scholarly journals Diabetic Fetopathy As an Outcome of Manifest Diabetes Mellitus First Detected During Pregnancy

2020 ◽  
Vol 16 (26) ◽  
pp. 44-49
Author(s):  
M.I. Sviridova ◽  
◽  
N.M. Startsevа ◽  
N.P. Romm ◽  
O.A. Ulyanova ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Neurological Disorders ◽  
Metabolic Disorders ◽  
Clinical Case ◽  
Morphological Changes ◽  
Heart Hypertrophy ◽  
Endocrine Diseases ◽  
High Risk Factors ◽  
Different Types ◽  
Left And Right

The article presents a clinical case of diabetic fetopathy in a newborn from a mother with diabetes mellitus, which manifested itself not only by phenotypic disorders, but also by morphological changes in the heart – hypertrophy of the left and right ventricles with obstruction of the outflow parts of the heart, the development of respiratory, heart failure, and neurological disorders. Disorder of carbohydrate metabolism in a patient with high risk factors for metabolic disorders, which was not detected in time, and the refusal of the necessary treatment led to the need to treat the newborn in the intensive care unit. The frequency of occurrence of diabetic fetopathy in different types of diabetes mellitus was shown on the basis of data from the Center for Endocrine Diseases of Pregnant Women on the basis of GKB No. 29

DIABETES IN A CAT

2021 ◽  
Author(s):  
N.I. Kulmakova ◽  
Keyword(s):  
Diabetes Mellitus ◽  
Clinical Case ◽  
Endocrine Diseases

The article describes a clinical case of diabetes mellitus in a cat. Currently, diabetes mellitus is the most frequently reported disease among all endocrine diseases. To a greater extent, it is susceptible to high-aged castrated animals, but patients are often found among young animals.

scholarly journals Correction of Metabolic Disorders in Patients with Pancreatic Cancer

2020 ◽  
Vol 16 (24) ◽  
pp. 84-90
Author(s):  
K.A. Nikolskaya ◽  
◽  
T.N. Kuzmina ◽  
Ye.A. Dubtsova ◽  
M.A. Kiryukova ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Pancreatic Cancer ◽  
Surgical Treatment ◽  
Nutritional Status ◽  
Metabolic Disorders ◽  
Clinical Case ◽  
Pancreatic Insufficiency ◽  
Resectable Pancreatic Cancer ◽  
Pancreatogenic Diabetes ◽  
Before And After

Presented the case of complex examination of a patient with pancreatic cancer using a bioimpedance method for assessing the nutritional status before and after surgical treatment. Provided the literature data related to this problem. The presented clinical case demonstrates the features of correction of the nutritional status of a patient with conditionally resectable pancreatic cancer in conditions of cholestasis, severe external pancreatic insufficiency and pancreatogenic diabetes mellitus on the background of constitutional obesity

Clinical, morphological and biochemical signs of polymycotoxicosis in highly productive cows

2020 ◽  
pp. 14-17
Author(s):  
Irina A. Shkuratova ◽  
◽  
Lyudmila I. Drozdova ◽  
Aleksander I. Belousov ◽  
Keyword(s):  
Metabolic Disorders ◽  
Hepatorenal Syndrome ◽  
Morphological Changes ◽  
Clinical Manifestations ◽  
The Body ◽  
Feed Mixture ◽  
Milk Productivity ◽  
Structural Disorders ◽  
Increased Sensitivity ◽  
Penicillium Spp

Mycotoxicological monitoring of forages shows that the problem of mycotoxicosis has been relevant for several decades. Minimal doses of mycotoxins in feed lead to a decrease in milk productivity, increased sensitivity to infectious and non-infectious diseases. When several mycotoxins enter the body simultaneously, a synergistic effect develops, causing a significant increase in toxicity. Feed contaminated with several types of fungi and their toxins is dangerous for dairy cattle. It was found that the feed mixture contained the types of associations of Aspergillus spp. fungi + Fusarium; Aspergillus spp. + Penicillium spp. + Mucor spp; Fusarium + Penicillium; Mucor spp. + Fusarium + Ustilaginales. Pathogenetic features of metabolic and morphological changes in highly productive cows with polymycotoxicosis were studied. Feeding food contaminated with various metabolites of mold fungi leads to the development of signs of chronic toxemia in animals. Clinical manifestations are the development of diarrhea and dehydration, with a decrease in milk productivity. Metabolic disorders feature the development of an inflammatory process, metabolic acidosis, hyperfermentonemia, with an increase in the amount of creatinine and urea in the blood serum. Metabolic signs indicate the development of hepatorenal syndrome due to structural disorders of the liver and kidneys. Histological signs of polymicotoxicosis are intracapillary and hemorrhagic glomerulonephritis, hepatocyte micronecrosis, and proliferation of connective tissue stroma cells, which leads to the development of atrophic cirrhosis in the interstitial and circular phases.

DIFFICULTIES IN DIAGNOSING MOYA-MOYA DISEASE (CLINICAL CASE)

2020 ◽  
pp. 48-53
Author(s):  
Novikova I.N. ◽  
Popova T.F. ◽  
Gribacheva I.A. ◽  
Petrova E.V. ◽  
Marushchak A.A. ◽  
...  
Keyword(s):  
Cerebral Angiography ◽  
Neurological Disorders ◽  
Clinical Case ◽  
Carotid Arteries ◽  
Internal Carotid ◽  
Cerebral Arteries ◽  
Moya Moya Disease ◽  
Middle Cerebral Arteries ◽  
Internal Carotid Arteries ◽  
Made In

Moya-Moya disease is a rare progressive chronic cer-ebrovascular disease characterized by a narrowing of the lumen of the intracranial segments of the internal carotid arteries, as well as the initial segments of the anterior and middle cerebral arteries with the devel-opment of a network of small vascular anastomoses. Violations of blood supply due to occlusion lead to the development of ischemic strokes in the correspond-ing pools, and ruptures of vascular anastomoses - to the development of hemorrhagic strokes, causing a variety of neurological disorders. The article presents a clinical case of Moya-Moya disease in a 31-year-old patient. The disease was manifested by acute disorders of cerebral circulation in ischemic and hemorrhagic types. The diagnosis was made in accordance with the diagnostic criteria of the disease based on the data of endovascular cerebral angiography.

scholarly journals The Relationship between the Gut Microbiome and Metformin as a Key for Treating Type 2 Diabetes Mellitus

2021 ◽  
Vol 22 (7) ◽  
pp. 3566
Author(s):  
Chae Bin Lee ◽  
Soon Uk Chae ◽  
Seong Jun Jo ◽  
Ui Min Jerng ◽  
Soo Kyung Bae
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glucose Metabolism ◽  
Gut Microbiome ◽  
Metabolic Disorders ◽  
Current Knowledge ◽  
Potential Target ◽  
The Relationship

Metformin is the first-line pharmacotherapy for treating type 2 diabetes mellitus (T2DM); however, its mechanism of modulating glucose metabolism is elusive. Recent advances have identified the gut as a potential target of metformin. As patients with metabolic disorders exhibit dysbiosis, the gut microbiome has garnered interest as a potential target for metabolic disease. Henceforth, studies have focused on unraveling the relationship of metabolic disorders with the human gut microbiome. According to various metagenome studies, gut dysbiosis is evident in T2DM patients. Besides this, alterations in the gut microbiome were also observed in the metformin-treated T2DM patients compared to the non-treated T2DM patients. Thus, several studies on rodents have suggested potential mechanisms interacting with the gut microbiome, including regulation of glucose metabolism, an increase in short-chain fatty acids, strengthening intestinal permeability against lipopolysaccharides, modulating the immune response, and interaction with bile acids. Furthermore, human studies have demonstrated evidence substantiating the hypotheses based on rodent studies. This review discusses the current knowledge of how metformin modulates T2DM with respect to the gut microbiome and discusses the prospect of harnessing this mechanism in treating T2DM.

Sign in / Sign up

Export Citation Format

Share Document