CLINICAL FEATURES AND COAGULATION ABNORMALITIES IN CHILDREN WITH SEPSIS AT DANANG HOSPITAL FOR WOMEN AND CHILDREN

2018 ◽  
pp. 97-103
Author(s):  
Huu Hoi Vo ◽  
Binh Bao Son Bui

Objective: To determine the relationship between coagulation abnormalities and main clinical features, and hematologic tests. Methods: A descriptive cross-sectional study was conducted in 65 children with sepsis at the PICU, Da Nang Hospital for Women and Children from April 2012 to June 2013. Results: The frequency of internal hemorrhage in septic shock children was significantly higher than in children with sepsis (p < 0.001). The rate of thrombocytopenia was 30.8%, in which 10.8% of the children had severe thrombocytopenia (<50 x 109/l). Hypofibrinogenemia was observed in 30.8% of the patients, in which severe hypofibrinogenemia (≤ 1 g/l) was observed in 16.9% of the children. The frequency of reduced prothrombin ratio was 40%, in which 23.1% of the patients had prothrombin ratio < 50%. 35.4% of the patients had rAPTT > 1.15. Positive D-dimer and DIC were observed in 53.8% and 20% of the patients, respectively. Hemostatic changes showed the significant relationship with hemorrhage and the mortality of sepsis. Conclusion: Children with sepsis, especially septic shock were at high risk of coagulation dysfunction and coagulation abnormalities showed the correlation with hemorrhage and the mortality of sepsis. Key words: coagulation abnormalities, sepsis, children

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Hlma Ismail ◽  
Mosa Shibani ◽  
Hanaa Wael Zahrawi ◽  
Ali Fouad Slitin ◽  
Mhd Amin Alzabibi ◽  
...  

Abstract Background Breast cancer is the most common cancer among women and the second leading cause of cancer death globally. Since early diagnosis is crucial to reducing mortality, high levels of knowledge regarding general information, risk factors, and symptoms are required among healthcare professionals to deliver breast cancer care. This study aimed to determine Syrian medical students’ knowledge about breast cancer in the fields of general knowledge, common clinical features, and risk factors. Methods This cross-sectional study was conducted at the Syrian Private University in October 2019 (Breast Cancer Awareness Month), Damascus, during the Syrian war crisis. Data were collected through self-administered surveys and analyzed using the Statistical Package for Social Sciences version 25.0 (SPSS Inc., United States). The chi-square test was applied to assess the relationship between the level of knowledge and gender. One way analysis of variance was performed to assess the overall differences in mean knowledge score by study year, GPA, mother’s education, and source of information. Unpaired Student’s T-test was used to analyze the differences in mean knowledge scores (continuous variable) based on smoking status and alcohol consumption. Results Of 320 students, 301 completed the questionnaire (response rate = 94.0%), of which 179(59.5%) were males. The study revealed above-average knowledge scores (total mean = 68.4%) regarding breast cancer, general information (71.9%), common clinical features (71.6%), and risk factors (71.6%). Clinical students (4th, 5th, and 6th years) scored higher compared with pre-clinical students (1st, 2nd, and 3rd years). Conclusion This study showed above-average knowledge scores regarding breast cancer. More efforts to correct misinformation, through reassessing the university curriculum and promoting awareness about breast cancer are required.


2018 ◽  
Vol 3 (4) ◽  
pp. e000786 ◽  
Author(s):  
Akira Shibanuma ◽  
Francis Yeji ◽  
Sumiyo Okawa ◽  
Emmanuel Mahama ◽  
Kimiyo Kikuchi ◽  
...  

IntroductionThe continuum of care has recently received attention in maternal, newborn and child health. It can be an effective policy framework to ensure that every woman and child receives timely and appropriate services throughout the continuum. However, a commonly used measurement does not evaluate if a pair of woman and child complies with the continuum of care. This study assessed the continuum of care based on two measurements: continuous visits to health facilities (measurement 1) and receiving key components of services (measurement 2). It also explored individual-level and area-level factors associated with the continuum of care achievement and then investigated how the continuum of care differed across areas.MethodsIn this cross-sectional study in Ghana in 2013, the continuum of care achievement and other characteristics of 1401 pairs of randomly selected women and children were collected. Multilevel logistic regression was used to estimate the factors associated with the continuum of care and its divergence across 22 areas.ResultsThroughout the pregnancy, delivery and post-delivery stages, 7.9% of women and children achieved the continuum of care through continuous visits to health facilities (measurement 1). Meanwhile, 10.3% achieved the continuum of care by receiving all key components of maternal, newborn and child health services (measurement 2). Only 1.8% of them achieved it under both measurements. Women and children from wealthier households were more likely to achieve the continuum of care under both measurements. Women’s education and complications were associated with higher continuum of care services-based achievement. Variance of a random intercept was larger in the continuum of care services-based model than the visit-based model.ConclusionsMost women and children failed to achieve the continuum of care in maternal, newborn and child health. Those who consistently visited health facilities did not necessarily receive key components of services.


2002 ◽  
Vol 24 (1) ◽  
pp. 18-25 ◽  
Author(s):  
Flávio Soares de Araújo ◽  
Kátia Petribú ◽  
Othon Bastos

OBJECTIVE: The authors carried out a cross-sectional study with the aim of characterizing and describing depressive pictures in schizophrenic patients seen at the Psychiatry Outpatient Clinic of the Federal University of Pernambuco (HC-UFPE). The patients had the diagnosis of schizophrenia confirmed on the basis of the operating criteria of the DSM-IV. METHODS: Those who where in the period of stabilization of the clinical picture were selected for the study defined according the following criteria:the last psychotic episode must be happened two months before at least, and during this period the alterations of the antipsychotics doses had been lower than 5 mg of haloperidol or equivalent doses of others neuroleptics. A total of one hundred and four patients took part. Following the identification of the depressive symptoms using the Calgary Depression Scale for Schizophrenia (CDSS), thirty-one patients (29.8%) fulfilled the diagnostic criteria described in the DSM-IV. Of these, 22.1% had the diagnosis of major depression and 7.7% of minor depression according the DSM-IV. Two groups were constituted: Group A, schizophrenics with a depressive syndrome, and Group B, schizophrenics without such a syndrome. An assessment was made of the distribution of the symptoms of the CDSS scores in both groups, the sociodemographic, clinical and therapeutic variables in relation to the frequency of the depressive syndrome, and the patients clinical course. For the investigation of certain clinical features, the following tools were used: problem list (psychosocial stressors) contained in axis IV of the DSM-IV intended to detect the presence of factors triggering the initial episode of schizophrenia and the Global Assessment of Functioning (GAF -- Axis V -- DSM-IV) to characterize the current functioning of the patients. CONCLUSIONS: The results obtained allowed the authors to draw the following conclusions: all the items that comprise the Brazilian version of the CDSS were statistically significant in characterizing the depressive syndrome; a comparison of the sociodemographic and therapeutic variables revealed no statistically significant differences between the two groups, and this was also the case with the majority of the clinical features. Statistically significant differences, however, were found in relation to the greater frequency of life events (psychosocial stressors) in triggering the first episode of schizophrenia and the higher incidence of affective disorders antecedents in family members (first and second degree) among the depressed patients. The mean duration of the depressive syndrome during follow-up of the patients was 5.30 months. The patients in whom there was a recurrence of the psychotic episode presented a delusional-hallucinatory clinical picture. This study seeks to contribute to the inclusion of the Postpsychotic Depressive Disorder (PSD) of Schizophrenia (DSM-IV), in the group of Schizophrenic Disorders.


2020 ◽  
Vol 42 (4) ◽  
pp. 373-381
Author(s):  
Hanife Kocakaya ◽  
Emrah Songur ◽  
Sedat Batmaz ◽  
Zekiye Çelikbaş ◽  
Önder Küçük

2016 ◽  
Vol 44 (5) ◽  
pp. 193
Author(s):  
Rini Sunarwati ◽  
Dwi Putro Widodo ◽  
Bambang Madiyono ◽  
Willy Edith HP

Background Symptoms of depression often emerge in childrenwith epilepsy, but parents or caregivers are not always able torecognize them.Objective To assess the prevalence and clinical features of de-pressive syndrome among pediatric epilepsy patients in CiptoMangunkusumo Hospital, Jakarta.Methods This was a cross-sectional study on children aged 8-18 years. Child Depression Inventory (CDI) was used as theinstrument for assessing depressive symptoms.Results Depressive syndrome was found in 34 out of 89 subjects.The three most frequent depression symptoms were self-deprecation (via peer comparison), indecisiveness, and pessimism.Frequency of seizures, mode of therapy, and EEG result wereimportant factors in the development of depressive syndrome inchildren with epilepsy.Conclusions The prevalence of depressive syndrome in childrenwith epilepsy was 38%. Symptoms of depression mostly found inthis study were self-deprecation (via peer comparison), indecisive-ness, and pessimism


2017 ◽  
Vol 7 (3) ◽  
pp. 25-28
Author(s):  
Amshu Dhakal ◽  
Shrooti Shah ◽  
Babita Singh

Background: Labor pain is a universal phenomenon and it is associated with the contraction of uterus. Rather than making the pain disappear with pharmacotherapy, the nurses can assist the laboring women to cope up with, build their self-confidence and maintain a sense of mastery of well-being. Thus, nurses must have knowledge to assess pain to implement pain relief strategies. Methods: A descriptive cross-sectional study was carried out among 52 nurses of Siddhartha Women and Children Hospital, Butwal, Nepal to assess Knowledge about Non-pharmacological Methods of Pain Relief during Labor using structured self-administered questionnaire. The reliability of the tool after pretesting was 0.883. Descriptive statistics was used to analyze the data. Results: Among 52 nurses, 36.5% were 18-22 years of age, 46.2% of them had qualification of Proficiency certificate level Nursing, 40.4% had experience of 3 years- 6 years. In this study, 46.2% had satisfactory knowledge about non-pharmacological methods of pain relief during labor, 32.6% had fair knowledge and remaining 21.2% had poor knowledge. Conclusion: This study concluded that less than half of the nurses had satisfactory knowledge about non-pharmacological methods of pain relief during labor. Since, there is an increased risk of complications resulting from pain and anxiety during labor, management of pain is very essential thus nurse’s knowledge on these methods is crucial. Hence, the nurses should be encouraged to enhance knowledge related to management of labor pain.


2021 ◽  
Vol 17 ◽  
Author(s):  
Mateusz Puchala ◽  
Andrzej Rydzewski ◽  
Ilona Kowalik ◽  
Małgorzata Wisłowska

Background: GPA is a necrotizing inflammation of the small vessels with granulomas. Kidney involvement deteriorated its prognosis. Objective: Comparison of GPA patients with kidney (KI) and without kidney involvement (nKI). Material and methods: We conducted a cross-sectional study of 50 consecutive adult GPA patients, 25 KI from Nephrology and 25 nKI from Rheumatology Department of Central Clinical Hospital Ministry of Interior in Warsaw. We analyzed clinical features, organ involvement, laboratory, serological, imaging, histopathological data, BVAS, treatment. Results: The mean age of KI patients was statistically older then nKI (67.3±9.5 vs 55.1±15.9, p=0.002). Generalized, severe, resistance disease was observed respectively in 92% vs 44%, p<0.001. The number of red blood cells (3.47 vs 4.41T/l, p<0.001), hemoglobin (10.0 vs 12.9g/dl, p<0.001) was lower in KI, higher mean serum creatinine (3.95 vs. 0.89mg/dl, p<0.001), lower GFR (20.1 vs. 79.3, p<0.001), higher CRP (median: 43.4 vs 2.0mg/l, p<0.001), BVAS (16.6±4.4 vs 10.1±6.2, p<0.001), c-ANCA (median: 119.0 vs 15.2CU, p=0.017). Nodules in 28% KI, in 4% nKI (p=0.048) in chest X-ray, infiltration in 43.5% KI, in 15% nKI (p=0.042) in HRCT were observed. Skin granulomas were found in 61.5% nKI vs 18.2% KI, (p=0.047). Renal biopsy revealed in KI patients focal segmental glomerulonephritis in 11.8%, crescentic glomerulonephritis in 17.6%, pauci-immune crescentic glomerulonephritis in 70.6%. Conclusions: In patients with KI more frequently we found generalized, severe, resistant GPA, higher BVAS in comparison in patients without KI. The results of laboratory parameters, were worse in patients with KI. Aggressive immunosuppressive treatment is often used in KI group.


The Knee ◽  
2019 ◽  
Vol 26 (1) ◽  
pp. 165-173 ◽  
Author(s):  
Eleuterio A. Sánchez-Romero ◽  
Daniel Pecos-Martín ◽  
Cesar Calvo-Lobo ◽  
David García-Jiménez ◽  
Victoria Ochoa-Sáez ◽  
...  

2020 ◽  
Vol 2 (1) ◽  
pp. 7-12
Author(s):  
Dinesh Kumar Thapa ◽  
Pankaj Raj Nepal ◽  
Karuna Tamrakar Karki

Background and purpose: The incidence of Epilepsy is high all over Nepal. This study was conducted to analyze the relationship between the incidence of seizure and neurocysticercosis (NCC) among patients admitted to our hospital in Far Eastern Nepal. Material and method: A descriptive cross-sectional study was done among patients diagnosed as NCC with a seizure disorder in B & C Medical College Teaching, from September 2017 to August 2018. Neurocysticercosis was diagnosed based on Computer Tomography (CT), Magnetic Resonance Imaging (MRI), clinical features and laboratory investigations matching Del Brutto’s absolute and major criteria. Result: 103 patients were admitted to the hospital with clinical features of seizure disorder. Neurocysticercosis was diagnosed in 29(28%) patients. Among them, 21(72.41%) were males and 8(27.59%) were females. Patients presented with Generalized tonic-clonic seizure (GTCS) were 18(62%) and 3(10.35%) patients had focal seizures. Focal Seizure with secondary generalization (FSSG) was seen in 5(17%), 2(7%) had status epilepticus and 1(3.45%) patient had presented with absence seizure. Most of the patients 18(62%) had a calcified stage of NCC with perilesional edema in neuroimaging. Phenytoin was the most commonly used intravenous antiepileptic drug (AED) followed by Levetiracetam and Sodium Valproate. Carbamazepine was the most common oral AED used.  Conclusion: NCC is the most common finding among seizure patients admitted to our hospital. The incidence of NCC is high in Eastern Nepal. Poor hygiene, insanitation, low socioeconomic status and lack of awareness were the key factors in spreading NCC.


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