scholarly journals PERBANDINGAN UJI EFEKTIVITAS EKSTRAK BENGKUANG (PACHYRIZUS AROSUS) DAN DAUN SIRIH HIJAU (PIPER BETLE L.) TERHADAP BAKTERI PROPIONIBACTERIUM ACNES

2021 ◽  
Vol 4 (1) ◽  
pp. 60-68
Author(s):  
I Nyoman Ehrich Lister
Keyword(s):  
Young Adults ◽  
Propionibacterium Acnes ◽  
Acne Vulgaris ◽  
Adolescents And Young Adults ◽  
Piper Betle ◽  
Gram Positive ◽  
Betel Leaf ◽  
Gram Positive Bacteria

Propionibacterium acnes is a gram-positive bacteria and consists of the Propionibacteriaceae family. Propionibacterium acnes is a bacteria that causes acne or acne vulgaris, a disease that is quite disturbing and gets the attention that occurs in adolescents and young adults. This research aimed to compare and determine the effectiveness of the extract of yam (Pachyrizus arosus) and green betel leaf (Piper betle L.) in inhibiting the growth of Propionibacterium acnes bacteria. The research variables were concentrations of yam extract (Pachyrizus arosus) 5%, 10%, 15%, 20% and green betel leaf (Piper betle L.) 1,5%, 3%, 5%, 7,5%. The results showed that there was an inhibiting zone against the growth of Propionibacterium acnes bacteria.

scholarly journals The Effectiveness Test of Betel Leaf Ethanol Extract Cream (Piper Betle Linn) Toward Propionibacterium acnes Bacterial Growth

2020 ◽  
Vol 4 (2) ◽  
pp. 10-17
Author(s):  
Resva Meinisasti ◽  
Zamharira Muslim ◽  
Krisyanella ◽  
Raden Sunita
Keyword(s):  
Antibacterial Activity ◽  
Active Substance ◽  
Propionibacterium Acnes ◽  
Skin Diseases ◽  
Acne Vulgaris ◽  
Ethanol Extract ◽  
Diffusion Method ◽  
Piper Betle ◽  
Betel Leaf ◽  
Acne Treatment

Background: One of skin diseases that is frequently taking attention among teenagers and young adults is acne or in medical term called acne vulgaris. Acne treatment can be treated by repairing follicular abnormalities, decreasing sebum production, decreasing the number of Propionibacterium acnes colonies and reducing inflammation of the skin. The bacterial population of Propionibacterium acnes can be reduced by giving an antibacterial substance such as erythromycin, clindamycin and benzoyl peroxide. In the treatment of acne we can get antibacterial originating from nature, one of which can be obtained in the secondary metabolism of plants. The extracts and essential oils of betel leaf contain antibacterial and antifungal activities. The effectiveness of the use of betel leaf ethanol extract (Piper betle Linn) in acne treatment can be improved by creating formulations in form of cream preparations. Formulations in cream preparations will affect the amount and speed of active substances that can be absorbed. Objectives: To determine the effectiveness of the ethanol extract cream of betel leaf (piper betle linn) cream in formulas with what percentage of active substance has the most-inhibitory effect on the growth of Propionibacterium acnes. Methods:The study used experimental research. Propionibacterium acnes samples were diluted in 0.9% physiological NaCl sterile and embedded in Nutrient Agar (NA) media. The media was inserted into an incubator at 37 ° C for 24 hours. The test of antibacterial activity used the disk diffusion method. The antibacterial activity test results were statistically analyzed using the Statistical Product Services Solution (SPSS 17) program with a confidence level of 95% (α = 0.05). Results: The three creams containing betel leaf ethanol extracts at percentages of 5%, 10% and 15% for each had inhibitory zones: 9.8 mm, 15.85 mm, 17.35 mm. Conclusion: Cream that contains 15% active substance has the strongest inhibition.

scholarly journals Prevalence of the Genus Propionibacterium in Primary and Persistent Endodontic Lesions: A Systematic Review

2020 ◽  
Vol 9 (3) ◽  
pp. 739 ◽  
Author(s):  
Mario Dioguardi ◽  
Mario Alovisi ◽  
Vito Crincoli ◽  
Riccardo Aiuto ◽  
Giancarlo Malagnino ◽  
...  
Keyword(s):  
Systematic Review ◽  
Propionibacterium Acnes ◽  
Meta Analysis ◽  
Secondary Outcome ◽  
Exclusion Criteria ◽  
Gram Positive ◽  
Gram Positive Bacteria ◽  
Endodontic Infections ◽  
Outcome Differences ◽  
Present Systematic Review

Propionibacterium are anaerobic/aero-tolerant rod Gram-positive bacteria, and numerous studies are associated with primary and secondary endodontic infections. The data in the literature on the prevalence of Propionibacterium are conflicting, and there are studies that report conflicting data on the prevalence in primary and secondary endodontic infections. This review aims to clarify the prevalence of bacteria of the genus Propionibacterium in endodontic lesions. The present systematic review work was performed on the basis of the Prisma protocol. A search was carried out on the PubMed and Scopus databases with the use of keywords. The research produced 410 records, which, after the elimination of the overlaps and the application of the inclusion and exclusion criteria, led to a number of 36 included articles divided by the three outcomes. The first outcome concerns prevalence of bacteria of the genus Propionibacterium in primary and secondary endodontic lesions. The secondary outcome, differences in the prevalence of bacteria of the genus Propionibacterium between primary endodontic infections and secondary endodontic infections. The tertiary outcome, differences in the prevalence of Propionibacterium Acnes compared to Propionibacterium propionicum in endodontic infections. The results of the meta-analysis show that the genus Propionibacterium bacteria are more prevalent in secondary endodontic infections and that P. acnes has a higher prevalence than P. propionicum.

scholarly journals The Epidemiology of Acne Vulgaris among Adolescents and Young Adults in Jordan University Hospital

2020 ◽  
Vol 10 (04) ◽  
pp. 353-366
Author(s):  
Ruba M. Jaber ◽  
Basma M. Alnshash ◽  
Suzan N. Mousa ◽  
Hanan S. Fayoumi ◽  
Lana M. Al-Qaderi ◽  
...  
Keyword(s):  
Young Adults ◽  
Acne Vulgaris ◽  
Adolescents And Young Adults ◽  
University Hospital

scholarly journals Draft Genome Sequences of Two Propionibacterium acnes Strains Isolated from Progressive Macular Hypomelanosis Lesions of Human Skin

2015 ◽  
Vol 3 (6) ◽  
Author(s):  
Rolf Petersen ◽  
Hans B. Lomholt ◽  
Christian F. P. Scholz ◽  
Holger Brüggemann
Keyword(s):  
Human Skin ◽  
Propionibacterium Acnes ◽  
Acne Vulgaris ◽  
Draft Genome ◽  
Skin Lesions ◽  
Skin Disorders ◽  
Genome Sequences ◽  
Positive Bacterium ◽  
Gram Positive ◽  
Type Iii

Propionibacterium acnes is a Gram-positive bacterium that is prevalent on human skin. It has been associated with skin disorders such as acne vulgaris and progressive macular hypomelanosis (PMH). Here, we report draft genome sequences of two type III P. acnes strains, PMH5 and PMH7, isolated from PMH skin lesions.

scholarly journals Silver nanoparticles incorporated into nanostructured biopolymer membranes produced by electrospinning: a study of antimicrobial activity

2015 ◽  
Vol 51 (4) ◽  
pp. 911-921 ◽  
Author(s):  
Karen Segala ◽  
Silvia Vaz Guerra Nista ◽  
Lívia Cordi ◽  
Maria Trindade Marques Bizarria ◽  
José de Ávila Júnior ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Escherichia Coli ◽  
Antimicrobial Activity ◽  
Silver Nanoparticles ◽  
Propionibacterium Acnes ◽  
Electrospun Nanofibers ◽  
Gram Positive ◽  
Gram Positive Bacteria ◽  
Nanostructured Membranes ◽  
Average Size

abstract This study examines the antimicrobial activity of silver nanoparticles incorporated into nanostructured membranes made of cellulose acetate (CA) and blends of chitosan/poly-(ethylene oxide, CTS/PEO) and prepared by electrospinning. The formation of chemically synthesized Ag nanoparticles (AgNPs) was monitored by UV-visible spectroscopy (UV-Vis) and characterized by transmission electron microscopy (TEM). The size distribution of the AgNPs was measured by dynamic light scattering (DLS), with an average size of approximately 20 nm. The presence of AgNPs on the surface of electrospun nanofibers was observed by field emission electron microscopy (FEG) and confirmed by TEM. The antimicrobial activity of AgNPs incorporated into nanostructured membranes made of CA and CTS/PEO electrospun nanofibers was evaluated in the presence of both Gram-positive bacteria, such as Staphylococcus aureus ATCC 29213 and Propionibacterium acnes ATCC 6919, and Gram-negative bacteria, such as Escherichia coli ATCC 25992 and Pseudomonas aeruginosa ATCC 17933. Microbiological results showed that the presence of AgNPs in CA and CTS/PEO nanostructured membranes has significant antimicrobial activity for the Gram-positive bacteria Escherichia coli and Propionibacterium acnes.

Characterization of the housekeeping sortase from the human pathogen Propionibacterium acnes: first investigation of a class F sortase

2019 ◽  
Vol 476 (4) ◽  
pp. 665-682 ◽  
Author(s):  
Salvatore Di Girolamo ◽  
Chasper Puorger ◽  
Mara Castiglione ◽  
Maren Vogel ◽  
Rémy Gébleux ◽  
...  
Keyword(s):  
Protein Engineering ◽  
Propionibacterium Acnes ◽  
Covalent Attachment ◽  
Sortase A ◽  
Engineering Applications ◽  
Gram Positive ◽  
Gram Positive Bacteria ◽  
Class A ◽  
Class F

Abstract Sortase enzymes play an important role in Gram-positive bacteria. They are responsible for the covalent attachment of proteins to the surface of the bacteria and perform this task via a highly sequence-specific transpeptidation reaction. Since these immobilized proteins are often involved in pathogenicity of Gram-positive bacteria, characterization of this type of enzyme is also of medical relevance. Different classes of sortases (A–F) have been found, which recognize characteristic recognition sequences present in substrate proteins. Up to date, sortase A from Staphylococcus aureus, a housekeeping class A sortase, is the most thoroughly studied representative of the sortase family of enzymes. Here we report the in-depth characterization of the class F sortase from Propionibacterium acnes, a class of sortases that has not been investigated before. As Sortase F is the only transpeptidase found in the P. acnes genome, it is the housekeeping sortase of this organism. Sortase F from P. acnes shows a behavior similar to sortases from class A in terms of pH dependence, recognition sequence and catalytic activity; furthermore, its activity is independent of bivalent ions, which contrasts to sortase A from S. aureus. We demonstrate that sortase F is useful for protein engineering applications, by producing a site-specifically conjugated homogenous antibody–drug conjugate with a potency similar to that of a conjugate prepared with sortase A. Thus, the detailed characterization presented here will not only enable the development of anti-virulence agents targeting P. acnes but also provides a powerful alternative to sortase A for protein engineering applications.

scholarly journals Efficient Photodynamic Killing of Gram-Positive Bacteria by Synthetic Curcuminoids

2020 ◽  
Vol 21 (23) ◽  
pp. 9024
Author(s):  
Sung-Jen Hung ◽  
Yi-An Hong ◽  
Kai-Yu Lin ◽  
Yi-Wen Hua ◽  
Chia-Jou Kuo ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Staphylococcus Epidermidis ◽  
Low Dose ◽  
Propionibacterium Acnes ◽  
Aerobic Bacteria ◽  
Gram Positive ◽  
Synthetic Compounds ◽  
Gram Positive Bacteria ◽  
Curcumin Analogs ◽  
Better Than

In our previous study, we have demonstrated that curcumin can efficiently kill the anaerobic bacterium Propionibacterium acnes by irradiation with low-dose blue light. The curcuminoids present in natural plant turmeric mainly include curcumin, demethoxycurcumin, and bisdemethoxycurcumin. However, only curcumin is commercially available. Eighteen different curcumin analogs, including demethoxycurcumin and bisdemethoxycurcumin, were synthesized in this study. Their antibacterial activity against Gram-positive aerobic bacteria Staphylococcus aureus and Staphylococcus epidermidis was investigated using the photodynamic inactivation method. Among the three compounds in turmeric, curcumin activity is the weakest, and bisdemethoxycurcumin possesses the strongest activity. However, two synthetic compounds, (1E,6E)-1,7-bis(5-methylthiophen-2-yl)hepta-1,6-diene-3,5-dione and (1E,6E)-1,7-di(thiophen-2-yl)hepta-1,6-diene-3,5-dione, possess the best antibacterial activity among all compounds examined in this study. Their chemical stability is also better than that of bisdemethoxycurcumin, and thus has potential for future clinical applications.

scholarly journals Dairy Intake and Acne Vulgaris: A Systematic Review and Meta-Analysis of 78,529 Children, Adolescents, and Young Adults

Nutrients ◽  
2018 ◽  
Vol 10 (8) ◽  
pp. 1049 ◽  
Author(s):  
Christian Juhl ◽  
Helle Bergholdt ◽  
Iben Miller ◽  
Gregor Jemec ◽  
Jørgen Kanters ◽  
...  
Keyword(s):  
Young Adults ◽  
Publication Bias ◽  
Meta Analysis ◽  
Acne Vulgaris ◽  
Skim Milk ◽  
Adolescents And Young Adults ◽  
Dairy Intake ◽  
Whole Milk ◽  
Study Characteristics ◽  
Meta Analyses

A meta-analysis can help inform the debate about the epidemiological evidence on dairy intake and development of acne. A systematic literature search of PubMed from inception to 11 December 2017 was performed to estimate the association of dairy intake and acne in children, adolescents, and young adults in observational studies. We estimated the pooled random effects odds ratio (OR) (95% CI), heterogeneity (I2-statistics, Q-statistics), and publication bias. We included 14 studies (n = 78,529; 23,046 acne-cases/55,483 controls) aged 7–30 years. ORs for acne were 1.25 (95% CI: 1.15–1.36; p = 6.13 × 10−8) for any dairy, 1.22 (1.08–1.38; p = 1.62 × 10−3) for full-fat dairy, 1.28 (1.13–1.44; p = 8.23 × 10−5) for any milk, 1.22 (1.06–1.41; p = 6.66 × 10−3) for whole milk, 1.32 (1.16–1.52; p = 4.33 × 10−5) for low-fat/skim milk, 1.22 (1.00–1.50; p = 5.21 × 10−2) for cheese, and 1.36 (1.05–1.77; p = 2.21 × 10−2) for yogurt compared to no intake. ORs per frequency of any milk intake were 1.24 (0.95–1.62) by 2–6 glasses per week, 1.41 (1.05–1.90) by 1 glass per day, and 1.43 (1.09–1.88) by ≥2 glasses per day compared to intake less than weekly. Adjusted results were attenuated and compared unadjusted. There was publication bias (p = 4.71 × 10−3), and heterogeneity in the meta-analyses were explained by dairy and study characteristics. In conclusion, any dairy, such as milk, yogurt, and cheese, was associated with an increased OR for acne in individuals aged 7–30 years. However, results should be interpreted with caution due to heterogeneity and bias across studies.

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