged 18-22 years (control group -I) and 36 patients -17 women, 19 men (aged 57-76 years) with complete mandibular removable dentures (comparison group -II) was proceeded. Patients of the group I underwent physiological masticatory test with agar-agar samples formed according to UMSA method, patients of group II- masticatory test procedure and interview survey. The second stage was performed by the group III–42 persons –23 women, 19 men (aged 56-89 years) at 1, 6 and 12 months after mandibular dental arch restoration with complete removable overdentures, fixed by spherical attachments. Chewing efficiency was determined using masticatory physiological test and problem-oriented questionnaires. Video registration by Nikon Digital Camera D3200 was used to determine chewing time, number of movements and peculiarities of the mastication process. All patients of groups II and III in personal interview survey answered 6 questions about indicators of oral health connected with the use of dentures. Questions were formed according to European Oral Health Indicators (2005). Statistical data analysis was performed by standard statistics variation methods with Statistica 6.0 Program use. Results and discussion. All the parameters of physiological masticatory test: duration of chewing, group I 25,3±2,8 sec. group II 67,3±3,7 sec., group III 60.5±3.5 sec, number of chewing movements in group I was 58.3±4,8, in group II − 82.3±6.3, in group III − 68.8±3,4, samples mass loss: group I − ≤0,13(4,3%), group II − ≤0,21(7,0%), group III − ≤0,18(5,9%). Diminution Index obtained: group I − 1.85±0.5, group II – 3.33±0.7, group III – 2.48±0.5). Masticatory efficiency level in patients of the group III prevailed over group II by the respective parameters. Masticatory test video registration data analysis showed that the patients of group I diminished test samples with bilateral chewing pattern, as the majority of group II patients, while patients in group II employed combined— uni- and bilateral chewing pattern. According to the average values of the expression of all oral health-related questionnaire indicators: chewing difficulties - 2.67 ± 1.35 vs 0.50 ± 0.20*; excessive bite closure efforts - 1.19 ± 0.65 vs 0.57 ± 0.30*; limited food consumption 2.83 ± 1.35 vs 0.59 ± 0.30*; oral lesions 2.39 ± 1.20 vs 0.56 ± 0.30*; difficulty non-chewing movements 2.14 ± 1.05 vs 0.51 ± 0.30*; uncertainty about reaching treatment goals 2.06 ± 1.10 vs 0.66 ± 0.30*. A statistically significant (p <0.05) difference in favor of group III was clearly demonstrated. Conclusions The results of physiological masticatory test and patients interview survey indicated favorable adaptation process to mandibular overdentures with reestablished masticatory function restoration during 12 months of use. Masticatory efficiency and oral health indicators, connected with dental prostheses usage proved the appropriate quality level of prosthetic treatment in mandibular single remaining teeth-attended patients, using dentures fixed by spherical attachments.

scholarly journals Prevention of inflammation, pain and loss of height of marginal bone tissue at the stage of dental implantation and direct prosthetics

2020 ◽  
Vol 104 (5) ◽  
pp. 36-43
Author(s):  
P. Leonenko ◽  
◽  
Yu. Kokoieva ◽  
Keyword(s):  
Bone Resorption ◽  
Bone Tissue ◽  
Dental Implant ◽  
Group Iii ◽  
Dental Implantation ◽  
Analgesic Therapy ◽  
Group I ◽  
Cox 2 ◽  
Anti Inflammatory ◽  
Group Ii

Summary. Inflammation and pain can lead not only to a deterioration in the patient’s condition, but also to such local consequences as: bone resorption, loss of soft tissue volume, an increase in the wound healing time and patient rehabilitation in general. Inflammation-induced bone resorption in the area of implantation with direct prosthetics, caused by the activity of cytokines and prostaglandins, negatively affects the entire result of treatment of dentition defects in general. This is because the quality and quantity of bone tissue is one of the key points in the success of prosthetics on dental implants, therefore, pharmacological support of dental implantation and direct prosthetics is an important component of treatment. Purpose: to investigate the effect of inflammation and pain on peri-implant bone tissue at the stages of dental implantation and direct prosthetics and scientifically substantiate pharmacological support in order to prevent inflammatory bone resorption. Materials and methods. A clinical prospective study of 57 patients was carried out at the stage of dental implantation and direct prosthetics with randomization according to the type of pharmacological accompaniment: 1) group I received anti-inflammatory therapy in the form of a balanced inhibitor of COX-1, COX-2 and 5-LOG – nimesulide and analgesic therapy – dexketaprofen trometamol; 2) group II received anti-inflammatory therapy – a selective COX-2 inhibitor – meloxicam and analgesic therapy – ibuprofen; 3) group III did not receive anti-inflammatory and analgesic therapy due to contraindications to the use of non-steroidal anti-inflammatory drugs. Patients of groups I, II, III underwent: clinical, radiological and functional research methods by monitoring the state in dynamics. Results. According to the data obtained, the indices of pain intensity in group I were significantly lower (p < 0.05) as of 1 and 2-d days, compared with groups II and III. The stabilization of inflammatory processes in group I was recorded on the 2-d day. There was a significant decrease (p < 0.05) in the signs of the inflammatory process in patients of group I on the 3rd day (3.01±0.11 units), and on the 7-th day – their complete absence (1.12±0.23 units). In group II, significant regression of inflammation was noted on the 4th day (3.14±0.12 units), and on the 7-th day, minimal signs were observed (2.04±0.17 units). A decrease in signs of inflammation in group III occurred from the 5th day (3.31±0.28 units), and inflammatory phenomena were observed on the 7th day of the study (2.65±0.27 units). In group I, there was a significant stop in the loss of stability of the connection between the bone tissue and the dental implant on the 20-th day (65.08±1.03 points). As of the 25-th day, in patients of group I of the study, there was significantly higher (p < 0.05) indicators of the coefficient of stability of the implant (66.21±1.40 points) in relation to group II of patients (62.93±0.94 points), in who used selective COX-2 inhibitors, and group III (62.90±0.75 points), where NSAID’s were not used. The loss of marginal bone around the dental implant during the study period in group I was 0.5±0.23 mm CI, in group II – 1.1±0.34 mm, in group III – 1.3±0.28 mm. Side effects in group I of the study were recorded in 5.3 % of patients taking drugs nimesulide and dexketoprofen, and in 15.8 % of those in group II who took drugs meloxicam and ibuprofen. Conclusions. Complex pharmacological support of dental implantation and direct prosthetics on implants in the treatment of dentition defects, consisting of perioperative analgesia – dexketoprofen trometamol, as well as nimesulide for anti-inflammatory therapy, made it possible to influence the trauma-induced bone resorption in the implantation area by controlling inflammation. As a result, on the 20-th day in the patients of the group I of the study, a significant stop was noted in the loss of stability of the connection of the bone tissue and the dental implant (65.08±1.03 units), and on the 25-th day of the study in the group I it was found significantly higher (p < 0.05) indicators of the coefficient of stability of the implant and less loss of height of marginal bone tissue in relation to groups II and III of patients. This pharmacological complex made it possible to achieve stabilization of pathological processes in soft tissues – stopping the formation of edema on the 2-d day, a significant decrease (p < 0.05) of signs of the inflammatory process on the 3-d day (3.01±0.11 points) and to implement effective pain prevention at the stages of dental implantation and direct prosthetics.

scholarly journals Effect of different irrigation porotocols on root dentine micro-hardness-An invitro study

2021 ◽  
Vol 6 (4) ◽  
pp. 217-221
Author(s):  
Ashish Choudhary ◽  
Sukhbir Kour ◽  
Azhar Malik
Keyword(s):  
Functional Performance ◽  
Test Group ◽  
Direct Consequence ◽  
Group Iv ◽  
Micro Hardness ◽  
Group Iii ◽  
Percentage Decrease ◽  
Group I ◽  
Significant Difference ◽  
Group Ii

IIrrigation solutions used and time of use has a definite effect on the micro hardness & other physical properties of dentin which in turn have direct consequence on the longevity functional performance of root canal treated teeth. To evaluate the effect of different irrigation solutions on micro hardness of root dentin.Forty extracted single rooted lower premolars were used. After instrumentation all the root halves were randomly assigned into 4groups (n=10) and brought in contact with one of the following irrigants for 5 minutes. Group I: 10 ml of 5% Sodium Hypochlorite (NaOCl).Group II: 10 ml of 17% ethylene diamine tetra-acetic acid (EDTA) followed by 10 ml of 5% NaOCl.Group III: 10 ml of 5% NaOCl followed by 10 ml of 2% chlorhexidine digluconate (CHX).Group IV: 10 ml of 5% NaOCL followed by flush of 10 ml distilled water then by 10ml of 2% CHX. Dentin micro hardness was measured at baseline and after treatment to determine the change in micro hardness, using Vickers tester.Data was analyzed using following parametric tests t-test, ANOVA test and Post Hoc test. Group II ie final irrigation with EDTA showed the highest percentage decrease in micro hardness values, followed by group III, then group IV and the lowest was group I. All groups showed a significant difference between each other (P &#60; 0.05), except group III and IV. The coronal third showed the highest percentage decrease with significant difference between apical and middle thirds (P &#60; 0.05).EDTA with NaOCl causes greatest changes in dentine micro hardness, an intermediate flush with normal saline should be given for prevention of precipitation with NaOCl & CHX.

scholarly journals Evaluation of Anti-Inflammatory Effect of Wedelolactone on Indomethacin Induced Colitis in Rats: Involvement of IL-6/STAT3 Pathway

2021 ◽  
Vol 12 (3) ◽  
pp. 2813-2825
Keyword(s):  
Disease Activity ◽  
Activity Index ◽  
Disease Activity Index ◽  
Group Iv ◽  
Rat Colon ◽  
Group Iii ◽  
Group I ◽  
Intestinal Immune System ◽  
Anti Inflammatory ◽  
Inflammatory Effect

The present study was carried out to study coumestan derivative wedelolactone in Indomethacin-induced enterocolitis in rats. Wistar rats were randomly divided into three groups containing six animals per group. Group I served as normal control. Group II, Group III & Group IV receive 7.5 mg/kg, s.c, indomethacin on two consecutive days. Group III and Group IV have received a wedelolactone dose of 50 mg/kg, and 100 mg/kg per oral, respectively, for 14 days after the induction with indomethacin. The protective effect was measured based on intestinal parameters of the disease activity index, colitis score, myeloperoxidase (MPO) activity in the colon. The inflammation biomarkers were quantified by ELISA in the rat colon. Further, activity was ascertained by histopathology. Pro-inflammatory functions IL-1a, IL-1b, IL-2, TNF, INFγ, STAT3, and CCL-5 play an important role in the variation of the intestinal immune system. Wedelolactone showed significantly decreased Disease activity index, Colitis score, Myeoloperoxidase activity. Expression of pro-inflammatory was increased in indomethacin-induced groups and was significantly suppressed in animals administered with wedelolactone at 50 mg/kg & 100 mg/kg dose (p<0.01 & p<0.001). Histological reports also revealed that treated groups have comparatively less damage than that of the induced groups. We concluded that wedelolactone showed an anti-inflammatory effect by downregulation of the IL-6/STAT3 inflammatory signaling pathway and the equilibrium production of pro-inflammatory cytokines.

scholarly journals Anti-inflammatory Effect of cream and ointment from 2,5- bis- (4-Nitrobenzilidine) cyclopentanoneagainst Edema in Mice Induced by Formalin

2016 ◽  
Vol 1 (2) ◽  
pp. 102
Author(s):  
Paulina Maya Octasari ◽  
Fransiska Ayuningtyas
Keyword(s):  
Group Iv ◽  
Test Statistics ◽  
Inflammatory Drug ◽  
Group Iii ◽  
Group I ◽  
Ointment Base ◽  
Gastrointestinal Side Effects ◽  
Anti Inflammatory ◽  
Topical Dosage ◽  
Inflammatory Effect

Cream<span style="text-decoration: line-through;">s </span>and ointment<span style="text-decoration: line-through;">s</span> are topical dosage forms used in the manufacture of drugs. Topical anti-inflammatory drug is a solution to problems of gastrointestinal side effects caused by taking nonsteroidal anti-inflammatory drug orally. The compound 2,5-bis (4-nitrobenzilidine) cyclopentanone is an analog of curcumin which has better anti-inflammatory activity than curcumin. This study aimed to determine the antiinflammatory effect of cream and ointment from 2,5-bis (4-nitrobenzilidine) cyclopentanoneagainst edema in mice induced by formalin. This research were experimental randomized complete design using a single factor. Twenty mice were divided into 4 groups: group I were given a cream base, the group II were given ointment base, group III were given cream compound 0.25% and group IV were given ointment compound 0.25%. The data were processed into AUC values and the percentage of anti-inflammatory effectwere calculated. Results were analyzed using ANOVA and T-test statistics. The results showed that between the dosage form had statistically difference of anti-inflammatory effect (p&lt;0.05). The ointmentshowed a greater value of antiinflammatory activity rather than cream.

scholarly journals Antiinflammatory therapy of neurotrophic corneal diseases

2019 ◽  
Vol 12 (4) ◽  
pp. 77-82
Author(s):  
E. V. Yani ◽  
E. N. Orlova ◽  
V. A. Golikova
Keyword(s):  
Combined Treatment ◽  
Eye Drops ◽  
Test Results ◽  
Antiinflammatory Therapy ◽  
Group Iii ◽  
Group I ◽  
New Directions ◽  
Neurotrophic Keratitis ◽  
Anti Inflammatory ◽  
Group Ii

Clinical data on new directions in combined treatment of neurotrophic keratitis, including anti-inflammatory therapy are presented.Purpose. To compare the effectiveness of bromfenac 0.09 %, nepafenac 0.1 % and indomethacin 0.1 % eye drops in the treatment of neurotrophic keratitis (NK).Materials and methods. 22 NK patients, aged 34 to 78, were divided into three groups. Group I received bromfenac 0.09 %, group II, nepafenac 0.1 %, and group III, indomethacin 0.1 %. Ophthalmic tests included visometry, biomicroscopy, corneal sensitivity determination, as well as diagnostic tests to determine indicators of tear production (Schirmer test, Norn test, LIPCOF test), and measuring lacrimal meniscus height.Results. Between visits V2 and V3, patients of group III showed an increase in conjunctival irritation to an average of 2.3 points, while groups I and II revealed the condition of the conjunctiva at 0.9 and 1.1 points, respectively. The lesion area was evaluated in points (max = 20) and averaged on V1 6.8 points in group I, 5.9 points in group II and 7.2 points in group III. Keratopathy in group I which was estimated at 3.8 points before V2, dropped to 1.4 points by V3. In group III it was 1.7 points by V3. In group II, keratopathy showed only 4.1 points by V3. The average Norn test on the day of treatment showed 2.7 seconds in group I, 2.5 seconds in group II, and 3.1 seconds in group III. No significant increase in Schirmer's test results in all groups was recorded.Conclusion. The use of non-steroidal anti-inflammatory eye drops of various groups — bromfenac 0.09%, nepafenac 0.1 % and indomethacin 0.1 % — gave a positive result in NK therapy. However, bromfenac 0.09% instillations administered once a day produce a higher anti-inflammatory effect then the same quantity of nepafenac 0.1% and indomethacin 0.1 % instillations.

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