scholarly journals Synthetic Polymers for Organ 3D Printing

Polymers ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 1765
Author(s):  
Fan Liu ◽  
Xiaohong Wang
Keyword(s):  
3D Printing ◽  
Degradation Products ◽  
Three Dimensional ◽  
Synthetic Polymers ◽  
Precise Control ◽  
Chemical Structures ◽  
Degradation Rates ◽  
Organ Printing ◽  
Printing Processes ◽  
Controllable Degradation

Three-dimensional (3D) printing, known as the most promising approach for bioartificial organ manufacturing, has provided unprecedented versatility in delivering multi-functional cells along with other biomaterials with precise control of their locations in space. The constantly emerging 3D printing technologies are the integration results of biomaterials with other related techniques in biology, chemistry, physics, mechanics and medicine. Synthetic polymers have played a key role in supporting cellular and biomolecular (or bioactive agent) activities before, during and after the 3D printing processes. In particular, biodegradable synthetic polymers are preferable candidates for bioartificial organ manufacturing with excellent mechanical properties, tunable chemical structures, non-toxic degradation products and controllable degradation rates. In this review, we aim to cover the recent progress of synthetic polymers in organ 3D printing fields. It is structured as introducing the main approaches of 3D printing technologies, the important properties of 3D printable synthetic polymers, the successful models of bioartificial organ printing and the perspectives of synthetic polymers in vascularized and innervated organ 3D printing areas.

scholarly journals Polymeric Bioinks for 3D Hepatic Printing

Chemistry ◽  
2021 ◽  
Vol 3 (1) ◽  
pp. 164-181
Author(s):  
Joyita Sarkar ◽  
Swapnil C. Kamble ◽  
Nilambari C. Kashikar
Keyword(s):  
Tissue Engineering ◽  
3D Printing ◽  
Soft Tissues ◽  
Three Dimensional ◽  
Stem Cell Differentiation ◽  
Synthetic Polymers ◽  
Bioactive Molecules ◽  
Complex Geometries ◽  
Printing Techniques ◽  
Natural And Synthetic

Three-dimensional (3D) printing techniques have revolutionized the field of tissue engineering. This is especially favorable to construct intricate tissues such as liver, as 3D printing allows for the precise delivery of biomaterials, cells and bioactive molecules in complex geometries. Bioinks made of polymers, of both natural and synthetic origin, have been very beneficial to printing soft tissues such as liver. Using polymeric bioinks, 3D hepatic structures are printed with or without cells and biomolecules, and have been used for different tissue engineering applications. In this review, with the introduction to basic 3D printing techniques, we discuss different natural and synthetic polymers including decellularized matrices that have been employed for the 3D bioprinting of hepatic structures. Finally, we focus on recent advances in polymeric bioinks for 3D hepatic printing and their applications. The studies indicate that much work has been devoted to improvising the design, stability and longevity of the printed structures. Others focus on the printing of tissue engineered hepatic structures for applications in drug screening, regenerative medicine and disease models. More attention must now be diverted to developing personalized structures and stem cell differentiation to hepatic lineage.

scholarly journals Embracing 3D Printing

2015 ◽  
Vol 137 (08) ◽  
pp. 42-45
Author(s):  
Mike Vasquez
Keyword(s):  
3D Printing ◽  
Three Dimensional ◽  
Product Line ◽  
Three Dimensional Objects ◽  
Clear Vision ◽  
Materials Used ◽  
Save Energy ◽  
High Level ◽  
Printing Processes ◽  
Lower Material

This article reviews the challenges for companies while adopting three-dimensional (3D) printing technology. A big challenge for companies figuring out whether they need to invest in 3-D printing is the different types of printing systems available in the market. At a high level, there are seven different families of 3-D printing processes. Each of the seven technologies is differentiated by the materials used and how the materials are fused together to create three-dimensional objects. Another barrier is that most companies have not yet found it viable to put the processes in place to incorporate the change in design, engineering, and manufacturing production that is required. Not only capital funds are needed to purchase machines, but to effectively use the technology to create a sellable product, one also needs to have a targeted product line and clear vision of the ways that 3-D printing can help lower material costs, save energy, and simplify manufacturing and assembly.

scholarly journals Polymers for Extrusion-Based 3D Printing of Pharmaceuticals: A Holistic Materials–Process Perspective

Pharmaceutics ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 124 ◽  
Author(s):  
Mohammad A. Azad ◽  
Deborah Olawuni ◽  
Georgia Kimbell ◽  
Abu Zayed Md Badruddoza ◽  
Md. Shahadat Hossain ◽  
...  
Keyword(s):  
3D Printing ◽  
Fused Deposition Modeling ◽  
Three Dimensional ◽  
Active Pharmaceutical Ingredient ◽  
Dosage Forms ◽  
Polymer Mixtures ◽  
Compression Process ◽  
Fused Deposition ◽  
Process Perspective ◽  
Printing Processes

Three dimensional (3D) printing as an advanced manufacturing technology is progressing to be established in the pharmaceutical industry to overcome the traditional manufacturing regime of 'one size fits for all'. Using 3D printing, it is possible to design and develop complex dosage forms that can be suitable for tuning drug release. Polymers are the key materials that are necessary for 3D printing. Among all 3D printing processes, extrusion-based (both fused deposition modeling (FDM) and pressure-assisted microsyringe (PAM)) 3D printing is well researched for pharmaceutical manufacturing. It is important to understand which polymers are suitable for extrusion-based 3D printing of pharmaceuticals and how their properties, as well as the behavior of polymer–active pharmaceutical ingredient (API) combinations, impact the printing process. Especially, understanding the rheology of the polymer and API–polymer mixtures is necessary for successful 3D printing of dosage forms or printed structures. This review has summarized a holistic materials–process perspective for polymers on extrusion-based 3D printing. The main focus herein will be both FDM and PAM 3D printing processes. It elaborates the discussion on the comparison of 3D printing with the traditional direct compression process, the necessity of rheology, and the characterization techniques required for the printed structure, drug, and excipients. The current technological challenges, regulatory aspects, and the direction toward which the technology is moving, especially for personalized pharmaceuticals and multi-drug printing, are also briefly discussed.

Application of Additive Technologies for Manufactoring Non-Electronic Components of Microsystems

2021 ◽  
Vol 23 (4) ◽  
pp. 193-200
Author(s):  
N.K. Tolochko ◽  
Keyword(s):  
3D Printing ◽  
Three Dimensional ◽  
Typical Feature ◽  
Additive Technologies ◽  
Electronic Components ◽  
Printing Processes ◽  
Near Future

It is problematic to apply traditional microtechnologies for the manufacturing three-dimensional (3D) components of microsystems due to a number of inherent disadvantages. It is much more promising to use additive technologies for these purposes. In present paper various additive technologies used for manufacturing non-electronic components of microsystems as well as various non-electronic components manufactured using these technologies are considered. The peculiarities of the implementation of additive technologies in the manufacture of non-electronic microcomponents are discussed. More than 20 types of additive technologies characterized by different principles for the implementation of 3D printing processes are presented and their brief description is given. Most of these technologies allow manufacturing the components with micrometer feature sizes and some of them — with nanometer feature sizes. Microcomponents produced by additive technologies are intended for use in micromechanics, microoptics and microfluidics. Many examples of such microcomponents are given with indication of their typical feature sizes. Additive technologies make it possible to create both individual parts of microdevices and completely finished micro-devices. Microcomponents are mainly made from photopolymers and thermoplastics, as well as metals. Among additive technologies those that provide the multi-material 3D printing as well as the embedding of discrete components into printed microdevices are especially promising. It is expected that in near future additive technologies will be widely used in the production of various non-electronic components of microsystems.

Fabrication of nanocellulose/PEGDA hydrogel by 3D printing

2018 ◽  
Vol 24 (8) ◽  
pp. 1265-1271 ◽  
Author(s):  
Aimin Tang ◽  
Qinwen Wang ◽  
Shan Zhao ◽  
Wangyu Liu
Keyword(s):  
Additive Manufacturing ◽  
3D Printing ◽  
3D Structure ◽  
Three Dimensional ◽  
Aqueous Dispersion ◽  
Compression Modulus ◽  
Content Type ◽  
Precise Control ◽  
Light Curing ◽  
Equilibrium Swelling Ratio

Purpose Nanocellulose is characterised by favourable biocompatibility, degradability, nanostructure effect, high modulus and high tensile strength and has been widely applied in various fields. The current research in the field of new nanocellulose materials mainly focuses on the hydrogel, aerogel and the tissue engineering scaffold. All of these are three-dimensional (3D) porous materials, but conventional manufacturing technology fails to realise precise control. Therefore, the method of preparing structural materials using 3D printing and adopting the nanocellulose as the 3D printing material has been proposed. Then, how to realise 3D printing of nanocellulose is the problem that should be solved. Design/methodology/approach By adding the photosensitive component polyethyleneglycol diacrylate (PEGDA) in the aqueous dispersion system of nanocellulose, the nanocellulose was endowed with photosensitivity. Then, nanocellulose/PEGDA hydrogels were prepared by the additive manufacturing of nanocellulose through light curing. Findings The results showed that the nanocellulose/PEGDA hydrogels had a uniform shape and a controllable structure. The nanocellulose supported the scaffold structure in the hydrogels. Prepared with 1.8 per cent nanocellulose through 40 s of light curing, the nanocellulose/PEGDA hydrogels had a maximum compression modulus of 0.91 MPa. The equilibrium swelling ratio of the nanocellulose/PEGDA hydrogel prepared with 1.8 per cent nanocellulose was 13.56, which increased by 44 per cent compared with that of the PEGDA hydrogel without nanocellulose. Originality/value The paper proposed a method for rapidly prototyping the nanocellulose with expected properties, which provided a theoretical basis and technological reference for the 3D additive manufacturing of nanocellulose 3D structure materials with a controlled accurate architecture.

A Parallel Multiple Layer Cryolithography Device for the Manufacture of Biological Material for Tissue Engineering

2019 ◽  
Vol 13 (3) ◽  
Author(s):  
Gideon Ukpai ◽  
Joseph Sahyoun ◽  
Robert Stuart ◽  
Sky Wang ◽  
Zichen Xiao ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Additive Manufacturing ◽  
3D Printing ◽  
3D Structure ◽  
Three Dimensional ◽  
3D Object ◽  
New Device ◽  
Biological Matter ◽  
Simple Product ◽  
Printing Processes

While three-dimensional (3D) printing of biological matter is of increasing interest, current linear 3D printing processes lack the efficiency at scale required to mass manufacture products made of biological matter. This paper introduces a device for a newly developed parallel additive manufacturing technology for production of 3D objects, which addresses the need for faster, industrial scale additive manufacturing methods. The technology uses multilayer cryolithography (MLCL) to make biological products faster and in larger quantities by simultaneously printing two-dimensional (2D) layers in parallel and assembling the layers into a 3D structure at an assembly site, instead of sequentially and linearly assembling a 3D object from individual elements as in conventional 3D printing. The technique uses freezing to bind the 2D layers together into a 3D object. This paper describes the basic principles of MLCL and demonstrates the technology with a new device used to manufacture a very simple product that could be used for tissue engineering, as an example. An evaluation of the interlayer bonding shows that a continuous and coherent structure can be made from the assembly of distinct layers using MLCL.

Manufacturability Feedback and Model Correction for Additive Manufacturing

2014 ◽  
Author(s):  
Saigopal Nelaturi ◽  
Walter Kim ◽  
Arvind Rangarajan ◽  
Tolga Kurtoglu
Keyword(s):  
Additive Manufacturing ◽  
3D Printing ◽  
Medial Axis ◽  
Three Dimensional ◽  
Medial Axis Transform ◽  
Specific Design ◽  
Model Correction ◽  
Geometric Deviations ◽  
Physical Limitations ◽  
Printing Processes

Additive manufacturing, or 3d printing, is the process of building three dimensional solid shapes by accumulating material laid out in sectional layers. Additive manufacturing has been recognized for enabling production of complex custom parts that are difficult to manufacture otherwise. However, the dependence on build orientation and physical limitations of printing processes invariably lead to geometric deviations between manufactured and designed shapes that are usually evaluated after manufacture. In this paper, we formalize the measurement of such deviations in terms of a printability map that simulates the printing process and partitions each printed layer into disjoint regions with distinct local measures of size. We show that manufacturing capabilities such as printing resolution, and material specific design recommendations such as minimal feature sizes may be coupled in the printability map to evaluate expected deviations before manufacture. Furthermore, we demonstrate how partitions with size measures below required resolutions may be modified using properties of the medial axis transform, and use the corrected printability map to construct a representation of the manufactured model. We conclude by discussing several applications of the printability map for additive manufacturing.

scholarly journals Three dimensional (3D) printing

2020 ◽  
Author(s):  
Paweł Fiedor ◽  
Joanna Ortyl
Keyword(s):  
3D Printing ◽  
Liquid Crystal Display ◽  
Three Dimensional ◽  
Digital Light Processing ◽  
3 Dimensional ◽  
3D Objects ◽  
Conscious Choice ◽  
Optical Applications ◽  
Manufacturing Technologies ◽  
Printing Processes

The following article introduces technologies that build 3 dimensional (3D) objects by adding layer-upon-layer of material, called also additive manufacturing technologies.  Furthermore most important features supporting the conscious choice of 3D printing methods for applications in micro and nanomanufacturing were covered. The micromanufacturing method covers photopolymerisation based methods such as Stereolithography (SLA), Digital Light Processing (DLP), Liquid Crystal Display – DLP coupled method, Two-Photon Polymerisation (TPP) and Inkjet based methods. Functional photocurable materials, with magnetic, conductive or specific optical applications in the 3D printing processes were also reviewed. 

scholarly journals Powder-Based 3D Printing for the Fabrication of Device with Micro and Mesoscale Features

Micromachines ◽  
2020 ◽  
Vol 11 (7) ◽  
pp. 658 ◽  
Author(s):  
Seow Yong Chin ◽  
Vishwesh Dikshit ◽  
Balasankar Meera Priyadarshini ◽  
Yi Zhang
Keyword(s):  
3D Printing ◽  
Medical Devices ◽  
Three Dimensional ◽  
High Accuracy ◽  
Printing Technology ◽  
Comprehensive Review ◽  
3D Printing Technology ◽  
Wide Range ◽  
Strong Candidate ◽  
Printing Processes

Customized manufacturing of a miniaturized device with micro and mesoscale features is a key requirement of mechanical, electrical, electronic and medical devices. Powder-based 3D-printing processes offer a strong candidate for micromanufacturing due to the wide range of materials, fast production and high accuracy. This study presents a comprehensive review of the powder-based three-dimensional (3D)-printing processes and how these processes impact the creation of devices with micro and mesoscale features. This review also focuses on applications of devices with micro and mesoscale size features that are created by powder-based 3D-printing technology.

Rheological Analysis of Low Viscosity Hydrogels for 3D Bio-Printing Processes

2021 ◽  
Author(s):  
Slesha Tuladhar ◽  
Cartwright Nelson ◽  
Md Ahasan Habib
Keyword(s):  
Mechanical Properties ◽  
3D Printing ◽  
Structural Integrity ◽  
Synthetic Polymers ◽  
Solid Content ◽  
Rheological Analysis ◽  
Low Viscosity ◽  
Steady Rate ◽  
Proper Design ◽  
Printing Processes

Abstract Following the success of 3D printing with synthetic polymers like ABS, FLA, Nylon, etc., scientists and researchers have been putting efforts into fabricating bio-compatible materials. It has not only broadened the field of bioengineering and manufacturing but also regenerative medicine. Unlike the traditional 3D printing process, additive bio-manufacturing, also known as 3D bio-printing has a lot of challenges like cell survivability and proliferation, and the mechanical properties of the biomaterials which involve printability and the ability to hold its structural integrity. Proper design of experiments with extensive rheological investigation can help identify useful mechanical property ranges which are directly related to the geometric fidelity of 3D bio-printed scaffolds. Therefore, to investigate the printability of a low viscosity Alginate-Carboxymethyl Cellulose (CMC), multiple concentrations of the mixture were tested maintaining a 8% (w/v) solid content. A set of rheological tests such as the Steady Rate Sweep Test, Three Point Thixotropic Test (3ITT), and Amplitude test were performed. The outcome of those tests showed that the rheological properties can be controlled with the percentage of CMC in the mixtures. The fabricated filaments and scaffolds in the 5 combinations of CMC percentages were analyzed for flowability and shape fidelity. The rheological results and the printability and shape fidelity results were analyzed.

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